Piera Pasinelli Jefferson Weinberg ALS Center Thomas Jefferson University Biography Publications Institution JoVE Articles Piera Pasinelli has not added a biography. If you are Piera Pasinelli and would like to personalize this page please email our Author Liaison for assistance. Publications Synaptic Dysfunction Induced by Glycine-alanine Dipeptides in C9orf72-ALS/FTD is Rescued by SV2 Replenishment EMBO Molecular Medicine. 05, 2020 | Pubmed ID: 32347002 AAV2-BDNF Promotes Respiratory Axon Plasticity and Recovery of Diaphragm Function Following Spinal Cord Injury FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 12, 2019 | Pubmed ID: 31577916 Excess Glutamate Secreted from Astrocytes Drives Upregulation of P-glycoprotein in Endothelial Cells in Amyotrophic Lateral Sclerosis Experimental Neurology. 06, 2019 | Pubmed ID: 30974102 Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies The AAPS Journal. 11, 2017 | Pubmed ID: 28779378 Mutation of the Caspase-3 Cleavage Site in the Astroglial Glutamate Transporter EAAT2 Delays Disease Progression and Extends Lifespan in the SOD1-G93A Mouse Model of ALS Experimental Neurology. 06, 2017 | Pubmed ID: 28342750 Pathogenic Determinants and Mechanisms of ALS/FTD Linked to Hexanucleotide Repeat Expansions in the C9orf72 Gene Neuroscience Letters. 01, 2017 | Pubmed ID: 27619540 Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD Cell Reports. 10, 2016 | Pubmed ID: 27732842 Astrocytes Drive Upregulation of the Multidrug Resistance Transporter ABCB1 (P-Glycoprotein) in Endothelial Cells of the Blood-brain Barrier in Mutant Superoxide Dismutase 1-linked Amyotrophic Lateral Sclerosis Glia. 08, 2016 | Pubmed ID: 27158936 Regulation of ABC Efflux Transporters at Blood-brain Barrier in Health and Neurological Disorders Brain Research. Dec, 2015 | Pubmed ID: 26187753 ABC Transporter-driven Pharmacoresistance in Amyotrophic Lateral Sclerosis Brain Research. May, 2015 | Pubmed ID: 25175835 Inhibiting Drug Efflux Transporters Improves Efficacy of ALS Therapeutics Annals of Clinical and Translational Neurology. Dec, 2014 | Pubmed ID: 25574474 Role of Mitochondria in Mutant SOD1 Linked Amyotrophic Lateral Sclerosis Biochimica Et Biophysica Acta. Aug, 2014 | Pubmed ID: 24568860 Defects in Synapse Structure and Function Precede Motor Neuron Degeneration in Drosophila Models of FUS-related ALS The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2013 | Pubmed ID: 24336723 Small Peptides Against the Mutant SOD1/Bcl-2 Toxic Mitochondrial Complex Restore Mitochondrial Function and Cell Viability in Mutant SOD1-mediated ALS The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2013 | Pubmed ID: 23843527 Selective Increase of Two ABC Drug Efflux Transporters at the Blood-spinal Cord Barrier Suggests Induced Pharmacoresistance in ALS Neurobiology of Disease. Aug, 2012 | Pubmed ID: 22521463 An Over-oxidized Form of Superoxide Dismutase Found in Sporadic Amyotrophic Lateral Sclerosis with Bulbar Onset Shares a Toxic Mechanism with Mutant SOD1 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2012 | Pubmed ID: 22416121 In Vivo and in Vitro Determination of Cell Death Markers in Neurons Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21913091 Motor Neuron Impairment Mediated by a Sumoylated Fragment of the Glial Glutamate Transporter EAAT2 Glia. Nov, 2011 | Pubmed ID: 21769946 Wild-type and Mutant SOD1 Share an Aberrant Conformation and a Common Pathogenic Pathway in ALS Nature Neuroscience. Nov, 2010 | Pubmed ID: 20953194 Voltage-dependent Inwardly Rectifying Potassium Conductance in the Outer Membrane of Neuronal Mitochondria The Journal of Biological Chemistry. Aug, 2010 | Pubmed ID: 20551319 ALS-linked Mutant SOD1 Damages Mitochondria by Promoting Conformational Changes in Bcl-2 Human Molecular Genetics. Aug, 2010 | Pubmed ID: 20460269 Nordihydroguaiaretic Acid Increases Glutamate Uptake in Vitro and in Vivo: Therapeutic Implications for Amyotrophic Lateral Sclerosis Experimental Neurology. Sep, 2008 | Pubmed ID: 18625223 A Caspase-3-cleaved Fragment of the Glial Glutamate Transporter EAAT2 is Sumoylated and Targeted to Promyelocytic Leukemia Nuclear Bodies in Mutant SOD1-linked Amyotrophic Lateral Sclerosis The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17823119 Astrocytes Expressing ALS-linked Mutant FUS Induce Motor Neuron Death Through Release of Tumor Necrosis Factor-alpha Glia. | Pubmed ID: 29380416 Pur-alpha Regulates Cytoplasmic Stress Granule Dynamics and Ameliorates FUS Toxicity Acta Neuropathologica. | Pubmed ID: 26728149 Antisense Proline-arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates That Initiate in Vitro and in Vivo Neuronal Death Neuron. | Pubmed ID: 25521377 एमियोट्रोफिक लेटरल स्केलेरोसिस के मॉडल में सिनैप्टिक कार्यों का वास्तविक समय फ्लोरोसेंट मापन Karthik Krishnamurthy*1, Davide Trotti1, Piera Pasinelli1, Brigid Jensen*1 1Jefferson Weinberg ALS Center, Thomas Jefferson University JoVE 62813 Neuroscience
एमियोट्रोफिक लेटरल स्केलेरोसिस के मॉडल में सिनैप्टिक कार्यों का वास्तविक समय फ्लोरोसेंट मापन Karthik Krishnamurthy*1, Davide Trotti1, Piera Pasinelli1, Brigid Jensen*1 1Jefferson Weinberg ALS Center, Thomas Jefferson University JoVE 62813 Neuroscience
