Patrick Vanscheeuwijck PMI R&D Philip Morris Products S.A. Biography Publications Institution JoVE Articles Patrick Vanscheeuwijck has not added a biography. If you are Patrick Vanscheeuwijck and would like to personalize this page please email our Author Liaison for assistance. Publications Discriminating Spontaneous From Cigarette Smoke and THS 2.2 Aerosol Exposure-Related Proliferative Lung Lesions in A/J Mice by Using Gene Expression and Mutation Spectrum Data Frontiers in Toxicology. 2021 | Pubmed ID: 35295134 Impact of 6-Month Exposure to Aerosols From Potential Modified Risk Tobacco Products Relative to Cigarette Smoke on the Rodent Gastrointestinal Tract Frontiers in Microbiology. 2021 | Pubmed ID: 34276574 A 6-month Inhalation Toxicology Study in Apoe Mice Demonstrates Substantially Lower Effects of E-vapor Aerosol Compared with Cigarette Smoke in the Respiratory Tract Archives of Toxicology. 05, 2021 | Pubmed ID: 33963423 Impact of Whole-body Versus Nose-only Inhalation Exposure Systems on Systemic, Respiratory, and Cardiovascular Endpoints in a 2-month Cigarette Smoke Exposure Study in the ApoE Mouse Model Journal of Applied Toxicology : JAT. 10, 2021 | Pubmed ID: 33825214 Profiling of a Natural Alkaloid, Anatabine, in Rodents: Pharmacokinetics and Anti-Inflammatory Efficacy Journal of Natural Products. 04, 2021 | Pubmed ID: 33706515 Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice Toxicological Sciences : an Official Journal of the Society of Toxicology. 11, 2020 | Pubmed ID: 32780831 Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke Toxicological Sciences : an Official Journal of the Society of Toxicology. 11, 2020 | Pubmed ID: 32780830 Multi-omics Systems Toxicology Study of Mouse Lung Assessing the Effects of Aerosols from Two Heat-not-burn Tobacco Products and Cigarette Smoke Computational and Structural Biotechnology Journal. 2020 | Pubmed ID: 32419906 Evaluation of Toxicity of Aerosols from Flavored E-liquids in Sprague-Dawley Rats in a 90-day OECD Inhalation Study, Complemented by Transcriptomics Analysis Archives of Toxicology. 06, 2020 | Pubmed ID: 32367274 Development of an Integrated Assay in Human TK6 Cells to Permit Comprehensive Genotoxicity Analysis in Vitro Mutation Research. Genetic Toxicology and Environmental Mutagenesis. Jan, 2020 | Pubmed ID: 32087850 Structural, Functional, and Molecular Impact on the Cardiovascular System in ApoE Mice Exposed to Aerosol from Candidate Modified Risk Tobacco Products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, Compared with Cigarette Smoke Chemico-biological Interactions. Jan, 2020 | Pubmed ID: 31705857 Lysosomotropic-related Limitations of the BALB/c 3T3 Cell-based Neutral Red Uptake Assay and an Alternative Testing Approach for Assessing E-liquid Cytotoxicity Toxicology in Vitro : an International Journal Published in Association with BIBRA. Dec, 2019 | Pubmed ID: 31518669 Respirable Aerosol Exposures of Nicotine Dry Powder Formulations to , , and Pre-clinical Models Demonstrate Consistency of Pharmacokinetic Profiles Inhalation Toxicology. 05, 2019 | Pubmed ID: 31496314 Mode-of-action Analysis of the Effects Induced by Nicotine in the in Vitro Micronucleus Assay Environmental and Molecular Mutagenesis. 12, 2019 | Pubmed ID: 31294873 Assessing the Lung Cancer Risk Reduction Potential of Candidate Modified Risk Tobacco Products Internal and Emergency Medicine. 09, 2019 | Pubmed ID: 30767158 A Six-month Systems Toxicology Inhalation/cessation Study in ApoE Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Modified Risk Tobacco Products, CHTP 1.2 and THS 2.2, Compared with Conventional Cigarettes Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Apr, 2019 | Pubmed ID: 30763686 Biological Changes in C57BL/6 Mice Following 3 weeks of Inhalation Exposure to Cigarette Smoke or E-vapor Aerosols Inhalation Toxicology. Nov - Dec, 2018 | Pubmed ID: 30849254 A 90-day OECD TG 413 Rat Inhalation Study with Systems Toxicology Endpoints Demonstrates Reduced Exposure Effects of the Aerosol from the Carbon Heated Tobacco Product Version 1.2 (CHTP1.2) Compared with Cigarette Smoke. I. Inhalation Exposure, Clinical Pathology and Histopathology Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Jun, 2018 | Pubmed ID: 29654848 A 90-day OECD TG 413 Rat Inhalation Study with Systems Toxicology Endpoints Demonstrates Reduced Exposure Effects of the Aerosol from the Carbon Heated Tobacco Product Version 1.2 (CHTP1.2) Compared with Cigarette Smoke. II. Systems Toxicology Assessment Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. May, 2018 | Pubmed ID: 29545142 Supporting Evidence-based Analysis for Modified Risk Tobacco Products Through a Toxicology Data-sharing Infrastructure F1000Research. 