Per Hammarström IFM-Department of Chemistry Linköping University Biography Publications Institution JoVE Articles Per Hammarström has not added a biography. If you are Per Hammarström and would like to personalize this page please email our Author Liaison for assistance. Publications Seed-dependent Templating of Murine AA Amyloidosis Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. Mar, 2017 | Pubmed ID: 28434369 Establishing and Validating the Fluorescent Amyloid Ligand H-FTAA (heptamer Formyl Thiophene Acetic Acid) to Identify Transthyretin Amyloid Deposits in Carpal Tunnel Syndrome Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. Jun, 2017 | Pubmed ID: 28434259 Nanoscale Structure and Spectroscopic Probing of Aβ1-40 Fibril Bundle Formation Frontiers in Chemistry. 2016 | Pubmed ID: 27921029 De Novo Design of a Biologically Active Amyloid Science (New York, N.Y.). 11, 2016 | Pubmed ID: 27846578 Differential Conformational Modulations of MreB Folding Upon Interactions with GroEL/ES and TRiC Chaperonin Components Scientific Reports. Jun, 2016 | Pubmed ID: 27328749 Novel Trans-Stilbene-based Fluorophores As Probes for Spectral Discrimination of Native and Protofibrillar Transthyretin ACS Chemical Neuroscience. Jul, 2016 | Pubmed ID: 27144293 (11)C and (18)F Radiolabeling of Tetra- and Pentathiophenes As PET-Ligands for Amyloid Protein Aggregates ACS Medicinal Chemistry Letters. Apr, 2016 | Pubmed ID: 27096043 Establishing the Fluorescent Amyloid Ligand H-FTAA for Studying Human Tissues with Systemic and Localized Amyloid Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. Jun, 2016 | Pubmed ID: 26987044 Protein Aggregation As an Antibiotic Design Strategy Molecular Microbiology. Mar, 2016 | Pubmed ID: 26559925 Pathological, Biochemical, and Biophysical Characteristics of the Transthyretin Variant Y114H (p.Y134H) Explain Its Very Mild Clinical Phenotype Journal of the Peripheral Nervous System : JPNS. Dec, 2015 | Pubmed ID: 26306725 Structure-based Drug Design Identifies Polythiophenes As Antiprion Compounds Science Translational Medicine. Aug, 2015 | Pubmed ID: 26246168 Porcine Prion Protein Amyloid Prion. 2015 | Pubmed ID: 26218890 Systematic Aβ Analysis in Drosophila Reveals High Toxicity for the 1-42, 3-42 and 11-42 Peptides, and Emphasizes N- and C-Terminal Residues PloS One. 2015 | Pubmed ID: 26208119 Considerably Unfolded Transthyretin Monomers Preceed and Exchange with Dynamically Structured Amyloid Protofibrils Scientific Reports. Jun, 2015 | Pubmed ID: 26108284 Generic Amyloidogenicity of Mammalian Prion Proteins from Species Susceptible and Resistant to Prions Scientific Reports. May, 2015 | Pubmed ID: 25960067 Sensitive and Rapid Assessment of Amyloid by Oligothiophene Fluorescence in Subcutaneous Fat Tissue Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. Mar, 2015 | Pubmed ID: 25847117 Multimodal Fluorescence Microscopy of Prion Strain Specific PrP Deposits Stained by Thiophene-based Amyloid Ligands Prion. 2014 | Pubmed ID: 25495506 Aβ Seeds Resist Inactivation by Formaldehyde Acta Neuropathologica. Oct, 2014 | Pubmed ID: 25193240 Direct Visualization of HIV-enhancing Endogenous Amyloid Fibrils in Human Semen Nature Communications. Apr, 2014 | Pubmed ID: 24691351 Is the Prevalent Human Prion Protein 129M/V Mutation a Living Fossil from a Paleolithic Panzootic Superprion Pandemic? Prion. Jan-Feb, 2014 | Pubmed ID: 24398570 Transient Conformational Remodeling of Folding Proteins by GroES-individually and in Concert with GroEL Journal of Chemical Biology. 