Paul Gadue Center for Cellular and Molecular Therapeutics The Children's Hospital of Philadelphia Biography Publications Institution JoVE Articles Paul Gadue has not added a biography. If you are Paul Gadue and would like to personalize this page please email our Author Liaison for assistance. Publications Modeling Monogenic Diabetes Using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A Cell Stem Cell. Aug, 2019 | Pubmed ID: 31374199 Generation of Spinocerebellar Ataxia Type 2 Induced Pluripotent Stem Cell Lines, CHOPi002-A and CHOPi003-A, from Patients with Abnormal CAG Repeats in the Coding Region of the ATXN2 Gene Stem Cell Research. 01, 2019 | Pubmed ID: 30611021 Highly Efficient CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells Current Protocols in Stem Cell Biology. 02, 2019 | Pubmed ID: 30358158 Generation of a Human Juvenile Myelomonocytic Leukemia IPSC Line, CHOPi001-A, with a Mutation in CBL Stem Cell Research. 08, 2018 | Pubmed ID: 30096712 GATA6 Suppression Enhances Lung Specification from Human Pluripotent Stem Cells The Journal of Clinical Investigation. 07, 2018 | Pubmed ID: 29889101 Exploring the Interaction Between EIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain Neuroscience. 02, 2018 | Pubmed ID: 29289717 Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications Arteriosclerosis, Thrombosis, and Vascular Biology. 11, 2017 | Pubmed ID: 28982668 GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells Stem Cell Reports. 03, 2017 | Pubmed ID: 28196690 Generation of Human Control IPS Cell Line CHOPWT10 from Healthy Adult Peripheral Blood Mononuclear Cells Stem Cell Research. Mar, 2016 | Pubmed ID: 27345999 Generation of Hermansky Pudlak Syndrome Type 2 (HPS2) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Mar, 2016 | Pubmed ID: 27345985 Generation of Hermansky-Pudlak Syndrome Type 1 (HPS1) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Mar, 2016 | Pubmed ID: 27345974 Generation of Human Control IPS Cell Line CHOPWT9 from Healthy Adult Peripheral Blood Mononuclear Cells Stem Cell Research. Jan, 2016 | Pubmed ID: 27345777 A Doxycycline-Inducible System for Genetic Correction of IPSC Disease Models Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 25630922 Generation of Poikiloderma with Neutropenia (PN) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Nov, 2015 | Pubmed ID: 26987923 OCT4 Coordinates with WNT Signaling to Pre-pattern Chromatin at the SOX17 Locus During Human ES Cell Differentiation into Definitive Endoderm Stem Cell Reports. Oct, 2015 | Pubmed ID: 26411902 Inducible Gata1 Suppression Expands Megakaryocyte-erythroid Progenitors from Embryonic Stem Cells The Journal of Clinical Investigation. Jun, 2015 | Pubmed ID: 25961454 Comparative Analysis of Human Ex Vivo-generated Platelets Vs Megakaryocyte-generated Platelets in Mice: a Cautionary Tale Blood. Jun, 2015 | Pubmed ID: 25852052 Emergence of a Stage-dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-deficient IPS Cells Stem Cell Reports. May, 2015 | Pubmed ID: 25843048 Pluripotent Stem Cells Reveal Erythroid-specific Activities of the GATA1 N-terminus The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25621499 Hematopoietic Differentiation of Pluripotent Stem Cells in Culture Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 25062629 Utilization of the AAVS1 Safe Harbor Locus for Hematopoietic Specific Transgene Expression and Gene Knockdown in Human ES Cells Stem Cell Research. May, 2014 | Pubmed ID: 24631742 The Negative Impact of Wnt Signaling on Megakaryocyte and Primitive Erythroid