Paul M.L. Janssen Department of Physiology and Cell Biology The Ohio State University Biography Publications Institution JoVE Articles Paul M.L. Janssen has not added a biography. If you are Paul M.L. Janssen and would like to personalize this page please email our Author Liaison for assistance. Publications Prednisolone Attenuates Improvement of Cardiac and Skeletal Contractile Function and Histopathology by Lisinopril and Spironolactone in the Mdx Mouse Model of Duchenne Muscular Dystrophy PloS One. 2014 | Pubmed ID: 24551095 Small and Large Animal Models in Cardiac Contraction Research: Advantages and Disadvantages Pharmacology & Therapeutics. Mar, 2014 | Pubmed ID: 24140081 Micro-dystrophin and Follistatin Co-delivery Restores Muscle Function in Aged DMD Model Human Molecular Genetics. Dec, 2013 | Pubmed ID: 23863459 Decreased RyR2 Refractoriness Determines Myocardial Synchronization of Aberrant Ca2+ Release in a Genetic Model of Arrhythmia Proceedings of the National Academy of Sciences of the United States of America. Jun, 2013 | Pubmed ID: 23733959 The Positive Inotropic Effect of Pyruvate Involves an Increase in Myofilament Calcium Sensitivity PloS One. 2013 | Pubmed ID: 23691074 N-Glycolylneuraminic Acid Deficiency Worsens Cardiac and Skeletal Muscle Pathophysiology in α-sarcoglycan-deficient Mice Glycobiology. Jul, 2013 | Pubmed ID: 23514716 Myocardial Rac1 Exhibits Partial Involvement in Thyroxin-induced Cardiomyocyte Hypertrophy and Its Inhibition is Not Sufficient to Improve Cardiac Dysfunction or Contractile Abnormalities in Mouse Papillary Muscles Journal of Cardiovascular Pharmacology. Jun, 2013 | Pubmed ID: 23429587 Effect of Muscle Length on Cross-bridge Kinetics in Intact Cardiac Trabeculae at Body Temperature The Journal of General Physiology. Jan, 2013 | Pubmed ID: 23277479 Tropomyosin Ser-283 Pseudo-phosphorylation Slows Myofibril Relaxation Archives of Biochemistry and Biophysics. Jul, 2013 | Pubmed ID: 23232082 Up-regulation of Sarcoplasmic Reticulum Ca(2+) Uptake Leads to Cardiac Hypertrophy, Contractile Dysfunction and Early Mortality in Mice Deficient in CASQ2 Cardiovascular Research. May, 2013 | Pubmed ID: 23135969 Post-translational Modifications of Myofilament Proteins Involved in Length-dependent Prolongation of Relaxation in Rabbit Right Ventricular Myocardium Archives of Biochemistry and Biophysics. Jul, 2013 | Pubmed ID: 23085150 The Force-temperature Relationship in Healthy and Dystrophic Mouse Diaphragm; Implications for Translational Study Design Frontiers in Physiology. 2012 | Pubmed ID: 23162469 Vascular Remodeling-associated Hypertension Leads to Left Ventricular Hypertrophy and Contractile Dysfunction in Profilin-1 Transgenic Mice Journal of Cardiovascular Pharmacology. Dec, 2012 | Pubmed ID: 22967989 Effects of Increased Systolic Ca(2+) and β-adrenergic Stimulation on Ca(2+) Transient Decline in NOS1 Knockout Cardiac Myocytes Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. Dec, 2012 | Pubmed ID: 22960389 Rac-induced Left Ventricular Dilation in Thyroxin-treated ZmRacD Transgenic Mice: Role of Cardiomyocyte Apoptosis and Myocardial Fibrosis PloS One. 2012 | Pubmed ID: 22936985 Role of Endothelin in the Induction of Cardiac Hypertrophy in Vitro PloS One. 2012 | Pubmed ID: 22912821 Impact of Hydroxyl Radical-induced Injury on Calcium Handling and Myofilament Sensitivity in Isolated Myocardium Journal of Applied Physiology (Bethesda, Md. : 1985). Sep, 2012 | Pubmed ID: 22773772 Cardiomyopathy in the Dystrophin/utrophin-deficient Mouse Model of Severe Muscular Dystrophy is Characterized by Dysregulation of Matrix Metalloproteinases Neuromuscular Disorders : NMD. Nov, 2012 | Pubmed ID: 22749475 Homologous Recombination Mediates Functional Recovery of Dysferlin Deficiency Following AAV5 Gene Transfer PloS One. 2012 | Pubmed ID: 22720081 The Rates of Ca2+ Dissociation and Cross-bridge Detachment from Ventricular Myofibrils As Reported by a Fluorescent Cardiac Troponin C The Journal of Biological Chemistry. Aug, 2012 | Pubmed ID: 22718768 Staurosporine Inhibits Frequency-dependent Myofilament Desensitization in Intact Rabbit Cardiac Trabeculae Biochemistry Research International. 