PILHAN KIM Graduate School of Medical Science and Engineering KAIST Biography Publications Institution JoVE Articles PILHAN KIM Dr. Pilhan Kim is an Associate Professor of Graduate School of Medical Science and Engineering (GSMSE) at Korea Advanced Institute of Science and Technology (KAIST). He received B.S. and Ph. D. degree in Electrical Engineering from Seoul National University, Korea, in 2000 and 2005, respectively. From 2005 to 2010, he worked as a postdoctoral research fellow at Harvard Medical School, Massachusetts General Hospital Boston, USA, with the cross-disciplinary postdoctoral fellowship from Human Frontier Science Program (HFSP). At 2010, he joined KAIST as a tenure-track faculty and was appointed as a tenured Associate Professor at 2018.His main research interest is the development of advanced state-of-arts in vivo cellular imaging technology based on a custom-built real-time laser-scanning intravital confocal and two-photon microscopy. Utilizing the image system, his group have achieved a systemic cellular-level visualization of various preclinical animal model to investigate the complex pathophysiology of human diseases and develop novel therapeutics. Publications Development and Evaluation of an Ultrasound-triggered Microbubble Combined Transarterial Chemoembolization (TACE) Formulation on Rabbit VX2 Liver Cancer Model Theranostics. Month, 2021 | Pubmed ID: 33391462 Quantitative Two-photon Microscopy Imaging Analysis of Human Skin to Evaluate Enhanced Transdermal Delivery by Hybrid-type Multi-lamellar Nanostructure: Retraction Biomedical Optics Express. Oct, 2020 | Pubmed ID: 33149992 Intravital Longitudinal Imaging of Hepatic Lipid Droplet Accumulation in a Murine Model for Nonalcoholic Fatty Liver Disease Biomedical Optics Express. Sep, 2020 | Pubmed ID: 33014604 Longitudinal Visualization of the Brain Neuroinflammatory Response at the Cellular Level in LysM-GFP Mice Induced by 3-nitropropionic Acid Biomedical Optics Express. Aug, 2020 | Pubmed ID: 32923081 Intraocular Distribution and Kinetics of Intravitreally Injected Antibodies and Nanoparticles in Rabbit Eyes Translational Vision Science & Technology. 05, 2020 | Pubmed ID: 32821517 In Vivo Imaging of the Hyaloid Vascular Regression and Retinal and Choroidal Vascular Development in Rat Eyes Using Optical Coherence Tomography Angiography Scientific Reports. 07, 2020 | Pubmed ID: 32733052 Micromirror-Embedded Coverslip Assembly for Bidirectional Microscopic Imaging Micromachines. Jun, 2020 | Pubmed ID: 32532128 Dll4 Suppresses Transcytosis for Arterial Blood-Retinal Barrier Homeostasis Circulation Research. 03, 2020 | Pubmed ID: 32078435 A Novel Pancreatic Imaging Window for Stabilized Longitudinal Observation of Pancreatic Islets in Murine Model Diabetes & Metabolism Journal. 02, 2020 | Pubmed ID: 31237131 PM2.5 Exposure in the Respiratory System Induces Distinct Inflammatory Signaling in the Lung and the Liver of Mice Journal of Immunology Research. Month, 2019 | Pubmed ID: 31871955 3D Cellular Visualization of Intact Mouse Tooth Using Optical Clearing Without Decalcification International Journal of Oral Science. 08, 2019 | Pubmed ID: 31451694 Longitudinal Depth-wise Visualization of Tumorigenesis by Needle-shaped Side-view Confocal Endomicroscopy Biomedical Optics Express. Jun, 2019 | Pubmed ID: 31259046 Tie2 Activation Promotes Choriocapillary Regeneration for Alleviating Neovascular Age-related Macular Degeneration Science Advances. 02, 2019 | Pubmed ID: 30788433 Neutrophils Disturb Pulmonary Microcirculation in Sepsis-induced Acute lung Injury The European Respiratory Journal. 03, 2019 | Pubmed ID: 30635296 Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors Via Interactions with Endothelial Selectins Small (Weinheim an Der Bergstrasse, Germany). 12, 2018 | Pubmed ID: 30411856 Quantitative Two-photon Microscopy Imaging Analysis of Human Skin to Evaluate Enhanced Transdermal Delivery by Hybrid-type Multi-lamellar Nanostructure Biomedical Optics Express. Aug, 2018 | Pubmed ID: 30338168 Intravital Imaging of a Pulmonary Endothelial Surface Layer in a Murine Sepsis Model Biomedical Optics Express. May, 2018 | Pubmed ID: 29760995 Effect of Resveratrol Treatment on Graft Revascularization After Islet Transplantation in Streptozotocin-induced Diabetic Mice Islets. 01, 2018 | Pubmed ID: 29333922 Highly Angiogenic, Nonthrombogenic Bone Marrow Mononuclear Cell-Derived Spheroids in Intraportal Islet Transplantation Diabetes. 