Progenitors Derived from Human Embryonic Stem Cells Stem Cell Research. Mar, 2014 | Pubmed ID: 24412757 High-level Transgene Expression in Induced Pluripotent Stem Cell-derived Megakaryocytes: Correction of Glanzmann Thrombasthenia Blood. Jan, 2014 | Pubmed ID: 24335497 Clonal Genetic and Hematopoietic Heterogeneity Among Human-induced Pluripotent Stem Cell Lines Blood. Sep, 2013 | Pubmed ID: 23940280 Ribosomal and Hematopoietic Defects in Induced Pluripotent Stem Cells Derived from Diamond Blackfan Anemia Patients Blood. Aug, 2013 | Pubmed ID: 23744582 AAV-mediated Gene Therapy for Choroideremia: Preclinical Studies in Personalized Models PloS One. 2013 | Pubmed ID: 23667438 21 トリソミー関連欠陥人間の原始造血の誘導多能性幹細胞を明らかにしました。 Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23045704 ひと多能性幹細胞から生成された取って代われる内皮前駆行。 Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482503 胚様体の分化ヒト胚性幹細胞のための高スループット スクリーニングの試金。 Current Protocols in Stem Cell Biology. Mar, 2012 | Pubmed ID: 22415836 デュアル抑圧を通じて肝仕様 Wnt とノッチの内皮細胞のニッチを誘導するシグナルします。 Stem Cells (Dayton, Ohio). Feb, 2011 | Pubmed ID: 21732480 マウス ES と IPS 細胞類似の決定的な内胚葉の捺印された遺伝子の違いにもかかわらずを形成できます。 The Journal of Clinical Investigation. Jun, 2011 | Pubmed ID: 21537085 ヒト胚性幹細胞の無血清分化プロトコルを最適化するためのハイスループット多重スクリーニングアッセイ Stem Cell Research. Mar, 2011 | Pubmed ID: 21169079 肝再生誘導多能性幹細胞から。 Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2010 | Pubmed ID: 21119691 単一のレンチ ウイルス幹細胞が物品税課税対象のカセットを使用して無料の Transgene 肺疾患特異ひと誘導多能性幹細胞の世代。 Stem Cells (Dayton, Ohio). Oct, 2010 | Pubmed ID: 20715179 転写能力と組織特異エンハンサー胚および誘導多能性幹細胞で定義された転写因子によるアクティブなマーキング。 Genes & Development. Dec, 2009 | Pubmed ID: 20008934 卵黄嚢の造血幹細胞を解読します。 Blood. Aug, 2009 | Pubmed ID: 19696206 内胚葉マウス初期に発現細胞表面分子の特異的モノクローナル抗体の世代。 Stem Cells (Dayton, Ohio). Sep, 2009 | Pubmed ID: 19522011 表皮細胞リプログラミングを改訂します。 Nature Biotechnology. Nov, 2008 | Pubmed ID: 18997762 無感覚 Wnt とノッチ、血管芽細胞からプリミティブ赤芽仕様を変調する相互作用を仲介します。 Development (Cambridge, England). Oct, 2008 | Pubmed ID: 18799543 Wnt シグナル、アクチビンと BMP シグナル伝達の異なる段階で胚性幹細胞から血液への発達経路を調節します。 Cell Stem Cell. Jan, 2008 | Pubmed ID: 18371422 同定とヒト胚性幹細胞における ROSA26 座のターゲットします。 Nature Biotechnology. Dec, 2007 | Pubmed ID: 18037879 BMP 4 マウス胚性幹細胞由来の決定的な胚葉の肝臓の仕様が必要です。 Nature Biotechnology. Nov, 2006 | Pubmed ID: 17086172 Wnt および TGF β シグナリングの胚性幹細胞を用いた原始線条形成の in Vitro モデルの誘導が必要です。 Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17077151 胚性幹細胞から胚葉の誘導。 Experimental Hematology. Sep, 2005 | Pubmed ID: 16140142 修復の NK T 細胞の開発は、TCR によるフュン変異マウスの早期 NK T 細胞の個体発生中フュン島のための要件を明らかにします。 Journal of Immunology (Baltimore, Md. : 1950). May, 2004 | Pubmed ID: 15128794 Mer 受容体チロシンキナーゼ: 発現と機能生得の免疫の役割を示唆します。 European Journal of Immunology. Aug, 2003 | Pubmed ID: 12884290 NK T 細胞前駆体は、差動のサイトカインの発現を展示し、Itk 効率的な成熟を必要とします。 Journal of Immunology (Baltimore, Md. : 1950). Sep, 2002 | Pubmed ID: 12193707 ヒト多能性幹細胞におけるCRISPR-CAS9を用いて定義されたゲノム修飾の生成 Fabian L. Cardenas-Diaz*1, Jean Ann Maguire*1, Paul Gadue1,2,3, Deborah L. French1,2,3 1Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, 3Department of Pathology and Laboratory Medicine, University of Pennsylvania JoVE 60085 Genetics STEMCCAレンチウイルスベクターを用いた末梢血からのヒト人工多能性幹細胞の生成 Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
ヒト多能性幹細胞におけるCRISPR-CAS9を用いて定義されたゲノム修飾の生成 Fabian L. Cardenas-Diaz*1, Jean Ann Maguire*1, Paul Gadue1,2,3, Deborah L. French1,2,3 1Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, 3Department of Pathology and Laboratory Medicine, University of Pennsylvania JoVE 60085 Genetics
STEMCCAレンチウイルスベクターを用いた末梢血からのヒト人工多能性幹細胞の生成 Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology