Pavel Georgiev

Publications

• Mechanisms of Enhancer-promoter Communication and Chromosomal Architecture in Mammals and
  Frontiers in Genetics. 2022  |   Pubmed ID: 36531247
• BTB Domains: A Structural View of Evolution, Multimerization, and Protein-protein Interactions
  BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Nov, 2022  |   Pubmed ID: 36449605
• Structure of the DNMT3B ADD Domain Suggests the Absence of a DNMT3A-like Autoinhibitory Mechanism
  Biochemical and Biophysical Research Communications. Sep, 2022  |   Pubmed ID: 35760008
• Comparative Interactome Analysis of the PRE DNA-binding Factors: Purification of the Combgap-, Zeste-, Psq-, and Adf1-associated Proteins
  Cellular and Molecular Life Sciences : CMLS. Jun, 2022  |   Pubmed ID: 35676368
• Structural Insights into Highly Similar Spatial Organization of Zinc-finger Associated Domains with a Very Low Sequence Similarity
  Structure (London, England : 1993). Jul, 2022  |   Pubmed ID: 35580610
• Dimerization Activity of a Disordered N-Terminal Domain from CLAMP Protein
  International Journal of Molecular Sciences. Mar, 2022  |   Pubmed ID: 35409222
• Mechanisms of CP190 Interaction with Architectural Proteins in Drosophila Melanogaster
  International Journal of Molecular Sciences. Nov, 2021  |   Pubmed ID: 34830280
• Redundant Enhancers in the Iab-5 Domain Cooperatively Activate Abd-B in the A5 and A6 Abdominal Segments of Drosophila
  Development (Cambridge, England). Oct, 2021  |   Pubmed ID: 34473267
• Drosophila Architectural Protein CTCF is Not Essential for Fly Survival and is Able to Function Independently of CP190
  Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. Oct, 2021  |   Pubmed ID: 34311130
• Clinical Correlations of Polycomb Repressive Complex 2 in Different Tumor Types
  Cancers. Jun, 2021  |   Pubmed ID: 34202528
• Boundaries Potentiate Polycomb Response Element-mediated Silencing
  BMC Biology. Jun, 2021  |   Pubmed ID: 34078365
• Mechanism and Functional Role of the Interaction Between CP190 and the Architectural Protein Pita in Drosophila Melanogaster
  Epigenetics & Chromatin. Mar, 2021  |   Pubmed ID: 33752739
• Structural Basis of Diversity and Homodimerization Specificity of Zinc-finger-associated Domains in Drosophila
  Nucleic Acids Research. Feb, 2021  |   Pubmed ID: 33638995
• A Non-stop Identity Complex (NIC) Supervises Enterocyte Identity and Protects from Premature Aging
  ELife. Feb, 2021  |   Pubmed ID: 33629655
• Mapping of Functional Elements of the Fab-6 Boundary Involved in the Regulation of the Abd-B Hox Gene in Drosophila Melanogaster
  Scientific Reports. Feb, 2021  |   Pubmed ID: 33603202
• Mechanisms of Enhancer-Promoter Interactions in Higher Eukaryotes
  International Journal of Molecular Sciences. Jan, 2021  |   Pubmed ID: 33445415
• The Insulator Functions of the Polydactyl C2H2 Zinc Finger Protein CTCF: Necessity Versus Sufficiency
  Science Advances. Mar, 2020  |   Pubmed ID: 32232161
• N-terminal Domain of the Architectural Protein CTCF Has Similar Structural Organization and Ability to Self-association in Bilaterian Organisms
  Scientific Reports. Feb, 2020  |   Pubmed ID: 32060375
• Small Drosophila Zinc Finger C2H2 Protein with an N-terminal Zinc Finger-associated Domain Demonstrates the Architecture Functions
  Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. Jan, 2020  |   Pubmed ID: 31706027
• HIPP1 Stabilizes the Interaction Between CP190 and Su(Hw) in the Drosophila Insulator Complex
  Scientific Reports. Dec, 2019  |   Pubmed ID: 31836797
