Per Hammarström IFM-Department of Chemistry Linköping University Biography Publications Institution JoVE Articles Per Hammarström has not added a biography. If you are Per Hammarström and would like to personalize this page please email our Author Liaison for assistance. Publications Seed-dependent Templating of Murine AA Amyloidosis Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. Mar, 2017 | Pubmed ID: 28434369 Establishing and Validating the Fluorescent Amyloid Ligand H-FTAA (heptamer Formyl Thiophene Acetic Acid) to Identify Transthyretin Amyloid Deposits in Carpal Tunnel Syndrome Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. Jun, 2017 | Pubmed ID: 28434259 Nanoscale Structure and Spectroscopic Probing of Aβ1-40 Fibril Bundle Formation Frontiers in Chemistry. 2016 | Pubmed ID: 27921029 De Novo Design of a Biologically Active Amyloid Science (New York, N.Y.). 11, 2016 | Pubmed ID: 27846578 Differential Conformational Modulations of MreB Folding Upon Interactions with GroEL/ES and TRiC Chaperonin Components Scientific Reports. Jun, 2016 | Pubmed ID: 27328749 Novel Trans-Stilbene-based Fluorophores As Probes for Spectral Discrimination of Native and Protofibrillar Transthyretin ACS Chemical Neuroscience. Jul, 2016 | Pubmed ID: 27144293 (11)C and (18)F Radiolabeling of Tetra- and Pentathiophenes As PET-Ligands for Amyloid Protein Aggregates ACS Medicinal Chemistry Letters. Apr, 2016 | Pubmed ID: 27096043 Establishing the Fluorescent Amyloid Ligand H-FTAA for Studying Human Tissues with Systemic and Localized Amyloid Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. Jun, 2016 | Pubmed ID: 26987044 Protein Aggregation As an Antibiotic Design Strategy Molecular Microbiology. Mar, 2016 | Pubmed ID: 26559925 Pathological, Biochemical, and Biophysical Characteristics of the Transthyretin Variant Y114H (p.Y134H) Explain Its Very Mild Clinical Phenotype Journal of the Peripheral Nervous System : JPNS. Dec, 2015 | Pubmed ID: 26306725 Structure-based Drug Design Identifies Polythiophenes As Antiprion Compounds Science Translational Medicine. Aug, 2015 | Pubmed ID: 26246168 Porcine Prion Protein Amyloid Prion. 2015 | Pubmed ID: 26218890 Systematic Aβ Analysis in Drosophila Reveals High Toxicity for the 1-42, 3-42 and 11-42 Peptides, and Emphasizes N- and C-Terminal Residues PloS One. 2015 | Pubmed ID: 26208119 Considerably Unfolded Transthyretin Monomers Preceed and Exchange with Dynamically Structured Amyloid Protofibrils Scientific Reports. Jun, 2015 | Pubmed ID: 26108284 Generic Amyloidogenicity of Mammalian Prion Proteins from Species Susceptible and Resistant to Prions Scientific Reports. May, 2015 | Pubmed ID: 25960067 Sensitive and Rapid Assessment of Amyloid by Oligothiophene Fluorescence in Subcutaneous Fat Tissue Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. Mar, 2015 | Pubmed ID: 25847117 Multimodal Fluorescence Microscopy of Prion Strain Specific PrP Deposits Stained by Thiophene-based Amyloid Ligands Prion. 2014 | Pubmed ID: 25495506 Aβ Seeds Resist Inactivation by Formaldehyde Acta Neuropathologica. Oct, 2014 | Pubmed ID: 25193240 Direct Visualization of HIV-enhancing Endogenous Amyloid Fibrils in Human Semen Nature Communications. Apr, 2014 | Pubmed ID: 24691351 Is the Prevalent Human Prion Protein 129M/V Mutation a Living Fossil from a Paleolithic Panzootic Superprion Pandemic? Prion. Jan-Feb, 2014 | Pubmed ID: 24398570 Transient Conformational Remodeling of Folding Proteins by GroES-individually and in Concert with GroEL Journal of Chemical Biology. 