Paul R. Thompson Department of Biochemistry and Molecular Pharmacology University of Massachusetts Medical School Biography Publications Institution JoVE Articles Paul R. Thompson has not added a biography. If you are Paul R. Thompson and would like to personalize this page please email our Author Liaison for assistance. Publications Chemical Biology of Protein Arginine Modifications in Epigenetic Regulation Chemical Reviews. May, 2015 | Pubmed ID: 25970731 Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation Current Drug Targets. Feb, 2015 | Pubmed ID: 25642720 Inhibiting Protein Arginine Deiminases Has Antioxidant Consequences The Journal of Pharmacology and Experimental Therapeutics. Apr, 2015 | Pubmed ID: 25635139 Inhibition of PAD4 Activity is Sufficient to Disrupt Mouse and Human NET Formation Nature Chemical Biology. Mar, 2015 | Pubmed ID: 25622091 Protein Arginine Deiminase 2 Binds Calcium in an Ordered Fashion: Implications for Inhibitor Design ACS Chemical Biology. Apr, 2015 | Pubmed ID: 25621824 Design, Synthesis, and Biological Evaluation of Tetrazole Analogs of Cl-amidine As Protein Arginine Deiminase Inhibitors Journal of Medicinal Chemistry. Feb, 2015 | Pubmed ID: 25559347 Protein Arginine Methyltransferase 5 Catalyzes Substrate Dimethylation in a Distributive Fashion Biochemistry. Dec, 2014 | Pubmed ID: 25485739 Peptidylarginine Deiminase Inhibition Disrupts NET Formation and Protects Against Kidney, Skin and Vascular Disease in Lupus-prone MRL/lpr Mice Annals of the Rheumatic Diseases. Aug, 2014 | Pubmed ID: 25104775 Mechanistic Studies of Protein Arginine Deiminase 2: Evidence for a Substrate-assisted Mechanism Biochemistry. Jul, 2014 | Pubmed ID: 24989433 A Novel Role for Protein Arginine Deiminase 4 in Pluripotency: the Emerging Role of Citrullinated Histone H1 in Cellular Programming BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Aug, 2014 | Pubmed ID: 24889365 Neutrophil Extracellular Trap-derived Enzymes Oxidize High-density Lipoprotein: an Additional Proatherogenic Mechanism in Systemic Lupus Erythematosus Arthritis & Rheumatology (Hoboken, N.J.). Sep, 2014 | Pubmed ID: 24838349 Peptidylarginine Deiminases: Novel Drug Targets for Prevention of Neuronal Damage Following Hypoxic Ischemic Insult (HI) in Neonates Journal of Neurochemistry. Aug, 2014 | Pubmed ID: 24762056 Pluripotency: Citrullination Unravels Stem Cells Nature Chemical Biology. May, 2014 | Pubmed ID: 24743255 Deimination of Linker Histones Links Neutrophil Extracellular Trap Release with Autoantibodies in Systemic Autoimmunity FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2014 | Pubmed ID: 24671707 Modulation of Calcium-induced Cell Death in Human Neural Stem Cells by the Novel Peptidylarginine Deiminase-AIF Pathway Biochimica Et Biophysica Acta. Jun, 2014 | Pubmed ID: 24607566 A FluoPol-ABPP PAD2 High-throughput Screen Identifies the First Calcium Site Inhibitor Targeting the PADs ACS Chemical Biology. Apr, 2014 | Pubmed ID: 24467619 Insights into the Mechanism of Streptonigrin-induced Protein Arginine Deiminase Inactivation Bioorganic & Medicinal Chemistry. Feb, 2014 | Pubmed ID: 24440480 Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis Circulation Research. Mar, 2014 | Pubmed ID: 24425713 Using Unnatural Amino Acid Mutagenesis to Probe the Regulation of PRMT1 ACS Chemical Biology. Mar, 2014 | Pubmed ID: 24358983 Inhibiting AMPylation: a Novel Screen to Identify the First Small Molecule Inhibitors of Protein AMPylation ACS Chemical Biology. Feb, 2014 | Pubmed ID: 24274060 Chemical and Biological Methods to Detect Post-translational Modifications of Arginine Biopolymers. Feb, 2014 | Pubmed ID: 23576281 Automethylation of Protein Arginine Methyltransferase 8 (PRMT8) Regulates Activity by Impeding S-adenosylmethionine Sensitivity The Journal of Biological Chemistry. Sep, 2013 | Pubmed ID: 23946480 Substrate Specificity, Processivity, and Kinetic Mechanism of Protein Arginine Methyltransferase 5 Biochemistry. Aug, 2013 | Pubmed ID: 23866019 Targeting the Arginine Phosphatase YwlE with a Catalytic Redox-based Inhibitor ACS Chemical Biology. Sep, 2013 | Pubmed ID: 23838530 Peptidylarginine Deiminase Inhibition is Immunomodulatory and Vasculoprotective in Murine Lupus The Journal of Clinical Investigation. Jul, 2013 | Pubmed ID: 23722903 Design, Synthesis, and Kinetic Characterization of Protein N-terminal Acetyltransferase Inhibitors ACS Chemical Biology. 2013 | Pubmed ID: 23557624 The Induction of MicroRNA-16 in Colon Cancer Cells by Protein Arginine Deiminase Inhibition Causes a P53-dependent Cell Cycle Arrest PloS One. 2013 | Pubmed ID: 23308284 The Protein Arginine Deiminases: Structure, Function, Inhibition, and Disease Biopolymers. Feb, 2013 | Pubmed ID: 23175390 D-amino Acid Based Protein Arginine Deiminase Inhibitors: Synthesis, Pharmacokinetics, and in Cellulo Efficacy ACS Medicinal Chemistry Letters. Oct, 2012 | Pubmed ID: 23420624 Activation of PAD4 in NET Formation Frontiers in Immunology. 2012 | Pubmed ID: 23264775 Identification of PADI2 As a Potential Breast Cancer Biomarker and Therapeutic Target BMC Cancer. 2012 | Pubmed ID: 23110523 Seeing Citrulline: Development of a Phenylglyoxal-based Probe to Visualize Protein Citrullination Journal of the American Chemical Society. Oct, 2012 | Pubmed ID: 23030787 Potential Role of Peptidylarginine Deiminase Enzymes and Protein Citrullination in Cancer Pathogenesis Biochemistry Research International. 2012 | Pubmed ID: 23019525 Peptidylarginine Deiminase 2-catalyzed Histone H3 Arginine 26 Citrullination Facilitates Estrogen Receptor α Target Gene Activation Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012 | Pubmed ID: 22853951 Potential Role for PADI-mediated Histone Citrullination in Preimplantation Development BMC Developmental Biology. 2012 | Pubmed ID: 22712504 Citrullination of Proteins: a Common Post-translational Modification Pathway Induced by Different Nanoparticles in Vitro and in Vivo Nanomedicine (London, England). Aug, 2012 | Pubmed ID: 22625207 Probing Adenylation: Using a Fluorescently Labelled ATP Probe to Directly Label and Immunoprecipitate VopS Substrates Molecular BioSystems. Jun, 2012 | Pubmed ID: 22456874 Human Protein N-terminal Acetyltransferase HNaa50p (hNAT5/hSAN) Follows Ordered Sequential Catalytic Mechanism: Combined Kinetic and NMR Study The Journal of Biological Chemistry. Mar, 2012 | Pubmed ID: 22311970 Kinetic Mechanism of Protein Arginine Methyltransferase 6 (PRMT6) The Journal of Biological Chemistry. Feb, 2012 | Pubmed ID: 22219200 Felty's Syndrome Autoantibodies Bind to Deiminated Histones and Neutrophil Extracellular Chromatin Traps Arthritis and Rheumatism. Apr, 2012 | Pubmed ID: 22034172 Synthesis and Screening of a Haloacetamidine Containing Library to Identify PAD4 Selective Inhibitors ACS Chemical Biology. Jan, 2012 | Pubmed ID: 22004374 The Development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine Amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine Amide (o-Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors Journal of Medicinal Chemistry. Oct, 2011 | Pubmed ID: 21882827 Activity-based Protein Profiling of Protein Arginine Methyltransferase 1 ACS Chemical Biology. Oct, 2011 | Pubmed ID: 21838253 Kinase Consensus Sequences: a Breeding Ground for Crosstalk