• Distinct Elements Confer the Blocking and Bypass Functions of the Bithorax Boundary
  Genetics. Nov, 2019  |   Pubmed ID: 31551239
• The Simultaneous Interaction of MSL2 with CLAMP and DNA Provides Redundancy in the Initiation of Dosage Compensation in Males
  Development (Cambridge, England). Aug, 2019  |   Pubmed ID: 31320325
• Complete Reconstitution of Bypass and Blocking Functions in a Minimal Artificial Insulator from Complex
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2019  |   Pubmed ID: 31209019
• Removal of Extra Sequences with I-SceI in Combination with CRISPR/Cas9 Technique for Precise Gene Editing in Drosophila
  BioTechniques. Apr, 2019  |   Pubmed ID: 30987444
• The Same Domain of Su(Hw) is Required for Enhancer Blocking and Direct Promoter Repression
  Scientific Reports. Mar, 2019  |   Pubmed ID: 30926937
• Transcription Termination Sequences Support the Expression of Transgene Product Secreted with Milk
  Transgenic Research. Aug, 2019  |   Pubmed ID: 30919251
• Functional Dissection of the Developmentally Restricted BEN Domain Chromatin Boundary Factor Insensitive
  Epigenetics & Chromatin. Jan, 2019  |   Pubmed ID: 30602385
• Boundaries Mediate Long-distance Interactions Between Enhancers and Promoters in the Drosophila Bithorax Complex
  PLoS Genetics. Dec, 2018  |   Pubmed ID: 30540750
• The Bithorax Complex Iab-7 Polycomb Response Element Has a Novel Role in the Functioning of the Fab-7 Chromatin Boundary
  PLoS Genetics. Aug, 2018  |   Pubmed ID: 30110328
• Conserved Sequences in the Drosophila Mod(mdg4) Intron Promote Poly(A)-independent Transcription Termination and Trans-splicing
  Nucleic Acids Research. Nov, 2018  |   Pubmed ID: 30102331
• The BEN Domain Protein Insensitive Binds to the Chromatin Boundary To Establish Proper Segmental Identity in
  Genetics. Oct, 2018  |   Pubmed ID: 30082280
• Role of Su(Hw) Zinc Finger 10 and Interaction with CP190 and Mod(mdg4) Proteins in Recruiting the Su(Hw) Complex to Chromatin Sites in Drosophila
  PloS One. 2018  |   Pubmed ID: 29474480
• Interactions Between BTB Domain of CP190 and Two Adjacent Regions in Su(Hw) Are Required for the Insulator Complex Formation
  Chromosoma. Mar, 2018  |   Pubmed ID: 28939920
• Presenilin-1 Delta E9 Mutant Induces STIM1-Driven Store-Operated Calcium Channel Hyperactivation in Hippocampal Neurons
  Molecular Neurobiology. Jun, 2018  |   Pubmed ID: 28707074
• Opbp is a New Architectural/insulator Protein Required for Ribosomal Gene Expression
  Nucleic Acids Research. Dec, 2017  |   Pubmed ID: 29036346
• Multiple Interactions Are Involved in a Highly Specific Association of the Mod(mdg4)-67.2 Isoform with the Su(Hw) Sites in
  Open Biology. Oct, 2017  |   Pubmed ID: 29021216
• Architectural Protein Pita Cooperates with DCTCF in Organization of Functional Boundaries in Bithorax Complex
  Development (Cambridge, England). Jul, 2017  |   Pubmed ID: 28619827
• The GAGA Factor Regulatory Network: Identification of GAGA Factor Associated Proteins
  PloS One. 2017  |   Pubmed ID: 28296955
• Boundaries of Loop Domains (insulators): Determinants of Chromosome Form and Function in Multicellular Eukaryotes
  BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Mar, 2017  |   Pubmed ID: 28133765
• Transvection in Drosophila: Trans-interaction Between Yellow Enhancers and Promoter is Strongly Suppressed by a Cis-promoter Only in Certain Genomic Regions
  Chromosoma. Jun, 2017  |   Pubmed ID: 27300555