2017 | Pubmed ID: 29123642 Toxicity of the Main Electronic Cigarette Components, Propylene Glycol, Glycerin, and Nicotine, in Sprague-Dawley Rats in a 90-day OECD Inhalation Study Complemented by Molecular Endpoints Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Nov, 2017 | Pubmed ID: 28882640 Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 Rat Inhalation Study with Systems Toxicology Endpoints Demonstrates Reduced Exposure Effects of a Mentholated Version Compared with Mentholated and Non-mentholated Cigarette Smoke Regulatory Toxicology and Pharmacology : RTP. Nov, 2016 | Pubmed ID: 27818348 Evaluation of the Tobacco Heating System 2.2. Part 7: Systems Toxicological Assessment of a Mentholated Version Revealed Reduced Cellular and Molecular Exposure Effects Compared with Mentholated and Non-mentholated Cigarette Smoke Regulatory Toxicology and Pharmacology : RTP. Nov, 2016 | Pubmed ID: 27818347 Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 Rat Inhalation Study with Systems Toxicology Endpoints Demonstrates Reduced Exposure Effects Compared with Cigarette Smoke Regulatory Toxicology and Pharmacology : RTP. Nov, 2016 | Pubmed ID: 27793746 Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical Composition, Genotoxicity, Cytotoxicity, and Physical Properties of the Aerosol Regulatory Toxicology and Pharmacology : RTP. Nov, 2016 | Pubmed ID: 27720919 Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the System and the Scientific Assessment Program Regulatory Toxicology and Pharmacology : RTP. Nov, 2016 | Pubmed ID: 27450400 Comprehensive Systems Biology Analysis of a 7-month Cigarette Smoke Inhalation Study in C57BL/6 Mice Scientific Data. 2016 | Pubmed ID: 26731301 An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes Toxicological Sciences : an Official Journal of the Society of Toxicology. Feb, 2016 | Pubmed ID: 26609137 A 7-month Cigarette Smoke Inhalation Study in C57BL/6 Mice Demonstrates Reduced Lung Inflammation and Emphysema Following Smoking Cessation or Aerosol Exposure from a Prototypic Modified Risk Tobacco Product Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Jun, 2015 | Pubmed ID: 25843363 Systems Toxicology Approaches Enable Mechanistic Comparison of Spontaneous and Cigarette Smoke-related Lung Tumor Development in the A/J Mouse Model Interdisciplinary Toxicology. Jun, 2014 | Pubmed ID: 26109882 A 28-day Rat Inhalation Study with an Integrated Molecular Toxicology Endpoint Demonstrates Reduced Exposure Effects for a Prototypic Modified Risk Tobacco Product Compared with Conventional Cigarettes Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Jun, 2014 | Pubmed ID: 24632068 Cigarette Smoke Induces Molecular Responses in Respiratory Tissues of ApoE(-/-) Mice That Are Progressively Deactivated Upon Cessation Toxicology. Dec, 2013 | Pubmed ID: 24096154 Use of Capillary Aerosol Generator in Continuous Production of Controlled Aerosol for Non-Clinical Studies Didier Goedertier1, Sandra Schorderet Weber1, Francesco Lucci1, Tom Lee2, Wei Teck Tan2, Falk Radtke1, Subash Krishnan2, Patrick Vanscheeuwijck1, Arkadiusz K. Kuczaj1,3, Julia Hoeng1 1PMI R&D, Philip Morris Products S.A., 2PMI R&D, Philip Morris Research Laboratories Pte. Ltd., 3Applied Mathematics, University of Twente JoVE 61021 Engineering
Use of Capillary Aerosol Generator in Continuous Production of Controlled Aerosol for Non-Clinical Studies Didier Goedertier1, Sandra Schorderet Weber1, Francesco Lucci1, Tom Lee2, Wei Teck Tan2, Falk Radtke1, Subash Krishnan2, Patrick Vanscheeuwijck1, Arkadiusz K. Kuczaj1,3, Julia Hoeng1 1PMI R&D, Philip Morris Products S.A., 2PMI R&D, Philip Morris Research Laboratories Pte. Ltd., 3Applied Mathematics, University of Twente JoVE 61021 Engineering