2013 | Pubmed ID: 24386013 Amyloid Beta(1-40)-induced Astrogliosis and the Effect of Genistein Treatment in Rat: a Three-dimensional Confocal Morphometric and Proteomic Study PloS One. 2013 | Pubmed ID: 24130779 Seeded Strain-like Transmission of β-amyloid Morphotypes in APP Transgenic Mice EMBO Reports. Nov, 2013 | Pubmed ID: 23999102 Evidence for Age-dependent in Vivo Conformational Rearrangement Within Aβ Amyloid Deposits ACS Chemical Biology. 2013 | Pubmed ID: 23521783 Enhanced Fluorescent Assignment of Protein Aggregates by an Oligothiophene-porphyrin-based Amyloid Ligand Macromolecular Rapid Communications. May, 2013 | Pubmed ID: 23468206 Localisation De Cholestérol, Amyloïde Et Cellules Gliales Dans Le Tissu De Cerveau De Souris Transgéniques De La Maladie D'Alzheimer à L'aide De La Spectrométrie De Masse Ionique Secondaire De Temps De Vol (ToF-SIMS) Et L'imagerie De L'immunofluorescence Acta Neuropathologica. Jan, 2013 | Pubmed ID: 22996963 Spectral Discrimination of Cerebral Amyloid Lesions After Peripheral Application of Luminescent Conjugated Oligothiophenes The American Journal of Pathology. Dec, 2012 | Pubmed ID: 23041059 Multiple Substitutions of Methionine 129 in Human Prion Protein Reveal Its Importance in the Amyloid Fibrillation Pathway The Journal of Biological Chemistry. Jul, 2012 | Pubmed ID: 22669942 Derivatization of a Bioorthogonal Protected Trisaccharide Linker-toward Multimodal Tools for Chemical Biology Bioconjugate Chemistry. Jun, 2012 | Pubmed ID: 22568531 A Pentameric Luminescent-conjugated Oligothiophene for Optical Imaging of in Vitro-formed Amyloid Fibrils and Protein Aggregates in Tissue Sections Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22528107 Polythiophenes Inhibit Prion Propagation by Stabilizing Prion Protein (PrP) Aggregates The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22493452 Power Tools for Alzheimer's Disease - an Electrochemical Preamp for Aβ Journal of Neurochemistry. Jul, 2012 | Pubmed ID: 22409410 Nanoscopic and Photonic Ultrastructural Characterization of Two Distinct Insulin Amyloid States International Journal of Molecular Sciences. 2012 | Pubmed ID: 22408402 Curcumin Promotes A-beta Fibrillation and Reduces Neurotoxicity in Transgenic Drosophila PloS One. 2012 | Pubmed ID: 22348084 Cell Interaction Study of Amyloid by Using Luminescent Conjugated Polythiophene: Implication That Amyloid Cytotoxicity is Correlated with Prolonged Cellular Binding Chembiochem : a European Journal of Chemical Biology. Feb, 2012 | Pubmed ID: 22262644 Synthesis of a Library of Oligothiophenes and Their Utilization As Fluorescent Ligands for Spectral Assignment of Protein Aggregates Organic & Biomolecular Chemistry. Dec, 2011 | Pubmed ID: 22051883 Observations in APP Bitransgenic Mice Suggest That Diffuse and Compact Plaques Form Via Independent Processes in Alzheimer's Disease The American Journal of Pathology. May, 2011 | Pubmed ID: 21514441 Thermodynamic Stability and Denaturation Kinetics of a Benign Natural Transthyretin Mutant Identified in a Danish Kindred Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. Jun, 2011 | Pubmed ID: 21406045 Spectroscopic Characterization of Diverse Amyloid Fibrils in Vitro by the Fluorescent Dye Nile Red Molecular BioSystems. Apr, 2011 | Pubmed ID: 21279219 An Auto-catalytic Surface for Conformational Replication of Amyloid Fibrils--genesis of an Amyloid World? Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life. Aug, 2011 | Pubmed ID: 21127982 GroEL-induced Topological Dislocation of a Substrate Protein β-sheet Core: a Solution EPR Spin-spin Distance Study Journal of Chemical Biology. Apr, 2010 | Pubmed ID: 21479077 Spatially Controlled Amyloid Reactions Using Organic Electronics Small (Weinheim an Der Bergstrasse, Germany). Oct, 2010 | Pubmed ID: 20814927 A Fluorescent Pentameric Thiophene Derivative Detects in Vitro-formed Prefibrillar Protein Aggregates Biochemistry. Aug, 2010 | Pubmed ID: 20604540 Efficient Imaging of Amyloid Deposits in Drosophila Models of Human Amyloidoses Nature Protocols. May, 2010 | Pubmed ID: 20431539 Amyloid Oligomers: Spectroscopic Characterization of Amyloidogenic Protein States The FEBS Journal. Mar, 2010 | Pubmed ID: 20148961 Chaperone Activity of Cyp18 Through Hydrophobic Condensation That Enables Rescue of Transient Misfolded Molten Globule Intermediates Biochemistry. Feb, 2010 | Pubmed ID: 20070121 Amyloid Fibrils of Human Prion Protein Are Spun and Woven from Morphologically Disordered Aggregates Prion. Oct-Dec, 2009 | Pubmed ID: 19923901 Novel Pentameric Thiophene Derivatives for in Vitro and in Vivo Optical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses ACS Chemical Biology. Aug, 2009 | Pubmed ID: 19624097 Protein Folding, Misfolding and Disease FEBS Letters. Aug, 2009 | Pubmed ID: 19616000 Small-molecule Suppression of Misfolding of Mutated Human Carbonic Anhydrase II Linked to Marble Brain Disease Biochemistry. Jun, 2009 | Pubmed ID: 19415900 Modeling Familial Amyloidotic Polyneuropathy (Transthyretin V30M) in Drosophila Melanogaster Neuro-degenerative Diseases. 2009 | Pubmed ID: 19372706 A Nonessential Role for Arg 55 in Cyclophilin18 for Catalysis of Proline Isomerization During Protein Folding Protein Science : a Publication of the Protein Society. Feb, 2009 | Pubmed ID: 19185003 A Highly Insoluble State of Abeta Similar to That of Alzheimer's Disease Brain is Found in Arctic APP Transgenic Mice Neurobiology of Aging. Sep, 2009 | Pubmed ID: 18192084 Prefibrillar Transthyretin Oligomers and Cold Stored Native Tetrameric Transthyretin Are Cytotoxic in Cell Culture Biochemical and Biophysical Research Communications. Dec, 2008 | Pubmed ID: 18983977 Misfolded Proteins Activate Factor XII in Humans, Leading to Kallikrein Formation Without Initiating Coagulation The Journal of Clinical Investigation. Sep, 2008 | Pubmed ID: 18725990 Native, Amyloid Fibrils and Beta-oligomers of the C-terminal Domain of Human Prion Protein Display Differential Activation of Complement and Bind C1q, Factor H and C4b-binding Protein Directly Molecular Immunology. Jun, 2008 | Pubmed ID: 18406463 Thermodynamic Interrogation of a Folding Disease. Mutant Mapping of Position 107 in Human Carbonic Anhydrase II Linked to Marble Brain Disease Biochemistry. Feb, 2008 | Pubmed ID: 18189416 Prion Strain Discrimination Using Luminescent Conjugated Polymers Nature Methods. Dec, 2007 | Pubmed ID: 18026110 Studies of Luminescent Conjugated Polythiophene Derivatives: Enhanced Spectral Discrimination of Protein Conformational States Bioconjugate Chemistry. Nov-Dec, 2007 | Pubmed ID: 17939727 Domain-specific Chaperone-induced Expansion is Required for Beta-actin Folding: a Comparison of Beta-actin Conformations Upon Interactions with GroEL and Tail-less Complex Polypeptide 1 Ring Complex (TRiC) Biochemistry. Nov, 2007 | Pubmed ID: 17939680 Imaging Distinct Conformational States of Amyloid-beta Fibrils in Alzheimer's Disease Using Novel Luminescent Probes