• EAST Affects the Activity of Su(Hw) Insulators by Two Different Mechanisms in Drosophila Melanogaster
  Chromosoma. Mar, 2017  |   Pubmed ID: 27136940
• Large-scale ATP-independent Nucleosome Unfolding by a Histone Chaperone
  Nature Structural & Molecular Biology. Dec, 2016  |   Pubmed ID: 27820806
• Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex
  PLoS Genetics. 07, 2016  |   Pubmed ID: 27428541
• Architectural Proteins Pita, Zw5,and ZIPIC Contain Homodimerization Domain and Support Specific Long-range Interactions in Drosophila
  Nucleic Acids Research. Sep, 2016  |   Pubmed ID: 27137890
• Transcriptional Read-through is Not Sufficient to Induce an Epigenetic Switch in the Silencing Activity of Polycomb Response Elements
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2015  |   Pubmed ID: 26504232
• EAST Organizes Drosophila Insulator Proteins in the Interchromosomal Nuclear Compartment and Modulates CP190 Binding to Chromatin
  PloS One. 2015  |   Pubmed ID: 26489095
• Functional Role of Dimerization and CP190 Interacting Domains of CTCF Protein in Drosophila Melanogaster
  BMC Biology. Aug, 2015  |   Pubmed ID: 26248466
• The Boundary Paradox in the Bithorax Complex
  Mechanisms of Development. Nov, 2015  |   Pubmed ID: 26215349
• Eukaryotic Enhancers: Common Features, Regulation, and Participation in Diseases
  Cellular and Molecular Life Sciences : CMLS. Jun, 2015  |   Pubmed ID: 25715743
• Two New Insulator Proteins, Pita and ZIPIC, Target CP190 to Chromatin
  Genome Research. Jan, 2015  |   Pubmed ID: 25342723
• Highly Conserved ENY2/Sus1 Protein Binds to Drosophila CTCF and is Required for Barrier Activity
  Epigenetics. Sep, 2014  |   Pubmed ID: 25147918
• Mechanisms and Proteins Involved in Long-distance Interactions
  Frontiers in Genetics. 2014  |   Pubmed ID: 24600469
• Making Connections: Insulators Organize Eukaryotic Chromosomes into Independent Cis-regulatory Networks
  BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Feb, 2014  |   Pubmed ID: 24277632
• Chromatin Insulators and Long-distance Interactions in Drosophila
  FEBS Letters. Jan, 2014  |   Pubmed ID: 24211836
• Transcription Through Enhancers Suppresses Their Activity in Drosophila
  Epigenetics & Chromatin. Sep, 2013  |   Pubmed ID: 24279291
• Effective Blocking of the White Enhancer Requires Cooperation Between Two Main Mechanisms Suggested for the Insulator Function
  PLoS Genetics. 2013  |   Pubmed ID: 23861668
• New Properties of Drosophila Scs and Scs' Insulators
  PloS One. 2013  |   Pubmed ID: 23638134
• Insulator Protein Su(Hw) Recruits SAGA and Brahma Complexes and Constitutes Part of Origin Recognition Complex-binding Sites in the Drosophila Genome
  Nucleic Acids Research. Jun, 2013  |   Pubmed ID: 23609538
• SUMO Conjugation is Required for the Assembly of Drosophila Su(Hw) and Mod(mdg4) into Insulator Bodies That Facilitate Insulator Complex Formation
  Journal of Cell Science. Apr, 2012  |   Pubmed ID: 22375064
• Insulators Form Gene Loops by Interacting with Promoters in Drosophila
  Development (Cambridge, England). Sep, 2011  |   Pubmed ID: 21862564
• Drosophila BTB/POZ Domains of "ttk Group" Can Form Multimers and Selectively Interact with Each Other
  Journal of Molecular Biology. Sep, 2011  |   Pubmed ID: 21821048
• Selective Interactions of Boundaries with Upstream Region of Abd-B Promoter in Drosophila Bithorax Complex and Role of DCTCF in This Process
  Nucleic Acids Research. Apr, 2011  |   Pubmed ID: 21149269
• Insulators, Not Polycomb Response Elements, Are Required for Long-range Interactions Between Polycomb Targets in Drosophila Melanogaster