2012 | Pubmed ID: 22649731 Sustaining Cardiac Claudin-5 Levels Prevents Functional Hallmarks of Cardiomyopathy in a Muscular Dystrophy Mouse Model Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2012 | Pubmed ID: 22547149 Effects of Increased Preload on the Force-frequency Response and Contractile Kinetics in Early Stages of Cardiac Muscle Hypertrophy American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2012 | Pubmed ID: 22467304 Contractile Parameters and Occurrence of Alternans in Isolated Rat Myocardium at Supra-physiological Stimulation Frequency American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2012 | Pubmed ID: 22467303 IKKα and Alternative NF-κB Regulate PGC-1β to Promote Oxidative Muscle Metabolism The Journal of Cell Biology. Feb, 2012 | Pubmed ID: 22351927 Contractile Strength During Variable Heart Duration is Species and Preload Dependent Journal of Biomedicine & Biotechnology. 2011 | Pubmed ID: 22131801 Mdx(⁵cv) Mice Manifest More Severe Muscle Dysfunction and Diaphragm Force Deficits Than Do Mdx Mice The American Journal of Pathology. Nov, 2011 | Pubmed ID: 21893021 Effect of Twitch Interval Duration on the Contractile Function of Subsequent Twitches in Isolated Rat, Rabbit, and Dog Myocardium Under Physiological Conditions Journal of Applied Physiology (Bethesda, Md. : 1985). Oct, 2011 | Pubmed ID: 21778421 Early Treatment with Lisinopril and Spironolactone Preserves Cardiac and Skeletal Muscle in Duchenne Muscular Dystrophy Mice Circulation. Aug, 2011 | Pubmed ID: 21768542 Effects of Increased Systolic Ca²⁺ and Phospholamban Phosphorylation During β-adrenergic Stimulation on Ca²⁺ Transient Kinetics in Cardiac Myocytes American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2011 | Pubmed ID: 21765055 In Vitro Studies of Early Cardiac Remodeling: Impact on Contraction and Calcium Handling Frontiers in Bioscience (Scholar Edition). 2011 | Pubmed ID: 21622254 Peptide-based Inhibition of NF-κB Rescues Diaphragm Muscle Contractile Dysfunction in a Murine Model of Duchenne Muscular Dystrophy Molecular Medicine (Cambridge, Mass.). May-Jun, 2011 | Pubmed ID: 21267511 Lengthening-contractions in Isolated Myocardium Impact Force Development and Worsen Cardiac Contractile Function in the Mdx Mouse Model of Muscular Dystrophy Journal of Applied Physiology (Bethesda, Md. : 1985). Feb, 2011 | Pubmed ID: 21127205 Effects of Hydroxyl Radical Induced-injury in Atrial Versus Ventricular Myocardium of Dog and Rabbit Frontiers in Physiology. 2010 | Pubmed ID: 21423367 Challenges in Cardiac Muscle Physiology Frontiers in Physiology. 2010 | Pubmed ID: 21423345 Myocardial Contraction-relaxation Coupling American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2010 | Pubmed ID: 20852049 Kinetics of Cardiac Muscle Contraction and Relaxation Are Linked and Determined by Properties of the Cardiac Sarcomere American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2010 | Pubmed ID: 20656885 A Genetic Model of Amyotrophic Lateral Sclerosis in Zebrafish Displays Phenotypic Hallmarks of Motoneuron Disease Disease Models & Mechanisms. Sep-Oct, 2010 | Pubmed ID: 20504969 Increased Phosphorylation of Tropomyosin, Troponin I, and Myosin Light Chain-2 After Stretch in Rabbit Ventricular Myocardium Under Physiological Conditions Journal of Molecular and Cellular Cardiology. May, 2010 | Pubmed ID: 20298699 Effects of Dietary Omega-3 Fatty Acids on Ventricular Function in Dogs with Healed Myocardial Infarctions: in Vivo and in Vitro Studies American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2010 | Pubmed ID: 20097770 Nitroxyl Enhances Myocyte Ca2+ Transients by Exclusively Targeting SR Ca2+-cycling Frontiers in Bioscience (Elite Edition). 