Peter ten Dijke Dept. Cell Chemical Biology Leiden University Medical Center Biography Publications Institution JoVE Articles Peter ten Dijke has not added a biography. If you are Peter ten Dijke and would like to personalize this page please email our Author Liaison for assistance. Publications A Comprehensive Enhancer Screen Identifies TRAM2 As a Key and Novel Mediator of YAP Oncogenesis Genome Biology. Jan, 2021 | Pubmed ID: 33514403 E3 Ubiquitin Ligases: Key Regulators of TGFβ Signaling in Cancer Progression International Journal of Molecular Sciences. Jan, 2021 | Pubmed ID: 33418880 Targeting TGFβ Signal Transduction for Cancer Therapy Signal Transduction and Targeted Therapy. Jan, 2021 | Pubmed ID: 33414388 Therapeutic Targeting of TGF-β in Cancer: Hacking a Master Switch of Immune Suppression Clinical Science (London, England : 1979). Jan, 2021 | Pubmed ID: 33399850 Uncovering the Deubiquitinase Activity Landscape of Breast Cancer Oncoscience. Nov, 2020 | Pubmed ID: 33457450 TGF-β Signaling in Liver Metastasis Clinical and Translational Medicine. Nov, 2020 | Pubmed ID: 33252863 Designed Nanomolar Small-molecule Inhibitors of Ena/VASP EVH1 Interaction Impair Invasion and Extravasation of Breast Cancer Cells Proceedings of the National Academy of Sciences of the United States of America. 11, 2020 | Pubmed ID: 33184177 Current Perspectives on Inhibitory SMAD7 in Health and Disease Critical Reviews in Biochemistry and Molecular Biology. Oct, 2020 | Pubmed ID: 33081543 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos Journal of the American Chemical Society. Sep, 2020 | Pubmed ID: 32886496 Mechanotransduction is a Context-dependent Activator of TGF-β Signaling in Mesenchymal Stem Cells Biomaterials. Nov, 2020 | Pubmed ID: 32836056 Cercosporamide Inhibits Bone Morphogenetic Protein Receptor Type I Kinase Activity in Zebrafish Disease Models & Mechanisms. Sep, 2020 | Pubmed ID: 32820031 Reactivation of BMP Signaling by Suboptimal Concentrations of MEK Inhibitor and FK506 Reduces Organ-specific Breast Cancer Metastasis Cancer Letters. Nov, 2020 | Pubmed ID: 32768522 On-Target Anti-TGF-β Therapies Are Not Succeeding in Clinical Cancer Treatments: What Are Remaining Challenges? Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 32733895 Role of Glycosylation in TGF-β Signaling and Epithelial-to-mesenchymal Transition in Cancer Protein & Cell. Jun, 2020 | Pubmed ID: 32583064 Differential - and Glycosphingolipid Glycosylation in Human Pancreatic Adenocarcinoma Cells With Opposite Morphology and Metastatic Behavior Frontiers in Oncology. 2020 | Pubmed ID: 32582529 MnTBAP Reverses Pulmonary Vascular Remodeling and Improves Cardiac Function in Experimentally Induced Pulmonary Arterial Hypertension International Journal of Molecular Sciences. Jun, 2020 | Pubmed ID: 32531895 Bone Morphogenetic Protein Receptors: Structure, Function and Targeting by Selective Small Molecule Kinase Inhibitors Bone. Sep, 2020 | Pubmed ID: 32522605 Secreted BMP Antagonists and Their Role in Cancer and Bone Metastases Bone. Aug, 2020 | Pubmed ID: 32473315 TGF-β-Induced Endothelial to Mesenchymal Transition in Disease and Tissue Engineering Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 32373613 TGFβ and EGF Signaling Orchestrates the AP-1- and P63 Transcriptional Regulation of Breast Cancer Invasiveness Oncogene. May, 2020 | Pubmed ID: 32350443 Development of a 96-well Plate Sample Preparation Method for Integrated N- and O-glycomics Using Porous Graphitized Carbon Liquid Chromatography-mass Spectrometry Molecular Omics. 08, 2020 | Pubmed ID: 32281997 Immunotherapeutic Potential of TGF-β Inhibition and Oncolytic Viruses Trends in Immunology. 05, 2020 | Pubmed ID: 32223932 A Signaling Crosstalk Between BMP9 and HGF/c-Met Regulates Mouse Adult Liver Progenitor Cell Survival Cells. 03, 2020 | Pubmed ID: 32204446 Controlling Smad4 Signaling with a Wip EMBO Reports. 05, 2020 | Pubmed ID: 32189449 Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas Cancer Cell. 03, 2020 | Pubmed ID: 32142668 THG-1 Suppresses SALL4 Degradation to Induce Stemness Genes and Tumorsphere Formation Through Antagonizing NRBP1 in Squamous Cell Carcinoma Cells Biochemical and Biophysical Research Communications. 03, 2020 | Pubmed ID: 31864704 TGFβ-induced Metabolic Reprogramming During Epithelial-to-mesenchymal Transition in Cancer Cellular and Molecular Life Sciences : CMLS. Jun, 2020 | Pubmed ID: 31822964 Tacrolimus-Induced BMP/SMAD Signaling Associates With Metabolic Stress-Activated FOXO1 to Trigger β-Cell Failure Diabetes. 02, 2020 | Pubmed ID: 31732500 VprBP Mitigates TGF-β and Activin Signaling by Promoting Smurf1-mediated Type I Receptor Degradation Journal of Molecular Cell Biology. 02, 2020 | Pubmed ID: 31291647 Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells JBMR Plus. Nov, 2019 | Pubmed ID: 31768489 JNK-Dependent CJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses Cells. 11, 2019 | Pubmed ID: 31766464 A Perspective on the Development of TGF-β Inhibitors for Cancer Treatment Biomolecules. 11, 2019 | Pubmed ID: 31744193 Author Correction: C-Met Activation Leads to the Establishment of a TGFβ-receptor Regulatory Network in Bladder Cancer Progression Nature Communications. Nov, 2019 | Pubmed ID: 31704935 GREM1 is Associated with Metastasis and Predicts Poor Prognosis in ER-negative Breast Cancer Patients Cell Communication and Signaling : CCS. 11, 2019 | Pubmed ID: 31694641 C-Met Activation Leads to the Establishment of a TGFβ-receptor Regulatory Network in Bladder Cancer Progression Nature Communications. 09, 2019 | Pubmed ID: 31554791 Cancer-associated Fibroblast-derived Gremlin 1 Promotes Breast Cancer Progression Breast Cancer Research : BCR. 09, 2019 | Pubmed ID: 31533776 In Vivo Imaging of TGFβ Signalling Components Using Positron Emission Tomography Drug Discovery Today. 12, 2019 | Pubmed ID: 31494189 Role of Soluble Endoglin in BMP9 Signaling Proceedings of the National Academy of Sciences of the United States of America. 