Peter Cherepanov

Publications

• Cryo-EM Reveals a Novel Octameric Integrase Structure for Betaretroviral Intasome Function
  Nature. Feb, 2016  |   Pubmed ID: 26887496
• HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases
  ACS Chemical Biology. Feb, 2016  |   Pubmed ID: 26808478
• Structural Basis for Retroviral Integration into Nucleosomes
  Nature. Jul, 2015  |   Pubmed ID: 26061770
• Key Determinants of Target DNA Recognition by Retroviral Intasomes
  Retrovirology. 2015  |   Pubmed ID: 25924943
• Retroviral Integrase Structure and DNA Recombination Mechanism
  Microbiology Spectrum. Dec, 2014  |   Pubmed ID: 26104441
• Retroviral Integrase Structure and DNA Recombination Mechanism
  Microbiology Spectrum. 2014  |   Pubmed ID: 25705574
• Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses
  Molecular Therapy. Methods & Clinical Development. Jan, 2014  |   Pubmed ID: 25383358
• Integrase Residues That Determine Nucleotide Preferences at Sites of HIV-1 Integration: Implications for the Mechanism of Target DNA Binding
  Nucleic Acids Research. Apr, 2014  |   Pubmed ID: 24520116
• Structural Basis for Nuclear Import of Splicing Factors by Human Transportin 3
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2014  |   Pubmed ID: 24449914
• Bromo- and Extraterminal Domain Chromatin Regulators Serve As Cofactors for Murine Leukemia Virus Integration
  Journal of Virology. Dec, 2013  |   Pubmed ID: 24049186
• Activities, Crystal Structures, and Molecular Dynamics of Dihydro-1H-isoindole Derivatives, Inhibitors of HIV-1 Integrase
  ACS Chemical Biology. Jan, 2013  |   Pubmed ID: 23075516
• Centralspindlin Links the Mitotic Spindle to the Plasma Membrane During Cytokinesis
  Nature. Dec, 2012  |   Pubmed ID: 23235882
• Crystal Structure of Human CDC7 Kinase in Complex with Its Activator DBF4
  Nature Structural & Molecular Biology. Nov, 2012  |   Pubmed ID: 23064647
• HRP2 Determines the Efficiency and Specificity of HIV-1 Integration in LEDGF/p75 Knockout Cells but Does Not Contribute to the Antiviral Activity of a Potent LEDGF/p75-binding Site Integrase Inhibitor
  Nucleic Acids Research. Dec, 2012  |   Pubmed ID: 23042676
• Solution Conformations of Prototype Foamy Virus Integrase and Its Stable Synaptic Complex with U5 Viral DNA
  Structure (London, England : 1993). Nov, 2012  |   Pubmed ID: 23000384
• 3'-processing and Strand Transfer Catalysed by Retroviral Integrase in Crystallo
  The EMBO Journal. Jun, 2012  |   Pubmed ID: 22580823
• The Structural Biology of HIV-1: Mechanistic and Therapeutic Insights
  Nature Reviews. Microbiology. Apr, 2012  |   Pubmed ID: 22421880
• Structural and Functional Analyses of the Second-generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)
  Molecular Pharmacology. Oct, 2011  |   Pubmed ID: 21719464
• Structural Insights into the Retroviral DNA Integration Apparatus
  Current Opinion in Structural Biology. Apr, 2011  |   Pubmed ID: 21277766
• Structural Biology of Retroviral DNA Integration
  Virology. Mar, 2011  |   Pubmed ID: 21216426
• The Mechanism of Retroviral Integration from X-ray Structures of Its Key Intermediates
  Nature. Nov, 2010  |   Pubmed ID: 21068843
• Molecular Mechanisms of Retroviral Integrase Inhibition and the Evolution of Viral Resistance
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010  |   Pubmed ID: 21030679
• Structure-based Modeling of the Functional HIV-1 Intasome and Its Inhibition
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010  |   Pubmed ID: 20733078
• Integrase Illuminated
  EMBO Reports. May, 2010  |   Pubmed ID: 20428106
• Retroviral Intasome Assembly and Inhibition of DNA Strand Transfer
  Nature. Mar, 2010  |   Pubmed ID: 20118915
• Transcriptional Co-activator LEDGF Interacts with Cdc7-activator of S-phase Kinase (ASK) and Stimulates Its Enzymatic Activity
  The Journal of Biological Chemistry. Jan, 2010  |   Pubmed ID: 19864417
• The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights
  Viruses. Dec, 2009  |   Pubmed ID: 21994569
• Application of General Formulas for the Correction of a Lattice-translocation Defect in Crystals of a Lentiviral Integrase in Complex with LEDGF
  Acta Crystallographica. Section D, Biological Crystallography. Sep, 2009  |   Pubmed ID: 19690374
• Structural Basis for Functional Tetramerization of Lentiviral Integrase
