Paul D. W. Eckford Programme in Molecular Structure and Function Hospital for Sick Children Biography Publications Institution JoVE Articles Paul D. W. Eckford has not added a biography. If you are Paul D. W. Eckford and would like to personalize this page please email our Author Liaison for assistance. Publications VX-809 and Related Corrector Compounds Exhibit Secondary Activity Stabilizing Active F508del-CFTR After Its Partial Rescue to the Cell Surface Chemistry & Biology. May, 2014 | Pubmed ID: 24726831 Proton-dependent Gating and Proton Uptake by Wzx Support O-antigen-subunit Antiport Across the Bacterial Inner Membrane MBio. 2013 | Pubmed ID: 24023388 Functional Rescue of F508del-CFTR Using Small Molecule Correctors Frontiers in Pharmacology. 2012 | Pubmed ID: 23055971 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiator VX-770 (ivacaftor) Opens the Defective Channel Gate of Mutant CFTR in a Phosphorylation-dependent but ATP-independent Manner The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22942289 Identification and Validation of Hits from High Throughput Screens for CFTR Modulators Current Pharmaceutical Design. 2012 | Pubmed ID: 22229556 Synthesis and Properties of Molecular Probes for the Rescue Site on Mutant Cystic Fibrosis Transmembrane Conductance Regulator Journal of Medicinal Chemistry. Dec, 2011 | Pubmed ID: 22074181 Insights into the Mechanisms Underlying CFTR Channel Activity, the Molecular Basis for Cystic Fibrosis and Strategies for Therapy Essays in Biochemistry. Sep, 2011 | Pubmed ID: 21967060 Structural Basis for Alginate Secretion Across the Bacterial Outer Membrane Proceedings of the National Academy of Sciences of the United States of America. Aug, 2011 | Pubmed ID: 21778407 Targeting the Regulation of CFTR Channels The Biochemical Journal. Apr, 2011 | Pubmed ID: 21726198 The Reconstituted Escherichia Coli MsbA Protein Displays Lipid Flippase Activity The Biochemical Journal. Jul, 2010 | Pubmed ID: 20412049 ABC Efflux Pump-based Resistance to Chemotherapy Drugs Chemical Reviews. Jul, 2009 | Pubmed ID: 19583429 Interaction of the P-glycoprotein Multidrug Efflux Pump with Cholesterol: Effects on ATPase Activity, Drug Binding and Transport Biochemistry. Dec, 2008 | Pubmed ID: 19049391 Functional Characterization of Escherichia Coli MsbA: Interaction with Nucleotides and Substrates The Journal of Biological Chemistry. May, 2008 | Pubmed ID: 18344567 P-glycoprotein (ABCB1) Interacts Directly with Lipid-based Anti-cancer Drugs and Platelet-activating Factors Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. Dec, 2006 | Pubmed ID: 17215888 New Insights into the Drug Binding, Transport and Lipid Flippase Activities of the P-glycoprotein Multidrug Transporter Journal of Bioenergetics and Biomembranes. Dec, 2005 | Pubmed ID: 16691487 The Reconstituted P-glycoprotein Multidrug Transporter is a Flippase for Glucosylceramide and Other Simple Glycosphingolipids The Biochemical Journal. Jul, 2005 | Pubmed ID: 15799713 Reconstitution of Membrane Transporters Methods in Molecular Biology (Clifton, N.J.). 2003 | Pubmed ID: 12824648 Functionele Het oplossen en Channel activiteit Metingen van gezuiverde wildtype en mutante CFTR eiwit Paul D. W. Eckford1, Canhui Li1, Christine E. Bear1,2,3 1Programme in Molecular Structure and Function, Hospital for Sick Children, 2Department of Biochemistry, University of Toronto, 3Department of Physiology, University of Toronto JoVE 52427 Biology
Functionele Het oplossen en Channel activiteit Metingen van gezuiverde wildtype en mutante CFTR eiwit Paul D. W. Eckford1, Canhui Li1, Christine E. Bear1,2,3 1Programme in Molecular Structure and Function, Hospital for Sick Children, 2Department of Biochemistry, University of Toronto, 3Department of Physiology, University of Toronto JoVE 52427 Biology
