Philip A. Marsden Institute of Medical Science University of Toronto Biography Publications Institution JoVE Articles Philip A. Marsden has not added a biography. If you are Philip A. Marsden and would like to personalize this page please email our Author Liaison for assistance. Publications C-Myb Regulates Transcriptional Activation of MiR-143/145 in Vascular Smooth Muscle Cells PloS One. Month, 2018 | Pubmed ID: 30169548 Angiogenic Patterning by STEEL, an Endothelial-enriched Long Noncoding RNA Proceedings of the National Academy of Sciences of the United States of America. 03, 2018 | Pubmed ID: 29467285 Histone Acetyltransferase 7 (KAT7)-dependent Intragenic Histone Acetylation Regulates Endothelial Cell Gene Regulation The Journal of Biological Chemistry. Mar, 2018 | Pubmed ID: 29414790 Epigenetic Determinants of Cardiovascular Gene Expression: Vascular Endothelium Epigenomics. 07, 2016 | Pubmed ID: 27381277 A Role of Stochastic Phenotype Switching in Generating Mosaic Endothelial Cell Heterogeneity Nature Communications. Jan, 2016 | Pubmed ID: 26744078 Robust Effects of Genetic Background on Responses to Subarachnoid Hemorrhage in Mice Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 11, 2016 | Pubmed ID: 26661216 Epigenetics in the Vascular Endothelium: Looking From a Different Perspective in the Epigenomics Era Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2015 | Pubmed ID: 26404488 Posttranscriptional Adaptations of the Vascular Endothelium to Hypoxia Current Opinion in Hematology. May, 2015 | Pubmed ID: 25767954 Epigenetics of Cardiovascular Disease - A New "Beat" in Coronary Artery Disease Medical Epigenetics. Apr, 2014 | Pubmed ID: 25408699 Nitric Oxide and Hypoxia Signaling Vitamins and Hormones. Month, 2014 | Pubmed ID: 25189387 Effect of Disturbed Blood Flow on Endothelial Cell Gene Expression: a Role for Changes in RNA Processing Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2014 | Pubmed ID: 25142881 Differential HIF and NOS Responses to Acute Anemia: Defining Organ-specific Hemoglobin Thresholds for Tissue Hypoxia American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jul, 2014 | Pubmed ID: 24760996 Competition and Collaboration Between RNA-binding Proteins and MicroRNAs Wiley Interdisciplinary Reviews. RNA. Jan-Feb, 2014 | Pubmed ID: 24124109 Dysregulation of Angiopoietin 1 and 2 in Escherichia Coli O157:H7 Infection and the Hemolytic-uremic Syndrome The Journal of Infectious Diseases. Sep, 2013 | Pubmed ID: 23801605 Active Stabilization of Human Endothelial Nitric Oxide Synthase MRNA by HnRNP E1 Protects Against Antisense RNA and MicroRNAs Molecular and Cellular Biology. May, 2013 | Pubmed ID: 23478261 A Mechanistic Role for DNA Methylation in Endothelial Cell (EC)-enriched Gene Expression: Relationship with DNA Replication Timing Blood. Apr, 2013 | Pubmed ID: 23449636 Epigenetics and Cardiovascular Disease The Canadian Journal of Cardiology. Jan, 2013 | Pubmed ID: 23261320 Functional Importance of Dicer Protein in the Adaptive Cellular Response to Hypoxia The Journal of Biological Chemistry. Aug, 2012 | Pubmed ID: 22745131 Shiga Toxin-associated Hemolytic Uremic Syndrome: Advances in Pathogenesis and Therapeutics Current Opinion in Nephrology and Hypertension. Jul, 2012 | Pubmed ID: 22660553 Bone Marrow Cell Therapies for Endothelial Repair and Their Relevance to Kidney Disease Seminars in Nephrology. Mar, 