09, 2019 | Pubmed ID: 31431534 Prevention of Progression of Pulmonary Hypertension by the Nur77 Agonist 6-mercaptopurine: Role of BMP Signalling The European Respiratory Journal. 09, 2019 | Pubmed ID: 31273046 Autophagy Contributes to BMP Type 2 Receptor Degradation And development of Pulmonary Arterial Hypertension The Journal of Pathology. 11, 2019 | Pubmed ID: 31257577 Generation of Non-standard Macrocyclic Peptides Specifically Binding TSC-22 Homologous Gene-1 Biochemical and Biophysical Research Communications. 08, 2019 | Pubmed ID: 31227214 TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis International Journal of Molecular Sciences. Jun, 2019 | Pubmed ID: 31195692 Epigenetic Reprogramming of TGF-β Signaling in Breast Cancer Cancers. May, 2019 | Pubmed ID: 31137748 Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models Cells. 04, 2019 | Pubmed ID: 30959852 TGF-β Family Signaling Pathways in Cellular Dormancy Trends in Cancer. 01, 2019 | Pubmed ID: 30616757 Inflammation Induces Endothelial-to-mesenchymal Transition and Promotes Vascular Calcification Through Downregulation of BMPR2 The Journal of Pathology. 03, 2019 | Pubmed ID: 30430573 Bone Morphogenetic Protein Receptor Signal Transduction in Human Disease The Journal of Pathology. 01, 2019 | Pubmed ID: 30246251 The Therapeutic Potential of Targeting the Endothelial-to-mesenchymal Transition Angiogenesis. 02, 2019 | Pubmed ID: 30076548 Epithelial-mesenchymal-transition-inducing Transcription Factors: New Targets for Tackling Chemoresistance in Cancer? Oncogene. 11, 2018 | Pubmed ID: 30002444 Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 12, 2018 | Pubmed ID: 29945992 Bone Morphogenetic Protein 9 As a Key Regulator of Liver Progenitor Cells in DDC-induced Cholestatic Liver Injury Liver International : Official Journal of the International Association for the Study of the Liver. 09, 2018 | Pubmed ID: 29751359 TGF-β Family Co-receptor Function and Signaling Acta Biochimica Et Biophysica Sinica. Jan, 2018 | Pubmed ID: 29293886 JUNB Governs a Feed-forward Network of TGFβ Signaling That Aggravates Breast Cancer Invasion Nucleic Acids Research. 02, 2018 | Pubmed ID: 29186616 Endothelial-to-mesenchymal Transition in Cardiovascular Diseases: Developmental Signaling Pathways Gone Awry Developmental Dynamics : an Official Publication of the American Association of Anatomists. 03, 2018 | Pubmed ID: 28891150 Breast Cancer Metastasis Suppressor OTUD1 Deubiquitinates SMAD7 Nature Communications. 12, 2017 | Pubmed ID: 29235476 TGF-β-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases International Journal of Molecular Sciences. Oct, 2017 | Pubmed ID: 29039786 Disparate Phospho-Smad2 Levels in Advanced Type 2 Diabetes Patients with Diabetic Nephropathy and Early Experimental Db/db Mouse Model Renal Failure. Nov, 2017 | Pubmed ID: 28805484 Bone Morphogenetic Protein 9 Protects Against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation Frontiers in Physiology. 2017 | Pubmed ID: 28751863 Targeting TGF-β Signaling in Cancer Trends in Cancer. 01, 2017 | Pubmed ID: 28718426 SUMO-triggered Ubiquitination of NR4A1 Controls Macrophage Cell Death Cell Death and Differentiation. 09, 2017 | Pubmed ID: 28622293 TGFβ1-induced SMAD2/3 and SMAD1/5 Phosphorylation Are Both ALK5-kinase-dependent in Primary Chondrocytes and Mediated by TAK1 Kinase Activity Arthritis Research & Therapy. May, 2017 | Pubmed ID: 28569204 Erratum To: BMP Type II Receptor As a Therapeutic Target in Pulmonary Arterial Hypertension Cellular and Molecular Life Sciences : CMLS. 08, 2017 | Pubmed ID: 28536788 USP4 Inhibits SMAD4 Monoubiquitination and Promotes Activin and BMP Signaling The EMBO Journal. 06, 2017 | Pubmed ID: 28468752 BMP Type II Receptor As a Therapeutic Target in Pulmonary Arterial Hypertension Cellular and Molecular Life Sciences : CMLS. 08, 2017 | Pubmed ID: 28447104 FAF1 Phosphorylation by AKT Accumulates TGF-β Type II Receptor and Drives Breast Cancer Metastasis Nature Communications. 04, 2017 | Pubmed ID: 28443643 Bone Morphogenetic Proteins in Vascular Homeostasis and Disease Cold Spring Harbor Perspectives in Biology. Mar, 2017 | Pubmed ID: 28348038 TGF-β Signaling in Control of Cardiovascular Function Cold Spring Harbor Perspectives in Biology. Mar, 2017 | Pubmed ID: 28348036 BMP-9 Interferes with Liver Regeneration and Promotes Liver Fibrosis Gut. May, 2017 | Pubmed ID: 28336518 Fluid Shear Stress-induced TGF-β/ALK5 Signaling in Renal Epithelial Cells is Modulated by MEK1/2 Cellular and Molecular Life Sciences : CMLS. Feb, 2017 | Pubmed ID: 28168444 TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation The Journal of Biological Chemistry. Mar, 2017 | Pubmed ID: 28115518 Smad2 Phosphorylation in Diabetic Kidney Tubule Epithelial Cells Is Associated with Modulation of Several Transforming Growth Factor-β Family Members Nephron. 2017 | Pubmed ID: 28064277 New Function of the Myostatin/activin Type I Receptor (ALK4) As a Mediator of Muscle Atrophy and Muscle Regeneration FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2017 | Pubmed ID: 27733450 Fish Tales: The Use of Zebrafish Xenograft Human Cancer Cell Models Histology and Histopathology. Dec, 2016 | Pubmed ID: 27933602 Immunoregulation by Members of the TGFβ Superfamily Nature Reviews. Immunology. 