Rachael Natrajan

Publications

• Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors
  Cell Reports. Oct, 2016  |   Pubmed ID: 27783942
• Comparative Proteomic Assessment of Matrisome Enrichment Methodologies
  The Biochemical Journal. Nov, 2016  |   Pubmed ID: 27589945
• Systematic Analysis of Tumour Cell-extracellular Matrix Adhesion Identifies Independent Prognostic Factors in Breast Cancer
  Oncotarget. Aug, 2016  |   Pubmed ID: 27556857
• Three-dimensional Modelling Identifies Novel Genetic Dependencies Associated with Breast Cancer Progression in the Isogenic MCF10 Model
  The Journal of Pathology. Nov, 2016  |   Pubmed ID: 27512948
• Risk Stratification and Intrinsic Subtype Classification of Breast Cancer: a Multi-Parameter Test to Rule Them All?
  Journal of the National Cancer Institute. Sep, 2016  |   Pubmed ID: 27130931
• Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines
  Cell Reports. Mar, 2016  |   Pubmed ID: 26947069
• Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology-Genomic Integration Analysis
  PLoS Medicine. Feb, 2016  |   Pubmed ID: 26881778
• The Status of Epidermal Growth Factor Receptor in Borderline Ovarian Tumours
  Oncotarget. Mar, 2016  |   Pubmed ID: 26870997
• An Ecological Measure of Immune-cancer Colocalization As a Prognostic Factor for Breast Cancer
  Breast Cancer Research : BCR. Sep, 2015  |   Pubmed ID: 26395345
• Genomic Landscape of Adenoid Cystic Carcinoma of the Breast
  The Journal of Pathology. Oct, 2015  |   Pubmed ID: 26095796
• Intra-tumor Genetic Heterogeneity and Alternative Driver Genetic Alterations in Breast Cancers with Heterogeneous HER2 Gene Amplification
  Genome Biology. May, 2015  |   Pubmed ID: 25994018
• Breast Cancer Heterogeneity: Parallel Evolution or Conscious Uncoupling?
  The Journal of Pathology. Sep, 2015  |   Pubmed ID: 25953517
• Corrigendum: Metastatic Breast Carcinomas Display Genomic and Transcriptomic Heterogeneity
  Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Apr, 2015  |   Pubmed ID: 25836989
• Robust BRCA1-like Classification of Copy Number Profiles of Samples Repeated Across Different Datasets and Platforms
  Molecular Oncology. Aug, 2015  |   Pubmed ID: 25825120
• SF3B1 Mutations Constitute a Novel Therapeutic Target in Breast Cancer
  The Journal of Pathology. Mar, 2015  |   Pubmed ID: 25424858
• Metaplastic Breast Carcinomas Display Genomic and Transcriptomic Heterogeneity [corrected].
  Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Mar, 2015  |   Pubmed ID: 25412848
• Unbiased Analysis of Potential Targets of Breast Cancer Susceptibility Loci by Capture Hi-C
  Genome Research. Nov, 2014  |   Pubmed ID: 25122612
• Integrative Genomic and Transcriptomic Characterization of Papillary Carcinomas of the Breast
  Molecular Oncology. Dec, 2014  |   Pubmed ID: 25041824
• Characterization of the Genomic Features and Expressed Fusion Genes in Micropapillary Carcinomas of the Breast
  The Journal of Pathology. Apr, 2014  |   Pubmed ID: 24395524
• Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 As a Novel Determinant of PARP1/2 Inhibitor Sensitivity
  Cancer Research. Jan, 2014  |   Pubmed ID: 24240700
• Genomic Profiling of Histological Special Types of Breast Cancer
  Breast Cancer Research and Treatment. Nov, 2013  |   Pubmed ID: 24162157
• From Integrative Genomics to Therapeutic Targets
  Cancer Research. Jun, 2013  |   Pubmed ID: 23740772
• Mutation Profiling of Adenoid Cystic Carcinomas from Multiple Anatomical Sites Identifies Mutations in the RAS Pathway, but No KIT Mutations
