Articles by Payam Vali in JoVE
The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation Payam Vali*1, Sylvia Gugino*2, Carmon Koenigsknecht2, Justin Helman2, Praveen Chandrasekharan2, Munmun Rawat2, Satyan Lakshminrusimha1, Jayasree Nair2 1Department of Pediatrics, University of California Davis, 2Department of Pediatrics, University at Buffalo Invasive instrumentation of the fetal lamb provides accurate physiologic measurements of the transitioning circulation in a model that closely mimics the newly born infant.
Other articles by Payam Vali on PubMed
The Fetus Can Teach Us: Oxygen and the Pulmonary Vasculature Children (Basel, Switzerland). Aug, 2017 | Pubmed ID: 28771211 Neonates suffering from pulmonary hypertension of the newborn (PPHN) continue to represent an important proportion of patients requiring intensive neonatal care, and have an increased risk of morbidity and mortality. The human fetus has evolved to maintain a high pulmonary vascular resistance (PVR) in utero to allow the majority of the fetal circulation to bypass the lungs, which do not participate in gas exchange, towards the low resistance placenta. At birth, oxygen plays a major role in decreasing PVR to enhance pulmonary blood flow and establish the lungs as the organ of gas exchange. The failure of PVR to fall following birth results in PPHN, and oxygen remains the mainstay therapeutic intervention in the management of PPHN. Knowledge gaps on what constitutes the optimal oxygenation target leads to a wide variation in practices, and often leads to excessive oxygen use. Owing to the risk of oxygen toxicity, avoiding hyperoxemia is as important as avoiding hypoxemia in the management of PPHN. Current evidence supports maintaining arterial oxygen tension in the range of 50-80 mm Hg, and oxygen saturation between 90-97% in term infants with hypoxemic respiratory failure. Clinical studies evaluating the optimal oxygenation in the treatment of PPHN will be enthusiastically awaited.