Peter Cherepanov Chromatin Structure and Mobile DNA The Francis Crick Institute Biography Publications Institution JoVE Articles Peter Cherepanov has not added a biography. If you are Peter Cherepanov and would like to personalize this page please email our Author Liaison for assistance. Publications Cryo-EM Reveals a Novel Octameric Integrase Structure for Betaretroviral Intasome Function Nature. Feb, 2016 | Pubmed ID: 26887496 HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases ACS Chemical Biology. Feb, 2016 | Pubmed ID: 26808478 Structural Basis for Retroviral Integration into Nucleosomes Nature. Jul, 2015 | Pubmed ID: 26061770 Key Determinants of Target DNA Recognition by Retroviral Intasomes Retrovirology. 2015 | Pubmed ID: 25924943 Retroviral Integrase Structure and DNA Recombination Mechanism Microbiology Spectrum. Dec, 2014 | Pubmed ID: 26104441 Retroviral Integrase Structure and DNA Recombination Mechanism Microbiology Spectrum. 2014 | Pubmed ID: 25705574 Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses Molecular Therapy. Methods & Clinical Development. Jan, 2014 | Pubmed ID: 25383358 Integrase Residues That Determine Nucleotide Preferences at Sites of HIV-1 Integration: Implications for the Mechanism of Target DNA Binding Nucleic Acids Research. Apr, 2014 | Pubmed ID: 24520116 Structural Basis for Nuclear Import of Splicing Factors by Human Transportin 3 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2014 | Pubmed ID: 24449914 Bromo- and Extraterminal Domain Chromatin Regulators Serve As Cofactors for Murine Leukemia Virus Integration Journal of Virology. Dec, 2013 | Pubmed ID: 24049186 Activities, Crystal Structures, and Molecular Dynamics of Dihydro-1H-isoindole Derivatives, Inhibitors of HIV-1 Integrase ACS Chemical Biology. Jan, 2013 | Pubmed ID: 23075516 Centralspindlin Links the Mitotic Spindle to the Plasma Membrane During Cytokinesis Nature. Dec, 2012 | Pubmed ID: 23235882 Crystal Structure of Human CDC7 Kinase in Complex with Its Activator DBF4 Nature Structural & Molecular Biology. Nov, 2012 | Pubmed ID: 23064647 HRP2 Determines the Efficiency and Specificity of HIV-1 Integration in LEDGF/p75 Knockout Cells but Does Not Contribute to the Antiviral Activity of a Potent LEDGF/p75-binding Site Integrase Inhibitor Nucleic Acids Research. Dec, 2012 | Pubmed ID: 23042676 Solution Conformations of Prototype Foamy Virus Integrase and Its Stable Synaptic Complex with U5 Viral DNA Structure (London, England : 1993). Nov, 2012 | Pubmed ID: 23000384 3'-processing and Strand Transfer Catalysed by Retroviral Integrase in Crystallo The EMBO Journal. Jun, 2012 | Pubmed ID: 22580823 The Structural Biology of HIV-1: Mechanistic and Therapeutic Insights Nature Reviews. Microbiology. Apr, 2012 | Pubmed ID: 22421880 Structural and Functional Analyses of the Second-generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572) Molecular Pharmacology. Oct, 2011 | Pubmed ID: 21719464 Structural Insights into the Retroviral DNA Integration Apparatus Current Opinion in Structural Biology. Apr, 2011 | Pubmed ID: 21277766 Structural Biology of Retroviral DNA Integration Virology. Mar, 2011 | Pubmed ID: 21216426 The Mechanism of Retroviral Integration from X-ray Structures of Its Key Intermediates Nature. Nov, 2010 | Pubmed ID: 21068843 Molecular Mechanisms of Retroviral Integrase Inhibition and the Evolution of Viral Resistance Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 21030679 Structure-based Modeling of the Functional HIV-1 Intasome and Its Inhibition Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20733078 Integrase Illuminated EMBO Reports. May, 2010 | Pubmed ID: 20428106 Retroviral Intasome Assembly and Inhibition of DNA Strand Transfer Nature. Mar, 2010 | Pubmed ID: 20118915 Transcriptional Co-activator LEDGF Interacts with Cdc7-activator of S-phase Kinase (ASK) and Stimulates Its Enzymatic Activity The Journal of Biological Chemistry. Jan, 2010 | Pubmed ID: 19864417 The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights Viruses. Dec, 2009 | Pubmed ID: 21994569 Application of General Formulas for the Correction of a Lattice-translocation Defect in Crystals of a Lentiviral Integrase in Complex with LEDGF Acta Crystallographica. Section D, Biological Crystallography. Sep, 2009 | Pubmed ID: 19690374 Structural Basis for Functional Tetramerization of Lentiviral Integrase PLoS Pathogens. Jul, 2009 | Pubmed ID: 19609359 The SET Complex Acts As a Barrier to Autointegration of HIV-1 PLoS Pathogens. Mar, 2009 | Pubmed ID: 19266025 HIV-1 Exploits Importin 7 to Maximize Nuclear Import of Its DNA Genome Retrovirology. 