11, 2016 | Pubmed ID: 27885276 Towards a Cure for Fibrodysplasia Ossificans Progressiva Annals of Translational Medicine. Oct, 2016 | Pubmed ID: 27867996 Mutational Activation of BRAF Confers Sensitivity to Transforming Growth Factor Beta Inhibitors in Human Cancer Cells Oncotarget. Dec, 2016 | Pubmed ID: 27835901 Targeting Tumour Vasculature by Inhibiting Activin Receptor-like Kinase (ALK)1 Function Biochemical Society Transactions. Aug, 2016 | Pubmed ID: 27528762 A Current Perspective on Applications of Macrocyclic-peptide-based High-affinity Ligands Biopolymers. Nov, 2016 | Pubmed ID: 27352774 C-Myb Enhances Breast Cancer Invasion and Metastasis Through the Wnt/β-Catenin/Axin2 Pathway Cancer Research. Jun, 2016 | Pubmed ID: 27197202 Delta-Like Ligand 4 Modulates Liver Damage by Down-Regulating Chemokine Expression The American Journal of Pathology. Jul, 2016 | Pubmed ID: 27171900 Regulation of the TGF-β Pathway by Deubiquitinases in Cancer The International Journal of Biochemistry & Cell Biology. Jul, 2016 | Pubmed ID: 27155333 Smad6 Determines BMP-regulated Invasive Behaviour of Breast Cancer Cells in a Zebrafish Xenograft Model Scientific Reports. Apr, 2016 | Pubmed ID: 27113436 Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease Journal of the American Society of Nephrology : JASN. Dec, 2016 | Pubmed ID: 27020852 Emerging Regulators of BMP Bioavailability Bone. Dec, 2016 | Pubmed ID: 26825814 The Rationale for Targeting TGF-β in Chronic Liver Diseases European Journal of Clinical Investigation. Apr, 2016 | Pubmed ID: 26823073 TGF-β Signalling and Liver Disease The FEBS Journal. Jun, 2016 | Pubmed ID: 26807763 Interrogating TGF-β Function and Regulation in Endothelial Cells Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26520125 Determining TGF-β Receptor Levels in the Cell Membrane Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26520116 In Brief: Endothelial-to-mesenchymal Transition The Journal of Pathology. Feb, 2016 | Pubmed ID: 26446982 Regulatory RNAs Controlling Vascular (dys)function by Affecting TGF-ß Family Signalling EXCLI Journal. 2015 | Pubmed ID: 26862319 Signal Transduction: Gain of Activin Turns Muscle into Bone Current Biology : CB. Dec, 2015 | Pubmed ID: 26654374 Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva Stem Cell Reports. Dec, 2015 | Pubmed ID: 26626181 Targeting BMP Signalling in Cardiovascular Disease and Anaemia Nature Reviews. Cardiology. Oct, 2015 | Pubmed ID: 26461965 Bone Morphogenetic Protein 6 and Oxidized Low-density Lipoprotein Synergistically Recruit Osteogenic Differentiation in Endothelial Cells Cardiovascular Research. Nov, 2015 | Pubmed ID: 26410368 Heterozygous Disruption of Activin Receptor-like Kinase 1 is Associated with Increased Arterial Pressure in Mice Disease Models & Mechanisms. Nov, 2015 | Pubmed ID: 26398936 Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2015 | Pubmed ID: 26373572 Bone Morphogenetic Protein Signaling in Bone Homeostasis Bone. Nov, 2015 | Pubmed ID: 26051467 A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins Journal of Virology. Aug, 2015 | Pubmed ID: 26041291 Genetic Depletion and Pharmacological Targeting of αv Integrin in Breast Cancer Cells Impairs Metastasis in Zebrafish and Mouse Xenograft Models Breast Cancer Research : BCR. Feb, 2015 | Pubmed ID: 25849225 Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2 Gastroenterology. Jun, 2015 | Pubmed ID: 25736321 14-3-3ζ Turns TGF-β to the Dark Side Cancer Cell. Feb, 2015 | Pubmed ID: 25670073 SLUG is Expressed in Endothelial Cells Lacking Primary Cilia to Promote Cellular Calcification Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2015 | Pubmed ID: 25633317 Clinical Utility Gene Card For: Fibrodysplasia Ossificans Progressiva European Journal of Human Genetics : EJHG. Oct, 2015 | Pubmed ID: 25604857 Inhibition of TGFβ Type I Receptor Activity Facilitates Liver Regeneration Upon Acute CCl4 Intoxication in Mice Archives of Toxicology. Jan, 2015 | Pubmed ID: 25566828 Ter94/VCP is a Novel Component Involved in BMP Signaling PloS One. 2014 | Pubmed ID: 25469707 Wild-type P53 Inhibits Pro-invasive Properties of TGF-β3 in Breast Cancer, in Part Through Regulation of EPHB2, a New TGF-β Target Gene Breast Cancer Research and Treatment. Nov, 2014 | Pubmed ID: 25257729 Assessment of Functional Competence of Endothelial Cells from Human Pluripotent Stem Cells in Zebrafish Embryos Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 25173378 Time-resolved Dissection of Early Phosphoproteome and Ensuing Proteome Changes in Response to TGF-β Science Signaling. Jul, 2014 | Pubmed ID: 25056879 Generation, Expansion and Functional Analysis of Endothelial Cells and Pericytes Derived from Human Pluripotent Stem Cells Nature Protocols. 2014 | Pubmed ID: 24874816 Loss of SMAD4 Alters BMP Signaling to Promote Colorectal Cancer Cell Metastasis Via Activation of Rho and ROCK Gastroenterology. Jul, 2014 | Pubmed ID: 24704720 Targeting TGF-β Signaling by Antisense Oligonucleotide-mediated Knockdown of TGF-β Type I Receptor Molecular Therapy. Nucleic Acids. Apr, 2014 | Pubmed ID: 24691207 Nuclear Receptor NR4A1 Promotes Breast Cancer Invasion and Metastasis by Activating TGF-β Signalling Nature Communications. 2014 | Pubmed ID: 24584437 ENDOGLIN is Dispensable for Vasculogenesis, but Required for Vascular Endothelial Growth Factor-induced Angiogenesis PloS One. 2014 | Pubmed ID: 24489709 Novel Ex Vivo Culture Method for the Study of Dupuytren's Disease: Effects of TGFβ Type 1 Receptor Modulation by Antisense Oligonucleotides Molecular Therapy. Nucleic Acids. 2014 | Pubmed ID: 24448195 Functionality of Endothelial Cells and Pericytes from Human Pluripotent Stem Cells Demonstrated in Cultured Vascular Plexus and Zebrafish Xenografts Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2014 | Pubmed ID: 24158517 Mutational Analysis of Sclerostin Shows Importance of the Flexible Loop and the Cystine-knot for Wnt-signaling Inhibition PloS One. 2013 | Pubmed ID: 24312339 Signaling Interplay Between Transforming Growth Factor-β Receptor and PI3K/AKT Pathways in Cancer Trends in Biochemical Sciences. Dec, 2013 | Pubmed ID: 24239264 Transforming Growth Factor-β Signalling Controls Human Breast Cancer Metastasis in a Zebrafish Xenograft Model Breast Cancer Research : BCR. Nov, 2013 | Pubmed ID: 24196484 Activin Receptor-like Kinase 1 As a Target for Anti-angiogenesis Therapy Expert Opinion on Investigational Drugs. Nov, 2013 | Pubmed ID: 24053899 Transforming Growth Factor-β (TGF-β)-mediated Connective Tissue Growth Factor (CTGF) Expression in Hepatic Stellate Cells Requires Stat3 Signaling Activation The Journal of Biological Chemistry. Oct, 2013 | Pubmed ID: 24005672 TRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer Metastasis Molecular Cell. Sep, 2013 | Pubmed ID: 23973329 FK506 Activates BMPR2, Rescues Endothelial