Paul R. Langford Section of Pediatric Infectious Diseases and Allergy, Department of Medicine Imperial College London Biography Publications Institution JoVE Articles Paul R. Langford has not added a biography. If you are Paul R. Langford and would like to personalize this page please email our Author Liaison for assistance. Publications Pathotyping the Zoonotic Pathogen Streptococcus Suis: Novel Genetic Markers To Differentiate Invasive Disease-Associated Isolates from Non-Disease-Associated Isolates from England and Wales Journal of Clinical Microbiology. Jul, 2019 | Pubmed ID: 30944194 Evidence of Illegitimate Recombination Between Two Plasmids Resulting in a Novel Multi-Resistance Replicon, PM3362MDR, in Frontiers in Microbiology. 2018 | Pubmed ID: 30405558 Bacterial Vaccine Antigen Discovery in the Reverse Vaccinology 2.0 Era: Progress and Challenges Frontiers in Immunology. 2018 | Pubmed ID: 30349542 Galleria Mellonella - a Novel Infection Model for the Mycobacterium Tuberculosis Complex Virulence. 2018 | Pubmed ID: 30067135 Cross-Reactive Bactericidal Antimeningococcal Antibodies Can Be Isolated From Convalescing Invasive Meningococcal Disease Patients Using Reverse Vaccinology 2.0 Frontiers in Immunology. 2018 | Pubmed ID: 30061891 Transcriptomic Analysis of Porcine PBMCs in Response to Actinobacillus Pleuropneumoniae Reveals the Dynamic Changes of Differentially Expressed Genes Related to Immuno-inflammatory Responses Antonie Van Leeuwenhoek. Jul, 2018 | Pubmed ID: 30008077 Comparative Sequence Analysis of the Capsular Polysaccharide Loci of Actinobacillus Pleuropneumoniae Serovars 1-18, and Development of Two Multiplex PCRs for Comprehensive Capsule Typing Veterinary Microbiology. Jul, 2018 | Pubmed ID: 29885806 Proposal of Serovars 17 and 18 of Actinobacillus Pleuropneumoniae Based on Serological and Genotypic Analysis Veterinary Microbiology. Apr, 2018 | Pubmed ID: 29615241 Use of Proteins Identified Through a Functional Genomic Screen To Develop a Protein Subunit Vaccine That Provides Significant Protection Against Virulent Streptococcus Suis in Pigs Infection and Immunity. 03, 2018 | Pubmed ID: 29203546 Characterization of the Actinobacillus Pleuropneumoniae SXT-related Integrative and Conjugative Element ICEApl2 and Analysis of the Encoded FloR Protein: Hydrophobic Residues in Transmembrane Domains Contribute Dynamically to Florfenicol and Chloramphenicol Efflux The Journal of Antimicrobial Chemotherapy. Jan, 2018 | Pubmed ID: 29029160 Regarding Flagellar Expression in Clinical Isolates of Non-typeable Haemophilus Influenzae Journal of Medical Microbiology. Dec, 2017 | Pubmed ID: 29087280 Patterns of Antimicrobial Resistance in Streptococcus Suis Isolates from Pigs with or Without Streptococcal Disease in England Between 2009 and 2014 Veterinary Microbiology. Aug, 2017 | Pubmed ID: 28757010 B Cell Cross-epitope of Propionibacterium Acnes and Actinobacillus Pleuropneumonia Selected by Phage Display Library Can Efficiently Protect from Actinobacillus Pleuropneumonia Infection Veterinary Microbiology. Jun, 2017 | Pubmed ID: 28622855 "Pathotyping" Multiplex PCR Assay for Haemophilus Parasuis: a Tool for Prediction of Virulence Journal of Clinical Microbiology. 09, 2017 | Pubmed ID: 28615466 Haemophilus Parasuis Cytolethal Distending Toxin Induces Cell Cycle Arrest and P53-dependent Apoptosis PloS One. 2017 | Pubmed ID: 28545143 P518, a Small FloR Plasmid from a South American Isolate of Actinobacillus Pleuropneumoniae Veterinary Microbiology. May, 2017 | Pubmed ID: 28532791 Identification of Novel Haemophilus Parasuis Serovar 5 Vaccine Candidates Using an Immunoproteomic Approach Journal of Proteomics. 