  PLoS Pathogens. Jul, 2009  |   Pubmed ID: 19609359
• The SET Complex Acts As a Barrier to Autointegration of HIV-1
  PLoS Pathogens. Mar, 2009  |   Pubmed ID: 19266025
• HIV-1 Exploits Importin 7 to Maximize Nuclear Import of Its DNA Genome
  Retrovirology. 2009  |   Pubmed ID: 19193229
• A Novel Co-crystal Structure Affords the Design of Gain-of-function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75
  PLoS Pathogens. Jan, 2009  |   Pubmed ID: 19132083
• Functional and Structural Characterization of the Integrase from the Prototype Foamy Virus
  Nucleic Acids Research. Jan, 2009  |   Pubmed ID: 19036793
• The Lentiviral Integrase Binding Protein LEDGF/p75 and HIV-1 Replication
  PLoS Pathogens. Mar, 2008  |   Pubmed ID: 18369482
• LEDGF/p75 Functions Downstream from Preintegration Complex Formation to Effect Gene-specific HIV-1 Integration
  Genes & Development. Jul, 2007  |   Pubmed ID: 17639082
• LEDGF/p75 Interacts with Divergent Lentiviral Integrases and Modulates Their Enzymatic Activity in Vitro
  Nucleic Acids Research. 2007  |   Pubmed ID: 17158150
• Structure-based Mutagenesis of the Integrase-LEDGF/p75 Interface Uncouples a Strict Correlation Between in Vitro Protein Binding and HIV-1 Fitness
  Virology. Jan, 2007  |   Pubmed ID: 16959283
• Transcriptional Co-activator P75 Binds and Tethers the Myc-interacting Protein JPO2 to Chromatin
  Journal of Cell Science. Jun, 2006  |   Pubmed ID: 16735438
• A Tripartite DNA-binding Element, Comprised of the Nuclear Localization Signal and Two AT-hook Motifs, Mediates the Association of LEDGF/p75 with Chromatin in Vivo
  Nucleic Acids Research. 2006  |   Pubmed ID: 16549878
• Structural Basis for the Recognition Between HIV-1 Integrase and Transcriptional Coactivator P75
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2005  |   Pubmed ID: 16260736
• Lys-34, Dispensable for Integrase Catalysis, is Required for Preintegration Complex Function and Human Immunodeficiency Virus Type 1 Replication
  Journal of Virology. Oct, 2005  |   Pubmed ID: 16160186
• Mutations in Both Env and Gag Genes Are Required for HIV-1 Resistance to the Polysulfonic Dendrimer SPL2923, As Corroborated by Chimeric Virus Technology
  Antiviral Chemistry & Chemotherapy. 2005  |   Pubmed ID: 16130523
• Solution Structure of the HIV-1 Integrase-binding Domain in LEDGF/p75
  Nature Structural & Molecular Biology. Jun, 2005  |   Pubmed ID: 15895093
• Class II Integrase Mutants with Changes in Putative Nuclear Localization Signals Are Primarily Blocked at a Postnuclear Entry Step of Human Immunodeficiency Virus Type 1 Replication
  Journal of Virology. Dec, 2004  |   Pubmed ID: 15542626
• Identification of an Evolutionarily Conserved Domain in Human Lens Epithelium-derived Growth Factor/transcriptional Co-activator P75 (LEDGF/p75) That Binds HIV-1 Integrase
  The Journal of Biological Chemistry. Nov, 2004  |   Pubmed ID: 15371438
• Identification and Characterization of a Functional Nuclear Localization Signal in the HIV-1 Integrase Interactor LEDGF/p75
  The Journal of Biological Chemistry. Aug, 2004  |   Pubmed ID: 15163664
• Expression of HIV-1 Integrase in CEM Cells Inhibits HIV-1 Replication
  The Journal of Gene Medicine. Mar, 2004  |   Pubmed ID: 15026988
• LEDGF/p75 is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells
  The Journal of Biological Chemistry. Aug, 2003  |   Pubmed ID: 12796494
• PH6 Antigen of Yersinia Pestis Interacts with Plasma Lipoproteins and Cell Membranes
  Journal of Lipid Research. Feb, 2003  |   Pubmed ID: 12576514
• HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells
  The Journal of Biological Chemistry. Jan, 2003  |   Pubmed ID: 12407101
• Env Chimeric Virus Technology for Evaluating Human Immunodeficiency Virus Susceptibility to Entry Inhibitors
  Antimicrobial Agents and Chemotherapy. Dec, 2002  |   Pubmed ID: 12435701
• In Search of Authentic Inhibitors of HIV-1 Integration
  Antiviral Chemistry & Chemotherapy. Jan, 2002  |   Pubmed ID: 12180645
• New Class of HIV Integrase Inhibitors That Block Viral Replication in Cell Culture
  Current Biology : CB. Jul, 2002  |   Pubmed ID: 12176326
• Role of Yersinia Murine Toxin in Survival of Yersinia Pestis in the Midgut of the Flea Vector
  Science (New York, N.Y.). Apr, 2002  |   Pubmed ID: 11976454