Paul Gadue

Publications

• Modeling Monogenic Diabetes Using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A
  Cell Stem Cell. Aug, 2019  |   Pubmed ID: 31374199
• Generation of Spinocerebellar Ataxia Type 2 Induced Pluripotent Stem Cell Lines, CHOPi002-A and CHOPi003-A, from Patients with Abnormal CAG Repeats in the Coding Region of the ATXN2 Gene
  Stem Cell Research. 01, 2019  |   Pubmed ID: 30611021
• Highly Efficient CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells
  Current Protocols in Stem Cell Biology. 02, 2019  |   Pubmed ID: 30358158
• Generation of a Human Juvenile Myelomonocytic Leukemia IPSC Line, CHOPi001-A, with a Mutation in CBL
  Stem Cell Research. 08, 2018  |   Pubmed ID: 30096712
• GATA6 Suppression Enhances Lung Specification from Human Pluripotent Stem Cells
  The Journal of Clinical Investigation. 07, 2018  |   Pubmed ID: 29889101
• Exploring the Interaction Between EIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain
  Neuroscience. 02, 2018  |   Pubmed ID: 29289717
• Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications
  Arteriosclerosis, Thrombosis, and Vascular Biology. 11, 2017  |   Pubmed ID: 28982668
• GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells
  Stem Cell Reports. 03, 2017  |   Pubmed ID: 28196690
• Generation of Human Control IPS Cell Line CHOPWT10 from Healthy Adult Peripheral Blood Mononuclear Cells
  Stem Cell Research. Mar, 2016  |   Pubmed ID: 27345999
• Generation of Hermansky Pudlak Syndrome Type 2 (HPS2) Induced Pluripotent Stem Cells (iPSCs)
  Stem Cell Research. Mar, 2016  |   Pubmed ID: 27345985
• Generation of Hermansky-Pudlak Syndrome Type 1 (HPS1) Induced Pluripotent Stem Cells (iPSCs)
  Stem Cell Research. Mar, 2016  |   Pubmed ID: 27345974
• Generation of Human Control IPS Cell Line CHOPWT9 from Healthy Adult Peripheral Blood Mononuclear Cells
  Stem Cell Research. Jan, 2016  |   Pubmed ID: 27345777
• A Doxycycline-Inducible System for Genetic Correction of IPSC Disease Models
  Methods in Molecular Biology (Clifton, N.J.). 2016  |   Pubmed ID: 25630922
• Generation of Poikiloderma with Neutropenia (PN) Induced Pluripotent Stem Cells (iPSCs)
  Stem Cell Research. Nov, 2015  |   Pubmed ID: 26987923
• OCT4 Coordinates with WNT Signaling to Pre-pattern Chromatin at the SOX17 Locus During Human ES Cell Differentiation into Definitive Endoderm
  Stem Cell Reports. Oct, 2015  |   Pubmed ID: 26411902
• Inducible Gata1 Suppression Expands Megakaryocyte-erythroid Progenitors from Embryonic Stem Cells
  The Journal of Clinical Investigation. Jun, 2015  |   Pubmed ID: 25961454
• Comparative Analysis of Human Ex Vivo-generated Platelets Vs Megakaryocyte-generated Platelets in Mice: a Cautionary Tale
  Blood. Jun, 2015  |   Pubmed ID: 25852052
• Emergence of a Stage-dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-deficient IPS Cells
  Stem Cell Reports. May, 2015  |   Pubmed ID: 25843048
• Pluripotent Stem Cells Reveal Erythroid-specific Activities of the GATA1 N-terminus
  The Journal of Clinical Investigation. Mar, 2015  |   Pubmed ID: 25621499
• Hematopoietic Differentiation of Pluripotent Stem Cells in Culture
  Methods in Molecular Biology (Clifton, N.J.). 2014  |   Pubmed ID: 25062629
• Utilization of the AAVS1 Safe Harbor Locus for Hematopoietic Specific Transgene Expression and Gene Knockdown in Human ES Cells
  Stem Cell Research. May, 2014  |   Pubmed ID: 24631742
• The Negative Impact of Wnt Signaling on Megakaryocyte and Primitive Erythroid Progenitors Derived from Human Embryonic Stem Cells
  Stem Cell Research. Mar, 2014  |   Pubmed ID: 24412757
• High-level Transgene Expression in Induced Pluripotent Stem Cell-derived Megakaryocytes: Correction of Glanzmann Thrombasthenia
  Blood. Jan, 2014  |   Pubmed ID: 24335497
• Clonal Genetic and Hematopoietic Heterogeneity Among Human-induced Pluripotent Stem Cell Lines