2010 | Pubmed ID: 20036906 Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates Science Translational Medicine. Nov, 2009 | Pubmed ID: 20368179 Impairment of Diastolic Function by Lack of Frequency-dependent Myofilament Desensitization Rabbit Right Ventricular Hypertrophy Circulation. Heart Failure. Sep, 2009 | Pubmed ID: 19808378 A Random Cycle Length Approach for Assessment of Myocardial Contraction in Isolated Rabbit Myocardium American Journal of Physiology. Heart and Circulatory Physiology. Nov, 2009 | Pubmed ID: 19749159 Pulmonary Artery Banding Alters the Expression of Ca2+ Transport Proteins in the Right Atrium in Rabbits American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2009 | Pubmed ID: 19376811 Temporal Changes in Expression of Connexin 43 After Load-induced Hypertrophy in Vitro American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2009 | Pubmed ID: 19136602 The Positive Force-frequency Relationship is Maintained in Absence of Sarcoplasmic Reticulum Function in Rabbit, but Not in Rat Myocardium Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology. May, 2009 | Pubmed ID: 19123061 Overexpression of Galgt2 in Skeletal Muscle Prevents Injury Resulting from Eccentric Contractions in Both Mdx and Wild-type Mice American Journal of Physiology. Cell Physiology. Mar, 2009 | Pubmed ID: 19109526 Variability in Interbeat Duration Influences Myocardial Contractility in Rat Cardiac Trabeculae The Open Cardiovascular Medicine Journal. 2008 | Pubmed ID: 19440237 Truncated CASK Does Not Alter Skeletal Muscle or Protein Interactors Muscle & Nerve. Sep, 2008 | Pubmed ID: 18642383 Claudin-5 Levels Are Reduced in Human End-stage Cardiomyopathy Journal of Molecular and Cellular Cardiology. Jul, 2008 | Pubmed ID: 18513742 Neuronal Nitric Oxide Synthase Signaling Within Cardiac Myocytes Targets Phospholamban American Journal of Physiology. Cell Physiology. Jun, 2008 | Pubmed ID: 18400986 Molecular Basis of Diastolic Dysfunction Heart Failure Clinics. Jan, 2008 | Pubmed ID: 18313621 Dissociation of Force Decline from Calcium Decline by Preload in Isolated Rabbit Myocardium Pflügers Archiv : European Journal of Physiology. May, 2008 | Pubmed ID: 18057959 Gender Comparison of Contractile Performance and Beta-adrenergic Response in Isolated Rat Cardiac Trabeculae Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology. Mar, 2008 | Pubmed ID: 18030479 Induction of Hypertrophy in Vitro by Mechanical Loading in Adult Rabbit Myocardium American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2007 | Pubmed ID: 17933962 Determinants of Frequency-dependent Contraction and Relaxation of Mammalian Myocardium Journal of Molecular and Cellular Cardiology. Nov, 2007 | Pubmed ID: 17919652 A Translational Approach for Limb Vascular Delivery of the Micro-dystrophin Gene Without High Volume or High Pressure for Treatment of Duchenne Muscular Dystrophy Journal of Translational Medicine. 2007 | Pubmed ID: 17892583 Atrial Glutathione Content, Calcium Current, and Contractility The Journal of Biological Chemistry. Sep, 2007 | Pubmed ID: 17656369 Influence of Pyruvate on Economy of Contraction in Isolated Rabbit Myocardium European Journal of Heart Failure. Aug, 2007 | Pubmed ID: 17532261 Interplay of IKK/NF-kappaB Signaling in Macrophages and Myofibers Promotes Muscle Degeneration in Duchenne Muscular Dystrophy The Journal of Clinical Investigation. Apr, 2007 | Pubmed ID: 17380205 Frequency-dependent Contractile Strength in Mice Over- and Underexpressing the Sarco(endo)plasmic Reticulum Calcium-ATPase American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jul, 2007 | Pubmed ID: 17255213 Frequency-dependent Acceleration of Relaxation Involves Decreased Myofilament Calcium Sensitivity American Journal of Physiology. Heart and Circulatory Physiology. May, 2007 | Pubmed ID: 17209002 SERCA Overexpression Reduces Hydroxyl Radical Injury in Murine Myocardium American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2006 | Pubmed ID: 16798816 LAMP-2 Deficient Mice Show Depressed Cardiac Contractile Function Without Significant Changes in Calcium Handling Basic Research in Cardiology. Jul, 2006 | Pubmed ID: 16604439 Measurement of Myofilament Calcium Sensitivity at Physiological Temperature in Intact Cardiac Trabeculae American Journal of Physiology. Heart and Circulatory Physiology. May, 2006 | Pubmed ID: 16603708 Frequency-dependent Contractile Response of Isolated Cardiac Trabeculae Under Hypo-, Normo-, and Hyperthermic Conditions Journal of Applied Physiology (Bethesda, Md. : 1985). May, 2006 | Pubmed ID: 16410377 Murine Strain Differences in Contractile Function Are Temperature- and Frequency-dependent Pflügers Archiv : European Journal of Physiology. May, 2006 | Pubmed ID: 16397793 Targeted Overexpression of Sarcolipin in the Mouse Heart Decreases Sarcoplasmic Reticulum Calcium Transport and Cardiac Contractility The Journal of Biological Chemistry. Feb, 2006 | Pubmed ID: 16365042 Effect of Muscle Dimensions on Trabecular Contractile Performance Under Physiological Conditions Pflügers Archiv : European Journal of Physiology. Feb, 2006 | Pubmed ID: 16082545 Utrophin Deficiency Worsens Cardiac Contractile Dysfunction Present in Dystrophin-deficient Mdx Mice American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2005 | Pubmed ID: 16024571 Cardiac Adenoviral S100A1 Gene Delivery Rescues Failing Myocardium The Journal of Clinical Investigation. Dec, 2004 | Pubmed ID: 15578088 Improved Systolic and Diastolic Myocardial Function with Intracoronary Pyruvate in Patients with Congestive Heart Failure European Journal of Heart Failure. Mar, 2004 | Pubmed ID: 14984729 Abnormal Frequency-dependent Responses Represent the Pathophysiologic Signature of Contractile Failure in Human Myocardium Journal of Molecular and Cellular Cardiology. Jan, 2004 | Pubmed ID: 14734045 Frequency- and Afterload-dependent Cardiac Modulation in Vivo by Troponin I with Constitutively Active Protein Kinase A Phosphorylation Sites Circulation Research. Mar, 2004 | Pubmed ID: 14726477 Selective Contractile Dysfunction of Left, Not Right, Ventricular Myocardium in the SHHF Rat American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2003 | Pubmed ID: 12424099 Physiological Determinants of Contractile Force Generation and Calcium Handling in Mouse Myocardium Journal of Molecular and Cellular Cardiology. Oct, 2002 | Pubmed ID: 12392997 Intracellular Beta-blockade: Overexpression of Galpha(i2) Depresses the Beta-adrenergic Response in Intact Myocardium Cardiovascular Research. Aug, 2002 | Pubmed ID: 12123769 Hydroxyl Radical-induced Acute Diastolic Dysfunction is Due to Calcium Overload Via Reverse-mode Na(+)-Ca(2+) Exchange Circulation Research. May, 2002 | Pubmed ID: 12016265 Influence of Pyruvate on Contractile Performance and Ca(2+) Cycling in Isolated Failing Human Myocardium Circulation. Jan, 2002 | Pubmed ID: 11790700 Myofilament Properties Comprise the Rate-limiting Step for Cardiac Relaxation at Body Temperature in the Rat American Journal of Physiology. Heart and Circulatory Physiology. Feb, 2002 | Pubmed ID: 11788397 Potentiation of Beta-adrenergic Inotropic Response by Pyruvate in Failing Human Myocardium Cardiovascular Research. Jan, 2002 | Pubmed ID: 11744019 Tissue Triage and Freezing for Models of Skeletal Muscle Disease Hui Meng1, Paul M.L. Janssen2, Robert W. Grange3, Lin Yang4, Alan H. Beggs5, Lindsay C. Swanson5, Stacy A. Cossette1,6, Alison Frase7, Martin K. Childers8, Henk Granzier9, Emanuela Gussoni5, Michael W. Lawlor1 1Division of Pediatric Pathology, Department of Pathology and Laboratory Medicine, Medical College of Wisconsin, 2Department of Physiology and Cell Biology, The Ohio State University, 3Department of Human Nutrition, Foods and Exercise, Virginia Tech, 4Division of Biomedical Informatics, Department of Biostatistics, Department of Computer Science, University of Kentucky, 5Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, 6Cure Congenital Muscular Dystrophy, 7Joshua Frase Foundation, 8Department of Rehabilitation Medicine, University of Washington, 9Department of Physiology, University of Arizona JoVE 51586 Biology
Tissue Triage and Freezing for Models of Skeletal Muscle Disease Hui Meng1, Paul M.L. Janssen2, Robert W. Grange3, Lin Yang4, Alan H. Beggs5, Lindsay C. Swanson5, Stacy A. Cossette1,6, Alison Frase7, Martin K. Childers8, Henk Granzier9, Emanuela Gussoni5, Michael W. Lawlor1 1Division of Pediatric Pathology, Department of Pathology and Laboratory Medicine, Medical College of Wisconsin, 2Department of Physiology and Cell Biology, The Ohio State University, 3Department of Human Nutrition, Foods and Exercise, Virginia Tech, 4Division of Biomedical Informatics, Department of Biostatistics, Department of Computer Science, University of Kentucky, 5Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, 6Cure Congenital Muscular Dystrophy, 7Joshua Frase Foundation, 8Department of Rehabilitation Medicine, University of Washington, 9Department of Physiology, University of Arizona JoVE 51586 Biology