Dysfunction, and Reverses Pulmonary Hypertension The Journal of Clinical Investigation. Aug, 2013 | Pubmed ID: 23867624 Antisense-oligonucleotide Mediated Exon Skipping in Activin-receptor-like Kinase 2: Inhibiting the Receptor That is Overactive in Fibrodysplasia Ossificans Progressiva PloS One. 2013 | Pubmed ID: 23861958 Three-dimensional Co-cultures of Human Endothelial Cells and Embryonic Stem Cell-derived Pericytes Inside a Microfluidic Device Lab on a Chip. Sep, 2013 | Pubmed ID: 23702711 Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-mediated Antagonism of Wnt/LRP6 Signaling PloS One. 2013 | Pubmed ID: 23638027 Snail and Slug, Key Regulators of TGF-β-induced EMT, Are Sufficient for the Induction of Single-cell Invasion Biochemical and Biophysical Research Communications. May, 2013 | Pubmed ID: 23618854 Preventive and Therapeutic Effects of Smad7 on Radiation-induced Oral Mucositis Nature Medicine. Apr, 2013 | Pubmed ID: 23475202 Fine-tuning BMP7 Signalling in Adipogenesis by UBE2O/E2-230K-mediated Monoubiquitination of SMAD6 The EMBO Journal. Apr, 2013 | Pubmed ID: 23455153 Deficit Di Endoglin Nel Sistema Vascolare Tumorale Indebolisce La Barriera Endoteliale Di Diffusione Metastatica The Journal of Experimental Medicine. Mar, 2013 | Pubmed ID: 23401487 UBE2O Negatively Regulates TRAF6-mediated NF-κB Activation by Inhibiting TRAF6 Polyubiquitination Cell Research. Mar, 2013 | Pubmed ID: 23381138 Endoglin for Tumor Imaging and Targeted Cancer Therapy Expert Opinion on Therapeutic Targets. Apr, 2013 | Pubmed ID: 23327677 Overactive Bone Morphogenetic Protein Signaling in Heterotopic Ossification and Duchenne Muscular Dystrophy Cellular and Molecular Life Sciences : CMLS. Feb, 2013 | Pubmed ID: 22752156 Soluble Fms-like Tyrosine Kinase 1 and Soluble Endoglin Are Elevated Circulating Anti-angiogenic Factors in Pre-eclampsia Pregnancy Hypertension. Oct, 2012 | Pubmed ID: 26105603 MicroRNA-155 Functions As a Negative Regulator of RhoA Signaling in TGF-β-induced Endothelial to Mesenchymal Transition MicroRNA (Shariqah, United Arab Emirates). 2012 | Pubmed ID: 25048084 Modelli Animali Di Malattie Croniche Del Fegato American Journal of Physiology. Gastrointestinal and Liver Physiology. Dec, 2012 | Pubmed ID: 23275613 MED12 Controls the Response to Multiple Cancer Drugs Through Regulation of TGF-β Receptor Signaling Cell. Nov, 2012 | Pubmed ID: 23178117 The Activities of Smad and Gli Mediated Signalling Pathways in High-grade Conventional Osteosarcoma European Journal of Cancer (Oxford, England : 1990). Dec, 2012 | Pubmed ID: 22868198 Fas-associated Factor 1 is a Scaffold Protein That Promotes β-transducin Repeat-containing Protein (β-TrCP)-mediated β-catenin Ubiquitination and Degradation The Journal of Biological Chemistry. Aug, 2012 | Pubmed ID: 22730322 TGF-β Signalling and Its Role in Cancer Progression and Metastasis Cancer Metastasis Reviews. Dec, 2012 | Pubmed ID: 22714591 BMP Signaling in Vascular Diseases FEBS Letters. Jul, 2012 | Pubmed ID: 22710160 USP4 is Regulated by AKT Phosphorylation and Directly Deubiquitylates TGF-β Type I Receptor Nature Cell Biology. Jun, 2012 | Pubmed ID: 22706160 TGFβ Signaling in Liver Regeneration Current Pharmaceutical Design. 2012 | Pubmed ID: 22630085 Deregulated Bone Morphogenetic Protein Receptor Signaling Underlies Fibrodysplasia Ossificans Progressiva Current Pharmaceutical Design. 2012 | Pubmed ID: 22630080 Role of Endoglin in Fibrosis and Scleroderma International Review of Cell and Molecular Biology. 2012 | Pubmed ID: 22608563 LRP8 Mediates Wnt/β-catenin Signaling and Controls Osteoblast Differentiation Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Oct, 2012 | Pubmed ID: 22589174 RNF12 Controls Embryonic Stem Cell Fate and Morphogenesis in Zebrafish Embryos by Targeting Smad7 for Degradation Molecular Cell. Jun, 2012 | Pubmed ID: 22560923 Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting The Journal of Biological Chemistry. May, 2012 | Pubmed ID: 22493445 Shear Induced Collateral Artery Growth Modulated by Endoglin but Not by ALK1 Journal of Cellular and Molecular Medicine. Oct, 2012 | Pubmed ID: 22436015 Vanilloid Receptor-1 Regulates Neurogenic Inflammation in Colon and Protects Mice from Colon Cancer Cancer Research. Apr, 2012 | Pubmed ID: 22396497 TGF-β Signaling in Endothelial-to-mesenchymal Transition: the Role of Shear Stress and Primary Cilia Science Signaling. Feb, 2012 | Pubmed ID: 22355187 Ruolo Chiave Per La Modifica Della Proteina Di Ubiquitin Nella Trasduzione Del Segnale TGFβ Upsala Journal of Medical Sciences. Feb, 2012 | Pubmed ID: 22335355 Segnalazione Wnt/β-catenina Cambia C2C12 Myoblast Proliferazione E Differenziazione Di Indurre L'espressione Id3 Biochemical and Biophysical Research Communications. Feb, 2012 | Pubmed ID: 22326917 Chiave Segnalazione Nodi Di Sviluppo Della Ghiandola Mammaria E Cancro: Integrazione Segnale Smad Nella Plasticità Delle Cellule Epiteliali Breast Cancer Research : BCR. Feb, 2012 | Pubmed ID: 22315972 Una Legame Covalente Dimerized Ricombinante Umano Bone Morphogenetic Protein-15 Variante Identifica Bone Morphogenetic Protein Receptor Tipo 1B Come Un Recettore Di Superficie Cellulare Chiave Su Cellule Di Granulosa Ovarica Endocrinology. Jan, 2012 | Pubmed ID: 22294741 Non-sinonimo Varianti Del Gene SMAD6 Predispongono a Malformazioni Cardiovascolari Congenite Human Mutation. Jan, 2012 | Pubmed ID: 22275001 Proteasi Ubiquitin-specifiche 4 Mitiga Toll-like/interleukin-1 Receptor Signaling E Regola L'attivazione Immunitaria Innata The Journal of Biological Chemistry. Jan, 2012 | Pubmed ID: 22262844 Malattie Cardiovascolari E Segnalazione Di TGFβ International Journal of Biological Sciences. 