  Blood. Sep, 2013  |   Pubmed ID: 23940280
• Ribosomal and Hematopoietic Defects in Induced Pluripotent Stem Cells Derived from Diamond Blackfan Anemia Patients
  Blood. Aug, 2013  |   Pubmed ID: 23744582
• AAV-mediated Gene Therapy for Choroideremia: Preclinical Studies in Personalized Models
  PloS One. 2013  |   Pubmed ID: 23667438
• Trisomy 21-associated Defects in Human Primitive Hematopoiesis Revealed Through Induced Pluripotent Stem Cells
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012  |   Pubmed ID: 23045704
• Self-renewing Endodermal Progenitor Lines Generated from Human Pluripotent Stem Cells
  Cell Stem Cell. Apr, 2012  |   Pubmed ID: 22482503
• High-throughput Screening Assay for Embryoid Body Differentiation of Human Embryonic Stem Cells
  Current Protocols in Stem Cell Biology. Mar, 2012  |   Pubmed ID: 22415836
• An Endothelial Cell Niche Induces Hepatic Specification Through Dual Repression of Wnt and Notch Signaling
  Stem Cells (Dayton, Ohio). Feb, 2011  |   Pubmed ID: 21732480
• Mouse ES and IPS Cells Can Form Similar Definitive Endoderm Despite Differences in Imprinted Genes
  The Journal of Clinical Investigation. Jun, 2011  |   Pubmed ID: 21537085
• A High-throughput Multiplexed Screening Assay for Optimizing Serum-free Differentiation Protocols of Human Embryonic Stem Cells
  Stem Cell Research. Mar, 2011  |   Pubmed ID: 21169079
• Liver Regeneration from Induced Pluripotent Stem Cells
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2010  |   Pubmed ID: 21119691
• Generation of Transgene-free Lung Disease-specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette
  Stem Cells (Dayton, Ohio). Oct, 2010  |   Pubmed ID: 20715179
• Transcriptional Competence and the Active Marking of Tissue-specific Enhancers by Defined Transcription Factors in Embryonic and Induced Pluripotent Stem Cells
  Genes & Development. Dec, 2009  |   Pubmed ID: 20008934
• Stem Cells Unscramble Yolk Sac Hematopoiesis
  Blood. Aug, 2009  |   Pubmed ID: 19696206
• Generation of Monoclonal Antibodies Specific for Cell Surface Molecules Expressed on Early Mouse Endoderm
  Stem Cells (Dayton, Ohio). Sep, 2009  |   Pubmed ID: 19522011
• Epidermal Cells Rev Up Reprogramming
  Nature Biotechnology. Nov, 2008  |   Pubmed ID: 18997762
• Numb Mediates the Interaction Between Wnt and Notch to Modulate Primitive Erythropoietic Specification from the Hemangioblast
  Development (Cambridge, England). Oct, 2008  |   Pubmed ID: 18799543
• Wnt, Activin, and BMP Signaling Regulate Distinct Stages in the Developmental Pathway from Embryonic Stem Cells to Blood
  Cell Stem Cell. Jan, 2008  |   Pubmed ID: 18371422
• Identification and Targeting of the ROSA26 Locus in Human Embryonic Stem Cells
  Nature Biotechnology. Dec, 2007  |   Pubmed ID: 18037879
• BMP-4 is Required for Hepatic Specification of Mouse Embryonic Stem Cell-derived Definitive Endoderm
  Nature Biotechnology. Nov, 2006  |   Pubmed ID: 17086172
• Wnt and TGF-beta Signaling Are Required for the Induction of an in Vitro Model of Primitive Streak Formation Using Embryonic Stem Cells
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006  |   Pubmed ID: 17077151
• Germ Layer Induction from Embryonic Stem Cells
  Experimental Hematology. Sep, 2005  |   Pubmed ID: 16140142
• Restoration of NK T Cell Development in Fyn-mutant Mice by a TCR Reveals a Requirement for Fyn During Early NK T Cell Ontogeny
  Journal of Immunology (Baltimore, Md. : 1950). May, 2004  |   Pubmed ID: 15128794
• The Mer Receptor Tyrosine Kinase: Expression and Function Suggest a Role in Innate Immunity
  European Journal of Immunology. Aug, 2003  |   Pubmed ID: 12884290
• NK T Cell Precursors Exhibit Differential Cytokine Regulation and Require Itk for Efficient Maturation
  Journal of Immunology (Baltimore, Md. : 1950). Sep, 2002  |   Pubmed ID: 12193707