Peter Macheroux

Publications

• Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases
  Angewandte Chemie (International Ed. in English). Jun, 2018  |   Pubmed ID: 29689601
• The Single Berberine Bridge Enzyme Homolog of Physcomitrella patens is a Cellobiose Oxidase
  The FEBS Journal. May, 2018  |   Pubmed ID: 29633551
• Oxidation of the FAD Cofactor to the 8-formyl-derivative in Human Electron-transferring Flavoprotein
  The Journal of Biological Chemistry. Feb, 2018  |   Pubmed ID: 29301933
• Crystal Structure of Dipeptidyl Peptidase III from the Human Gut Symbiont Bacteroides Thetaiotaomicron
  PloS One. 2017  |   Pubmed ID: 29095893
• Regioselective Para-Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase
  Angewandte Chemie (International Ed. in English). Oct, 2017  |   Pubmed ID: 28857436
• Biosensor for the Characterisation of HMAO B Inhibitors and the Quantification of Selegiline
  Talanta. Nov, 2017  |   Pubmed ID: 28738644
• The Family of Berberine Bridge Enzyme-like Enzymes: A Treasure-trove of Oxidative Reactions
  Archives of Biochemistry and Biophysics. 10, 2017  |   Pubmed ID: 28676375
• Structure, Biochemical and Kinetic Properties of Recombinant Pst2p from Saccharomyces Cerevisiae, a FMN-dependent NAD(P)H:quinone Oxidoreductase
  Biochimica Et Biophysica Acta. 08, 2017  |   Pubmed ID: 28499769
• Evidence for the Generation of Myristylated FMN by Bacterial Luciferase
  Molecular Microbiology. Jun, 2017  |   Pubmed ID: 28345146
• Catalytic Competence, Structure and Stability of the Cancer-associated R139W Variant of the Human NAD(P)H:quinone Oxidoreductase 1 (NQO1)
  The FEBS Journal. 04, 2017  |   Pubmed ID: 28236663
• Synthesis of α,β-unsaturated Aldehydes As Potential Substrates for Bacterial Luciferases
  Bioorganic & Medicinal Chemistry. 02, 2017  |   Pubmed ID: 28126438
• Leucine 208 in Human Histamine N-methyltransferase Emerges As a Hotspot for Protein Stability Rationalizing the Role of the L208P Variant in Intellectual Disability
  Biochimica Et Biophysica Acta. Jan, 2017  |   Pubmed ID: 27769936
• Structure and Biochemical Properties of Recombinant Human Dimethylglycine Dehydrogenase and Comparison to the Disease-related H109R Variant
  The FEBS Journal. 10, 2016  |   Pubmed ID: 27486859
• Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae
  PloS One. 2016  |   Pubmed ID: 27276217
• Substrate Complexes of Human Dipeptidyl Peptidase III Reveal the Mechanism of Enzyme Inhibition
  Scientific Reports. Mar, 2016  |   Pubmed ID: 27025154
• Structural and Kinetic Studies on RosA, the Enzyme Catalysing the Methylation of 8-demethyl-8-amino-d-riboflavin to the Antibiotic Roseoflavin
  The FEBS Journal. Apr, 2016  |   Pubmed ID: 26913589
• Structural and Biochemical Properties of LuxF from Photobacterium Leiognathi
  Biochimica Et Biophysica Acta. Oct, 2015  |   Pubmed ID: 26209460
• Mutations in the Histamine N-methyltransferase Gene, HNMT, Are Associated with Nonsyndromic Autosomal Recessive Intellectual Disability
  Human Molecular Genetics. Oct, 2015  |   Pubmed ID: 26206890
• Structure-Based Mechanism of Oleate Hydratase from Elizabethkingia Meningoseptica
  Chembiochem : a European Journal of Chemical Biology. Aug, 2015  |   Pubmed ID: 26077980
• Oxidation of Monolignols by Members of the Berberine Bridge Enzyme Family Suggests a Role in Plant Cell Wall Metabolism
  The Journal of Biological Chemistry. Jul, 2015  |   Pubmed ID: 26037923
• Anthranoyl-CoA Monooxygenase/reductase from Azoarcus Evansii Possesses Both FMN and FAD in Two Distinct and Independent Active Sites
  Biochimica Et Biophysica Acta. Aug, 2015  |   Pubmed ID: 25843773
• Rationally Engineered Flavin-dependent Oxidase Reveals Steric Control of Dioxygen Reduction
  The FEBS Journal. Aug, 2015  |   Pubmed ID: 25619330
• Structure and Stability of an Unusual Zinc-binding Protein from Bacteroides Thetaiotaomicron
  Biochimica Et Biophysica Acta. Dec, 2014  |   Pubmed ID: 25263158
• Collapse of the Native Structure Caused by a Single Amino Acid Exchange in Human NAD(P)H:quinone Oxidoreductase(1.)