2012 | Pubmed ID: 22253564 TGF-β Nella Progressione Della Malattia Epatica Cell and Tissue Research. Jan, 2012 | Pubmed ID: 22006249 BMP-7 Inibisce Invasione TGF-β-indotta Delle Cellule Di Cancro Al Seno Attraverso L'inibizione Dell'integrina β(3) Espressione Cellular Oncology (Dordrecht). Feb, 2012 | Pubmed ID: 21935711 Regolazione Della Plasticità Delle Cellule Endoteliali Da TGF-β Cell and Tissue Research. Jan, 2012 | Pubmed ID: 21866313 Alterazione Di Età-dipendente Di Segnalazione Di TGF-β in Osteoartrite Cell and Tissue Research. Jan, 2012 | Pubmed ID: 21638205 Regolamento Della Funzione Di Barriera Endoteliale Di TGF-β Tipo I Recettori ALK5: Ruolo Potenziale Dei Meccanismi Contrattili E Proteine Di Scossa Di Calore 90 Journal of Cellular Physiology. Feb, 2012 | Pubmed ID: 21465483 Regolamento Specifico Tipo Di Cellule Della Miostatina Segnalazione The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2011 | Pubmed ID: 22202673 Induzione Transgene Smad7 Temporale Nell'epidermide Del Mouse Accelera La Guarigione Delle Ferite Della Pelle The American Journal of Pathology. Oct, 2011 | Pubmed ID: 21944279 Inattivazione GSK3β Induce L'apoptosi Delle Cellule Di Leucemia Di Reprimere La Funzione Del C-Myb Molecular Biology of the Cell. Sep, 2011 | Pubmed ID: 21795403 Controllo Dell'angiogenesi Da Due Unici TGF-β Di Tipo Receptor Signaling Pathways Histology and Histopathology. Sep, 2011 | Pubmed ID: 21751154 Esplorare Le Terapie Anti-TGF-β Nel Cancro E Fibrosi Growth Factors (Chur, Switzerland). Aug, 2011 | Pubmed ID: 21718111 Elevato Fattore Di Crescita Trasformante β E Percorsi Della Chinasi Di Proteina Mitogene-attivata Mediano Fibrotici Tratti Di Fibroblasti Di Morbo Di Dupuytren Fibrogenesis & Tissue Repair. 2011 | Pubmed ID: 21711521 TGF-β Receptor Signaling Pathways in Angiogenesi; Destinazioni Emergenti Per La Terapia Anti-angiogenesi Current Pharmaceutical Biotechnology. May, 2011 | Pubmed ID: 21619534 Bifasico Effetti Di Trasformazione Di Fattore Di Crescita β Sulla Differenziazione Degli Osteoblasti Indotta Da Proteine Morfogenetiche Ossee Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jun, 2011 | Pubmed ID: 21611961 TGFβ/Alk5 Di Segnalazione è Necessaria Per L'espressione Klf2 Shear Stress Indotto in Cellule Endoteliali Embrionali Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jul, 2011 | Pubmed ID: 21604321 Dual Exon Skipping in Miostatina E Distrofina Per La Distrofia Muscolare Di Duchenne BMC Medical Genomics. 2011 | Pubmed ID: 21507246 TGF-β Segnalazione in Breast Cancer Cell Invasione E Metastasi Dell'osso Journal of Mammary Gland Biology and Neoplasia. Jun, 2011 | Pubmed ID: 21494783 Migrazione Di Monociti TGF-β1/ALK5-indotto Coinvolge Vie PI3K E P38 E Non è Influenzato Negativamente Da Diabete Mellito Cardiovascular Research. Aug, 2011 | Pubmed ID: 21478266 FAS-associated Factor 1 Antagonizza Segnalazione Wnt, Promuovendo La Degradazione Di β-catenina Molecular Biology of the Cell. May, 2011 | Pubmed ID: 21411632 Mancanza Di Ciliari Primes Shear-induced Endothelial Mesenchimali Transizione Circulation Research. Apr, 2011 | Pubmed ID: 21393577 Endoglin Promuove La Segnalazione Di TGF-β/Smad1 Nei Fibroblasti Di Sclerodermia Journal of Cellular Physiology. Dec, 2011 | Pubmed ID: 21344387 ALK2 Mutazione in Un Paziente Con Sindrome Di Down E Un Cuore Congenito Difetto European Journal of Human Genetics : EJHG. Apr, 2011 | Pubmed ID: 21248739 TGFbeta Attiva Attivata Mitogene E Lo Stress Della Proteina Chinasi-1 (MSK1) Per Attenuare La Morte Delle Cellule The Journal of Biological Chemistry. Feb, 2011 | Pubmed ID: 21106525 I Ruoli Dinamici Di TGF-β Nel Cancro The Journal of Pathology. Jan, 2011 | Pubmed ID: 20957627 ACTIVIN A Induce Un Fenotipo Non Fibrotico Nelle Cellule Muscolari Lisce a Differenza Di TGF-β Experimental Cell Research. Jan, 2011 | Pubmed ID: 20955695 BMP Antagonisti Migliorano La Differenziazione Miogena E Migliorare Il Fenotipo Distrofica in Un Modello Murino DMD Neurobiology of Disease. Feb, 2011 | Pubmed ID: 20940052 Il Percorso Di TGF-β/Smad Induce Al Seno Cancro Cellule Invasione Attraverso La Up-regulation Di Matrix Metalloproteinase 2 E 9 in Un Sistema Modello Di Invasione Sferoide Breast Cancer Research and Treatment. Aug, 2011 | Pubmed ID: 20821046 Effetti Bifasico Di Trasformare La Differenziazione Degli Osteoblasti Growth Factor-β Su Bone Morphogenetic Protein-indotta Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Dec, 2010 | Pubmed ID: 21162084 Misurazione Dell'attività Costitutiva Di BMP Di Tipo I Recettori Methods in Enzymology. 2010 | Pubmed ID: 21036238 Distinte Modalità Di Inibizione Da Sclerostin Su Bone Morphogenetic Protein E Vie Di Segnalazione Wnt The Journal of Biological Chemistry. Dec, 2010 | Pubmed ID: 20952383 Segnalazione Da Parte Dei Membri Della Famiglia TGF-beta Nella Morfogenesi Vascolare E Malattia Trends in Cell Biology. Sep, 2010 | Pubmed ID: 20656490 Integrazione Dei Segnali Trascrizionali Davanti Tumore Delle Cellule Invasive Cell Cycle (Georgetown, Tex.). Jul, 2010 | Pubmed ID: 20647778 Elevata TGFbeta-Smad Segnalazione in Modelli Sperimentali Di Pkd1 E Pazienti Umani Con Rene Policistico The Journal of Pathology. Sep, 2010 | Pubmed ID: 20549648 Rilevamento Di Prossimità in Situ Legatura Dei Dimeri Di C-Jun/AP-1 Rivela Aumento Dei Livelli Di C-Jun/Fra1 Complessi in Linee Di Seno Aggressivo Cancro Cellule in Vitro E in Vivo Molecular & Cellular Proteomics : MCP. Sep, 2010 | Pubmed ID: 20511396 Matrix Metalloproteinase-14 (MT1-MMP)-mediata Endoglin Spargimento Inibisce L'angiogenesi Tumorale Cancer Research. May, 2010 | Pubmed ID: 20424116 Annexina A1 Regola La Segnalazione Di TGF-beta E Promuove La Formazione Di Metastasi Delle Cellule Di Cancro Al Seno Basal-like Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010 | Pubmed ID: 20308542 TMEPAI, Una Proteina Transmembrana Di TGF-beta-inducible, Sequestra Le Proteine Smad Dalla Partecipazione Attiva Nella Segnalazione Di TGF-beta Molecular Cell. Jan, 2010 | Pubmed ID: 20129061 Genetica E Farmacologica Di Targeting Di Activin Receptor-like Chinasi 1 Altera L'angiogenesi E La Crescita Tumorale The Journal of Experimental Medicine. Jan, 2010 | Pubmed ID: 20065063 Identificazione Di Un Residuo Chiave Mediando Bone Morphogenetic Protein (BMP) -6 Resistenza All'inibizione Di Zucca Permette BMPs Ingegnerizzati Con Attività Agonista Superiore The Journal of Biological Chemistry. Apr, 