ACS Chemical Biology. Aug, 2007 | Pubmed ID: 17672509 Conformational Rearrangements of Tail-less Complex Polypeptide 1 (TCP-1) Ring Complex (TRiC)-bound Actin Biochemistry. May, 2007 | Pubmed ID: 17417821 Lysozyme Amyloidogenesis is Accelerated by Specific Nicking and Fragmentation but Decelerated by Intact Protein Binding and Conversion Journal of Molecular Biology. Feb, 2007 | Pubmed ID: 17196616 Conjugated Polyelectrolytes--conformation-sensitive Optical Probes for Staining and Characterization of Amyloid Deposits Chembiochem : a European Journal of Chemical Biology. Jul, 2006 | Pubmed ID: 16729336 Retention of Misfolded Mutant Transthyretin by the Chaperone BiP/GRP78 Mitigates Amyloidogenesis Journal of Molecular Biology. Feb, 2006 | Pubmed ID: 16376939 Activity, Folding, Misfolding, and Aggregation in Vitro of the Naturally Occurring Human Tissue Factor Mutant R200W Biochemistry. May, 2005 | Pubmed ID: 15865421 The Biological and Chemical Basis for Tissue-selective Amyloid Disease Cell. Apr, 2005 | Pubmed ID: 15820680 Detection and Characterization of Aggregates, Prefibrillar Amyloidogenic Oligomers, and Protofibrils Using Fluorescence Spectroscopy Biophysical Journal. Jun, 2005 | Pubmed ID: 15764666 Conjugated Polyelectrolytes: Conformation-sensitive Optical Probes for Detection of Amyloid Fibril Formation Biochemistry. Mar, 2005 | Pubmed ID: 15751948 Synthesis of a Regioregular Zwitterionic Conjugated Oligoelectrolyte, Usable As an Optical Probe for Detection of Amyloid Fibril Formation at Acidic PH Journal of the American Chemical Society. Feb, 2005 | Pubmed ID: 15713111 The Cyclooxygenase-2 Inhibitor Celecoxib is a Potent Inhibitor of Human Carbonic Anhydrase II Inflammation. Oct, 2004 | Pubmed ID: 16134002 Unfolding a Folding Disease: Folding, Misfolding and Aggregation of the Marble Brain Syndrome-associated Mutant H107Y of Human Carbonic Anhydrase II Journal of Molecular Biology. Sep, 2004 | Pubmed ID: 15327960 Reshaping the Folding Energy Landscape by Chloride Salt: Impact on Molten-globule Formation and Aggregation Behavior of Carbonic Anhydrase FEBS Letters. May, 2004 | Pubmed ID: 15147875 D18G Transthyretin is Monomeric, Aggregation Prone, and Not Detectable in Plasma and Cerebrospinal Fluid: a Prescription for Central Nervous System Amyloidosis? Biochemistry. Jun, 2003 | Pubmed ID: 12779320 Energetic Characteristics of the New Transthyretin Variant A25T May Explain Its Atypical Central Nervous System Pathology Laboratory Investigation; a Journal of Technical Methods and Pathology. Mar, 2003 | Pubmed ID: 12649341 Prevention of Transthyretin Amyloid Disease by Changing Protein Misfolding Energetics Science (New York, N.Y.). Jan, 2003 | Pubmed ID: 12560553 Sequence-dependent Denaturation Energetics: A Major Determinant in Amyloid Disease Diversity Proceedings of the National Academy of Sciences of the United States of America. Dec, 2002 | Pubmed ID: 12351683 Imagerie des tissus amyloïdes colorées avec Luminescent thiol conjugués par Hyperspectral confocale microscopie et imagerie de Fluorescence Lifetime Sofie Nyström1, Marcus Bäck1, K. Peter R. Nilsson1, Per Hammarström1 1IFM-Department of Chemistry, Linköping University JoVE 56279 Biochemistry
Imagerie des tissus amyloïdes colorées avec Luminescent thiol conjugués par Hyperspectral confocale microscopie et imagerie de Fluorescence Lifetime Sofie Nyström1, Marcus Bäck1, K. Peter R. Nilsson1, Per Hammarström1 1IFM-Department of Chemistry, Linköping University JoVE 56279 Biochemistry