2012 | Pubmed ID: 22617771 Gene Regulation in the Vascular Endothelium: Why Epigenetics is Important for the Kidney Seminars in Nephrology. Mar, 2012 | Pubmed ID: 22617766 Nitric Oxide Signaling in Hypoxia Journal of Molecular Medicine (Berlin, Germany). Mar, 2012 | Pubmed ID: 22349396 The CXCR4/CXCR7/SDF-1 Pathway Contributes to the Pathogenesis of Shiga Toxin-associated Hemolytic Uremic Syndrome in Humans and Mice The Journal of Clinical Investigation. Feb, 2012 | Pubmed ID: 22232208 Priming of Hypoxia-inducible Factor by Neuronal Nitric Oxide Synthase is Essential for Adaptive Responses to Severe Anemia Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21976486 Epigenetics in Cardiovascular Disease Current Opinion in Cardiology. May, 2011 | Pubmed ID: 21415727 Simvastatin Re-couples Dysfunctional Endothelial Nitric Oxide Synthase in Experimental Subarachnoid Hemorrhage PloS One. Feb, 2011 | Pubmed ID: 21373645 Reassessing the Risk of Hemodilutional Anemia: Some New Pieces to an Old Puzzle Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie. Aug, 2010 | Pubmed ID: 20512540 Epigenetics of the Vascular Endothelium Journal of Applied Physiology (Bethesda, Md. : 1985). Sep, 2010 | Pubmed ID: 20413423 Culture-modified Bone Marrow Cells Attenuate Cardiac and Renal Injury in a Chronic Kidney Disease Rat Model Via a Novel Antifibrotic Mechanism PloS One. Mar, 2010 | Pubmed ID: 20209052 Enhanced Translation of Heme Oxygenase-2 Preserves Human Endothelial Cell Viability During Hypoxia The Journal of Biological Chemistry. Mar, 2010 | Pubmed ID: 20118244 Hypoxic Repression of Endothelial Nitric-oxide Synthase Transcription is Coupled with Eviction of Promoter Histones The Journal of Biological Chemistry. Jan, 2010 | Pubmed ID: 19880524 Role of a Distal Enhancer in the Transcriptional Responsiveness of the Human CD200 Gene to Interferon-gamma and Tumor Necrosis Factor-alpha Molecular Immunology. Jun, 2009 | Pubmed ID: 19386363 Regulation of Endocytosis Via the Oxygen-sensing Pathway Nature Medicine. Mar, 2009 | Pubmed ID: 19252501 Verotoxin Biology: Molecular Events in Vascular Endothelial Injury Kidney International. Supplement. Feb, 2009 | Pubmed ID: 19180125 Dicer Cuts the Kidney Journal of the American Society of Nephrology : JASN. Nov, 2008 | Pubmed ID: 18923053 Endothelial Nitric Oxide Synthase Gene Expression During Murine Embryogenesis: Commencement of Expression in the Embryo Occurs with the Establishment of a Unidirectional Circulatory System Circulation Research. Jul, 2008 | Pubmed ID: 18556578 Relative Reduction of Endothelial Nitric-oxide Synthase Expression and Transcription in Atherosclerosis-prone Regions of the Mouse Aorta and in an in Vitro Model of Disturbed Flow The American Journal of Pathology. Nov, 2007 | Pubmed ID: 17982133 Low-molecular-weight S-nitrosothiols and Blood Vessel Injury The Journal of Clinical Investigation. Sep, 2007 | Pubmed ID: 17786231 Role of VEGF in Maintaining Renal Structure and Function Under Normotensive and Hypertensive Conditions Proceedings of the National Academy of Sciences of the United States of America. Sep, 2007 | Pubmed ID: 17726104 Hypoxia-inducible Expression of a Natural Cis-antisense Transcript Inhibits Endothelial Nitric-oxide Synthase The Journal of Biological Chemistry. May, 2007 | Pubmed ID: 17403686 VHL Promotes E2 Box-dependent E-cadherin Transcription by HIF-mediated Regulation of SIP1 and