2010 | Pubmed ID: 20048150 Mutazione ALK2 R206H Collegato a Fibrodisplasia Ossificante Progressiva Conferisce Attività Costitutiva Di BMP Del Recettore Di Tipo I E Sensibilizza Le Cellule Mesenchimali Alla Formazione Di Osso E Differenziazione Degli Osteoblasti Indotta Da BMP Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jun, 2010 | Pubmed ID: 19929436 Acido 5-aminosalicilico Inibisce La Segnalazione Di TGF-beta1 in Cellule Di Cancro Del Colon-retto Cancer Letters. Jan, 2010 | Pubmed ID: 19541409 Autocrino Osso Morphogenetic Protein-9 Segnali Attraverso Activin Receptor-like Chinasi-2/Smad1/Smad4 Per Promuovere La Proliferazione Delle Cellule Di Cancro Ovarico Cancer Research. Dec, 2009 | Pubmed ID: 19996292 VEGF E Inibitori Del TGFbeta Tipo-io Della Chinasi Del Recettore Sinergicamente Promuovere La Formazione Di Vasi Sanguigni Inducendo Espressione Alpha5-integrina Journal of Cell Science. Sep, 2009 | Pubmed ID: 19706683 SMAD3 è Un Mediatore Chiave Nonredundant Della Trasformazione Di Fattore Di Crescita Beta Segnalazione Delle Cellule Epiteliali Mammarie Nme Del Mouse Molecular Cancer Research : MCR. Aug, 2009 | Pubmed ID: 19671686 Endoglin Aploinsufficienza Riduce Indotta Da Radiazioni Formazione Fibrosi E Telangectasie Nei Reni Mouse Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology. Sep, 2009 | Pubmed ID: 19576647 Dominante Negativo ALK2 Allele Si Associa a Difetti Cardiaci Congeniti Circulation. Jun, 2009 | Pubmed ID: 19506109 Trasformando L'angiogenesi Tumorale E Di Segnalazione Growth Factor-beta Frontiers in Bioscience : a Journal and Virtual Library. 2009 | Pubmed ID: 19482591 Formazione Povera Nave in Embrioni Di Topi Knock-in Esprimendo ALK5 Con Mutazione Del Ciclo L45 Difettoso in Attivazione Smad Laboratory Investigation; a Journal of Technical Methods and Pathology. Jul, 2009 | Pubmed ID: 19398960 Radiazioni Ionizzanti Sposta L'equilibrio Di PAI-1/ID-1 E Attiva La Tacca Di Segnalazione in Cellule Endoteliali International Journal of Radiation Oncology, Biology, Physics. Feb, 2009 | Pubmed ID: 19147015 TGF-beta Segnalazione in Disfunzione E Biologia Vascolare Cell Research. Jan, 2009 | Pubmed ID: 19114994 Complessi Co-repressor Sci Mantengono Lo Stato Represso Basale Del Gene Dell'obiettivo Di TGF-beta, SMAD7, Via HDAC3 E PRMT5 Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Jan, 2009 | Pubmed ID: 19032343 Trasformando Il Fattore Di Crescita Beta-induced Endothelial Mesenchimali Transizione: Un Interruttore Di Fibrosi Cardiaca? Trends in Cardiovascular Medicine. Nov, 2008 | Pubmed ID: 19345316 Smad1 Pathway è Attivato in Fibroblasti Di Sclerosi Sistemica E Preso Di Mira Dal Imatinib Mesylate Arthritis and Rheumatism. Aug, 2008 | Pubmed ID: 18668566 Il Pathway Della Proteina Morfogenetica Ossea è Inattivato Nella Maggior Parte Dei Tumori Del Colon-retto Sporadici Gastroenterology. May, 2008 | Pubmed ID: 18471510 VE-caderina è Un Regolatore Critico Endoteliale Di Segnalazione Di TGF-beta The EMBO Journal. Apr, 2008 | Pubmed ID: 18337748 ALK1 Oppone ALK5/Smad3 Di Segnalazione E Di Espressione Dei Componenti Della Matrice Extracellulare Nei Condrociti Umani Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jun, 2008 | Pubmed ID: 18333754 L E S-endoglin Modulare Differenzialmente TGFbeta1 Segnalazione Mediata Da ALK1 E ALK5 in L6E9 Myoblasts Journal of Cell Science. Mar, 2008 | Pubmed ID: 18303046 Derivato Da Osteocita Sclerostin Inibisce La Formazione Di Osso: Suo Ruolo Nella Bone Morphogenetic Protein E Segnalazione Wnt The Journal of Bone and Joint Surgery. American Volume. Feb, 2008 | Pubmed ID: 18292354 Endoglin in Malattie Vascolari E L'angiogenesi Angiogenesis. 2008 | Pubmed ID: 18283546 Due Recettori Di Tipo Romanzo II Mediano Segnalazione BMP E Sono Tenuti a Stabilire Asimmetria Sinistra-destra Nello Zebrafish Developmental Biology. Mar, 2008 | Pubmed ID: 18222420 Trasformando Growth Factor Beta E Wound Healing in Colesteatoma Umana The Laryngoscope. Jan, 2008 | Pubmed ID: 17989584 Segnalazione Compensativo Indotta Nel Sistema Vascolare Sacco Vitellino Dalla Cancellazione Dei Recettori TGFbeta Nei Topi Journal of Cell Science. Dec, 2007 | Pubmed ID: 18029401 TGF-beta E BMP7 Interazioni in Metastasi Osso E Progressione Tumorale Clinical & Experimental Metastasis. 2007 | Pubmed ID: 18008174 Controllo Extracellulare Del TGFbeta Segnalazione in Malattia E Sviluppo Vascolare Nature Reviews. Molecular Cell Biology. Nov, 2007 | Pubmed ID: 17895899 Una Rapida E Sensibile Analisi Biologica Per Misurare L'attività Della Proteina Morfogenetica Ossea BMC Cell Biology. 2007 | Pubmed ID: 17880711 Bone Morphogenetic Protein 7 Lo Sviluppo E Il Trattamento Delle Metastasi Ossee Da Cancro Al Seno Cancer Research. Sep, 2007 | Pubmed ID: 17875715 BMP7, Un Putativo Regolatore Dell'omeostasi Epitelio Di Prostata Umana, è Un Potente Inibitore Delle Metastasi Ossee Di Carcinoma Prostatico in Vivo The American Journal of Pathology. Sep, 2007 | Pubmed ID: 17724140 Induzione Di Mediatori Di Sonic Hedgehog Trasformando Growth Factor-beta: Attivazione Smad3-dipendente Dell'espressione Gli2 E Gli1 in Vitro E in Vivo Cancer Research. Jul, 2007 | Pubmed ID: 17638910 Segnalazione Da ALK5 Da Intermediario Espressione Di TGF-beta-induced ET-1 in Cellule Endoteliali: Un Ruolo Per La Migrazione E La Proliferazione Journal of Cell Science. Apr, 2007 | Pubmed ID: 17376964 Trasformando Il Recettore Di Tipo Growth Factor-beta Programma Di Gene Fibrogenic-dipendente è Mediato Tramite Attivazione Delle Vie Smad1 E Di ERK1/2 The Journal of Biological Chemistry. Apr, 2007 | Pubmed ID: 17317656 Regolazione Negativa Della Trasduzione Del Segnale Di TGF-beta Del Recettore/Smad Current Opinion in Cell Biology. Apr, 2007 | Pubmed ID: 17317136 Aberrant Bmp Signaling and Notochord Delamination in the Pathogenesis of Esophageal Atresia Developmental Dynamics : an Official Publication of the American Association of Anatomists. Mar, 2007 | Pubmed ID: 17260385 SOST Espressione è Limitata Alle Grandi Arterie Durante Lo Sviluppo Embrionale E Neonatale Cardiovascolare