Philippe Soubeyran Pancreatic Cancer Team Cancer Research Center of Marseille Biography Publications Institution JoVE Articles Philippe SoubeyranPrincipal investigator Philippe Soubeyran obtained his PhD from the Aix-Marseille University in 2000. At this time, his work was dedicated to the study of two homeotic genes, CDX1 and CDX2, involved in gut development and under-expressed in colon cancers. From 2000 to 2003, he worked as a postdoc at the Ludwig Institute for Cancer Research of Uppsala (Sweden) in the group of Prof. Ivan Dikic. The main goals of this training was to decipher the role of two scaffold proteins, CIN85 and ArgBP2, in the transduction and regulation of cell signaling. In 2005, he was recruited by the French National Institute for Health and Medical Research (INSERM) to work as a principal investigator in the Cellular Stress laboratory, from 2005 to 2012. Since 2012, he is a member of the Pancreatic Cancer team of CRCM (Cancer Research Center of Marseille). His current projects are dedicated to the identification of new resistance mechanisms of pancreatic cancer cells involving alterations of post-translational modifications of ubiquitin-like type. Publications Ligand-based Design Identifies a Potent NUPR1 Inhibitor Exerting Anticancer Activity Via Necroptosis The Journal of Clinical Investigation. 03, 2019 | Pubmed ID: 30920390 Pancreatic Cancer Chemo-resistance is Driven by Tumor Phenotype Rather Than Tumor Genotype Heliyon. Dec, 2018 | Pubmed ID: 30582059 Ribonuclease MCPiP1 Contributes to the Loss of Micro-RNA-200 Family Members in Pancreatic Cancer Cells Oncotarget. Nov, 2018 | Pubmed ID: 30542509 Inactivation of NUPR1 Promotes Cell Death by Coupling ER-stress Responses with Necrosis Scientific Reports. 11, 2018 | Pubmed ID: 30451898 Chloroquine Plays a Cell-dependent Role in the Response to Treatment of Pancreatic Adenocarcinoma Oncotarget. Jul, 2018 | Pubmed ID: 30112111 Regulation of NUB1 Activity Through Non-Proteolytic Mdm2-Mediated Ubiquitination PloS One. Month, 2017 | Pubmed ID: 28099510 Redox-sensitive TP53INP1 SUMOylation As an Oxidative Stress Sensor to Activate TP53 Molecular & Cellular Oncology. Jul-Sep, 2014 | Pubmed ID: 27308354 Identification of New Mechanisms of Cellular Response to Chemotherapy by Tracking Changes in Post-translational Modifications by Ubiquitin and Ubiquitin-like Proteins Journal of Proteome Research. May, 2014 | Pubmed ID: 24654937 Tropheryma Whipplei, the Agent of Whipple's Disease, Affects the Early to Late Phagosome Transition and Survives in a Rab5- and Rab7-positive Compartment PloS One. Month, 2014 | Pubmed ID: 24586722 Oligomerization and Phosphorylation Dependent Regulation of ArgBP2 Adaptive Capabilities and Associated Functions PloS One. Month, 2014 | Pubmed ID: 24475245 Profilering Ubiquitin og Ubiquitin-lignende avhengige post-translational modifikasjoner og identifisering av vesentlige endringer Mirna Swayden1, Aurélie Dobric1, Yolande Berthois1, Hugo Villalba1, Stéphane Audebert1, Luc Camoin1, Juan Iovanna1, Philippe Soubeyran1 1Aix-Marseille Univ, INSERM, CNRS, Institut Paoli-Calmettes, CRCM JoVE 60402 Biochemistry
Profilering Ubiquitin og Ubiquitin-lignende avhengige post-translational modifikasjoner og identifisering av vesentlige endringer Mirna Swayden1, Aurélie Dobric1, Yolande Berthois1, Hugo Villalba1, Stéphane Audebert1, Luc Camoin1, Juan Iovanna1, Philippe Soubeyran1 1Aix-Marseille Univ, INSERM, CNRS, Institut Paoli-Calmettes, CRCM JoVE 60402 Biochemistry
