Peter ten Dijke Dept. Cell Chemical Biology Leiden University Medical Center Biography Publications Institution JoVE Articles Peter ten Dijke has not added a biography. If you are Peter ten Dijke and would like to personalize this page please email our Author Liaison for assistance. Publications A Comprehensive Enhancer Screen Identifies TRAM2 As a Key and Novel Mediator of YAP Oncogenesis Genome Biology. Jan, 2021 | Pubmed ID: 33514403 E3 Ubiquitin Ligases: Key Regulators of TGFβ Signaling in Cancer Progression International Journal of Molecular Sciences. Jan, 2021 | Pubmed ID: 33418880 Targeting TGFβ Signal Transduction for Cancer Therapy Signal Transduction and Targeted Therapy. Jan, 2021 | Pubmed ID: 33414388 Therapeutic Targeting of TGF-β in Cancer: Hacking a Master Switch of Immune Suppression Clinical Science (London, England : 1979). Jan, 2021 | Pubmed ID: 33399850 Uncovering the Deubiquitinase Activity Landscape of Breast Cancer Oncoscience. Nov, 2020 | Pubmed ID: 33457450 TGF-β Signaling in Liver Metastasis Clinical and Translational Medicine. Nov, 2020 | Pubmed ID: 33252863 Designed Nanomolar Small-molecule Inhibitors of Ena/VASP EVH1 Interaction Impair Invasion and Extravasation of Breast Cancer Cells Proceedings of the National Academy of Sciences of the United States of America. 11, 2020 | Pubmed ID: 33184177 Current Perspectives on Inhibitory SMAD7 in Health and Disease Critical Reviews in Biochemistry and Molecular Biology. Oct, 2020 | Pubmed ID: 33081543 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos Journal of the American Chemical Society. Sep, 2020 | Pubmed ID: 32886496 Mechanotransduction is a Context-dependent Activator of TGF-β Signaling in Mesenchymal Stem Cells Biomaterials. Nov, 2020 | Pubmed ID: 32836056 Cercosporamide Inhibits Bone Morphogenetic Protein Receptor Type I Kinase Activity in Zebrafish Disease Models & Mechanisms. Sep, 2020 | Pubmed ID: 32820031 Reactivation of BMP Signaling by Suboptimal Concentrations of MEK Inhibitor and FK506 Reduces Organ-specific Breast Cancer Metastasis Cancer Letters. Nov, 2020 | Pubmed ID: 32768522 On-Target Anti-TGF-β Therapies Are Not Succeeding in Clinical Cancer Treatments: What Are Remaining Challenges? Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 32733895 Role of Glycosylation in TGF-β Signaling and Epithelial-to-mesenchymal Transition in Cancer Protein & Cell. Jun, 2020 | Pubmed ID: 32583064 Differential - and Glycosphingolipid Glycosylation in Human Pancreatic Adenocarcinoma Cells With Opposite Morphology and Metastatic Behavior Frontiers in Oncology. 2020 | Pubmed ID: 32582529 MnTBAP Reverses Pulmonary Vascular Remodeling and Improves Cardiac Function in Experimentally Induced Pulmonary Arterial Hypertension International Journal of Molecular Sciences. Jun, 2020 | Pubmed ID: 32531895 Bone Morphogenetic Protein Receptors: Structure, Function and Targeting by Selective Small Molecule Kinase Inhibitors Bone. Sep, 2020 | Pubmed ID: 32522605 Secreted BMP Antagonists and Their Role in Cancer and Bone Metastases Bone. Aug, 2020 | Pubmed ID: 32473315 TGF-β-Induced Endothelial to Mesenchymal Transition in Disease and Tissue Engineering Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 32373613 TGFβ and EGF Signaling Orchestrates the AP-1- and P63 Transcriptional Regulation of Breast Cancer Invasiveness Oncogene. May, 2020 | Pubmed ID: 32350443 Development of a 96-well Plate Sample Preparation Method for Integrated N- and O-glycomics Using Porous Graphitized Carbon Liquid Chromatography-mass Spectrometry Molecular Omics. 08, 2020 | Pubmed ID: 32281997 Immunotherapeutic Potential of TGF-β Inhibition and Oncolytic Viruses Trends in Immunology. 05, 2020 | Pubmed ID: 32223932 A Signaling Crosstalk Between BMP9 and HGF/c-Met Regulates Mouse Adult Liver Progenitor Cell Survival Cells. 03, 2020 | Pubmed ID: 32204446 Controlling Smad4 Signaling with a Wip EMBO Reports. 05, 2020 | Pubmed ID: 32189449 Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas Cancer Cell. 03, 2020 | Pubmed ID: 32142668 THG-1 Suppresses SALL4 Degradation to Induce Stemness Genes and Tumorsphere Formation Through Antagonizing NRBP1 in Squamous Cell Carcinoma Cells Biochemical and Biophysical Research Communications. 03, 2020 | Pubmed ID: 31864704 TGFβ-induced Metabolic Reprogramming During Epithelial-to-mesenchymal Transition in Cancer Cellular and Molecular Life Sciences : CMLS. Jun, 2020 | Pubmed ID: 31822964 Tacrolimus-Induced BMP/SMAD Signaling Associates With Metabolic Stress-Activated FOXO1 to Trigger β-Cell Failure Diabetes. 02, 2020 | Pubmed ID: 31732500 VprBP Mitigates TGF-β and Activin Signaling by Promoting Smurf1-mediated Type I Receptor Degradation Journal of Molecular Cell Biology. 02, 2020 | Pubmed ID: 31291647 Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells JBMR Plus. Nov, 2019 | Pubmed ID: 31768489 JNK-Dependent CJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses Cells. 11, 2019 | Pubmed ID: 31766464 A Perspective on the Development of TGF-β Inhibitors for Cancer Treatment Biomolecules. 11, 2019 | Pubmed ID: 31744193 Author Correction: C-Met Activation Leads to the Establishment of a TGFβ-receptor Regulatory Network in Bladder Cancer Progression Nature Communications. Nov, 2019 | Pubmed ID: 31704935 GREM1 is Associated with Metastasis and Predicts Poor Prognosis in ER-negative Breast Cancer Patients Cell Communication and Signaling : CCS. 11, 2019 | Pubmed ID: 31694641 C-Met Activation Leads to the Establishment of a TGFβ-receptor Regulatory Network in Bladder Cancer Progression Nature Communications. 09, 2019 | Pubmed ID: 31554791 Cancer-associated Fibroblast-derived Gremlin 1 Promotes Breast Cancer Progression Breast Cancer Research : BCR. 09, 2019 | Pubmed ID: 31533776 In Vivo Imaging of TGFβ Signalling Components Using Positron Emission Tomography Drug Discovery Today. 12, 2019 | Pubmed ID: 31494189 Role of Soluble Endoglin in BMP9 Signaling Proceedings of the National Academy of Sciences of the United States of America. 