2009 | Pubmed ID: 19193229 A Novel Co-crystal Structure Affords the Design of Gain-of-function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75 PLoS Pathogens. Jan, 2009 | Pubmed ID: 19132083 Functional and Structural Characterization of the Integrase from the Prototype Foamy Virus Nucleic Acids Research. Jan, 2009 | Pubmed ID: 19036793 The Lentiviral Integrase Binding Protein LEDGF/p75 and HIV-1 Replication PLoS Pathogens. Mar, 2008 | Pubmed ID: 18369482 LEDGF/p75 Functions Downstream from Preintegration Complex Formation to Effect Gene-specific HIV-1 Integration Genes & Development. Jul, 2007 | Pubmed ID: 17639082 LEDGF/p75 Interacts with Divergent Lentiviral Integrases and Modulates Their Enzymatic Activity in Vitro Nucleic Acids Research. 2007 | Pubmed ID: 17158150 Structure-based Mutagenesis of the Integrase-LEDGF/p75 Interface Uncouples a Strict Correlation Between in Vitro Protein Binding and HIV-1 Fitness Virology. Jan, 2007 | Pubmed ID: 16959283 Transcriptional Co-activator P75 Binds and Tethers the Myc-interacting Protein JPO2 to Chromatin Journal of Cell Science. Jun, 2006 | Pubmed ID: 16735438 A Tripartite DNA-binding Element, Comprised of the Nuclear Localization Signal and Two AT-hook Motifs, Mediates the Association of LEDGF/p75 with Chromatin in Vivo Nucleic Acids Research. 2006 | Pubmed ID: 16549878 Structural Basis for the Recognition Between HIV-1 Integrase and Transcriptional Coactivator P75 Proceedings of the National Academy of Sciences of the United States of America. Nov, 2005 | Pubmed ID: 16260736 Lys-34, Dispensable for Integrase Catalysis, is Required for Preintegration Complex Function and Human Immunodeficiency Virus Type 1 Replication Journal of Virology. Oct, 2005 | Pubmed ID: 16160186 Mutations in Both Env and Gag Genes Are Required for HIV-1 Resistance to the Polysulfonic Dendrimer SPL2923, As Corroborated by Chimeric Virus Technology Antiviral Chemistry & Chemotherapy. 2005 | Pubmed ID: 16130523 Solution Structure of the HIV-1 Integrase-binding Domain in LEDGF/p75 Nature Structural & Molecular Biology. Jun, 2005 | Pubmed ID: 15895093 Class II Integrase Mutants with Changes in Putative Nuclear Localization Signals Are Primarily Blocked at a Postnuclear Entry Step of Human Immunodeficiency Virus Type 1 Replication Journal of Virology. Dec, 2004 | Pubmed ID: 15542626 Identification of an Evolutionarily Conserved Domain in Human Lens Epithelium-derived Growth Factor/transcriptional Co-activator P75 (LEDGF/p75) That Binds HIV-1 Integrase The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15371438 Identification and Characterization of a Functional Nuclear Localization Signal in the HIV-1 Integrase Interactor LEDGF/p75 The Journal of Biological Chemistry. Aug, 2004 | Pubmed ID: 15163664 Expression of HIV-1 Integrase in CEM Cells Inhibits HIV-1 Replication The Journal of Gene Medicine. Mar, 2004 | Pubmed ID: 15026988 LEDGF/p75 is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12796494 PH6 Antigen of Yersinia Pestis Interacts with Plasma Lipoproteins and Cell Membranes Journal of Lipid Research. Feb, 2003 | Pubmed ID: 12576514 HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12407101 Env Chimeric Virus Technology for Evaluating Human Immunodeficiency Virus Susceptibility to Entry Inhibitors Antimicrobial Agents and Chemotherapy. Dec, 2002 | Pubmed ID: 12435701 In Search of Authentic Inhibitors of HIV-1 Integration Antiviral Chemistry & Chemotherapy. Jan, 2002 | Pubmed ID: 12180645 New Class of HIV Integrase Inhibitors That Block Viral Replication in Cell Culture Current Biology : CB. Jul, 2002 | Pubmed ID: 12176326 Role of Yersinia Murine Toxin in Survival of Yersinia Pestis in the Midgut of the Flea Vector Science (New York, N.Y.). Apr, 2002 | Pubmed ID: 11976454 Forsterkning, Neste generasjons sekvensering, og Genomisk DNA Kartlegging av Retrovirale Integrasjons nettsteder Erik Serrao1, Peter Cherepanov2, Alan N. Engelman1 1Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, 2Chromatin Structure and Mobile DNA, The Francis Crick Institute Biology
Forsterkning, Neste generasjons sekvensering, og Genomisk DNA Kartlegging av Retrovirale Integrasjons nettsteder Erik Serrao1, Peter Cherepanov2, Alan N. Engelman1 1Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, 2Chromatin Structure and Mobile DNA, The Francis Crick Institute Biology