06, 2017 | Pubmed ID: 28528009 Disruption of Drug-resistant Biofilms Using De Novo Designed Short α-helical Antimicrobial Peptides with Idealized Facial Amphiphilicity Acta Biomaterialia. 07, 2017 | Pubmed ID: 28457962 Whole Genome Sequencing for Surveillance of Antimicrobial Resistance in Frontiers in Microbiology. 2017 | Pubmed ID: 28321207 Inactivation of , Encoding a Sel1-Like Repeat (SLR) Protein, in Neisseria Meningitidis Is Associated with Differential Expression of Genes Belonging to the Fur Regulon and Reduced Intraepithelial Replication Infection and Immunity. 05, 2017 | Pubmed ID: 28264906 The N-linking Glycosylation System from Actinobacillus Pleuropneumoniae is Required for Adhesion and Has Potential Use in Glycoengineering Open Biology. 01, 2017 | Pubmed ID: 28077594 A Unique Capsule Locus in the Newly Designated Actinobacillus Pleuropneumoniae Serovar 16 and Development of a Diagnostic PCR Assay Journal of Clinical Microbiology. 03, 2017 | Pubmed ID: 28053219 A Computational Strategy for the Search of Regulatory Small RNAs in Actinobacillus Pleuropneumoniae RNA (New York, N.Y.). 09, 2016 | Pubmed ID: 27402897 ICEApl1, an Integrative Conjugative Element Related to ICEHin1056, Identified in the Pig Pathogen Actinobacillus Pleuropneumoniae Frontiers in Microbiology. 2016 | Pubmed ID: 27379024 Unnatural Amino Acid Analogues of Membrane-active Helical Peptides with Anti-mycobacterial Activity and Improved Stability The Journal of Antimicrobial Chemotherapy. 08, 2016 | Pubmed ID: 27118774 Complete Genome Sequence of MIDG2331, a Genetically Tractable Serovar 8 Clinical Isolate of Actinobacillus Pleuropneumoniae Genome Announcements. Jan, 2016 | Pubmed ID: 26823596 Whole Genome Investigation of a Divergent Clade of the Pathogen Streptococcus Suis Frontiers in Microbiology. 2015 | Pubmed ID: 26583006 Role of (p)ppGpp in Viability and Biofilm Formation of Actinobacillus Pleuropneumoniae S8 PloS One. 2015 | Pubmed ID: 26509499 Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria Meningitidis and Brucella Abortus Journal of Bacteriology. Dec, 2015 | Pubmed ID: 26459556 Development of a Multiplex PCR Assay for Rapid Molecular Serotyping of Haemophilus Parasuis Journal of Clinical Microbiology. Dec, 2015 | Pubmed ID: 26424843 PHiD-CV Induces Anti-Protein D Antibodies but Does Not Augment Pulmonary Clearance of Nontypeable Haemophilus Influenzae in Mice Vaccine. Sep, 2015 | Pubmed ID: 26212006 Late-Onset Bloodstream Infection and Perturbed Maturation of the Gastrointestinal Microbiota in Premature Infants PloS One. 2015 | Pubmed ID: 26167683 Characterisation of a Mobilisable Plasmid Conferring Florfenicol and Chloramphenicol Resistance in Actinobacillus Pleuropneumoniae Veterinary Microbiology. Aug, 2015 | Pubmed ID: 26049592 Identification of DfrA14 in Two Distinct Plasmids Conferring Trimethoprim Resistance in Actinobacillus Pleuropneumoniae The Journal of Antimicrobial Chemotherapy. Aug, 2015 | Pubmed ID: 25957382 Genomic Signatures of Human and Animal Disease in the Zoonotic Pathogen Streptococcus Suis Nature Communications. 