09, 2019 | Pubmed ID: 31431534 Prevention of Progression of Pulmonary Hypertension by the Nur77 Agonist 6-mercaptopurine: Role of BMP Signalling The European Respiratory Journal. 09, 2019 | Pubmed ID: 31273046 Autophagy Contributes to BMP Type 2 Receptor Degradation And development of Pulmonary Arterial Hypertension The Journal of Pathology. 11, 2019 | Pubmed ID: 31257577 Generation of Non-standard Macrocyclic Peptides Specifically Binding TSC-22 Homologous Gene-1 Biochemical and Biophysical Research Communications. 08, 2019 | Pubmed ID: 31227214 TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis International Journal of Molecular Sciences. Jun, 2019 | Pubmed ID: 31195692 Epigenetic Reprogramming of TGF-β Signaling in Breast Cancer Cancers. May, 2019 | Pubmed ID: 31137748 Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models Cells. 04, 2019 | Pubmed ID: 30959852 TGF-β Family Signaling Pathways in Cellular Dormancy Trends in Cancer. 01, 2019 | Pubmed ID: 30616757 Inflammation Induces Endothelial-to-mesenchymal Transition and Promotes Vascular Calcification Through Downregulation of BMPR2 The Journal of Pathology. 03, 2019 | Pubmed ID: 30430573 Bone Morphogenetic Protein Receptor Signal Transduction in Human Disease The Journal of Pathology. 01, 2019 | Pubmed ID: 30246251 The Therapeutic Potential of Targeting the Endothelial-to-mesenchymal Transition Angiogenesis. 02, 2019 | Pubmed ID: 30076548 Epithelial-mesenchymal-transition-inducing Transcription Factors: New Targets for Tackling Chemoresistance in Cancer? Oncogene. 11, 2018 | Pubmed ID: 30002444 Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 12, 2018 | Pubmed ID: 29945992 Bone Morphogenetic Protein 9 As a Key Regulator of Liver Progenitor Cells in DDC-induced Cholestatic Liver Injury Liver International : Official Journal of the International Association for the Study of the Liver. 09, 2018 | Pubmed ID: 29751359 TGF-β Family Co-receptor Function and Signaling Acta Biochimica Et Biophysica Sinica. Jan, 2018 | Pubmed ID: 29293886 JUNB Governs a Feed-forward Network of TGFβ Signaling That Aggravates Breast Cancer Invasion Nucleic Acids Research. 02, 2018 | Pubmed ID: 29186616 Endothelial-to-mesenchymal Transition in Cardiovascular Diseases: Developmental Signaling Pathways Gone Awry Developmental Dynamics : an Official Publication of the American Association of Anatomists. 03, 2018 | Pubmed ID: 28891150 Breast Cancer Metastasis Suppressor OTUD1 Deubiquitinates SMAD7 Nature Communications. 12, 2017 | Pubmed ID: 29235476 TGF-β-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases International Journal of Molecular Sciences. Oct, 2017 | Pubmed ID: 29039786 Disparate Phospho-Smad2 Levels in Advanced Type 2 Diabetes Patients with Diabetic Nephropathy and Early Experimental Db/db Mouse Model Renal Failure. Nov, 2017 | Pubmed ID: 28805484 Bone Morphogenetic Protein 9 Protects Against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation Frontiers in Physiology. 2017 | Pubmed ID: 28751863 Targeting TGF-β Signaling in Cancer Trends in Cancer. 01, 2017 | Pubmed ID: 28718426 SUMO-triggered Ubiquitination of NR4A1 Controls Macrophage Cell Death Cell Death and Differentiation. 09, 2017 | Pubmed ID: 28622293 TGFβ1-induced SMAD2/3 and SMAD1/5 Phosphorylation Are Both ALK5-kinase-dependent in Primary Chondrocytes and Mediated by TAK1 Kinase Activity Arthritis Research & Therapy. May, 2017 | Pubmed ID: 28569204 Erratum To: BMP Type II Receptor As a Therapeutic Target in Pulmonary Arterial Hypertension Cellular and Molecular Life Sciences : CMLS. 08, 2017 | Pubmed ID: 28536788 USP4 Inhibits SMAD4 Monoubiquitination and Promotes Activin and BMP Signaling The EMBO Journal. 06, 2017 | Pubmed ID: 28468752 BMP Type II Receptor As a Therapeutic Target in Pulmonary Arterial Hypertension Cellular and Molecular Life Sciences : CMLS. 08, 2017 | Pubmed ID: 28447104 FAF1 Phosphorylation by AKT Accumulates TGF-β Type II Receptor and Drives Breast Cancer Metastasis Nature Communications. 04, 2017 | Pubmed ID: 28443643 Bone Morphogenetic Proteins in Vascular Homeostasis and Disease Cold Spring Harbor Perspectives in Biology. Mar, 2017 | Pubmed ID: 28348038 TGF-β Signaling in Control of Cardiovascular Function Cold Spring Harbor Perspectives in Biology. Mar, 2017 | Pubmed ID: 28348036 BMP-9 Interferes with Liver Regeneration and Promotes Liver Fibrosis Gut. May, 2017 | Pubmed ID: 28336518 Fluid Shear Stress-induced TGF-β/ALK5 Signaling in Renal Epithelial Cells is Modulated by MEK1/2 Cellular and Molecular Life Sciences : CMLS. Feb, 2017 | Pubmed ID: 28168444 TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation The Journal of Biological Chemistry. Mar, 2017 | Pubmed ID: 28115518 Smad2 Phosphorylation in Diabetic Kidney Tubule Epithelial Cells Is Associated with Modulation of Several Transforming Growth Factor-β Family Members Nephron. 2017 | Pubmed ID: 28064277 New Function of the Myostatin/activin Type I Receptor (ALK4) As a Mediator of Muscle Atrophy and Muscle Regeneration FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2017 | Pubmed ID: 27733450 Fish Tales: The Use of Zebrafish Xenograft Human Cancer Cell Models Histology and Histopathology. Dec, 2016 | Pubmed ID: 27933602 Immunoregulation by Members of the TGFβ Superfamily Nature Reviews. Immunology. 11, 2016 | Pubmed ID: 27885276 Towards a Cure for Fibrodysplasia Ossificans Progressiva Annals of Translational Medicine. Oct, 2016 | Pubmed ID: 27867996 Mutational Activation of BRAF Confers Sensitivity to Transforming Growth Factor Beta Inhibitors in Human Cancer Cells Oncotarget. Dec, 2016 | Pubmed ID: 27835901 Targeting Tumour Vasculature by Inhibiting Activin Receptor-like Kinase (ALK)1 Function Biochemical Society Transactions. Aug, 2016 | Pubmed ID: 27528762 A Current Perspective on Applications of Macrocyclic-peptide-based High-affinity Ligands Biopolymers. Nov, 2016 | Pubmed ID: 27352774 C-Myb Enhances Breast Cancer Invasion and Metastasis Through the Wnt/β-Catenin/Axin2 Pathway Cancer Research. Jun, 2016 | Pubmed ID: 27197202 Delta-Like Ligand 4 Modulates Liver Damage by Down-Regulating Chemokine Expression The American Journal of Pathology. Jul, 2016 | Pubmed ID: 27171900 Regulation of the TGF-β Pathway by Deubiquitinases in Cancer The International Journal of Biochemistry & Cell Biology. Jul, 2016 | Pubmed ID: 27155333 Smad6 Determines BMP-regulated Invasive Behaviour of Breast Cancer Cells in a Zebrafish Xenograft Model Scientific Reports. Apr, 2016 | Pubmed ID: 27113436 Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease Journal of the American Society of Nephrology : JASN. Dec, 2016 | Pubmed ID: 27020852 Emerging Regulators of BMP Bioavailability Bone. Dec, 2016 | Pubmed ID: 26825814 The Rationale for Targeting TGF-β in Chronic Liver Diseases European Journal of Clinical Investigation. Apr, 2016 | Pubmed ID: 26823073 TGF-β Signalling and Liver Disease The FEBS Journal. Jun, 2016 | Pubmed ID: 26807763 Interrogating TGF-β Function and Regulation in Endothelial Cells Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26520125 Determining TGF-β Receptor Levels in the Cell Membrane Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26520116 In Brief: Endothelial-to-mesenchymal Transition The Journal of Pathology. Feb, 2016 | Pubmed ID: 26446982 Regulatory RNAs Controlling Vascular (dys)function by Affecting TGF-ß Family Signalling EXCLI Journal. 2015 | Pubmed ID: 26862319 Signal Transduction: Gain of Activin Turns Muscle into Bone Current Biology : CB. Dec, 2015 | Pubmed ID: 26654374 Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva Stem Cell Reports. Dec, 2015 | Pubmed ID: 26626181 Targeting BMP Signalling in Cardiovascular Disease and Anaemia Nature Reviews. Cardiology. Oct, 2015 | Pubmed ID: 26461965 Bone Morphogenetic Protein 6 and Oxidized Low-density Lipoprotein Synergistically Recruit Osteogenic Differentiation in Endothelial Cells Cardiovascular Research. Nov, 2015 | Pubmed ID: 26410368 Heterozygous Disruption of Activin Receptor-like Kinase 1 is Associated with Increased Arterial Pressure in Mice Disease Models & Mechanisms. Nov, 2015 | Pubmed ID: 26398936 Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2015 | Pubmed ID: 26373572 Bone Morphogenetic Protein Signaling in Bone Homeostasis Bone. Nov, 2015 | Pubmed ID: 26051467 A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins Journal of Virology. Aug, 2015 | Pubmed ID: 26041291 Genetic Depletion and Pharmacological Targeting of αv Integrin in Breast Cancer Cells Impairs Metastasis in Zebrafish and Mouse Xenograft Models Breast Cancer Research : BCR. Feb, 2015 | Pubmed ID: 25849225 Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2 Gastroenterology. Jun, 2015 | Pubmed ID: 25736321 14-3-3ζ Turns TGF-β to the Dark Side Cancer Cell. Feb, 2015 | Pubmed ID: 25670073 SLUG is Expressed in Endothelial Cells Lacking Primary Cilia to Promote Cellular Calcification Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2015 | Pubmed ID: 25633317 Clinical Utility Gene Card For: Fibrodysplasia Ossificans Progressiva European Journal of Human Genetics : EJHG. Oct, 2015 | Pubmed ID: 25604857 Inhibition of TGFβ Type I Receptor Activity Facilitates Liver Regeneration Upon Acute CCl4 Intoxication in Mice Archives of Toxicology. Jan, 2015 | Pubmed ID: 25566828 Ter94/VCP is a Novel Component Involved in BMP Signaling PloS One. 2014 | Pubmed ID: 25469707 Wild-type P53 Inhibits Pro-invasive Properties of TGF-β3 in Breast Cancer, in Part Through Regulation of EPHB2, a New TGF-β Target Gene Breast Cancer Research and Treatment. Nov, 2014 | Pubmed ID: 25257729 Assessment of Functional Competence of Endothelial Cells from Human Pluripotent Stem Cells in Zebrafish Embryos Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 25173378 Time-resolved Dissection of Early Phosphoproteome and Ensuing Proteome Changes in Response to TGF-β Science Signaling. Jul, 2014 | Pubmed ID: 25056879 Generation, Expansion and Functional Analysis of Endothelial Cells and Pericytes Derived from Human Pluripotent Stem Cells Nature Protocols. 2014 | Pubmed ID: 24874816 Loss of SMAD4 Alters BMP Signaling to Promote Colorectal Cancer Cell Metastasis Via Activation of Rho and ROCK Gastroenterology. Jul, 2014 | Pubmed ID: 24704720 Targeting TGF-β Signaling by Antisense Oligonucleotide-mediated Knockdown of TGF-β Type I Receptor Molecular Therapy. Nucleic Acids. Apr, 2014 | Pubmed ID: 24691207 Nuclear Receptor NR4A1 Promotes Breast Cancer Invasion and Metastasis by Activating TGF-β Signalling Nature Communications. 2014 | Pubmed ID: 24584437 ENDOGLIN is Dispensable for Vasculogenesis, but Required for Vascular Endothelial Growth Factor-induced Angiogenesis PloS One. 2014 | Pubmed ID: 24489709 Novel Ex Vivo Culture Method for the Study of Dupuytren's Disease: Effects of TGFβ Type 1 Receptor Modulation by Antisense Oligonucleotides Molecular Therapy. Nucleic Acids. 2014 | Pubmed ID: 24448195 Functionality of Endothelial Cells and Pericytes from Human Pluripotent Stem Cells Demonstrated in Cultured Vascular Plexus and Zebrafish Xenografts Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2014 | Pubmed ID: 24158517 Mutational Analysis of Sclerostin Shows Importance of the Flexible Loop and the Cystine-knot for Wnt-signaling Inhibition PloS One. 2013 | Pubmed ID: 24312339 Signaling Interplay Between Transforming Growth Factor-β Receptor and PI3K/AKT Pathways in Cancer Trends in Biochemical Sciences. Dec, 2013 | Pubmed ID: 24239264 Transforming Growth Factor-β Signalling Controls Human Breast Cancer Metastasis in a Zebrafish Xenograft Model Breast Cancer Research : BCR. Nov, 2013 | Pubmed ID: 24196484 Activin Receptor-like Kinase 1 As a Target for Anti-angiogenesis Therapy Expert Opinion on Investigational Drugs. Nov, 2013 | Pubmed ID: 24053899 Transforming Growth Factor-β (TGF-β)-mediated Connective Tissue Growth Factor (CTGF) Expression in Hepatic Stellate Cells Requires Stat3 Signaling Activation The Journal of Biological Chemistry. Oct, 2013 | Pubmed ID: 24005672 TRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer Metastasis Molecular Cell. Sep, 2013 | Pubmed ID: 23973329 FK506 Activates BMPR2, Rescues Endothelial Dysfunction, and Reverses Pulmonary Hypertension The Journal of Clinical Investigation. Aug, 2013 | Pubmed ID: 23867624 Antisense-oligonucleotide Mediated Exon Skipping in Activin-receptor-like Kinase 2: Inhibiting the Receptor That is Overactive in Fibrodysplasia Ossificans Progressiva PloS One. 2013 | Pubmed ID: 23861958 Three-dimensional Co-cultures of Human Endothelial Cells and Embryonic Stem Cell-derived Pericytes Inside a Microfluidic Device Lab on a Chip. Sep, 2013 | Pubmed ID: 23702711 Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-mediated Antagonism of Wnt/LRP6 Signaling PloS One. 2013 | Pubmed ID: 23638027 Snail and Slug, Key Regulators of TGF-β-induced EMT, Are Sufficient for the Induction of Single-cell Invasion Biochemical and Biophysical Research Communications. May, 2013 | Pubmed ID: 23618854 Preventive and Therapeutic Effects of Smad7 on Radiation-induced Oral Mucositis Nature Medicine. Apr, 2013 | Pubmed ID: 23475202 Fine-tuning BMP7 Signalling in Adipogenesis by UBE2O/E2-230K-mediated Monoubiquitination of SMAD6 The EMBO Journal. Apr, 2013 | Pubmed ID: 23455153 Deficiency for Endoglin in Tumor Vasculature Weakens the Endothelial Barrier to Metastatic Dissemination The Journal of Experimental Medicine. Mar, 2013 | Pubmed ID: 23401487 UBE2O Negatively Regulates TRAF6-mediated NF-κB Activation by Inhibiting TRAF6 Polyubiquitination Cell Research. Mar, 2013 | Pubmed ID: 23381138 Endoglin for Tumor Imaging and Targeted Cancer Therapy Expert Opinion on Therapeutic Targets. Apr, 2013 | Pubmed ID: 23327677 Overactive Bone Morphogenetic Protein Signaling in Heterotopic Ossification and Duchenne Muscular Dystrophy Cellular and Molecular Life Sciences : CMLS. Feb, 2013 | Pubmed ID: 22752156 Soluble Fms-like Tyrosine Kinase 1 and Soluble Endoglin Are Elevated Circulating Anti-angiogenic Factors in Pre-eclampsia Pregnancy Hypertension. Oct, 2012 | Pubmed ID: 26105603 MicroRNA-155 Functions As a Negative Regulator of RhoA Signaling in TGF-β-induced Endothelial to Mesenchymal Transition MicroRNA (Shariqah, United Arab Emirates). 2012 | Pubmed ID: 25048084 Tiermodellen Für Chronische Erkrankungen Der Leber American Journal of Physiology. Gastrointestinal and Liver Physiology. Dec, 2012 | Pubmed ID: 23275613 MED12 Controls the Response to Multiple Cancer Drugs Through Regulation of TGF-β Receptor Signaling Cell. Nov, 2012 | Pubmed ID: 23178117 The Activities of Smad and Gli Mediated Signalling Pathways in High-grade Conventional Osteosarcoma European Journal of Cancer (Oxford, England : 1990). Dec, 2012 | Pubmed ID: 22868198 Fas-associated Factor 1 is a Scaffold Protein That Promotes β-transducin Repeat-containing Protein (β-TrCP)-mediated β-catenin Ubiquitination and Degradation The Journal of Biological Chemistry. Aug, 2012 | Pubmed ID: 22730322 TGF-β Signalling and Its Role in Cancer Progression and Metastasis Cancer Metastasis Reviews. Dec, 2012 | Pubmed ID: 22714591 BMP Signaling in Vascular Diseases FEBS Letters. Jul, 2012 | Pubmed ID: 22710160 USP4 is Regulated by AKT Phosphorylation and Directly Deubiquitylates TGF-β Type I Receptor Nature Cell Biology. Jun, 2012 | Pubmed ID: 22706160 TGFβ Signaling in Liver Regeneration Current Pharmaceutical Design. 2012 | Pubmed ID: 22630085 Deregulated Bone Morphogenetic Protein Receptor Signaling Underlies Fibrodysplasia Ossificans Progressiva Current Pharmaceutical Design. 2012 | Pubmed ID: 22630080 Role of Endoglin in Fibrosis and Scleroderma International Review of Cell and Molecular Biology. 2012 | Pubmed ID: 22608563 LRP8 Mediates Wnt/β-catenin Signaling and Controls Osteoblast Differentiation Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Oct, 2012 | Pubmed ID: 22589174 RNF12 Controls Embryonic Stem Cell Fate and Morphogenesis in Zebrafish Embryos by Targeting Smad7 for Degradation Molecular Cell. Jun, 2012 | Pubmed ID: 22560923 Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting The Journal of Biological Chemistry. May, 2012 | Pubmed ID: 22493445 Shear Induced Collateral Artery Growth Modulated by Endoglin but Not by ALK1 Journal of Cellular and Molecular Medicine. Oct, 2012 | Pubmed ID: 22436015 Vanilloid Receptor-1 Regulates Neurogenic Inflammation in Colon and Protects Mice from Colon Cancer Cancer Research. Apr, 2012 | Pubmed ID: 22396497 TGF-β Signaling in Endothelial-to-mesenchymal Transition: the Role of Shear Stress and Primary Cilia Science Signaling. Feb, 2012 | Pubmed ID: 22355187 Schlüsselrolle Für Ubiquitin-Protein-Änderung in TGFβ-Signaltransduktion Upsala Journal of Medical Sciences. Feb, 2012 | Pubmed ID: 22335355 WNT/β-Catenin Signalisieren ändert C2C12 Myoblast Proliferation Und Differenzierung Durch Induzieren Id3-Ausdruck Biochemical and Biophysical Research Communications. Feb, 2012 | Pubmed ID: 22326917 Schlüssel, Die Signalisierung Von Knoten in Der Brustdrüse Entwicklung Und Krebs: Smad Signal Integration in Epithelzellen Plastizität Breast Cancer Research : BCR. Feb, 2012 | Pubmed ID: 22315972 Eine Kovalent Dimerized Rekombinanten Menschlichen Knochen Morphogenetische Protein-15 Variante Identifiziert Bone Morphogenetische Protein-Rezeptor Typ 1 B Als Ein Schlüsselzelle Oberfläche Rezeptor Am Eierstock Granulosa Zellen Endocrinology. Jan, 2012 | Pubmed ID: 22294741 Non-Synonym Varianten Des SMAD6-Gens Prädisponieren Für Angeborene Herz-Kreislauf-Fehlbildungen Human Mutation. Jan, 2012 | Pubmed ID: 22275001 Ubiquitin-spezifische Protease 4 Mildert Die Toll-artigen/interleukin-1 Rezeptor Signalgebung Und Regelt Angeboren Immun-Aktivierung The Journal of Biological Chemistry. Jan, 2012 | Pubmed ID: 22262844 TGFβ-Signalisierung Und Herz-Kreislauf-Krankheiten International Journal of Biological Sciences. 2012 | Pubmed ID: 22253564 TGF-β Im Fortschreiten Der Lebererkrankung Cell and Tissue Research. Jan, 2012 | Pubmed ID: 22006249 BMP-7 Hemmt TGF-β-induzierte Invasion Von Brustkrebs-Zellen Durch Hemmung Der Integrin β(3) Ausdruck Cellular Oncology (Dordrecht). Feb, 2012 | Pubmed ID: 21935711 Regulierung Der Endothelial Zelle Plastizität Von TGF-β Cell and Tissue Research. Jan, 2012 | Pubmed ID: 21866313 Altersbedingt Änderung Des TGF-β-Signalisierung in Arthrose Cell and Tissue Research. Jan, 2012 | Pubmed ID: 21638205 Regulierung Der Endothelialen Barrierefunktion Durch TGF-β Typ I Rezeptor ALK5: Mögliche Rolle Der Kontraktilen Mechanismen Und Hitze-Schock-Protein 90 Journal of Cellular Physiology. Feb, 2012 | Pubmed ID: 21465483 Zelltyp Spezifische Verordnung Myostatin Zu Signalisieren The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2011 | Pubmed ID: 22202673 Zeitliche Smad7 Transgene Induktion in Maus Oberhaut Beschleunigt Die Wundheilung Der Haut The American Journal of Pathology. Oct, 2011 | Pubmed ID: 21944279 GSK3β Inaktivierung Induziert Apoptose Der Leukämie-Zellen Durch Unterdrückung Der Funktion Der C-Myb Molecular Biology of the Cell. Sep, 2011 | Pubmed ID: 21795403 Steuernde Angiogenese Durch Zwei Einzigartige TGF-β Typ I Rezeptor Signalgebung Wege Histology and Histopathology. Sep, 2011 | Pubmed ID: 21751154 Erkunden Anti-TGF-β-Therapien Bei Krebs Und Fibrose Growth Factors (Chur, Switzerland). Aug, 2011 | Pubmed ID: 21718111 Erhöhten Transforming Growth Factor β Und Mitogen-aktivierte Protein-Kinase-Wege Vermitteln Fibrotische Merkmale Der Dupuytren Krankheit Fibroblasten Fibrogenesis & Tissue Repair. 2011 | Pubmed ID: 21711521 TGF-β-Rezeptor Signaling Pathways in Angiogenesis; Neue Ziele Für Die Anti-Angiogenese-Therapie Current Pharmaceutical Biotechnology. May, 2011 | Pubmed ID: 21619534 Biphasische Wirkung Wachstumsfaktor β Auf Knochen Morphogenetische Protein-induzierte Osteoblasten Differenzierung Zu Verwandeln Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jun, 2011 | Pubmed ID: 21611961 TGFβ/Alk5-Signalisierung Ist Erforderlich Für Schubspannung Induzierte Klf2 Ausdruck in Den Embryonalen Zellen Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jul, 2011 | Pubmed ID: 21604321 Dual Exon Skipping Myostatin Und Dystrophin Für Duchenne-Muskeldystrophie BMC Medical Genomics. 2011 | Pubmed ID: 21507246 TGF-β Signalisieren in Brust-Krebs Zelle Invasion Und Knochen-Metastasen Journal of Mammary Gland Biology and Neoplasia. Jun, 2011 | Pubmed ID: 21494783 TGF-β1/ALK5-induzierte Monozyte Migration Beinhaltet PI3K Und P38 Bahnen Und Wird Durch Diabetes Mellitus Nicht Negativ Beeinflusst Cardiovascular Research. Aug, 2011 | Pubmed ID: 21478266 FAS-assoziierter Faktor 1 Antagonizes Wnt Signalisieren Durch Die Förderung Von β-Catenin Abbau Molecular Biology of the Cell. May, 2011 | Pubmed ID: 21411632 Mangel an Primären Zilien Primzahlen Induziert Durch Scherung Endothelial-zu-Mesenchymale Übergang Circulation Research. Apr, 2011 | Pubmed ID: 21393577 Endoglin Fördert TGF-β/Smad1 Signalisieren in Sklerodermie-Fibroblasten Journal of Cellular Physiology. Dec, 2011 | Pubmed ID: 21344387 ALK2-Mutation Bei Patienten Mit Down-Syndrom Und Eine Angeborene Herz Defekt European Journal of Human Genetics : EJHG. Apr, 2011 | Pubmed ID: 21248739 TGFbeta Aktiviert Mitogen - Und Stress-activated Protein Kinase-1 (MSK1) Zum Zelltod Zu Dämpfen The Journal of Biological Chemistry. Feb, 2011 | Pubmed ID: 21106525 Die Dynamischen Rollen Von TGF-β Bei Krebs The Journal of Pathology. Jan, 2011 | Pubmed ID: 20957627 Activin A Induziert Einen Nicht-fibrotische Phänotyp in Glatten Muskelzellen Im Gegensatz Zu TGF-β Experimental Cell Research. Jan, 2011 | Pubmed ID: 20955695 BMP-Antagonisten Erhöhen Myogener Differenzierung Und Lindern Die Dystrophische Phänotyp in Einem Mausmodell DMD Neurobiology of Disease. Feb, 2011 | Pubmed ID: 20940052 Die TGF-β/Smad-Pathway Induziert Brust Krebs Zelle Invasion Durch Die Bis-Verordnung Von Matrix-Metalloproteasen 2 Und 9 in Sphäroid Einmarsch Modellsystem Breast Cancer Research and Treatment. Aug, 2011 | Pubmed ID: 20821046 Biphasische Auswirkungen Der Transforming Growth Factor-β Auf Knochen Morphogenetische Protein-induzierte Osteoblasten Differenzierung Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Dec, 2010 | Pubmed ID: 21162084 Messung Der Konstitutiven Aktivität Von BMP Typ I Rezeptoren Methods in Enzymology. 2010 | Pubmed ID: 21036238 Unterschiedliche Arten Der Hemmung Von Sclerostin Auf Knochen Morphogenetische Protein Und Wnt Signalisieren Wege The Journal of Biological Chemistry. Dec, 2010 | Pubmed ID: 20952383 Signalisierung Von Mitgliedern Der Familie Der TGF-Beta in Vaskuläre Morphogenese Und Krankheit Trends in Cell Biology. Sep, 2010 | Pubmed ID: 20656490 Integration Von Transkriptionelle Signale an Der Invasiven Tumor Zelle-Front Cell Cycle (Georgetown, Tex.). Jul, 2010 | Pubmed ID: 20647778 Erhöhten TGFbeta-Smad-Signalisierung in Pkd1 Versuchsmodelle Und Menschlichen Patienten Mit Polyzystischen Nierenerkrankung The Journal of Pathology. Sep, 2010 | Pubmed ID: 20549648 In-situ Abstandserkennung Verbindung Von C-Jun/AP-1-Dimer Zeigt Erhöhte Konzentration Von C-Jun/Fra1 Komplexe in Aggressiven Brustkrebs Krebs-Zelllinien in Vitro Und in Vivo Molecular & Cellular Proteomics : MCP. Sep, 2010 | Pubmed ID: 20511396 Matrix Metalloprotease-14 (MT1-MMP)-vermittelte Endoglin Vergießen Tumorangiogenese Hemmt Cancer Research. May, 2010 | Pubmed ID: 20424116 Annexin A1 Reguliert Die Signalisierung Von TGF-Beta Und Fördert Die Metastasierung Von Basal-wie Brustkrebs-Zellen Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010 | Pubmed ID: 20308542 TMEPAI, Eine TGF-Beta-inducible Transmembraneprotein Sequester Smad-Proteine Aus Der Teilnahme an TGF-Beta Zu Signalisieren Molecular Cell. Jan, 2010 | Pubmed ID: 20129061 Genetische Und Pharmakologische Ausrichtung Der Activin Rezeptor-wie Kinase 1 Beeinträchtigt Tumorwachstum Und Angiogenesis The Journal of Experimental Medicine. Jan, 2010 | Pubmed ID: 20065063 Identifizierung Der Wichtigsten Rückstände Vermittlung Knochen Morphogenetic Proteins (BMP)-6 Widerstand Gegen Birne Hemmung Ermöglicht Veränderte BMPs Mit überlegener Agonist Tätigkeit