  Molecular and Cellular Biology. Feb, 2011  |   Pubmed ID: 21135119
• Interaction Between a Pair of Gypsy Insulators or Between Heterologous Gypsy and Wari Insulators Modulates Flp Site-specific Recombination in Drosophila Melanogaster
  Chromosoma. Aug, 2010  |   Pubmed ID: 20354861
• E(y)2/Sus1 is Required for Blocking PRE Silencing by the Wari Insulator in Drosophila Melanogaster
  Chromosoma. Jun, 2010  |   Pubmed ID: 20082086
• Drosophila Mini-white Model System: New Insights into Positive Position Effects and the Role of Transcriptional Terminators and Gypsy Insulator in Transgene Shielding
  Nucleic Acids Research. Jan, 2010  |   Pubmed ID: 19854952
• Zeste Can Facilitate Long-range Enhancer-promoter Communication and Insulator Bypass in Drosophila Melanogaster
  Chromosoma. Oct, 2009  |   Pubmed ID: 19578867
• Orientation-dependent Interaction Between Drosophila Insulators is a Property of This Class of Regulatory Elements
  Nucleic Acids Research. Dec, 2008  |   Pubmed ID: 18987002
• Enhancer-promoter Communication is Regulated by Insulator Pairing in a Drosophila Model Bigenic Locus
  Molecular and Cellular Biology. Sep, 2008  |   Pubmed ID: 18573869
• Functional Interaction Between the Fab-7 and Fab-8 Boundaries and the Upstream Promoter Region in the Drosophila Abd-B Gene
  Molecular and Cellular Biology. Jun, 2008  |   Pubmed ID: 18426914
• 'Insulator Bodies' Are Aggregates of Proteins but Not of Insulators
  EMBO Reports. May, 2008  |   Pubmed ID: 18369369
• Red Flag on the White Reporter: a Versatile Insulator Abuts the White Gene in Drosophila and is Omnipresent in Mini-white Constructs
  Nucleic Acids Research. Feb, 2008  |   Pubmed ID: 18086699
• Drosophila Gypsy Insulator and Yellow Enhancers Regulate Activity of Yellow Promoter Through the Same Regulatory Element
  Chromosoma. Apr, 2008  |   Pubmed ID: 17994318
• Long-distance Interactions Between Regulatory Elements Are Suppressed at the End of a Terminally Deficient Chromosome in Drosophila Melanogaster
  Chromosoma. Feb, 2008  |   Pubmed ID: 17876596
• New Properties of Drosophila Fab-7 Insulator
  Genetics. Sep, 2007  |   Pubmed ID: 17890362
• Characterization of Drosophila Telomeric Retroelement TAHRE: Transcription, Transpositions, and RNAi-based Regulation of Expression
  Molecular Biology and Evolution. Nov, 2007  |   Pubmed ID: 17890237
• Evolutionarily Conserved E(y)2/Sus1 Protein is Essential for the Barrier Activity of Su(Hw)-dependent Insulators in Drosophila
  Molecular Cell. Jul, 2007  |   Pubmed ID: 17643381
• Study of the Functional Interaction Between Mcp Insulators from the Drosophila Bithorax Complex: Effects of Insulator Pairing on Enhancer-promoter Communication
  Molecular and Cellular Biology. Apr, 2007  |   Pubmed ID: 17283051
• Integrity of the Mod(mdg4)-67.2 BTB Domain is Critical to Insulator Function in Drosophila Melanogaster
  Molecular and Cellular Biology. Feb, 2007  |   Pubmed ID: 17101769
• Two Isoforms of Drosophila TRF2 Are Involved in Embryonic Development, Premeiotic Chromatin Condensation, and Proper Differentiation of Germ Cells of Both Sexes
  Molecular and Cellular Biology. Oct, 2006  |   Pubmed ID: 17015475
• Telomere Elongation is Under the Control of the RNAi-based Mechanism in the Drosophila Germline
  Genes & Development. Feb, 2006  |   Pubmed ID: 16452506
• Study of Long-distance Functional Interactions Between Su(Hw) Insulators That Can Regulate Enhancer-promoter Communication in Drosophila Melanogaster