ACS Chemical Biology. Sep, 2011 | Pubmed ID: 21721511 Genome-wide Analysis Reveals PADI4 Cooperates with Elk-1 to Activate C-Fos Expression in Breast Cancer Cells PLoS Genetics. Jun, 2011 | Pubmed ID: 21655091 Protein Deiminases: New Players in the Developmentally Regulated Loss of Neural Regenerative Ability Developmental Biology. Jul, 2011 | Pubmed ID: 21539830 Autodeimination of Protein Arginine Deiminase 4 Alters Protein-protein Interactions but Not Activity Biochemistry. May, 2011 | Pubmed ID: 21466234 Mechanistic Studies on Transcriptional Coactivator Protein Arginine Methyltransferase 1 Biochemistry. Apr, 2011 | Pubmed ID: 21417440 Suppression of Colitis in Mice by Cl-amidine: a Novel Peptidylarginine Deiminase Inhibitor American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2011 | Pubmed ID: 21415415 Boronic Acid Functionalized Peptidyl Synthetic Lectins: Combinatorial Library Design, Peptide Sequencing, and Selective Glycoprotein Recognition ACS Combinatorial Science. May, 2011 | Pubmed ID: 21405093 N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-induced Arthritis Journal of Immunology (Baltimore, Md. : 1950). Apr, 2011 | Pubmed ID: 21346230 Development and Use of Clickable Activity Based Protein Profiling Agents for Protein Arginine Deiminase 4 ACS Chemical Biology. May, 2011 | Pubmed ID: 21265574 Protein Arginine Deiminase 4: a Target for an Epigenetic Cancer Therapy Cellular and Molecular Life Sciences : CMLS. Feb, 2011 | Pubmed ID: 20706768 A Combinatorial Approach to Characterize the Substrate Specificity of Protein Arginine Methyltransferase 1 Molecular BioSystems. Jan, 2011 | Pubmed ID: 20607165 Mechanistic Studies of Agmatine Deiminase from Multiple Bacterial Species Biochemistry. Nov, 2010 | Pubmed ID: 20939536 A Fluopol-ABPP HTS Assay to Identify PAD Inhibitors Chemical Communications (Cambridge, England). Oct, 2010 | Pubmed ID: 20740228 A Chloroacetamidine-based Inactivator of Protein Arginine Methyltransferase 1: Design, Synthesis, and in Vitro and in Vivo Evaluation Chembiochem : a European Journal of Chemical Biology. Jun, 2010 | Pubmed ID: 20480486 Substrate Specificity and Kinetic Studies of PADs 1, 3, and 4 Identify Potent and Selective Inhibitors of Protein Arginine Deiminase 3 Biochemistry. Jun, 2010 | Pubmed ID: 20469888 Characterization and Inactivation of an Agmatine Deiminase from Helicobacter Pylori Bioorganic Chemistry. Apr, 2010 | Pubmed ID: 20036411 Haloacetamidine-based Inactivators of Protein Arginine Deiminase 4 (PAD4): Evidence That General Acid Catalysis Promotes Efficient Inactivation Chembiochem : a European Journal of Chemical Biology. Jan, 2010 | Pubmed ID: 20014086 Protein Arginine Deiminase 4 (PAD4): Current Understanding and Future Therapeutic Potential Current Opinion in Drug Discovery & Development. Sep, 2009 | Pubmed ID: 19736621 The Tomato Brassinosteroid Receptor BRI1 Increases Binding of Systemin to Tobacco Plasma Membranes, but is Not Involved in Systemin Signaling Plant Molecular Biology. Jul, 2009 | Pubmed ID: 19404750 An Improved Synthesis of Haloaceteamidine-based Inactivators of Protein Arginine Deiminase 4 (PAD4) Tetrahedron Letters. Jul, 2008 | Pubmed ID: 19587776 The Protein Acetyltransferase ARD1: a Novel Cancer Drug Target? Current Cancer Drug Targets. Nov, 2008 | Pubmed ID: 18991565 Kinetic Mechanism of Protein Arginine Methyltransferase 1 Biochemistry. Sep, 2008 | Pubmed ID: 18771293 Regulation of P53 Target Gene Expression by Peptidylarginine Deiminase 4 Molecular and Cellular Biology. Aug, 2008 | Pubmed ID: 18505818 Histone Arg Modifications and P53 Regulate the Expression of OKL38, a Mediator of Apoptosis The