The Journal of Biological Chemistry. Apr, 2010 | Pubmed ID: 20048150 ALK2-R206H-Mutation, Die Verbindung Mit Fibrodysplasia Ossificans Progressiva Verleiht Konstitutive Aktivität Der BMP Typ I Rezeptor Und Sensibilisiert Mesenchymale Zellen Induziert Durch BMP Osteoblasten Differenzierung Und Knochen-Bildung Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jun, 2010 | Pubmed ID: 19929436 5-Aminosalicylsäure Säure Hemmt TGF-beta1-Signalisierung in Colorectal Krebszellen Cancer Letters. Jan, 2010 | Pubmed ID: 19541409 Autocrine Knochen Morphogenetische Protein-9 Signalisiert Durch Activin Rezeptor-wie Kinase-2/Smad1/Smad4 Ovarian Krebs Zellproliferation Zu Fördern Cancer Research. Dec, 2009 | Pubmed ID: 19996292 VEGF Und Inhibitoren Der TGFbeta Zu Geben-ich Rezeptor Kinase Fördern Synergistisch Blutgefäß Bildung Durch Induzieren Alpha5-Integrin-Ausdruck Journal of Cell Science. Sep, 2009 | Pubmed ID: 19706683 Smad3 Ist Ein Wichtiger Nicht Redundantes Vermittler Von Transforming-Growth-Factor Beta Signalisieren in Nme Maus Milch-Epithelzellen Molecular Cancer Research : MCR. Aug, 2009 | Pubmed ID: 19671686 Endoglin Haploinsuffizienz Reduziert Strahleninduzierten Fibrose Und Teleangiektasien-Formation in Maus-Nieren Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology. Sep, 2009 | Pubmed ID: 19576647 Dominant-negativen ALK2 Allel Ordnet Angeborene Herzfehler Circulation. Jun, 2009 | Pubmed ID: 19506109 Wachstumsfaktor-Beta-Signalisierung Und Tumor-Angiogenese Zu Verwandeln Frontiers in Bioscience : a Journal and Virtual Library. 2009 | Pubmed ID: 19482591 Armen Schiffes Formation Im Embryonen Von Knock-in Mäusen ALK5 Mit L45 Schleife Mutation Defekt Im Smad-Aktivierung Zum Ausdruck Zu Bringen Laboratory Investigation; a Journal of Technical Methods and Pathology. Jul, 2009 | Pubmed ID: 19398960 Ionisierende Strahlung Verschiebt Sich Das PAI-1/ID-1-Gleichgewicht Und Aktiviert Kerbe Signalisieren in Endothelzellen International Journal of Radiation Oncology, Biology, Physics. Feb, 2009 | Pubmed ID: 19147015 TGF-Beta Signalisieren in Vaskuläre Biologie Und Dysfunktion Cell Research. Jan, 2009 | Pubmed ID: 19114994 Ski-Co-repressor-komplexe Beibehalten Den Basalen Verdrängten Zustand Im TGF-Beta-Ziel-gen, SMAD7, über HDAC3 Und PRMT5 Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Jan, 2009 | Pubmed ID: 19032343 Umwandlung Von Wachstumsfaktor Beta-induzierte Endotheliale, Mesenchymale Übergang: Ein Wechsel Zu Kardialer Fibrose? Trends in Cardiovascular Medicine. Nov, 2008 | Pubmed ID: 19345316 Smad1 Weg in Systemischer Sklerose Fibroblasten Aktiviert Und Von Imatinib Mesylat Ausgerichtet Ist Arthritis and Rheumatism. Aug, 2008 | Pubmed ID: 18668566 Die Knochen Morphogenetische Protein-Pathway Ist in Den Meisten Sporadischen Colorectal Krebse Inaktiviert Gastroenterology. May, 2008 | Pubmed ID: 18471510 VE-Cadherin Ist Ein Kritischer Endothelial Regulator Der TGF-Beta Zu Signalisieren The EMBO Journal. Apr, 2008 | Pubmed ID: 18337748 ALK1 Lehnt ALK5/Smad3 Signalisierung Und Ausdruck Von Komponenten Der Extrazellulären Matrix in Menschlichen Chondrozyten Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jun, 2008 | Pubmed ID: 18333754 L Und S-Endoglin Modulieren Differentiell TGFbeta1 Signalisierung Von ALK1 Und ALK5 in L6E9 Myoblasts Vermittelt Journal of Cell Science. Mar, 2008 | Pubmed ID: 18303046 Osteozyt Abgeleitete Sclerostin Hemmt Knochenbildung: Ihre Rolle Im Knochen Morphogenetische Protein Und Wnt Signalisieren The Journal of Bone and Joint Surgery. American Volume. Feb, 2008 | Pubmed ID: 18292354 Endoglin in Angiogenese Und Gefäßerkrankungen Angiogenesis. 2008 | Pubmed ID: 18283546 Zwei Neuartige Typ-II-Rezeptoren Vermitteln BMP Signalisierung Und Sind Verpflichtet, Links-rechts-Asymmetrie Im Zebrafisch Zu Regeln Developmental Biology. Mar, 2008 | Pubmed ID: 18222420 Umwandlung Von Wachstumsfaktor-Beta Und Wundheilung Im Menschlichen Cholesteatoma The Laryngoscope. Jan, 2008 | Pubmed ID: 17989584 Kompensatorische Signalisierung Induziert in Der Dottersack Gefäßsystem Durch Streichung Von TGFbeta-Rezeptoren in Den Mäusen Journal of Cell Science. Dec, 2007 | Pubmed ID: 18029401 TGF-Beta Und BMP7 Interaktionen Im Tumor-Progression Und Knochen-Metastasen Clinical & Experimental Metastasis. 2007 | Pubmed ID: 18008174 Extrazellulären Kontrolle Der TGFbeta Signalisierung Bei Vaskulären Entwicklung Und Krankheit Nature Reviews. Molecular Cell Biology. Nov, 2007 | Pubmed ID: 17895899 Eine Schnelle Und Vertrauliche Bioassay, Knochen Morphogenetische Protein-Aktivität Zu Messen BMC Cell Biology. 2007 | Pubmed ID: 17880711 Knochen Sie Morphogenetische Protein 7 in Der Entwicklung Und Behandlung Von Knochenmetastasen an Brustkrebs Cancer Research. Sep, 2007 | Pubmed ID: 17875715 BMP7, Ein Mutmaßliches Regulator Der Epithelialen Homöostase in Der Menschlichen Prostata, Ist Ein Potenter Inhibitor Von Prostatakrebs Knochen Metastasen In-vivo The American Journal of Pathology. Sep, 2007 | Pubmed ID: 17724140 Induktion Von Sonic Hedgehog Mediatoren Durch Transforming-Growth-Factor-Beta: Smad3-abhängige Aktivierung Von Gli2 Und Gli1 Ausdruck in Vitro Und in Vivo Cancer Research. Jul, 2007 | Pubmed ID: 17638910 Signalisierung Durch ALK5 Ausdruck Der TGF-Beta-induzierte ET-1 in Endothelzellen Vermittelt: Eine Rolle Für Die Migration Und Proliferation Journal of Cell Science. Apr, 2007 | Pubmed ID: 17376964 Die Umwandlung Von Wachstumsfaktor-Beta-Rezeptor-Typ, Die Durch Die Aktivierung Des Smad1 Und ERK1/2-Wege-abhängige Fibrogenic Gen Programm Vermittelt Wird The Journal of Biological Chemistry. Apr, 2007 | Pubmed ID: 17317656 Negative Regelung Der TGF-Beta-Rezeptor/Smad-Signaltransduktion Current Opinion in Cell Biology. Apr, 2007 | Pubmed ID: 17317136 Aberrant Bmp Signaling and Notochord Delamination in the Pathogenesis of Esophageal Atresia Developmental Dynamics : an Official Publication of the American Association of Anatomists. Mar, 2007 | Pubmed ID: 17260385 SOST Ausdruck Beschränkt Sich Auf Die Großen Arterien Während