  Histopathology. Mar, 2013  |   Pubmed ID: 23398044
• Cross-platform Pathway-based Analysis Identifies Markers of Response to the PARP Inhibitor Olaparib
  Breast Cancer Research and Treatment. Sep, 2012  |   Pubmed ID: 22875744
• Molecular Evidence in Support of the Neoplastic and Precursor Nature of Microglandular Adenosis
  Histopathology. May, 2012  |   Pubmed ID: 22486256
• Functional Characterization of the 19q12 Amplicon in Grade III Breast Cancers
  Breast Cancer Research : BCR. Mar, 2012  |   Pubmed ID: 22433433
• A Whole-genome Massively Parallel Sequencing Analysis of BRCA1 Mutant Oestrogen Receptor-negative and -positive Breast Cancers
  The Journal of Pathology. May, 2012  |   Pubmed ID: 22362584
• APRIN is a Cell Cycle Specific BRCA2-interacting Protein Required for Genome Integrity and a Predictor of Outcome After Chemotherapy in Breast Cancer
  The EMBO Journal. Mar, 2012  |   Pubmed ID: 22293751
• Genomic and Mutational Profiling of Ductal Carcinomas in Situ and Matched Adjacent Invasive Breast Cancers Reveals Intra-tumour Genetic Heterogeneity and Clonal Selection
  The Journal of Pathology. May, 2012  |   Pubmed ID: 22252965
• Immunophenotypic and Genomic Characterization of Papillary Carcinomas of the Breast
  The Journal of Pathology. Feb, 2012  |   Pubmed ID: 22025283
• Adenoid Cystic Carcinomas Constitute a Genomically Distinct Subgroup of Triple-negative and Basal-like Breast Cancers
  The Journal of Pathology. Jan, 2012  |   Pubmed ID: 22015727
• Non-existence of Caveolin-1 Gene Mutations in Human Breast Cancer
  Breast Cancer Research and Treatment. Jan, 2012  |   Pubmed ID: 21909981
• Genomic Profiling of Mitochondrion-rich Breast Carcinoma: Chromosomal Changes May Be Relevant for Mitochondria Accumulation and Tumour Biology
  Breast Cancer Research and Treatment. Feb, 2012  |   Pubmed ID: 21509527
• Functionally Recurrent Rearrangements of the MAST Kinase and Notch Gene Families in Breast Cancer
  Nature Medicine. Dec, 2011  |   Pubmed ID: 22101766
• Identification of Gene Fusion Transcripts by Transcriptome Sequencing in BRCA1-mutated Breast Cancers and Cell Lines
  BMC Medical Genomics. Oct, 2011  |   Pubmed ID: 22032724
• Functional Viability Profiles of Breast Cancer
  Cancer Discovery. Aug, 2011  |   Pubmed ID: 21984977
• Identification of a Disease-defining Gene Fusion in Epithelioid Hemangioendothelioma
  Science Translational Medicine. Aug, 2011  |   Pubmed ID: 21885404
• Molecular Profiling Reveals Frequent Gain of MYCN and Anaplasia-specific Loss of 4q and 14q in Wilms Tumor
  Genes, Chromosomes & Cancer. Dec, 2011  |   Pubmed ID: 21882282
• High-throughput Detection of Fusion Genes in Cancer Using the Sequenom MassARRAY Platform
  Laboratory Investigation; a Journal of Technical Methods and Pathology. Oct, 2011  |   Pubmed ID: 21808235
• Functional Characterization of EMSY Gene Amplification in Human Cancers
  The Journal of Pathology. Sep, 2011  |   Pubmed ID: 21735447
• FGFR Signaling Promotes the Growth of Triple-negative and Basal-like Breast Cancer Cell Lines Both in Vitro and in Vivo
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2011  |   Pubmed ID: 21712446
• Next-generation Sequencing Applied to Molecular Diagnostics
  Expert Review of Molecular Diagnostics. May, 2011  |   Pubmed ID: 21545259
• Microarray-based Class Discovery for Molecular Classification of Breast Cancer: Analysis of Interobserver Agreement
  Journal of the National Cancer Institute. Apr, 2011  |   Pubmed ID: 21421860
