Rachael Natrajan The Breast Cancer Now Toby Robins Research Centre, Division of Breast Cancer The Institute of Cancer Research Biography Publications Institution JoVE Articles Rachael Natrajan has not added a biography. If you are Rachael Natrajan and would like to personalize this page please email our Author Liaison for assistance. Publications Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors Cell Reports. Oct, 2016 | Pubmed ID: 27783942 Comparative Proteomic Assessment of Matrisome Enrichment Methodologies The Biochemical Journal. Nov, 2016 | Pubmed ID: 27589945 Systematic Analysis of Tumour Cell-extracellular Matrix Adhesion Identifies Independent Prognostic Factors in Breast Cancer Oncotarget. Aug, 2016 | Pubmed ID: 27556857 Three-dimensional Modelling Identifies Novel Genetic Dependencies Associated with Breast Cancer Progression in the Isogenic MCF10 Model The Journal of Pathology. Nov, 2016 | Pubmed ID: 27512948 Risk Stratification and Intrinsic Subtype Classification of Breast Cancer: a Multi-Parameter Test to Rule Them All? Journal of the National Cancer Institute. Sep, 2016 | Pubmed ID: 27130931 Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines Cell Reports. Mar, 2016 | Pubmed ID: 26947069 Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology-Genomic Integration Analysis PLoS Medicine. Feb, 2016 | Pubmed ID: 26881778 The Status of Epidermal Growth Factor Receptor in Borderline Ovarian Tumours Oncotarget. Mar, 2016 | Pubmed ID: 26870997 An Ecological Measure of Immune-cancer Colocalization As a Prognostic Factor for Breast Cancer Breast Cancer Research : BCR. Sep, 2015 | Pubmed ID: 26395345 Genomic Landscape of Adenoid Cystic Carcinoma of the Breast The Journal of Pathology. Oct, 2015 | Pubmed ID: 26095796 Intra-tumor Genetic Heterogeneity and Alternative Driver Genetic Alterations in Breast Cancers with Heterogeneous HER2 Gene Amplification Genome Biology. May, 2015 | Pubmed ID: 25994018 Breast Cancer Heterogeneity: Parallel Evolution or Conscious Uncoupling? The Journal of Pathology. Sep, 2015 | Pubmed ID: 25953517 Corrigendum: Metastatic Breast Carcinomas Display Genomic and Transcriptomic Heterogeneity Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Apr, 2015 | Pubmed ID: 25836989 Robust BRCA1-like Classification of Copy Number Profiles of Samples Repeated Across Different Datasets and Platforms Molecular Oncology. Aug, 2015 | Pubmed ID: 25825120 SF3B1 Mutations Constitute a Novel Therapeutic Target in Breast Cancer The Journal of Pathology. Mar, 2015 | Pubmed ID: 25424858 Metaplastic Breast Carcinomas Display Genomic and Transcriptomic Heterogeneity [corrected]. Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Mar, 2015 | Pubmed ID: 25412848 Unbiased Analysis of Potential Targets of Breast Cancer Susceptibility Loci by Capture Hi-C Genome Research. Nov, 2014 | Pubmed ID: 25122612 Integrative Genomic and Transcriptomic Characterization of Papillary Carcinomas of the Breast Molecular Oncology. Dec, 2014 | Pubmed ID: 25041824 Characterization of the Genomic Features and Expressed Fusion Genes in Micropapillary Carcinomas of the Breast The Journal of Pathology. Apr, 2014 | Pubmed ID: 24395524 Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 As a Novel Determinant of PARP1/2 Inhibitor Sensitivity Cancer Research. Jan, 2014 | Pubmed ID: 24240700 Genomic Profiling of Histological Special Types of Breast Cancer Breast Cancer Research and Treatment. Nov, 2013 | Pubmed ID: 24162157 From Integrative Genomics to Therapeutic Targets Cancer Research. Jun, 2013 | Pubmed ID: 23740772 Mutation Profiling of Adenoid Cystic Carcinomas from Multiple Anatomical Sites Identifies Mutations in the RAS Pathway, but No KIT Mutations Histopathology. Mar, 2013 | Pubmed ID: 23398044 Cross-platform Pathway-based Analysis Identifies Markers of Response to the PARP Inhibitor Olaparib Breast Cancer Research and Treatment. Sep, 2012 | Pubmed ID: 22875744 Molecular Evidence in Support of the Neoplastic and Precursor Nature of Microglandular Adenosis Histopathology. May, 2012 | Pubmed ID: 22486256 Functional Characterization of the 19q12 Amplicon in Grade III Breast Cancers Breast Cancer Research : BCR. Mar, 2012 | Pubmed ID: 22433433 全ゲノムの大量並列シーケンス分析 BRCA1 変異体のエストロゲン受容体否定と肯定的な乳癌の。 The Journal of Pathology. May, 2012 | Pubmed ID: 22362584 APRIN is a Cell Cycle Specific BRCA2-interacting Protein Required for Genome Integrity and a Predictor of Outcome After Chemotherapy in Breast Cancer The EMBO Journal. Mar, 2012 | Pubmed ID: 22293751 Genomic and Mutational Profiling of Ductal Carcinomas in Situ and Matched Adjacent Invasive Breast Cancers Reveals Intra-tumour Genetic Heterogeneity and Clonal Selection The Journal of Pathology. May, 2012 | Pubmed ID: 22252965 Immunophenotypic and Genomic Characterization of Papillary Carcinomas of the Breast The Journal of Pathology. Feb, 2012 | Pubmed ID: 22025283 Adenoid Cystic Carcinomas Constitute a Genomically Distinct Subgroup of Triple-negative and Basal-like Breast Cancers The Journal of Pathology. Jan, 2012 | Pubmed ID: 22015727 Non-existence of Caveolin-1 Gene Mutations in Human Breast Cancer Breast Cancer Research and Treatment. Jan, 2012 | Pubmed ID: 21909981 Genomic Profiling of Mitochondrion-rich Breast Carcinoma: Chromosomal Changes May Be Relevant for Mitochondria Accumulation and Tumour Biology Breast Cancer Research and Treatment. Feb, 2012 | Pubmed ID: 21509527 Functionally Recurrent Rearrangements of the MAST Kinase and Notch Gene Families in Breast Cancer Nature Medicine. Dec, 2011 | Pubmed ID: 22101766 Identification of Gene Fusion Transcripts by Transcriptome Sequencing in BRCA1-mutated Breast Cancers and Cell Lines BMC Medical Genomics. Oct, 2011 | Pubmed ID: 22032724 Functional Viability Profiles of Breast Cancer Cancer Discovery. Aug, 2011 | Pubmed ID: 21984977 Identification of a Disease-defining Gene Fusion in Epithelioid Hemangioendothelioma Science Translational Medicine. Aug, 2011 | Pubmed ID: 21885404 分子プロファイリング MYCN の頻繁に利得と細胞異型度固有の損失の第 4 四半期として 14 Q ウィルムス腫瘍で明らかにします。 Genes, Chromosomes & Cancer. Dec, 2011 | Pubmed ID: 21882282 High-throughput Detection of Fusion Genes in Cancer Using the Sequenom MassARRAY Platform Laboratory Investigation; a Journal of Technical Methods and Pathology. Oct, 2011 | Pubmed ID: 21808235 Functional Characterization of EMSY Gene Amplification in Human Cancers The Journal of Pathology. Sep, 2011 | Pubmed ID: 21735447 FGFR Signaling Promotes the Growth of Triple-negative and Basal-like Breast Cancer Cell Lines Both in Vitro and in Vivo Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2011 | Pubmed ID: 21712446 Next-generation Sequencing Applied to Molecular Diagnostics Expert Review of Molecular Diagnostics. May, 2011 | Pubmed ID: 21545259 Microarray-based Class Discovery for Molecular Classification of Breast Cancer: Analysis of Interobserver Agreement Journal of the National Cancer Institute. Apr, 2011 | Pubmed ID: 21421860 Genomic Analysis Reveals the Molecular Heterogeneity of Ovarian Clear Cell Carcinomas Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2011 | Pubmed ID: 21411445 Enhanced RAD21 Cohesin Expression Confers Poor Prognosis and Resistance to Chemotherapy in High Grade Luminal, Basal and HER2 Breast Cancers Breast