Journal of Biological Chemistry. Jul, 2008 | Pubmed ID: 18499678 In Situ Generation of a Bisubstrate Analogue for Protein Arginine Methyltransferase 1 Journal of the American Chemical Society. Apr, 2008 | Pubmed ID: 18338885 The Structural Basis of Protein Acetylation by the P300/CBP Transcriptional Coactivator Nature. Feb, 2008 | Pubmed ID: 18273021 Profiling Protein Arginine Deiminase 4 (PAD4): a Novel Screen to Identify PAD4 Inhibitors Bioorganic & Medicinal Chemistry. Jan, 2008 | Pubmed ID: 17964793 Protein Arginine Methyltransferase 1: Positively Charged Residues in Substrate Peptides Distal to the Site of Methylation Are Important for Substrate Binding and Catalysis Biochemistry. Nov, 2007 | Pubmed ID: 17960915 Peptide Borono Lectins (PBLs): a New Tool for Glycomics and Cancer Diagnostics Chembiochem : a European Journal of Chemical Biology. Nov, 2007 | Pubmed ID: 17924602 A Selective Chemical Probe for Coenzyme A-requiring Enzymes Angewandte Chemie (International Ed. in English). 2007 | Pubmed ID: 17768748 Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism Biochemistry. Jun, 2007 | Pubmed ID: 17497940 Methyllysine Analogs: Rewriting the Code Nature Chemical Biology. May, 2007 | Pubmed ID: 17438548 Histone Citrullination by Protein Arginine Deiminase: is Arginine Methylation a Green Light or a Roadblock? ACS Chemical Biology. Aug, 2006 | Pubmed ID: 17168521 Activity-based Protein Profiling Reagents for Protein Arginine Deiminase 4 (PAD4): Synthesis and in Vitro Evaluation of a Fluorescently Labeled Probe Journal of the American Chemical Society. Nov, 2006 | Pubmed ID: 17090024 Inhibitors and Inactivators of Protein Arginine Deiminase 4: Functional and Structural Characterization Biochemistry. Oct, 2006 | Pubmed ID: 17002273 A Fluoroacetamidine-based Inactivator of Protein Arginine Deiminase 4: Design, Synthesis, and in Vitro and in Vivo Evaluation Journal of the American Chemical Society. Feb, 2006 | Pubmed ID: 16433522 Kinetic Characterization of Protein Arginine Deiminase 4: a Transcriptional Corepressor Implicated in the Onset and Progression of Rheumatoid Arthritis Biochemistry. Aug, 2005 | Pubmed ID: 16060666 Bisubstrate Analogue Structure-activity Relationships for P300 Histone Acetyltransferase Inhibitors Bioorganic & Medicinal Chemistry. Jun, 2004 | Pubmed ID: 15158807 Regulation of the P300 HAT Domain Via a Novel Activation Loop Nature Structural & Molecular Biology. Apr, 2004 | Pubmed ID: 15004546 Selective HAT Inhibitors As Mechanistic Tools for Protein Acetylation Methods in Enzymology. 2004 | Pubmed ID: 14975306 Synthesis and Analysis of Potential Prodrugs of Coenzyme A Analogues for the Inhibition of the Histone Acetyltransferase P300 Bioorganic & Medicinal Chemistry. Jul, 2003 | Pubmed ID: 12837541 Mechanism of Aminoglycoside Antibiotic Kinase APH(3')-IIIa: Role of the Nucleotide Positioning Loop Biochemistry. Jun, 2002 | Pubmed ID: 12033933 Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells Sachi Horibata1, Tommy V. Vo2, Venkataraman Subramanian3, Paul R. Thompson3, Scott A. Coonrod1 1Department of Baker Institute for Animal Health, Cornell University, 2Department of Molecular Biology and Genetics, Cornell University, 3Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School JoVE 52727 Medicine
Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells Sachi Horibata1, Tommy V. Vo2, Venkataraman Subramanian3, Paul R. Thompson3, Scott A. Coonrod1 1Department of Baker Institute for Animal Health, Cornell University, 2Department of Molecular Biology and Genetics, Cornell University, 3Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School JoVE 52727 Medicine