• Genomic Analysis Reveals the Molecular Heterogeneity of Ovarian Clear Cell Carcinomas
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2011  |   Pubmed ID: 21411445
• Enhanced RAD21 Cohesin Expression Confers Poor Prognosis and Resistance to Chemotherapy in High Grade Luminal, Basal and HER2 Breast Cancers
  Breast Cancer Research : BCR. Jan, 2011  |   Pubmed ID: 21255398
• β-Catenin Pathway Activation in Breast Cancer is Associated with Triple-negative Phenotype but Not with CTNNB1 Mutation
  Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Feb, 2011  |   Pubmed ID: 21076461
• Down-regulation of the MiRNA Master Regulators Drosha and Dicer is Associated with Specific Subgroups of Breast Cancer
  European Journal of Cancer (Oxford, England : 1990). Jan, 2011  |   Pubmed ID: 20832293
• PTEN Deficiency in Endometrioid Endometrial Adenocarcinomas Predicts Sensitivity to PARP Inhibitors
  Science Translational Medicine. Oct, 2010  |   Pubmed ID: 20944090
• Mucinous Carcinoma of the Breast is Genomically Distinct from Invasive Ductal Carcinomas of No Special Type
  The Journal of Pathology. Nov, 2010  |   Pubmed ID: 20815046
• BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells
  Cell Stem Cell. Sep, 2010  |   Pubmed ID: 20804975
• Transcriptomic Analysis of Tubular Carcinomas of the Breast Reveals Similarities and Differences with Molecular Subtype-matched Ductal and Lobular Carcinomas
  The Journal of Pathology. Sep, 2010  |   Pubmed ID: 20593406
• PPM1D Gene Amplification and Overexpression in Breast Cancer: a QRT-PCR and Chromogenic in Situ Hybridization Study
  Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Oct, 2010  |   Pubmed ID: 20543821
• DNA Amplifications in Breast Cancer: Genotypic-phenotypic Correlations
  Future Oncology (London, England). Jun, 2010  |   Pubmed ID: 20528234
• Genomic and Immunohistochemical Analysis of Adenosquamous Carcinoma of the Breast
  Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Jul, 2010  |   Pubmed ID: 20453835
• Cortactin Gene Amplification and Expression in Breast Cancer: a Chromogenic in Situ Hybridisation and Immunohistochemical Study
  Breast Cancer Research and Treatment. Dec, 2010  |   Pubmed ID: 20213079
• Breast Cancer Molecular Profiling with Single Sample Predictors: a Retrospective Analysis
  The Lancet. Oncology. Apr, 2010  |   Pubmed ID: 20181526
• FGFR1 Amplification Drives Endocrine Therapy Resistance and is a Therapeutic Target in Breast Cancer
  Cancer Research. Mar, 2010  |   Pubmed ID: 20179196
• Molecular Analysis Reveals a Genetic Basis for the Phenotypic Diversity of Metaplastic Breast Carcinomas
  The Journal of Pathology. Apr, 2010  |   Pubmed ID: 20099298
• The Molecular Underpinning of Lobular Histological Growth Pattern: a Genome-wide Transcriptomic Analysis of Invasive Lobular Carcinomas and Grade- and Molecular Subtype-matched Invasive Ductal Carcinomas of No Special Type
  The Journal of Pathology. Jan, 2010  |   Pubmed ID: 19877120
• An Integrative Genomic and Transcriptomic Analysis Reveals Molecular Pathways and Networks Regulated by Copy Number Aberrations in Basal-like, HER2 and Luminal Cancers
  Breast Cancer Research and Treatment. Jun, 2010  |   Pubmed ID: 19688261
• CD44 is Overexpressed in Basal-like Breast Cancers but is Not a Driver of 11p13 Amplification
  Breast Cancer Research and Treatment. Feb, 2010  |   Pubmed ID: 19350388
• Complex Landscapes of Somatic Rearrangement in Human Breast Cancer Genomes
  Nature. Dec, 2009  |   Pubmed ID: 20033038
