Peter G. Alexander Department of Orthopaedic Surgery University of Pittsburgh School of Medicine Biography Publications Institution JoVE Articles Peter G. Alexander has not added a biography. If you are Peter G. Alexander and would like to personalize this page please email our Author Liaison for assistance. Publications Pathogenesis of Acquired Heterotopic Ossification: Risk Factors, Cellular Mechanisms, and Therapeutic Implications Bone. Dec, 2022 | Pubmed ID: 36581258 Differences in the Intrinsic Chondrogenic Potential of Human Mesenchymal Stromal Cells and IPSC-derived Multipotent Cells Clinical and Translational Medicine. Dec, 2022 | Pubmed ID: 36536500 Experimental Models to Study Osteoarthritis Pain and Develop Therapeutics Osteoarthritis and Cartilage Open. Dec, 2022 | Pubmed ID: 36474784 Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes Biology. Jun, 2022 | Pubmed ID: 36101377 Modeling Early Changes Associated with Cartilage Trauma Using Human-cell-laden Hydrogel Cartilage Models Stem Cell Research & Therapy. Aug, 2022 | Pubmed ID: 35927702 Generation of Hyaline-like Cartilage Tissue from Human Mesenchymal Stromal Cells Within the Self-generated Extracellular Matrix Acta Biomaterialia. Sep, 2022 | Pubmed ID: 35779770 Human Mesenchymal Stem Cell-Derived Miniature Joint System for Disease Modeling and Drug Testing Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Jul, 2022 | Pubmed ID: 35436042 Engineering Pre-vascularized Bone-like Tissue from Human Mesenchymal Stem Cells Through Simulating Endochondral Ossification Biomaterials. Apr, 2022 | Pubmed ID: 35259584 Role of Canonical Wnt/β-Catenin Pathway in Regulating Chondrocytic Hypertrophy in Mesenchymal Stem Cell-Based Cartilage Tissue Engineering Frontiers in Cell and Developmental Biology. 2022 | Pubmed ID: 35141220 Novel Role of Estrogen Receptor-α on Regulating Chondrocyte Phenotype and Response to Mechanical Loading Osteoarthritis and Cartilage. Feb, 2022 | Pubmed ID: 34767957 Engineering Osteoarthritic Cartilage Model Through Differentiating Senescent Human Mesenchymal Stem Cells for Testing Disease-modifying Drugs Science China. Life Sciences. Feb, 2022 | Pubmed ID: 34109475 Graphene Oxide-functionalized Nanocomposites Promote Osteogenesis of Human Mesenchymal Stem Cells Via Enhancement of BMP-SMAD1/5 Signaling Pathway Biomaterials. Oct, 2021 | Pubmed ID: 34464823 Urolithin A Protects Chondrocytes From Mechanical Overloading-Induced Injuries Frontiers in Pharmacology. 2021 | Pubmed ID: 34220525 A Novel Mouse Model for SNP in Steroid Receptor Co-Activator-1 Reveals Role in Bone Density and Breast Cancer Metastasis Endocrinology. Aug, 2021 | Pubmed ID: 33963375 An in Vitro Chondro-osteo-vascular Triphasic Model of the Osteochondral Complex Biomaterials. May, 2021 | Pubmed ID: 33798958 Development of a Large Animal Rabbit Model for Chronic Periprosthetic Joint Infection Bone & Joint Research. Mar, 2021 | Pubmed ID: 33641351 Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling Handbook of Experimental Pharmacology. 2021 | Pubmed ID: 33471201 Dead Muscle Tissue Promotes Dystrophic Calcification by Lowering Circulating TGF-β1 Level Bone & Joint Research. Nov, 2020 | Pubmed ID: 33135464 Mesenchymal Stem Cell-derived Extracellular Matrix (mECM): a Bioactive and Versatile Scaffold for Musculoskeletal Tissue Engineering Biomedical Materials (Bristol, England). Dec, 2020 | Pubmed ID: 32906098 Injectable BMP-2 Gene-activated Scaffold for the Repair of Cranial Bone Defect in Mice Stem Cells Translational Medicine. Dec, 2020 | Pubmed ID: 32785966 Pathogenesis of Osteoarthritis: Risk Factors, Regulatory Pathways in Chondrocytes, and Experimental Models Biology. Jul, 2020 | Pubmed ID: 32751156 Antimicrobial Activity of Mesenchymal Stem Cells Against Staphylococcus Aureus Stem Cell Research & Therapy. Jul, 2020 | Pubmed ID: 32680544 TGF-β1 Plays a Protective Role in Glucocorticoid-induced Dystrophic Calcification Bone. Jul, 2020 | Pubmed ID: 32259685 Obesity Does Not Increase Blood Loss or Incidence of Immediate Postoperative Complications During Simultaneous Total Knee Arthroplasty: A Multicenter Study The Knee. Jun, 2020 | Pubmed ID: 32057638 Osteochondral Tissue Chip Derived From IPSCs: Modeling OA Pathologies and Testing Drugs Frontiers in Bioengineering and Biotechnology. 