  The FEBS Journal. Oct, 2014  |   Pubmed ID: 25143260
• Identification of Promiscuous Ene-reductase Activity by Mining Structural Databases Using Active Site Constellations
  Nature Communications. Jun, 2014  |   Pubmed ID: 24954722
• Disruption of the Methyltransferase-like 23 Gene METTL23 Causes Mild Autosomal Recessive Intellectual Disability
  Human Molecular Genetics. Aug, 2014  |   Pubmed ID: 24626631
• The Flavoproteome of the Yeast Saccharomyces Cerevisiae
  Biochimica Et Biophysica Acta. Mar, 2014  |   Pubmed ID: 24373875
• Determination of Free and Bound Riboflavin in Cow's Milk Using a Novel Flavin-binding Protein
  Food Chemistry. Mar, 2014  |   Pubmed ID: 24176318
• One-Pot Deracemization of Sec-Alcohols: Enantioconvergent Enzymatic Hydrolysis of Alkyl Sulfates Using Stereocomplementary Sulfatases
  Angewandte Chemie (Weinheim an Der Bergstrasse, Germany). Mar, 2013  |   Pubmed ID: 25821253
• The Human Flavoproteome
  Archives of Biochemistry and Biophysics. Jul, 2013  |   Pubmed ID: 23500531
• One-pot Deracemization of Sec-alcohols: Enantioconvergent Enzymatic Hydrolysis of Alkyl Sulfates Using Stereocomplementary Sulfatases
  Angewandte Chemie (International Ed. in English). Mar, 2013  |   Pubmed ID: 23401148
• Structure and Mechanism of an Inverting Alkylsulfatase from Pseudomonas Sp. DSM6611 Specific for Secondary Alkyl Sulfates
  The FEBS Journal. Dec, 2012  |   Pubmed ID: 23061549
• Structural and Functional Characterization of NikO, an Enolpyruvyl Transferase Essential in Nikkomycin Biosynthesis
  The Journal of Biological Chemistry. Sep, 2012  |   Pubmed ID: 22810238
• Catalytic and Structural Role of a Conserved Active Site Histidine in Berberine Bridge Enzyme
  Biochemistry. Aug, 2012  |   Pubmed ID: 22757961
• Reverse Structural Genomics: an Unusual Flavin-binding Site in a Putative Protease from Bacteroides Thetaiotaomicron
  The Journal of Biological Chemistry. Aug, 2012  |   Pubmed ID: 22718753
• Activity-based Probes for Studying the Activity of Flavin-dependent Oxidases and for the Protein Target Profiling of Monoamine Oxidase Inhibitors
  Angewandte Chemie (International Ed. in English). Jul, 2012  |   Pubmed ID: 22689512
• Entropy-driven Binding of Opioid Peptides Induces a Large Domain Motion in Human Dipeptidyl Peptidase III
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2012  |   Pubmed ID: 22493238
• A Novel N,N-8-amino-8-demethyl-D-riboflavin Dimethyltransferase (RosA) Catalyzing the Two Terminal Steps of Roseoflavin Biosynthesis in Streptomyces Davawensis
  The Journal of Biological Chemistry. Nov, 2011  |   Pubmed ID: 21911488
• Characterization of the PLP-dependent Aminotransferase NikK from Streptomyces Tendae and Its Putative Role in Nikkomycin Biosynthesis
  The FEBS Journal. Nov, 2011  |   Pubmed ID: 21884568
• A Stereoselective Inverting Sec-alkylsulfatase for the Deracemization of Sec-alcohols
  Organic Letters. Aug, 2011  |   Pubmed ID: 21770430
• Biocatalytic Organic Synthesis of Optically Pure (S)-scoulerine and Berbine and Benzylisoquinoline Alkaloids