  Molecular and Cellular Biology. Feb, 2006  |   Pubmed ID: 16428433
• Transposition of Regulatory Elements by P-Element-Mediated Rearrangements in Drosophila Melanogaster
  Genetics. Apr, 2006  |   Pubmed ID: 16387869
• Handling Three Regulatory Elements in One Transgene: Combined Use of Cre-lox, FLP-FRT, and I-Scel Recombination Systems
  BioTechniques. Dec, 2005  |   Pubmed ID: 16382906
• Pairing Between Gypsy Insulators Facilitates the Enhancer Action in Trans Throughout the Drosophila Genome
  Molecular and Cellular Biology. Nov, 2005  |   Pubmed ID: 16227580
• Drosophila Telomeres: the Non-telomerase Alternative
  Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 2005  |   Pubmed ID: 16132809
• The Mcp Element from the Bithorax Complex Contains an Insulator That is Capable of Pairwise Interactions and Can Facilitate Enhancer-promoter Communication
  Molecular and Cellular Biology. May, 2005  |   Pubmed ID: 15831473
• The Ku Protein Complex is Involved in Length Regulation of Drosophila Telomeres
  Genetics. May, 2005  |   Pubmed ID: 15781709
• A Novel Multidomain Transcription Coactivator SAYP Can Also Repress Transcription in Heterochromatin
  The EMBO Journal. Jan, 2005  |   Pubmed ID: 15616585
• Drosophila Su(Hw) Insulator Can Stimulate Transcription of a Weakened Yellow Promoter over a Distance
  Genetics. Jul, 2005  |   Pubmed ID: 15520254
• Interaction Between the GAGA Factor and Mod(mdg4) Proteins Promotes Insulator Bypass in Drosophila
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2004  |   Pubmed ID: 15465920
• The Mod(mdg4) Component of the Su(Hw) Insulator Inserted in the P Transposon Can Repress Its Mobility in Drosophila Melanogaster
  Genetics. Jul, 2004  |   Pubmed ID: 15280241
• An Endogenous Su(Hw) Insulator Separates the Yellow Gene from the Achaete-scute Gene Complex in Drosophila
  Development (Cambridge, England). Jul, 2003  |   Pubmed ID: 12783795
• Transvection at the End of the Truncated Chromosome in Drosophila Melanogaster
  Genetics. Apr, 2003  |   Pubmed ID: 12702682
• Enhancer of Terminal Gene Conversion, a New Mutation in Drosophila Melanogaster That Induces Telomere Elongation by Gene Conversion
  Genetics. Nov, 2002  |   Pubmed ID: 12454074
• P Element-mediated Duplications of Genomic Regions in Drosophila Melanogaster
  Chromosoma. Jul, 2002  |   Pubmed ID: 12111335
• The Gypsy Insulators Flanking Yellow Enhancers Do Not Form a Separate Transcriptional Domain in Drosophila Melanogaster: the Enhancers Can Activate an Isolated Yellow Promoter
  Genetics. Apr, 2002  |   Pubmed ID: 11973309
• Heterochromatin Protein 1 is Involved in Control of Telomere Elongation in Drosophila Melanogaster
  Molecular and Cellular Biology. May, 2002  |   Pubmed ID: 11940677
• The Novel Transcription Factor E(y)2 Interacts with TAF(II)40 and Potentiates Transcription Activation on Chromatin Templates
  Molecular and Cellular Biology. Aug, 2001  |   Pubmed ID: 11438676
• Attachment of HeT-A Sequences to Chromosomal Termini in Drosophila Melanogaster May Occur by Different Mechanisms
  Molecular and Cellular Biology. Oct, 2000  |   Pubmed ID: 11003659
• TAFII40 Protein is Encoded by the E(y)1 Gene: Biological Consequences of Mutations
  Molecular and Cellular Biology. May, 1999  |   Pubmed ID: 10207100
• The Su(Hw) Insulator Can Disrupt Enhancer-promoter Interactions when Located More Than 20 Kilobases Away from the Drosophila Achaete-scute Complex
  Molecular and Cellular Biology. May, 1999  |   Pubmed ID: 10207068