Der Embryonalen Und Neonatale Herz-Kreislauf-Entwicklung Developmental Dynamics : an Official Publication of the American Association of Anatomists. Feb, 2007 | Pubmed ID: 17195180 KLF2 Unterdrückt TGF-Beta Signalisieren in Endothel Durch Induktion Von Smad7 Und Hemmung Von AP-1 Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2007 | Pubmed ID: 17194892 WNT Aber Nicht BMP Signalisieren Die Hemmende Wirkung Von Sclerostin über BMP-stimuliert Knochenbildung Beteiligt Ist Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jan, 2007 | Pubmed ID: 17032150 Methylierung Von Smad6 Von Protein-Arginin-N-Methyltransferase 1 FEBS Letters. Dec, 2006 | Pubmed ID: 17118358 Endoglin Hat Eine Entscheidende Rolle Im Blut Zellvermittelte Gefäßreparation Circulation. Nov, 2006 | Pubmed ID: 17088457 Ein Tarif-Gleichung-Ansatz Für Die Kinetik Und Die Robustheit Des Signalweges TGF-Beta Zu Erhellen Biophysical Journal. Dec, 2006 | Pubmed ID: 17012329 Smad7-induzierte Beta-Catenin Abbau ändert Epidermale Anhängsel-Entwicklung Developmental Cell. Sep, 2006 | Pubmed ID: 16950122 Id1 Ist Ein Wichtiger Vermittler Im TGF-Beta-induzierte Transdifferenzierung Ratte Hepatische Stellate Zellen Hepatology (Baltimore, Md.). May, 2006 | Pubmed ID: 16628634 Smad7 Und Protein-Phosphatase-1alpha Sind Kritische Faktoren Bei Der Dauer Von TGF-Beta/ALK1 Signalisieren in Endothelzellen BMC Cell Biology. 2006 | Pubmed ID: 16571110 Die Tumorsuppressor Smad4 Ist Erforderlich Für Transformierende Wachstumsfaktor Beta-induzierte Epitheliale, Mesenchymale Übergang Und Knochen Metastasierung Von Brustkrebszellen Cancer Research. Feb, 2006 | Pubmed ID: 16489022 Wachstumsfaktor-Beta Signaltransduktion in Angiogenese Und Gefäßerkrankungen Zu Verwandeln Chest. Dec, 2005 | Pubmed ID: 16373850 Das Enzym Deubiquitinierende UCH37 Interagiert Mit Smads Und Reguliert TGF-beta-Signalisierung Oncogene. Dec, 2005 | Pubmed ID: 16027725 Globale Analyse Von Smad2/3-dependent TGF-beta Signaltransduktion in Lebenden Mäusen Enthüllt Prominente Gewebe-spezifische Reaktionen Auf Verletzungen Journal of Immunology (Baltimore, Md. : 1950). Jul, 2005 | Pubmed ID: 15972691 Transforming Growth Factor-beta1 Bis Auf Die Knochen Endocrine Reviews. Oct, 2005 | Pubmed ID: 15901668 SOST / Sclerostin, Ein Osteozyt-derived Negativer Regulator Der Knochenbildung Cytokine & Growth Factor Reviews. Jun, 2005 | Pubmed ID: 15869900 Neue Mechanismen Der Angeborenen Immunität Haut: ASK1-vermittelte Differenzierung Der Keratinozyten Reguliert Die Expression Von Beta-Defensine, LL37 Und TLR2 European Journal of Immunology. Jun, 2005 | Pubmed ID: 15864780 TGF-beta-Rezeptor-Funktion in Das Endothel Cardiovascular Research. Feb, 2005 | Pubmed ID: 15664386 Defekte Parakrine Signalisierung Von TGFbeta Im Dottersack Gefäßsystem Endoglin Mutierten Mäusen: Ein Paradigma Für Hereditäre Hämorrhagische Teleangiektasie Development (Cambridge, England). Dec, 2004 | Pubmed ID: 15548578 Endoglin Fördert Endothelzellproliferation Und TGF-beta/ALK1 Signaltransduktion The EMBO Journal. Oct, 2004 | Pubmed ID: 15385967 Connective Tissue Growth Factor Expression Und Smad Signalweg Während Der Herzentwicklung Maus Und Myokardinfarkt Developmental Dynamics : an Official Publication of the American Association of Anatomists. Nov, 2004 | Pubmed ID: 15376321 Räumlich-zeitliche Aktivierung Smad1 Smad5 Und in Vivo: Überwachung Transkriptionelle Aktivität Des Smad-Proteine Journal of Cell Science. Sep, 2004 | Pubmed ID: 15331632 RLP Ist Ein Neuartiger Ras-ähnliche Protein Ist Ein Immediate-early-Transforming Growth Factor Beta (TGF-beta) Zielgen, Welches Negativ Reguliert Transkriptionsaktivität Durch TGF-beta Induziert The Biochemical Journal. Oct, 2004 | Pubmed ID: 15239668 Neue Einblicke in TGF-beta-Smad-Signalisierung Trends in Biochemical Sciences. May, 2004 | Pubmed ID: 15130563 Sclerostin Ist Ein Osteozyt-exprimierten Negativer Regulator Der Knochenbildung, Aber Kein Klassisches BMP-Antagonist The Journal of Experimental Medicine. Mar, 2004 | Pubmed ID: 15024046 Nerve Growth Factor Vermittelt Die Aktivierung Des Smad-Weg in PC12-Zellen European Journal of Biochemistry / FEBS. Mar, 2004 | Pubmed ID: 15009204 Controlling Zelle Schicksal Von Knochen-morphogenetischen Protein-Rezeptoren Molecular and Cellular Endocrinology. Dec, 2003 | Pubmed ID: 14656483 Activin Rezeptor-ähnliche Kinase (ALK) 1 Ist Eine Antagonistische Vermittler Von Seitlichen TGFbeta/ALK5 Signalisierung Molecular Cell. Oct, 2003 | Pubmed ID: 14580334 Controlling Mesenchymalen Stammzell-Differenzierung Durch TGFbeta Familienmitglieder Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association. 2003 | Pubmed ID: 14557946 Signaltransduktion Von Knochenmorphogenetische Proteine in Osteoblasten-Differenzierung The Journal of Bone and Joint Surgery. American Volume. 2003 | Pubmed ID: 12925607 Gene Array-Analyse Von Knochenmorphogenetischem Protein Typ I-Rezeptor-induzierte Differenzierung Von Osteoblasten Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jul, 2003 | Pubmed ID: 12854827 Smad7 Verhindert Die Aktivierung Von Hepatischen Sternzellen Und Leberfibrose in Ratten Gastroenterology. Jul, 2003 | Pubmed ID: 12851882 Nuclear YY1 Inhibiert Transforming Growth Factor Beta-und Knochenmorphogenetischem Protein-induzierte Zelldifferenzierung Molecular and Cellular Biology. Jul, 2003 | Pubmed ID: 12808092 Verteilung Der Phosphorylierten Smad2 Identifiziert Zielgewebe TGF-beta-Liganden in Der Maus Entwicklung Gene Expression Patterns : GEP. Jun, 2003 | Pubmed ID: 12799085 DSmurf Selektiv Abbaut Decapentaplegic-aktivierten MAD, Und Dessen Überexpression Stört Imaginalscheibe Entwicklung The Journal of Biological Chemistry. Jul, 2003 | Pubmed ID: 12754252 Smad-Protein Und TGF-beta-Signalübertragung in Vaskulären Glatten Muskelzellen International Journal of Molecular Medicine. May, 2003 | Pubmed ID: 12684705 Synthetische Triterpenoide Erweitern Transforming Growth Factor Beta / Smad-Signalisierung Cancer Research. Mar, 2003 | Pubmed ID: 12649201 Transforming Growth