  The Journal of Organic Chemistry. Aug, 2011  |   Pubmed ID: 21739961
• Flavogenomics--a Genomic and Structural View of Flavin-dependent Proteins
  The FEBS Journal. Aug, 2011  |   Pubmed ID: 21635694
• The Redox-sensing Quinone Reductase Lot6p Acts As an Inducer of Yeast Apoptosis
  FEMS Yeast Research. Sep, 2009  |   Pubmed ID: 19709309
• A Single Intersubunit Salt Bridge Affects Oligomerization and Catalytic Activity in a Bacterial Quinone Reductase
  The FEBS Journal. Sep, 2009  |   Pubmed ID: 19682074
• Mechanism of Flavin Reduction and Oxidation in the Redox-sensing Quinone Reductase Lot6p from Saccharomyces Cerevisiae
  Biochemistry. Sep, 2009  |   Pubmed ID: 19618916
• Berberine Bridge Enzyme Catalyzes the Six Electron Oxidation of (S)-reticuline to Dehydroscoulerine
  Phytochemistry. Jun, 2009  |   Pubmed ID: 19570558
• Structural and Mechanistic Studies Reveal the Functional Role of Bicovalent Flavinylation in Berberine Bridge Enzyme
  The Journal of Biological Chemistry. Jul, 2009  |   Pubmed ID: 19457868
• Quinone Reductase Acts As a Redox Switch of the 20S Yeast Proteasome
  EMBO Reports. Jan, 2009  |   Pubmed ID: 19029946
• A Concerted Mechanism for Berberine Bridge Enzyme
  Nature Chemical Biology. Dec, 2008  |   Pubmed ID: 18953357
• Replacement of Two Invariant Serine Residues in Chorismate Synthase Provides Evidence That a Proton Relay System is Essential for Intermediate Formation and Catalytic Activity
  The FEBS Journal. Apr, 2008  |   Pubmed ID: 18279385
• Conservation of NADPH Utilization by Chorismate Synthase and Its Implications for the Evolution of the Shikimate Pathway
  Molecular Microbiology. Sep, 2007  |   Pubmed ID: 17662045
• 6-S-cysteinylation of Bi-covalently Attached FAD in Berberine Bridge Enzyme Tunes the Redox Potential for Optimal Activity
  The Journal of Biological Chemistry. Aug, 2007  |   Pubmed ID: 17573342
• Mutagenic Analysis of an Invariant Aspartate Residue in Chorismate Synthase Supports Its Role As an Active Site Base
  Biochemistry. Mar, 2007  |   Pubmed ID: 17326665
• Lot6p from Saccharomyces Cerevisiae is a FMN-dependent Reductase with a Potential Role in Quinone Detoxification
  The FEBS Journal. Mar, 2007  |   Pubmed ID: 17298444
• Crystal Structure of 12-oxophytodienoate Reductase 3 from Tomato: Self-inhibition by Dimerization
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2006  |   Pubmed ID: 16983071
• Characterization of a Thermostable NADPH:FMN Oxidoreductase from the Mesophilic Bacterium Bacillus Subtilis
  Biochemistry. Jun, 2006  |   Pubmed ID: 16752898
• Biochemical Evidence That Berberine Bridge Enzyme Belongs to a Novel Family of Flavoproteins Containing a Bi-covalently Attached FAD Cofactor
  The Journal of Biological Chemistry. Jul, 2006  |   Pubmed ID: 16728404
• Reduced Flavin: NMR Investigation of N5-H Exchange Mechanism, Estimation of Ionisation Constants and Assessment of Properties As Biological Catalyst
  BMC Biochemistry. Nov, 2005  |   Pubmed ID: 16309555