• Microglandular Adenosis or Microglandular Adenoma? A Molecular Genetic Analysis of a Case Associated with Atypia and Invasive Carcinoma
  Histopathology. Dec, 2009  |   Pubmed ID: 19922592
• Loss of Heterozygosity at 2q37 in Sporadic Wilms' Tumor: Putative Role for MiR-562
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2009  |   Pubmed ID: 19789318
• Mixed Micropapillary-ductal Carcinomas of the Breast: a Genomic and Immunohistochemical Analysis of Morphologically Distinct Components
  The Journal of Pathology. Jul, 2009  |   Pubmed ID: 19479727
• Integrated Functional, Gene Expression and Genomic Analysis for the Identification of Cancer Targets
  PloS One. 2009  |   Pubmed ID: 19357772
• Tiling Path Genomic Profiling of Grade 3 Invasive Ductal Breast Cancers
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2009  |   Pubmed ID: 19318498
• PPM1D is a Potential Therapeutic Target in Ovarian Clear Cell Carcinomas
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2009  |   Pubmed ID: 19293255
• Loss of 16q in High Grade Breast Cancer is Associated with Estrogen Receptor Status: Evidence for Progression in Tumors with a Luminal Phenotype?
  Genes, Chromosomes & Cancer. Apr, 2009  |   Pubmed ID: 19156836
• ESR1 Gene Amplification in Breast Cancer: a Common Phenomenon?
  Nature Genetics. Jul, 2008  |   Pubmed ID: 18583966
• Genomic Analysis of the HER2/TOP2A Amplicon in Breast Cancer and Breast Cancer Cell Lines
  Laboratory Investigation; a Journal of Technical Methods and Pathology. May, 2008  |   Pubmed ID: 18332872
• Resistance to Therapy Caused by Intragenic Deletion in BRCA2
  Nature. Feb, 2008  |   Pubmed ID: 18264088
• Multifaceted Dysregulation of the Epidermal Growth Factor Receptor Pathway in Clear Cell Sarcoma of the Kidney
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2007  |   Pubmed ID: 17646270
• Chromogenic and Fluorescent in Situ Hybridization in Breast Cancer
  Human Pathology. Aug, 2007  |   Pubmed ID: 17640550
• Getting It Right: Designing Microarray (and Not 'microawry') Comparative Genomic Hybridization Studies for Cancer Research
  Laboratory Investigation; a Journal of Technical Methods and Pathology. Aug, 2007  |   Pubmed ID: 17558419
• Delineation of a 1Mb Breakpoint Region at 1p13 in Wilms Tumors by Fine-tiling Oligonucleotide Array CGH
  Genes, Chromosomes & Cancer. Jun, 2007  |   Pubmed ID: 17370329
• Amplification and Overexpression of CACNA1E Correlates with Relapse in Favorable Histology Wilms' Tumors
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2006  |   Pubmed ID: 17189400
• Blastemal Expression of Type I Insulin-like Growth Factor Receptor in Wilms' Tumors is Driven by Increased Copy Number and Correlates with Relapse
  Cancer Research. Dec, 2006  |   Pubmed ID: 17145858
• Unlocking Pathology Archives for Molecular Genetic Studies: a Reliable Method to Generate Probes for Chromogenic and Fluorescent in Situ Hybridization
  Laboratory Investigation; a Journal of Technical Methods and Pathology. Apr, 2006  |   Pubmed ID: 16446704
• Array CGH Using Whole Genome Amplification of Fresh-frozen and Formalin-fixed, Paraffin-embedded Tumor DNA
  Genomics. Feb, 2006  |   Pubmed ID: 16271290
• Prognostic Classification of Relapsing Favorable Histology Wilms Tumor Using CDNA Microarray Expression Profiling and Support Vector Machines
  Genes, Chromosomes & Cancer. Sep, 2004  |   Pubmed ID: 15236318
• High-resolution Deletion Mapping of 15q13.2-q21.1 in Transitional Cell Carcinoma of the Bladder
  Cancer Research. Nov, 2003  |   Pubmed ID: 14633686