2019 | Pubmed ID: 31921815 Modeling Appendicular Skeletal Cartilage Development with Modified High-density Micromass Cultures of Adult Human Bone Marrow-derived Mesenchymal Progenitor Cells Stem Cell Research & Therapy. Dec, 2019 | Pubmed ID: 31842986 Muscle Injury Promotes Heterotopic Ossification by Stimulating Local Bone Morphogenetic Protein-7 Production Journal of Orthopaedic Translation. Jul, 2019 | Pubmed ID: 31508317 The Efficacy and Safety of Tranexamic Acid for Reducing Blood Loss Following Simultaneous Bilateral Total Knee Arthroplasty: a Multicenter Retrospective Study BMC Musculoskeletal Disorders. Jul, 2019 | Pubmed ID: 31299945 Optimization of Photocrosslinked Gelatin/hyaluronic Acid Hybrid Scaffold for the Repair of Cartilage Defect Journal of Tissue Engineering and Regenerative Medicine. Aug, 2019 | Pubmed ID: 31066519 Conduits Harnessing Spatially Controlled Cell-secreted Neurotrophic Factors Improve Peripheral Nerve Regeneration Biomaterials. May, 2019 | Pubmed ID: 30857644 Enhancing Chondrogenesis and Mechanical Strength Retention in Physiologically Relevant Hydrogels with Incorporation of Hyaluronic Acid and Direct Loading of TGF-β Acta Biomaterialia. Jan, 2019 | Pubmed ID: 30458242 Clinical Applications of Bone Tissue Engineering in Orthopedic Trauma Current Pathobiology Reports. Jun, 2018 | Pubmed ID: 36506709 Effect of Platelet-Rich Plasma on Chondrogenic Differentiation of Adipose- and Bone Marrow-Derived Mesenchymal Stem Cells Tissue Engineering. Part A. Oct, 2018 | Pubmed ID: 30036140 Engineering In-vitro Stem Cell-based Vascularized Bone Models for Drug Screening and Predictive Toxicology Stem Cell Research & Therapy. Apr, 2018 | Pubmed ID: 29678192 Neurotrophic Support by Traumatized Muscle-derived Multipotent Progenitor Cells: Role of Endothelial Cells and Vascular Endothelial Growth Factor-A Stem Cell Research & Therapy. Oct, 2017 | Pubmed ID: 29029631 Anatomical Region-dependent Enhancement of 3-dimensional Chondrogenic Differentiation of Human Mesenchymal Stem Cells by Soluble Meniscus Extracellular Matrix Acta Biomaterialia. Feb, 2017 | Pubmed ID: 27876676 Prenatal Exposure to Environmental Factors and Congenital Limb Defects Birth Defects Research. Part C, Embryo Today : Reviews. Sep, 2016 | Pubmed ID: 27768243 Augmented Repair of Radial Meniscus Tear with Biomimetic Electrospun Scaffold: an in Vitro Mechanical Analysis Journal of Experimental Orthopaedics. Dec, 2016 | Pubmed ID: 27624439 Platelet-Rich Plasma Inhibits Mechanically Induced Injury in Chondrocytes Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association. Jun, 2015 | Pubmed ID: 25769480 Three-dimensional Osteogenic and Chondrogenic Systems to Model Osteochondral Physiology and Degenerative Joint Diseases Experimental Biology and Medicine (Maywood, N.J.). Sep, 2014 | Pubmed ID: 24994814 Stem Cell-based Microphysiological Osteochondral System to Model Tissue Response to Interleukin-1β Molecular Pharmaceutics. Jul, 2014 | Pubmed ID: 24830762 Cartilage Tissue Engineering Application of Injectable Gelatin Hydrogel with in Situ Visible-light-activated Gelation Capability in Both Air and Aqueous Solution Tissue Engineering. Part A. Sep, 2014 | Pubmed ID: 24575844 High Efficiency Transfection of Embryonic Limb Mesenchyme with Plasmid DNA Using Square Wave Pulse Electroporation and Sucrose Buffer BioTechniques. 2014 | Pubmed ID: 24502798 Development of a Spring-Loaded Impact Device to Deliver Injurious Mechanical Impacts to the Articular Cartilage Surface Cartilage. Jan, 2013 | Pubmed ID: 26069650 Enhancement of Tenogenic Differentiation of Human Adipose Stem Cells by Tendon-derived Extracellular Matrix Biomaterials. Dec, 2013 | Pubmed ID: 24044998 Application of Visible Light-based Projection Stereolithography for Live Cell-scaffold Fabrication with Designed Architecture Biomaterials. Jan, 2013 | Pubmed ID: 23092861 Mesenchymal Progenitor Cells Derived from Traumatized Muscle Enhance Neurite Growth Journal of Tissue Engineering and Regenerative Medicine. Jun, 2013 | Pubmed ID: 22552971 Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs Meagan J. Makarcyzk1,2, Zhong Alan Li1,3, Ilhan Yu1, Haruyo Yagi1, Xiurui Zhang1, Lauren Yocum1, Eileen Li1, Madalyn R. Fritch1, Qi Gao4, Bruce A. Bunnell5, Stuart B. Goodman4,6, Rocky S. Tuan1,8, Peter G. Alexander1,7, Hang Lin1,2,7 1Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 2Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, 3Department of Neurobiology, University of Pittsburgh School of Medicine, 4Department of Orthopaedic Surgery, Stanford University, 5Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, 6Department of Bioengineering, Stanford University, 7McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, 8The Chinese University of Hong Kong JoVE 64186 Bioengineering
Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs Meagan J. Makarcyzk1,2, Zhong Alan Li1,3, Ilhan Yu1, Haruyo Yagi1, Xiurui Zhang1, Lauren Yocum1, Eileen Li1, Madalyn R. Fritch1, Qi Gao4, Bruce A. Bunnell5, Stuart B. Goodman4,6, Rocky S. Tuan1,8, Peter G. Alexander1,7, Hang Lin1,2,7 1Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 2Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, 3Department of Neurobiology, University of Pittsburgh School of Medicine, 4Department of Orthopaedic Surgery, Stanford University, 5Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, 6Department of Bioengineering, Stanford University, 7McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, 8The Chinese University of Hong Kong JoVE 64186 Bioengineering