Other Publications (1)
Articles by Peter Dröge in JoVE
Denaturing Urea Polyacrylamide Gel Electrophoresis (Urea PAGE) Heike Summer1, René Grämer2, Peter Dröge1 1School of Biological Sciences, Nanyang Technological University, Singapore - NTU, 2Singapore-MIT Alliance for Reserach and Technology (SMART) Denaturing urea polyacrylamide gel electrophoresis is used to separate single-stranded DNA or RNA up to a limit of 500 nucleotides. Urea in combination with heat denatures samples and unstructured single strands migrate within the gel matrix according to their molecular weight.
Other articles by Peter Dröge on PubMed
Multiple Sclerosis: Free Light Chains in Cerebrospinal Fluid Neurology. Oct, 1985 | Pubmed ID: 3929159 We found free light chains in the CSF of 18 MS patients, but not in any of 14 patients with other neurologic disease. CSF from all MS patients contained kappa and lambda chain dimers, less frequently contained light chain monomers, and never contained free gamma heavy chains. Light chains were not detected in matched serum samples. CSF from MS patients did not release free light chains from whole IgG in CSF of controls. The findings suggest that these free light chains originate in plasma cells, not from degradation of whole IgG.