2013 | Pubmed ID: 24386013 Amyloid Beta(1-40)-induced Astrogliosis and the Effect of Genistein Treatment in Rat: a Three-dimensional Confocal Morphometric and Proteomic Study PloS One. 2013 | Pubmed ID: 24130779 Seeded Strain-like Transmission of β-amyloid Morphotypes in APP Transgenic Mice EMBO Reports. Nov, 2013 | Pubmed ID: 23999102 Evidence for Age-dependent in Vivo Conformational Rearrangement Within Aβ Amyloid Deposits ACS Chemical Biology. 2013 | Pubmed ID: 23521783 Enhanced Fluorescent Assignment of Protein Aggregates by an Oligothiophene-porphyrin-based Amyloid Ligand Macromolecular Rapid Communications. May, 2013 | Pubmed ID: 23468206 Localization of Cholesterol, Amyloid and Glia in Alzheimer's Disease Transgenic Mouse Brain Tissue Using Time-of-flight Secondary Ion Mass Spectrometry (ToF-SIMS) and Immunofluorescence Imaging Acta Neuropathologica. Jan, 2013 | Pubmed ID: 22996963 Spectral Discrimination of Cerebral Amyloid Lesions After Peripheral Application of Luminescent Conjugated Oligothiophenes The American Journal of Pathology. Dec, 2012 | Pubmed ID: 23041059 Multiple Substitutions of Methionine 129 in Human Prion Protein Reveal Its Importance in the Amyloid Fibrillation Pathway The Journal of Biological Chemistry. Jul, 2012 | Pubmed ID: 22669942 Derivatization of a Bioorthogonal Protected Trisaccharide Linker-toward Multimodal Tools for Chemical Biology Bioconjugate Chemistry. Jun, 2012 | Pubmed ID: 22568531 A Pentameric Luminescent-conjugated Oligothiophene for Optical Imaging of in Vitro-formed Amyloid Fibrils and Protein Aggregates in Tissue Sections Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22528107 Polythiophenes Inhibit Prion Propagation by Stabilizing Prion Protein (PrP) Aggregates The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22493452 Power Tools for Alzheimer's Disease - an Electrochemical Preamp for Aβ Journal of Neurochemistry. Jul, 2012 | Pubmed ID: 22409410 Nanoscopic and Photonic Ultrastructural Characterization of Two Distinct Insulin Amyloid States International Journal of Molecular Sciences. 2012 | Pubmed ID: 22408402 Curcumin Promotes A-beta Fibrillation and Reduces Neurotoxicity in Transgenic Drosophila PloS One. 2012 | Pubmed ID: 22348084 Cell Interaction Study of Amyloid by Using Luminescent Conjugated Polythiophene: Implication That Amyloid Cytotoxicity is Correlated with Prolonged Cellular Binding Chembiochem : a European Journal of Chemical Biology. Feb, 2012 | Pubmed ID: 22262644 Synthesis of a Library of Oligothiophenes and Their Utilization As Fluorescent Ligands for Spectral Assignment of Protein Aggregates Organic & Biomolecular Chemistry. Dec, 2011 | Pubmed ID: 22051883 Observations in APP Bitransgenic Mice Suggest That Diffuse and Compact Plaques Form Via Independent Processes in Alzheimer's Disease The American Journal of Pathology. May, 2011 | Pubmed ID: 21514441 Thermodynamic Stability and Denaturation Kinetics of a Benign Natural Transthyretin Mutant Identified in a Danish Kindred Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. Jun, 2011 | Pubmed ID: 21406045 Spectroscopic Characterization of Diverse Amyloid Fibrils in Vitro by the Fluorescent Dye Nile Red Molecular BioSystems. Apr, 2011 | Pubmed ID: 21279219 An Auto-catalytic Surface for Conformational Replication of Amyloid Fibrils--genesis of an Amyloid World? Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life. Aug, 2011 | Pubmed ID: 21127982 GroEL-induced Topological Dislocation of a Substrate Protein β-sheet Core: a Solution EPR Spin-spin Distance Study Journal of Chemical Biology. Apr, 2010 | Pubmed ID: 21479077 Spatially Controlled Amyloid Reactions Using Organic Electronics Small (Weinheim an Der Bergstrasse, Germany). Oct, 2010 | Pubmed ID: 20814927 A Fluorescent Pentameric Thiophene Derivative Detects in Vitro-formed Prefibrillar Protein Aggregates Biochemistry. Aug, 2010 | Pubmed ID: 20604540 Efficient Imaging of Amyloid Deposits in Drosophila Models of Human Amyloidoses Nature Protocols. May, 2010 | Pubmed ID: 20431539 Amyloid Oligomers: Spectroscopic Characterization of Amyloidogenic Protein States The FEBS Journal. Mar, 2010 | Pubmed ID: 20148961 Chaperone Activity of Cyp18 Through Hydrophobic Condensation That Enables Rescue of Transient Misfolded Molten Globule Intermediates Biochemistry. Feb, 2010 | Pubmed ID: 20070121 Amyloid Fibrils of Human Prion Protein Are Spun and Woven from Morphologically Disordered Aggregates Prion. Oct-Dec, 2009 | Pubmed ID: 19923901 Novel Pentameric Thiophene Derivatives for in Vitro and in Vivo Optical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses ACS Chemical Biology. Aug, 2009 | Pubmed ID: 19624097 Protein Folding, Misfolding and Disease FEBS Letters. Aug, 2009 | Pubmed ID: 19616000 Small-molecule Suppression of Misfolding of Mutated Human Carbonic Anhydrase II Linked to Marble Brain Disease Biochemistry. Jun, 2009 | Pubmed ID: 19415900 Modeling Familial Amyloidotic Polyneuropathy (Transthyretin V30M) in Drosophila Melanogaster Neuro-degenerative Diseases. 2009 | Pubmed ID: 19372706 A Nonessential Role for Arg 55 in Cyclophilin18 for Catalysis of Proline Isomerization During Protein Folding Protein Science : a Publication of the Protein Society. Feb, 2009 | Pubmed ID: 19185003 A Highly Insoluble State of Abeta Similar to That of Alzheimer's Disease Brain is Found in Arctic APP Transgenic Mice Neurobiology of Aging. Sep, 2009 | Pubmed ID: 18192084 Prefibrillar Transthyretin Oligomers and Cold Stored Native Tetrameric Transthyretin Are Cytotoxic in Cell Culture Biochemical and Biophysical Research Communications. Dec, 2008 | Pubmed ID: 18983977 Misfolded Proteins Activate Factor XII in Humans, Leading to Kallikrein Formation Without Initiating Coagulation The Journal of Clinical Investigation. Sep, 2008 | Pubmed ID: 18725990 Native, Amyloid Fibrils and Beta-oligomers of the C-terminal Domain of Human Prion Protein Display Differential Activation of Complement and Bind C1q, Factor H and C4b-binding Protein Directly Molecular Immunology. Jun, 2008 | Pubmed ID: 18406463 Thermodynamic Interrogation of a Folding Disease. Mutant Mapping of Position 107 in Human Carbonic Anhydrase II Linked to Marble Brain Disease Biochemistry. Feb, 2008 | Pubmed ID: 18189416 Prion Strain Discrimination Using Luminescent Conjugated Polymers Nature Methods. Dec, 2007 | Pubmed ID: 18026110 Studies of Luminescent Conjugated Polythiophene Derivatives: Enhanced Spectral Discrimination of Protein Conformational States Bioconjugate Chemistry. Nov-Dec, 2007 | Pubmed ID: 17939727 Domain-specific Chaperone-induced Expansion is Required for Beta-actin Folding: a Comparison of Beta-actin Conformations Upon Interactions with GroEL and Tail-less Complex Polypeptide 1 Ring Complex (TRiC) Biochemistry. Nov, 2007 | Pubmed ID: 17939680 Imaging Distinct Conformational States of Amyloid-beta Fibrils in Alzheimer's Disease Using Novel Luminescent Probes ACS Chemical Biology. Aug, 2007 | Pubmed ID: 17672509 