03, 2018 | Pubmed ID: 29298810 Intravital Longitudinal Wide-area Imaging of Dynamic Bone Marrow Engraftment and Multilineage Differentiation Through Nuclear-cytoplasmic Labeling PloS One. Month, 2017 | Pubmed ID: 29099870 Cellular-level Real-time Pharmacokinetic Imaging of Free-form and Liposomal Indocyanine Green in Liver Biomedical Optics Express. Oct, 2017 | Pubmed ID: 29082096 Caspase-8 Controls the Secretion of Inflammatory Lysyl-tRNA Synthetase in Exosomes from Cancer Cells The Journal of Cell Biology. 07, 2017 | Pubmed ID: 28611052 VEGFR2 but Not VEGFR3 Governs Integrity and Remodeling of Thyroid Angiofollicular Unit in Normal State and During Goitrogenesis EMBO Molecular Medicine. 06, 2017 | Pubmed ID: 28438786 Sustained Inflammation After Pericyte Depletion Induces Irreversible Blood-retina Barrier Breakdown JCI Insight. 02, 2017 | Pubmed ID: 28194443 Secreted Tryptophanyl-tRNA Synthetase As a Primary Defence System Against Infection Nature Microbiology. 10, 2016 | Pubmed ID: 27748732 Holographic Intravital Microscopy for 2-D and 3-D Imaging Intact Circulating Blood Cells in Microcapillaries of Live Mice Scientific Reports. 09, 2016 | Pubmed ID: 27605489 Imaging Laser-Induced Choroidal Neovascularization in the Rodent Retina Using Optical Coherence Tomography Angiography Investigative Ophthalmology & Visual Science. Jul, 2016 | Pubmed ID: 27409490 In Vivo Fluorescence Retinal Imaging Following AAV2-Mediated Gene Delivery in the Rat Retina Investigative Ophthalmology & Visual Science. 06, 2016 | Pubmed ID: 27367507 Corrigendum to "Identification of Cromolyn Sodium As an Anti-fibrotic Agent Targeting Both Hepatocytes and Hepatic Stellate Cells" [Pharmacol. Res. 102 (2015) 176-183] Pharmacological Research. Aug, 2016 | Pubmed ID: 27137797 Amelioration of Sepsis by TIE2 Activation-induced Vascular Protection Science Translational Medicine. 04, 2016 | Pubmed ID: 27099174 Urokinase Exerts Antimetastatic Effects by Dissociating Clusters of Circulating Tumor Cells Cancer Research. Nov, 2015 | Pubmed ID: 26527605 Optical Clearing Based Cellular-level 3D Visualization of Intact Lymph Node Cortex Biomedical Optics Express. Oct, 2015 | Pubmed ID: 26504662 In Vivo Longitudinal Cellular Imaging of Small Intestine by Side-view Endomicroscopy Biomedical Optics Express. Oct, 2015 | Pubmed ID: 26504646 Identification of Cromolyn Sodium As an Anti-fibrotic Agent Targeting Both Hepatocytes and Hepatic Stellate Cells Pharmacological Research. Dec, 2015 | Pubmed ID: 26453959 Intravital Imaging of Intestinal Lacteals Unveils Lipid Drainage Through Contractility The Journal of Clinical Investigation. Nov, 2015 | Pubmed ID: 26436648 In Vivo Quantitation of Injected Circulating Tumor Cells from Great Saphenous Vein Based on Video-rate Confocal Microscopy Biomedical Optics Express. Jun, 2015 | Pubmed ID: 26114035 Longitudinal Tracing of Spontaneous Regression and Anti-angiogenic Response of Individual Microadenomas During Colon Tumorigenesis Theranostics. Month, 2015 | Pubmed ID: 25897337 Interaction of Tetraspan(in) TM4SF5 with CD44 Promotes Self-renewal and Circulating Capacities of Hepatocarcinoma Cells Hepatology (Baltimore, Md.). Jun, 2015 | Pubmed ID: 25627085 Lymphatic Regulator PROX1 Determines Schlemm's Canal Integrity and Identity The Journal of Clinical Investigation. Sep, 2014 | Pubmed ID: 25061877 In Vivo High Spatiotemporal Resolution Visualization of Circulating T Lymphocytes in High Endothelial Venules of Lymph Nodes Journal of Biomedical Optics. Mar, 2013 | Pubmed ID: 23462969 Endoscopic Time-lapse Imaging of Immune Cells in Infarcted Mouse Hearts Circulation Research. Mar, 2013 | Pubmed ID: 23392842 Fabrication and Operation of GRIN Probes for in Vivo Fluorescence Cellular Imaging of Internal Organs in Small Animals Nature Protocols. Jul, 2012 | Pubmed ID: 22767088 Stabilized Longitudinal In Vivo Cellular-Level Visualization of the Pancreas in a Murine Model with a Pancreatic Intravital Imaging Window Inwon Park1, Pilhan Kim2,3 1Department of Emergency Medicine, Seoul National University Bundang Hospital, 2Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, 3KI for Health Science and Technology, Korea Advanced Institute of Science and Technology JoVE 62538 Medicine
Stabilized Longitudinal In Vivo Cellular-Level Visualization of the Pancreas in a Murine Model with a Pancreatic Intravital Imaging Window Inwon Park1, Pilhan Kim2,3 1Department of Emergency Medicine, Seoul National University Bundang Hospital, 2Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, 3KI for Health Science and Technology, Korea Advanced Institute of Science and Technology JoVE 62538 Medicine