Factor-beta1 (TGF-beta)-induzierte Apoptose Von Prostatakrebszellen Umfasst Smad7-abhängige Aktivierung Von P38 Durch TGF-beta-aktivierte Kinase 1 Und Mitogen-aktivierte Proteinkinase-Kinase 3 Molecular Biology of the Cell. Feb, 2003 | Pubmed ID: 12589052 Growth Differentiation Factor-9 Induziert Smad2-Aktivierung Und Inhibin B-Produktion in Kultivierten Menschlichen Granulosa-Luteinzellen The Journal of Clinical Endocrinology and Metabolism. Feb, 2003 | Pubmed ID: 12574210 Transforming Growth Factor-beta 1-Mutationen in Camurati Engelmann Krankheit Führen Zu Einer Erhöhten Signalisierung Durch Ändern Entweder Aktivierung Oder Sekretion Des Mutierten Proteins The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12493741 Die Aufklärung Der Smad Anforderung in Transforming Growth Factor-beta Typ I-Rezeptor-induzierten Reaktionen The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12446693 BMP Signalwege Werden in Ohrkapsel Bildung Und Epithelial-mesenchymale Signalisierung in Den Entwicklungsländern Huhn Innenohr Beteiligt Developmental Biology. Nov, 2002 | Pubmed ID: 12435365 Die Stimulation Von Id1 Expression Von Knochenmorphogenetischem Protein Ausreichend Und Notwendig Für Knochenmorphogenetisches Protein-induzierte Aktivierung Von Endothelzellen Circulation. Oct, 2002 | Pubmed ID: 12390958 Immunhistochemische Lokalisation Osteogene Protein (OP-1) Und Seinen Rezeptoren in Kaninchen Gelenkknorpel The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Oct, 2002 | Pubmed ID: 12364567 Der Eingriff Der Activin Und Knochenmorphogenetischem Protein-Signalweg Smad-Proteine bei Der Induktion Von Inhibin B Produktion in Ovariellen Granulosazellen Molecular and Cellular Endocrinology. Sep, 2002 | Pubmed ID: 12354674 Aktivierung Von Knochenmorphogenetischem Protein / Smad Signalisierung in Bronchiale Epithelzellen Während Entzündung Der Atemwege American Journal of Respiratory Cell and Molecular Biology. Aug, 2002 | Pubmed ID: 12151307 Eine Überexpression Von Smad7 Führt Zu Schweren Pathologischen Veränderungen in Mehreren Epithelialen Geweben The EMBO Journal. Jun, 2002 | Pubmed ID: 12032071 Transforming Growth Factor Beta Signaltransduktion Journal of Leukocyte Biology. May, 2002 | Pubmed ID: 11994497 Ausbalancieren Der Aktivierungszustand Des Endothels über Zwei Verschiedene TGF-beta-Typ I-Rezeptoren The EMBO Journal. Apr, 2002 | Pubmed ID: 11927558 Regulation Der Zellproliferation Durch Smad-Proteine Journal of Cellular Physiology. Apr, 2002 | Pubmed ID: 11920677 Mangelhafte Smad7 Ausdruck: Eine Putative Molekulare Defekt Bei Sklerodermie Proceedings of the National Academy of Sciences of the United States of America. Mar, 2002 | Pubmed ID: 11904440 Aktion Bereich Von BMP Wird Durch Die N-terminale Basische Aminosäure Kern Definiert Current Biology : CB. Feb, 2002 | Pubmed ID: 11839272 Physikalische Und Funktionelle Interaktion Zwischen GATA-3 Und Smad3 Erlaubt TGF-beta Regulierung Von GATA-Zielgene Current Biology : CB. Jan, 2002 | Pubmed ID: 11790301 Vorübergehende Unterbrechung Der Autokrinen TGF-beta-Signalisierung Führt Zu Einer Verbesserten Überleben Und Die Proliferation Potenzial in Einzelnen Primitiven Menschlichen Blutbildenden Vorläuferzellen Journal of Immunology (Baltimore, Md. : 1950). Jan, 2002 | Pubmed ID: 11777969 Identifizierung Und Funktionelle Charakterisierung Von Unterschiedlichen Entscheidender Bedeutung Knochenmorphogenetisches Protein-spezifischen Response-Elementen in Der Id1-Promotors The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11729207 Deubiquitinase Activity Profiling Identifies UCHL1 As a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. | Pubmed ID: 31857432 TGF-β-vermittelter endothelialer zu mesenchymaler Übergang (EndMT) und die funktionelle Bewertung von EndMT-Effektoren mittels CRISPR/Cas9-Gen-Editing Jin Ma1,2, Gerard van der Zon1,2, Gonzalo Sanchez-Duffhues1, Peter ten Dijke1,2 1Dept. Cell Chemical Biology, Leiden University Medical Center, 2Oncode Institute, Leiden University Medical Center JoVE 62198 Biology Untersuchung von TGF-β Signalisierung und TGF-β-induzierten epitheliaal-mesenchymalen Übergang bei Brustkrebs und normalen Zellen Jing Zhang1, Midory Thorikay1, Gerard van der Zon1, Maarten van Dinther1, Peter ten Dijke1 1Oncode Institute and Department of Cell Chemical Biology, Leiden University Medical Center JoVE 61830 Cancer Research Invasive Verhalten von menschlichen Brustkrebszellen in embryonalem Zebrabärbling Jiang Ren*1, Sijia Liu*1, Chao Cui1, Peter ten Dijke1 1Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center JoVE 55459 Cancer Research Spheroid Assay zur TGF-β-induzierte Invasion Measure Hildegonda P.H. Naber1, Eliza Wiercinska1, Peter ten Dijke1, Theo van Laar1 1Department of Molecular Cell Biology and Centre for Biomedial Genetics, Leiden University Medical Centre JoVE 3337 Medicine
TGF-β-vermittelter endothelialer zu mesenchymaler Übergang (EndMT) und die funktionelle Bewertung von EndMT-Effektoren mittels CRISPR/Cas9-Gen-Editing Jin Ma1,2, Gerard van der Zon1,2, Gonzalo Sanchez-Duffhues1, Peter ten Dijke1,2 1Dept. Cell Chemical Biology, Leiden University Medical Center, 2Oncode Institute, Leiden University Medical Center JoVE 62198 Biology
Untersuchung von TGF-β Signalisierung und TGF-β-induzierten epitheliaal-mesenchymalen Übergang bei Brustkrebs und normalen Zellen Jing Zhang1, Midory Thorikay1, Gerard van der Zon1, Maarten van Dinther1, Peter ten Dijke1 1Oncode Institute and Department of Cell Chemical Biology, Leiden University Medical Center JoVE 61830 Cancer Research
Invasive Verhalten von menschlichen Brustkrebszellen in embryonalem Zebrabärbling Jiang Ren*1, Sijia Liu*1, Chao Cui1, Peter ten Dijke1 1Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center JoVE 55459 Cancer Research
Spheroid Assay zur TGF-β-induzierte Invasion Measure Hildegonda P.H. Naber1, Eliza Wiercinska1, Peter ten Dijke1, Theo van Laar1 1Department of Molecular Cell Biology and Centre for Biomedial Genetics, Leiden University Medical Centre JoVE 3337 Medicine