In JoVE (1)
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Articles by Patrick W. F. Hadoke in JoVE
Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography Nicholas S. Kirkby1, Lucinda Low1, Junxi Wu1, Eileen Miller1, Jonathan R. Seckl1, Brian R. Walker1, David J. Webb1, Patrick W. F. Hadoke1 1University/ BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen's Medical Research Institute Ex vivo analysis of arterial lesions from animal models of cardiovascular disease classically relies on histological and immunohistochemical techniques. These provide 2-dimensional measurements in 3-dimensional lesions. This manuscript describes the generation of arterial lesions for quantitative analysis in 3-dimensions using optical projection tomography.