Developmental Dynamics : an Official Publication of the American Association of Anatomists. Feb, 2007 | Pubmed ID: 17195180 KLF2 Sopprime TGF-beta Segnalazione Nell'endotelio Attraverso Induzione Di Smad7 E Inibizione Di AP-1 Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2007 | Pubmed ID: 17194892 Ma Non BMP è Coinvolto Nell'azione Inibitoria Di Sclerostin Sulla Formazione Ossea BMP-stimolato Di Segnalazione Wnt Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jan, 2007 | Pubmed ID: 17032150 Metilazione Del Smad6 Di Arginina Della Proteina N-metiltransferasi 1 FEBS Letters. Dec, 2006 | Pubmed ID: 17118358 Endoglin Ha Un Ruolo Fondamentale Nella Riparazione Vascolare Mediata Delle Cellule Del Sangue Circulation. Nov, 2006 | Pubmed ID: 17088457 Un Approccio Di Equazione Di Tasso Per Delucidare La Cinetica E La Robustezza Del Percorso TGF-beta Biophysical Journal. Dec, 2006 | Pubmed ID: 17012329 Degrado Indotto SMAD7 Beta-catenina Altera Lo Sviluppo Epidermico Appendice Developmental Cell. Sep, 2006 | Pubmed ID: 16950122 Id1 è Un Mediatore Critico Di Transdifferenziazione TGF-beta-indotta Delle Cellule Stellate Epatiche Di Ratto Hepatology (Baltimore, Md.). May, 2006 | Pubmed ID: 16628634 SMAD7 E Proteine Fosfatasi 1alpha Sono Critici Determinanti Nella Durata Di Segnalazione Di TGF-beta/ALK1 Nelle Cellule Endoteliali BMC Cell Biology. 2006 | Pubmed ID: 16571110 Il Soppressore Del Tumore Smad4 è Richiesto Per Il Fattore Di Crescita Trasformante Beta-indotta Epiteliali Di Mesenchymal Transizione E Metastasi Ossee Delle Cellule Di Cancro Al Seno Cancer Research. Feb, 2006 | Pubmed ID: 16489022 Trasduzione Del Segnale Transforming Growth Factor-beta Nei Disturbi Vascolari E L'angiogenesi Chest. Dec, 2005 | Pubmed ID: 16373850 L'enzima Deubiquitinating UCH37 Interagisce Con SMAD E Regola La Segnalazione Di TGF-beta Oncogene. Dec, 2005 | Pubmed ID: 16027725 Analisi Globale Di Smad2/3-dipendente TGF-beta Segnalazione Nei Topi Viventi Rivelano Prominente Tessuto-specifiche Risposte a Lesioni Journal of Immunology (Baltimore, Md. : 1950). Jul, 2005 | Pubmed ID: 15972691 Fattore Di Crescita Trasformante-beta1 Fino All'osso Endocrine Reviews. Oct, 2005 | Pubmed ID: 15901668 SOST/sclerostin, Un Derivato Osteocita Regolatore Negativo Della Formazione Ossea Cytokine & Growth Factor Reviews. Jun, 2005 | Pubmed ID: 15869900 Nuovi Meccanismi Di Immunità Innata Della Pelle: Differenziazione Dei Cheratinociti Mediata Da ASK1 Regola L'espressione Di Beta-defensine, LL37 E TLR2 European Journal of Immunology. Jun, 2005 | Pubmed ID: 15864780 Funzione Di Recettore TGF-beta in Endotelio Cardiovascular Research. Feb, 2005 | Pubmed ID: 15664386 Difettoso Paracrina Segnalazione Da TGFbeta Nel Sistema Vascolare Del Sacco Vitellino Di Topi Mutanti Endoglin: Un Paradigma Per La Teleangiectasia Emorragica Ereditaria Development (Cambridge, England). Dec, 2004 | Pubmed ID: 15548578 Endoglin Promuove La Proliferazione Delle Cellule Endoteliali E Trasduzione Del Segnale Del TGF-beta/ALK1 The EMBO Journal. Oct, 2004 | Pubmed ID: 15385967 Espressione Del Fattore Di Crescita Del Tessuto Connettivo E Smad Segnalazione Durante Il Mouse Cuore Sviluppo E Infarto Del Miocardio Developmental Dynamics : an Official Publication of the American Association of Anatomists. Nov, 2004 | Pubmed ID: 15376321 Attivazione Spazio-temporale Di Smad1 E Smad5 in Vivo: Monitoraggio Dell'attività Trascrizionale Di Proteine Smad Journal of Cell Science. Sep, 2004 | Pubmed ID: 15331632 RLP, Un Romanzo Proteina Ras-simile, è Un Immediato Inizio Trasformante Gene Di Destinazione Growth Factor-beta (TGF-beta) Che Regola Negativamente L'attività Trascrizionale Indotta Da TGF-beta The Biochemical Journal. Oct, 2004 | Pubmed ID: 15239668 Nuove Intuizioni Di Segnalazione Di TGF-beta-Smad Trends in Biochemical Sciences. May, 2004 | Pubmed ID: 15130563 Sclerostin è Un Regolatore Negativo Espresso Osteocita Della Formazione Ossea, Ma Non Un Classico Antagonista BMP The Journal of Experimental Medicine. Mar, 2004 | Pubmed ID: 15024046 Fattore Di Crescita Nervosa Media L'attivazione Del Percorso in Cellule PC12 Smad European Journal of Biochemistry / FEBS. Mar, 2004 | Pubmed ID: 15009204 Controllare Il Destino Delle Cellule Da Bone Morphogenetic Protein Receptors Molecular and Cellular Endocrinology. Dec, 2003 | Pubmed ID: 14656483 Activin Receptor-like Chinasi (ALK) 1 è Un Mediatore Antagonistico Di Segnalazione TGFbeta/ALK5 Laterale Molecular Cell. Oct, 2003 | Pubmed ID: 14580334 Controllare La Differenziazione Delle Cellule Staminali Mesenchimali Da Membri Della Famiglia TGFBeta Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association. 2003 | Pubmed ID: 14557946 Trasduzione Del Segnale Di Proteine Morfogenetiche Ossee Nella Differenziazione Degli Osteoblasti The Journal of Bone and Joint Surgery. American Volume. 2003 | Pubmed ID: 12925607 Analisi Matrice Del Gene Della Proteina Morfogenetica Ossea Di Tipo Differenziazione Indotta Dal Recettore Degli Osteoblasti Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jul, 2003 | Pubmed ID: 12854827 SMAD7 Impedisce L'attivazione Delle Cellule Stellate Epatiche E Fibrosi Epatica Nel Ratto Gastroenterology. Jul, 2003 | Pubmed ID: 12851882 Fattore Nucleare YY1 Inibisce Transforming Growth Factor Beta - Bone Morphogenetic Protein-indotta Delle Cellule Differenziazione E Molecular and Cellular Biology. Jul, 2003 | Pubmed ID: 12808092 Distribuzione Di Smad2 Fosforilata Identifica Tessuti Bersaglio Dei Ligandi TGF Beta Nello Sviluppo Del Mouse Gene Expression Patterns : GEP. Jun, 2003 | Pubmed ID: 12799085 DSmurf Degrada Selettivamente Attivati Decapentaplegic MAD, E Sconvolge La Sua Sovraespressione Sviluppo Disco Immaginale The Journal of Biological Chemistry. Jul, 2003 | Pubmed ID: 12754252 Proteine SMAD E TGF-beta Segnalazione in Vascolare Liscio Delle Cellule Muscolari International Journal of Molecular Medicine. May, 2003 | Pubmed ID: 12684705 Triterpenoidi Sintetici Migliorano Transforming Growth Factor Beta/Smad Segnalazione Cancer Research. Mar, 2003 | Pubmed ID: 12649201 