Philipp Koch

Publications

• In Vitro Segregation and Isolation of Human Pluripotent Stem Cell-derived Neural Crest Cells
  Methods (San Diego, Calif.). Oct, 2017  |   Pubmed ID: 29037816
• A Little Bit of Guidance: Mini Brains on Their Route to Adolescence
  Cell Stem Cell. Aug, 2017  |   Pubmed ID: 28777940
• The Alzheimer's Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for P3 Peptides
  Cell Reports. Jun, 2017  |   Pubmed ID: 28591569
• An Organoid-Based Model of Cortical Development Identifies Non-Cell-Autonomous Defects in Wnt Signaling Contributing to Miller-Dieker Syndrome
  Cell Reports. Apr, 2017  |   Pubmed ID: 28380362
• Whole-brain 3D Mapping of Human Neural Transplant Innervation
  Nature Communications. Jan, 2017  |   Pubmed ID: 28102196
• MTSS1 is Epigenetically Regulated in Glioma Cells and Inhibits Glioma Cell Motility
  Translational Oncology. Feb, 2017  |   Pubmed ID: 27988423
• Specific Triazine Herbicides Induce Amyloid-β42 Production
  Journal of Alzheimer's Disease : JAD. Sep, 2016  |   Pubmed ID: 27589520
• Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein
  Cell Reports. Mar, 2016  |   Pubmed ID: 26923602
• Phosphorylation of the Amyloid β-peptide at Ser26 Stabilizes Oligomeric Assembly and Increases Neurotoxicity
  Acta Neuropathologica. Apr, 2016  |   Pubmed ID: 26898910
• Direct Conversion Provides Old Neurons from Aged Donor's Skin
  Cell Stem Cell. Dec, 2015  |   Pubmed ID: 26637936
• Arylsulfatase A Overexpressing Human IPSC-derived Neural Cells Reduce CNS Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2015  |   Pubmed ID: 26061647
• Human Induced Pluripotent Stem Cells Improve Recovery in Stroke-injured Aged Rats
  Restorative Neurology and Neuroscience. 2014  |   Pubmed ID: 24916776
• Auto-attraction of Neural Precursors and Their Neuronal Progeny Impairs Neuronal Migration
  Nature Neuroscience. Jan, 2014  |   Pubmed ID: 24241396
• APP Processing in Human Pluripotent Stem Cell-derived Neurons is Resistant to NSAID-based γ-secretase Modulation
  Stem Cell Reports. 2013  |   Pubmed ID: 24371804
• Anticancer Effects of Niclosamide in Human Glioblastoma
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2013  |   Pubmed ID: 23908450
• Leveling Waddington: the Emergence of Direct Programming and the Loss of Cell Fate Hierarchies
  Nature Reviews. Molecular Cell Biology. Apr, 2013  |   Pubmed ID: 23847783
• MicroRNA-based Promotion of Human Neuronal Differentiation and Subtype Specification
  PloS One. 2013  |   Pubmed ID: 23527072
• Embryonic Stem Cell-based Modeling of Tau Pathology in Human Neurons
  The American Journal of Pathology. May, 2013  |   Pubmed ID: 23499461
• Leveling Waddington: the Emergence of Direct Programming and the Loss of Cell Fate Hierarchies
  Nature Reviews. Molecular Cell Biology. Apr, 2013  |   Pubmed ID: 23486282
• Targeting the Cytosolic Innate Immune Receptors RIG-I and MDA5 Effectively Counteracts Cancer Cell Heterogeneity in Glioblastoma
  Stem Cells (Dayton, Ohio). Jun, 2013  |   Pubmed ID: 23390110
• Functional Neuronal Cells Generated by Human Parthenogenetic Stem Cells
  PloS One. 2012  |   Pubmed ID: 22880113
• Presenilin-1 L166P Mutant Human Pluripotent Stem Cell-derived Neurons Exhibit Partial Loss of γ-secretase Activity in Endogenous Amyloid-β Generation
  The American Journal of Pathology. Jun, 2012  |   Pubmed ID: 22510327
• Small Molecules Enable Highly Efficient Neuronal Conversion of Human Fibroblasts
  Nature Methods. Jun, 2012  |   Pubmed ID: 22484851
• Capture of Neuroepithelial-like Stem Cells from Pluripotent Stem Cells Provides a Versatile System for in Vitro Production of Human Neurons
  PloS One. 2012  |   Pubmed ID: 22272239
• Human Embryonic Stem Cell-derived Neurons Establish Region-specific, Long-range Projections in the Adult Brain
  Cellular and Molecular Life Sciences : CMLS. Feb, 2012  |   Pubmed ID: 21779868
• Excitation-induced Ataxin-3 Aggregation in Neurons from Patients with Machado-Joseph Disease
  Nature. Nov, 2011  |   Pubmed ID: 22113611
• A Novel Human High-risk Ependymoma Stem Cell Model Reveals the Differentiation-inducing Potential of the Histone Deacetylase Inhibitor Vorinostat
  Acta Neuropathologica. Nov, 2011  |   Pubmed ID: 21863243
• Inhibition of Notch Signaling in Human Embryonic Stem Cell-derived Neural Stem Cells Delays G1/S Phase Transition and Accelerates Neuronal Differentiation in Vitro and in Vivo
  Stem Cells (Dayton, Ohio). May, 2010  |   Pubmed ID: 20235098
• Laser-assisted Photoablation of Human Pluripotent Stem Cells from Differentiating Cultures
  Stem Cell Reviews. Jun, 2010  |   Pubmed ID: 20186504
• Emerging Concepts in Neural Stem Cell Research: Autologous Repair and Cell-based Disease Modelling
  The Lancet. Neurology. Sep, 2009  |   Pubmed ID: 19679274
• A Rosette-type, Self-renewing Human ES Cell-derived Neural Stem Cell with Potential for in Vitro Instruction and Synaptic Integration
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009  |   Pubmed ID: 19218428
• Lineage Selection of Functional and Cryopreservable Human Embryonic Stem Cell-derived Neurons
  Stem Cells (Dayton, Ohio). Jul, 2008  |   Pubmed ID: 18420830
• Nucleofection of Human Embryonic Stem Cells
  Methods in Molecular Biology (Clifton, N.J.). 2008  |   Pubmed ID: 18370194
• Transduction of Human Embryonic Stem Cells by Ecotropic Retroviral Vectors
  Nucleic Acids Research. 2006  |   Pubmed ID: 16998181
• Site-specific Recombination in Human Embryonic Stem Cells Induced by Cell-permeant Cre Recombinase
  Nature Methods. Jun, 2006  |   Pubmed ID: 16721380
• Nucleofection of Human Embryonic Stem Cells
  Stem Cells and Development. Aug, 2005  |   Pubmed ID: 16137226