Conformational Rearrangements of Tail-less Complex Polypeptide 1 (TCP-1) Ring Complex (TRiC)-bound Actin Biochemistry. May, 2007 | Pubmed ID: 17417821 Lysozyme Amyloidogenesis is Accelerated by Specific Nicking and Fragmentation but Decelerated by Intact Protein Binding and Conversion Journal of Molecular Biology. Feb, 2007 | Pubmed ID: 17196616 Conjugated Polyelectrolytes--conformation-sensitive Optical Probes for Staining and Characterization of Amyloid Deposits Chembiochem : a European Journal of Chemical Biology. Jul, 2006 | Pubmed ID: 16729336 Retention of Misfolded Mutant Transthyretin by the Chaperone BiP/GRP78 Mitigates Amyloidogenesis Journal of Molecular Biology. Feb, 2006 | Pubmed ID: 16376939 Activity, Folding, Misfolding, and Aggregation in Vitro of the Naturally Occurring Human Tissue Factor Mutant R200W Biochemistry. May, 2005 | Pubmed ID: 15865421 The Biological and Chemical Basis for Tissue-selective Amyloid Disease Cell. Apr, 2005 | Pubmed ID: 15820680 Detection and Characterization of Aggregates, Prefibrillar Amyloidogenic Oligomers, and Protofibrils Using Fluorescence Spectroscopy Biophysical Journal. Jun, 2005 | Pubmed ID: 15764666 Conjugated Polyelectrolytes: Conformation-sensitive Optical Probes for Detection of Amyloid Fibril Formation Biochemistry. Mar, 2005 | Pubmed ID: 15751948 Synthesis of a Regioregular Zwitterionic Conjugated Oligoelectrolyte, Usable As an Optical Probe for Detection of Amyloid Fibril Formation at Acidic PH Journal of the American Chemical Society. Feb, 2005 | Pubmed ID: 15713111 The Cyclooxygenase-2 Inhibitor Celecoxib is a Potent Inhibitor of Human Carbonic Anhydrase II Inflammation. Oct, 2004 | Pubmed ID: 16134002 Unfolding a Folding Disease: Folding, Misfolding and Aggregation of the Marble Brain Syndrome-associated Mutant H107Y of Human Carbonic Anhydrase II Journal of Molecular Biology. Sep, 2004 | Pubmed ID: 15327960 Reshaping the Folding Energy Landscape by Chloride Salt: Impact on Molten-globule Formation and Aggregation Behavior of Carbonic Anhydrase FEBS Letters. May, 2004 | Pubmed ID: 15147875 D18G Transthyretin is Monomeric, Aggregation Prone, and Not Detectable in Plasma and Cerebrospinal Fluid: a Prescription for Central Nervous System Amyloidosis? Biochemistry. Jun, 2003 | Pubmed ID: 12779320 Energetic Characteristics of the New Transthyretin Variant A25T May Explain Its Atypical Central Nervous System Pathology Laboratory Investigation; a Journal of Technical Methods and Pathology. Mar, 2003 | Pubmed ID: 12649341 Prevention of Transthyretin Amyloid Disease by Changing Protein Misfolding Energetics Science (New York, N.Y.). Jan, 2003 | Pubmed ID: 12560553 Sequence-dependent Denaturation Energetics: A Major Determinant in Amyloid Disease Diversity Proceedings of the National Academy of Sciences of the United States of America. Dec, 2002 | Pubmed ID: 12351683 Imaging амилоида тканей витражи с светящиеся конъюгированных Oligothiophenes путем использования гиперспектральных конфокальная микроскопия и флуоресценции жизни изображений Sofie Nyström1, Marcus Bäck1, K. Peter R. Nilsson1, Per Hammarström1 1IFM-Department of Chemistry, Linköping University JoVE 56279 Biochemistry
Imaging амилоида тканей витражи с светящиеся конъюгированных Oligothiophenes путем использования гиперспектральных конфокальная микроскопия и флуоресценции жизни изображений Sofie Nyström1, Marcus Bäck1, K. Peter R. Nilsson1, Per Hammarström1 1IFM-Department of Chemistry, Linköping University JoVE 56279 Biochemistry