2015 | Pubmed ID: 25824154 Galleria Mellonella is an Effective Model to Study Actinobacillus Pleuropneumoniae Infection Microbiology (Reading, England). Feb, 2015 | Pubmed ID: 25414045 Dysbiosis Anticipating Necrotizing Enterocolitis in Very Premature Infants Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Feb, 2015 | Pubmed ID: 25344536 The Use of Genome Wide Association Methods to Investigate Pathogenicity, Population Structure and Serovar in Haemophilus Parasuis BMC Genomics. 2014 | Pubmed ID: 25539682 The Generation of Successive Unmarked Mutations and Chromosomal Insertion of Heterologous Genes in Actinobacillus Pleuropneumoniae Using Natural Transformation PloS One. 2014 | Pubmed ID: 25409017 Diagnosis of Childhood Tuberculosis and Host RNA Expression in Africa The New England Journal of Medicine. May, 2014 | Pubmed ID: 24785206 Multiplex PCR Assay for Unequivocal Differentiation of Actinobacillus Pleuropneumoniae Serovars 1 to 3, 5 to 8, 10, and 12 Journal of Clinical Microbiology. Jul, 2014 | Pubmed ID: 24759717 Transposon Mutagenesis in Mycoplasma Hyopneumoniae Using a Novel Mariner-based System for Generating Random Mutations Veterinary Research. Dec, 2013 | Pubmed ID: 24359443 Detection of Tuberculosis in HIV-infected and -uninfected African Adults Using Whole Blood RNA Expression Signatures: a Case-control Study PLoS Medicine. Oct, 2013 | Pubmed ID: 24167453 Identification of Proteins of Propionibacterium Acnes for Use As Vaccine Candidates to Prevent Infection by the Pig Pathogen Actinobacillus Pleuropneumoniae Vaccine. Oct, 2013 | Pubmed ID: 24051157 Transcriptional Profiling of Neisseria Meningitidis Interacting with Human Epithelial Cells in a Long-term in Vitro Colonization Model Infection and Immunity. Nov, 2013 | Pubmed ID: 23980104 Impairment of IFN-gamma Response to Synthetic Peptides of Mycobacterium Tuberculosis in a 7-day Whole Blood Assay PloS One. 2013 | Pubmed ID: 23951140 Development of a Self-replicating Plasmid System for Mycoplasma Hyopneumoniae Veterinary Research. 2013 | Pubmed ID: 23895236 Gene Content and Diversity of the Loci Encoding Biosynthesis of Capsular Polysaccharides of the 15 Serovar Reference Strains of Haemophilus Parasuis Journal of Bacteriology. Sep, 2013 | Pubmed ID: 23873912 Transcriptional Profiling of Serogroup B Neisseria Meningitidis Growing in Human Blood: an Approach to Vaccine Antigen Discovery PloS One. 2012 | Pubmed ID: 22745818 Lineage-specific Virulence Determinants of Haemophilus Influenzae Biogroup Aegyptius Emerging Infectious Diseases. Mar, 2012 | Pubmed ID: 22377449 Genome Wide Expression Profiling Reveals Suppression of Host Defence Responses During Colonisation by Neisseria Meningitides but Not N. Lactamica PloS One. 2011 | Pubmed ID: 22028815 Meningitis: Latest Developments Future Microbiology. Jul, 2011 | Pubmed ID: 21797686 Population-based Analysis of Actinobacillus Pleuropneumoniae ApxIVA for Use As a DIVA Antigen Vaccine. Jul, 2010 | Pubmed ID: 20483193 Regulation of Pga Operon Expression and Biofilm Formation in Actinobacillus Pleuropneumoniae by SigmaE and H-NS Journal of Bacteriology. May, 2010 | Pubmed ID: 20207760 Proteomic Analysis of Endometrium from Fertile and Infertile Patients Suggests a Role for Apolipoprotein A-I in Embryo Implantation Failure and Endometriosis Molecular Human Reproduction. Apr, 2010 | Pubmed ID: 20008415 New Plasmid Tools for Genetic Analysis of Actinobacillus Pleuropneumoniae and Other Pasteurellaceae Applied and Environmental Microbiology. Oct, 2009 | Pubmed ID: 19666733 Natural Competence in Strains of Actinobacillus Pleuropneumoniae FEMS Microbiology Letters. Sep, 2009 | Pubmed ID: 19659732 Meningococcal Biofilm Growth on an Abiotic Surface - a Model for Epithelial