Trasformando Il Fattore Di Crescita-beta1 (TGF-beta)-indotto Apoptosi Delle Cellule Tumorali Della Prostata Comporta Attivazione Smad7-dipendente Di P38 Chinasi Attivata TGF-beta 1 E Chinasi Della Chinasi Di Proteina Mitogene-attivato 3 Molecular Biology of the Cell. Feb, 2003 | Pubmed ID: 12589052 Crescita Fattore Di Differenziazione-9 Induce Attivazione Smad2 E Produzione Di Inibina B in Cellule Di Granulosa-luteale Umane Colte The Journal of Clinical Endocrinology and Metabolism. Feb, 2003 | Pubmed ID: 12574210 Trasformando Le Mutazioni Growth Factor-beta 1 in Piombo Malattia Sindrome Di Camurati-Engelmann Per Segnalazione Aumentata Alterando O Attivazione O Secrezione Della Proteina Mutante The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12493741 Delucidazione Del Requisito Smad Nel Trasformare Growth Factor-beta Tipo Risposte Indotta Dal Recettore The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12446693 Percorsi BMP Sono Coinvolti Nella Formazione Di Capsula Otic Ed Epiteliali-mesenchimali Segnalazione Nell'orecchio Interno Pollo in Via Di Sviluppo Developmental Biology. Nov, 2002 | Pubmed ID: 12435365 Stimolazione Dell'espressione Id1 Da Bone Morphogenetic Protein è Sufficiente E Necessario Per L'attivazione Indotta Da Proteine Morfogenetiche Ossee Delle Cellule Endoteliali Circulation. Oct, 2002 | Pubmed ID: 12390958 Localizzazione Di Immunohistochemical Di Proteina Osteogenetic (OP-1) E Suoi Recettori Nella Cartilagine Articolare Coniglio The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Oct, 2002 | Pubmed ID: 12364567 Impegno Di Activin E Bone Morphogenetic Protein Signaling Proteine Smad Pathway Nell'induzione Della Produzione Di Inibina B in Cellule Di Granulosa Ovarica Molecular and Cellular Endocrinology. Sep, 2002 | Pubmed ID: 12354674 Attivazione Della Proteina Morfogenetica Ossea/Smad Segnalazione Delle Cellule Epiteliali Bronchiali Durante L'infiammazione Delle Vie Aeree American Journal of Respiratory Cell and Molecular Biology. Aug, 2002 | Pubmed ID: 12151307 Sovraespressione Di Smad7 Provoca Gravi Alterazioni Patologiche Nei Tessuti Epiteliali Multiple The EMBO Journal. Jun, 2002 | Pubmed ID: 12032071 Trasformare La Trasduzione Del Segnale Di Fattore Di Sviluppo Beta Journal of Leukocyte Biology. May, 2002 | Pubmed ID: 11994497 Lo Stato Di Attivazione Dell'endotelio Tramite Due Distinte Di Bilanciamento TGF-beta Tipo I Recettori The EMBO Journal. Apr, 2002 | Pubmed ID: 11927558 Regolazione Della Proliferazione Cellulare Di Proteine Smad Journal of Cellular Physiology. Apr, 2002 | Pubmed ID: 11920677 Carente Smad7 Espressione: Un Difetto Molecolare Putativo Nella Sclerodermia Proceedings of the National Academy of Sciences of the United States of America. Mar, 2002 | Pubmed ID: 11904440 Azione Gamma Delle BMP è Definito Dal Suo Nucleo Di Base Dell'amminoacido N-terminale Current Biology : CB. Feb, 2002 | Pubmed ID: 11839272 Fisica E Funzionale Interazione Tra GATA-3 E Smad3 Permette TGF-beta Regolazione Dei Geni Bersaglio GATA Current Biology : CB. Jan, 2002 | Pubmed ID: 11790301 Perturbazione Transitoria Della Segnalazione Di Autocrine TGF-beta Porta a Una Maggiore Sopravvivenza E Potenziale Proliferazione Di Cellule Progenitrici Emopoietiche Umane Primitivi Singolo Journal of Immunology (Baltimore, Md. : 1950). Jan, 2002 | Pubmed ID: 11777969 Identificazione E Caratterizzazione Funzionale Di Distinti Elementi Di Risposta Specifica Della Proteina Morfogenetica Ossea Criticamente Importante Nel Promotore Id1 The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11729207 Deubiquitinase Activity Profiling Identifies UCHL1 As a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. | Pubmed ID: 31857432 TGF-β endoteliale mediato a transizione mesenchimale (EndMT) e la valutazione funzionale degli effettori EndMT utilizzando crispr/cas9 gene editing Jin Ma1,2, Gerard van der Zon1,2, Gonzalo Sanchez-Duffhues1, Peter ten Dijke1,2 1Dept. Cell Chemical Biology, Leiden University Medical Center, 2Oncode Institute, Leiden University Medical Center JoVE 62198 Biology Studio della segnalazione β TGF e della transizione epiteliale-mesenchimale indotta da TGF-β nel cancro al seno e nelle cellule normali Jing Zhang1, Midory Thorikay1, Gerard van der Zon1, Maarten van Dinther1, Peter ten Dijke1 1Oncode Institute and Department of Cell Chemical Biology, Leiden University Medical Center JoVE 61830 Cancer Research Invasiva comportamento delle cellule cancro al seno umano in Zebrafish embrionali Jiang Ren*1, Sijia Liu*1, Chao Cui1, Peter ten Dijke1 1Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center JoVE 55459 Cancer Research Saggio sferoide Misura TGF-β-indotta Invasion Hildegonda P.H. Naber1, Eliza Wiercinska1, Peter ten Dijke1, Theo van Laar1 1Department of Molecular Cell Biology and Centre for Biomedial Genetics, Leiden University Medical Centre JoVE 3337 Medicine
TGF-β endoteliale mediato a transizione mesenchimale (EndMT) e la valutazione funzionale degli effettori EndMT utilizzando crispr/cas9 gene editing Jin Ma1,2, Gerard van der Zon1,2, Gonzalo Sanchez-Duffhues1, Peter ten Dijke1,2 1Dept. Cell Chemical Biology, Leiden University Medical Center, 2Oncode Institute, Leiden University Medical Center JoVE 62198 Biology
Studio della segnalazione β TGF e della transizione epiteliale-mesenchimale indotta da TGF-β nel cancro al seno e nelle cellule normali Jing Zhang1, Midory Thorikay1, Gerard van der Zon1, Maarten van Dinther1, Peter ten Dijke1 1Oncode Institute and Department of Cell Chemical Biology, Leiden University Medical Center JoVE 61830 Cancer Research
Invasiva comportamento delle cellule cancro al seno umano in Zebrafish embrionali Jiang Ren*1, Sijia Liu*1, Chao Cui1, Peter ten Dijke1 1Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center JoVE 55459 Cancer Research
Saggio sferoide Misura TGF-β-indotta Invasion Hildegonda P.H. Naber1, Eliza Wiercinska1, Peter ten Dijke1, Theo van Laar1 1Department of Molecular Cell Biology and Centre for Biomedial Genetics, Leiden University Medical Centre JoVE 3337 Medicine