Snail Molecular and Cellular Biology. Jan, 2007 | Pubmed ID: 17060462 Increased Expression of HIF-1alpha, NNOS, and VEGF in the Cerebral Cortex of Anemic Rats American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jan, 2007 | Pubmed ID: 16973934 Loss of the Tumor Suppressor Vhlh Leads to Upregulation of Cxcr4 and Rapidly Progressive Glomerulonephritis in Mice Nature Medicine. Sep, 2006 | Pubmed ID: 16906157 RNA Transfection is a Versatile Tool to Investigate Endothelin-1 Posttranscriptional Regulation Experimental Biology and Medicine (Maywood, N.J.). Jun, 2006 | Pubmed ID: 16740984 C-Jun N-terminal Kinase-mediated Stabilization of Microsomal Prostaglandin E2 Synthase-1 MRNA Regulates Delayed Microsomal Prostaglandin E2 Synthase-1 Expression and Prostaglandin E2 Biosynthesis by Cardiomyocytes The Journal of Biological Chemistry. Jun, 2006 | Pubmed ID: 16627484 Tyrosine Phosphatase MEG2 Modulates Murine Development and Platelet and Lymphocyte Activation Through Secretory Vesicle Function The Journal of Experimental Medicine. Dec, 2005 | Pubmed ID: 16330817 Hypoxia Induces a Functionally Significant and Translationally Efficient Neuronal NO Synthase MRNA Variant The Journal of Clinical Investigation. Nov, 2005 | Pubmed ID: 16276418 Epigenetic Basis for the Transcriptional Hyporesponsiveness of the Human Inducible Nitric Oxide Synthase Gene in Vascular Endothelial Cells Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005 | Pubmed ID: 16148131 Extensive Variation in the 5'-UTR of Dicer MRNAs Influences Translational Efficiency Biochemical and Biophysical Research Communications. Sep, 2005 | Pubmed ID: 16095561 Post-transcriptional Regulation of Endothelial Nitric-oxide Synthase by an Overlapping Antisense MRNA Transcript The Journal of Biological Chemistry. Sep, 2004 | Pubmed ID: 15234981 Role of the 3'-untranslated Region of Human Endothelin-1 in Vascular Endothelial Cells. Contribution to Transcript Lability and the Cellular Heat Shock Response The Journal of Biological Chemistry. Mar, 2004 | Pubmed ID: 14660616 The Fgl2/fibroleukin Prothrombinase Contributes to Immunologically Mediated Thrombosis in Experimental and Human Viral Hepatitis The Journal of Clinical Investigation. Jul, 2003 | Pubmed ID: 12840059 Germline Polymorphisms in Cardiovascular Medicine. Is That the Whole Story? The Canadian Journal of Cardiology. Apr, 1999 | Pubmed ID: 10350676 Gene Expression Analysis of Endothelial Cells Exposed to Shear Stress Using Multiple Parallel-plate Flow Chambers H.S. Jeffrey Man1,2, Aravin N. Sukumar1,2, Kyung Ha Ku2,3, Michelle K. Dubinsky1,2, Noeline Subramaniam1,2, Philip A. Marsden1,2,3,4 1Institute of Medical Science, University of Toronto, 2Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, 3Department of Laboratory Medicine and Pathobiology, University of Toronto, 4Department of Medicine, University of Toronto JoVE 58478 Bioengineering
Gene Expression Analysis of Endothelial Cells Exposed to Shear Stress Using Multiple Parallel-plate Flow Chambers H.S. Jeffrey Man1,2, Aravin N. Sukumar1,2, Kyung Ha Ku2,3, Michelle K. Dubinsky1,2, Noeline Subramaniam1,2, Philip A. Marsden1,2,3,4 1Institute of Medical Science, University of Toronto, 2Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, 3Department of Laboratory Medicine and Pathobiology, University of Toronto, 4Department of Medicine, University of Toronto JoVE 58478 Bioengineering