Colonization? Microbiology (Reading, England). Jun, 2009 | Pubmed ID: 19383679 A Neisseria Meningitidis NMB1966 Mutant is Impaired for Invasion of Respiratory Epithelial Cells, Survival in Human Blood and for Virulence in Vivo Medical Microbiology and Immunology. Feb, 2009 | Pubmed ID: 19050914 Pasteurellaceae ComE1 Proteins Combine the Properties of Fibronectin Adhesins and DNA Binding Competence Proteins PloS One. 2008 | Pubmed ID: 19098981 Analysis of the Actinobacillus Pleuropneumoniae ArcA Regulon Identifies Fumarate Reductase As a Determinant of Virulence Infection and Immunity. Jun, 2008 | Pubmed ID: 18378638 The Complete Genome Sequence of Actinobacillus Pleuropneumoniae L20 (serotype 5b) Journal of Bacteriology. Feb, 2008 | Pubmed ID: 18065534 Biomarker Discovery in Infectious Diseases Using SELDI Future Microbiology. Feb, 2007 | Pubmed ID: 17661674 A Novel Neisserial Shuttle Plasmid: a Useful New Tool for Meningococcal Research FEMS Microbiology Letters. Oct, 2005 | Pubmed ID: 16112819 Deletion of the Ferric Uptake Regulator Fur Impairs the in Vitro Growth and Virulence of Actinobacillus Pleuropneumoniae Infection and Immunity. Jun, 2005 | Pubmed ID: 15908404 Expression of Heterologous Antigens in Commensal Neisseria Spp.: Preservation of Conformational Epitopes with Vaccine Potential Infection and Immunity. Nov, 2004 | Pubmed ID: 15501782 Functional Diversity of Three Different DsbA Proteins from Neisseria Meningitidis Microbiology (Reading, England). Sep, 2004 | Pubmed ID: 15347757 The Role of the Shigella Flexneri YihE Gene in LPS Synthesis and Virulence Microbiology (Reading, England). Apr, 2004 | Pubmed ID: 15073317 Harnessing Natural Transformation in Actinobacillus Pleuropneumoniae: a Simple Method for Allelic Replacements FEMS Microbiology Letters. Apr, 2004 | Pubmed ID: 15063496 Two TonB Systems in Actinobacillus Pleuropneumoniae: Their Roles in Iron Acquisition and Virulence Infection and Immunity. Feb, 2004 | Pubmed ID: 14742511 Identification of Actinobacillus Pleuropneumoniae Genes Important for Survival During Infection in Its Natural Host Infection and Immunity. Jul, 2003 | Pubmed ID: 12819083 Identification and Characterization of Genomic Loci Unique to the Brazilian Purpuric Fever Clonal Group of H. Influenzae Biogroup Aegyptius: Functionality Explored Using Meningococcal Homology Molecular Microbiology. Feb, 2003 | Pubmed ID: 12581362 Uso do invertebrado Galleria mellonella como modelo de infecção para estudo do complexo Mycobacterium tuberculosis Masanori Asai*1, Yanwen Li*1, Jasmeet Singh Khara1,2, Camilla A. Gladstone1, Brian D. Robertson3, Paul R. Langford*1, Sandra M. Newton*1 1Section of Pediatric Infectious Diseases and Allergy, Department of Medicine, Imperial College London, 2Department of Pharmacy, National University of Singapore, 3MRC Centre for Molecular Bacteriology and Infection, Department of Medicine, Imperial College London JoVE 59703 Immunology and Infection
Uso do invertebrado Galleria mellonella como modelo de infecção para estudo do complexo Mycobacterium tuberculosis Masanori Asai*1, Yanwen Li*1, Jasmeet Singh Khara1,2, Camilla A. Gladstone1, Brian D. Robertson3, Paul R. Langford*1, Sandra M. Newton*1 1Section of Pediatric Infectious Diseases and Allergy, Department of Medicine, Imperial College London, 2Department of Pharmacy, National University of Singapore, 3MRC Centre for Molecular Bacteriology and Infection, Department of Medicine, Imperial College London JoVE 59703 Immunology and Infection