Cancer Research : BCR. Jan, 2011 | Pubmed ID: 21255398 β-Catenin Pathway Activation in Breast Cancer is Associated with Triple-negative Phenotype but Not with CTNNB1 Mutation Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Feb, 2011 | Pubmed ID: 21076461 Down-regulation of the MiRNA Master Regulators Drosha and Dicer is Associated with Specific Subgroups of Breast Cancer European Journal of Cancer (Oxford, England : 1990). Jan, 2011 | Pubmed ID: 20832293 PTEN Deficiency in Endometrioid Endometrial Adenocarcinomas Predicts Sensitivity to PARP Inhibitors Science Translational Medicine. Oct, 2010 | Pubmed ID: 20944090 Mucinous Carcinoma of the Breast is Genomically Distinct from Invasive Ductal Carcinomas of No Special Type The Journal of Pathology. Nov, 2010 | Pubmed ID: 20815046 BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells Cell Stem Cell. Sep, 2010 | Pubmed ID: 20804975 Transcriptomic Analysis of Tubular Carcinomas of the Breast Reveals Similarities and Differences with Molecular Subtype-matched Ductal and Lobular Carcinomas The Journal of Pathology. Sep, 2010 | Pubmed ID: 20593406 PPM1D Gene Amplification and Overexpression in Breast Cancer: a QRT-PCR and Chromogenic in Situ Hybridization Study Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Oct, 2010 | Pubmed ID: 20543821 DNA Amplifications in Breast Cancer: Genotypic-phenotypic Correlations Future Oncology (London, England). Jun, 2010 | Pubmed ID: 20528234 Genomic and Immunohistochemical Analysis of Adenosquamous Carcinoma of the Breast Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Jul, 2010 | Pubmed ID: 20453835 Cortactin Gene Amplification and Expression in Breast Cancer: a Chromogenic in Situ Hybridisation and Immunohistochemical Study Breast Cancer Research and Treatment. Dec, 2010 | Pubmed ID: 20213079 Breast Cancer Molecular Profiling with Single Sample Predictors: a Retrospective Analysis The Lancet. Oncology. Apr, 2010 | Pubmed ID: 20181526 FGFR1 Amplification Drives Endocrine Therapy Resistance and is a Therapeutic Target in Breast Cancer Cancer Research. Mar, 2010 | Pubmed ID: 20179196 Molecular Analysis Reveals a Genetic Basis for the Phenotypic Diversity of Metaplastic Breast Carcinomas The Journal of Pathology. Apr, 2010 | Pubmed ID: 20099298 The Molecular Underpinning of Lobular Histological Growth Pattern: a Genome-wide Transcriptomic Analysis of Invasive Lobular Carcinomas and Grade- and Molecular Subtype-matched Invasive Ductal Carcinomas of No Special Type The Journal of Pathology. Jan, 2010 | Pubmed ID: 19877120 An Integrative Genomic and Transcriptomic Analysis Reveals Molecular Pathways and Networks Regulated by Copy Number Aberrations in Basal-like, HER2 and Luminal Cancers Breast Cancer Research and Treatment. Jun, 2010 | Pubmed ID: 19688261 CD44 is Overexpressed in Basal-like Breast Cancers but is Not a Driver of 11p13 Amplification Breast Cancer Research and Treatment. Feb, 2010 | Pubmed ID: 19350388 Complex Landscapes of Somatic Rearrangement in Human Breast Cancer Genomes Nature. Dec, 2009 | Pubmed ID: 20033038 Microglandular Adenosis or Microglandular Adenoma? A Molecular Genetic Analysis of a Case Associated with Atypia and Invasive Carcinoma Histopathology. Dec, 2009 | Pubmed ID: 19922592 Loss of Heterozygosity at 2q37 in Sporadic Wilms' Tumor: Putative Role for MiR-562 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2009 | Pubmed ID: 19789318 Mixed Micropapillary-ductal Carcinomas of the Breast: a Genomic and Immunohistochemical Analysis of Morphologically Distinct Components The Journal of Pathology. Jul, 2009 | Pubmed ID: 19479727 Integrated Functional, Gene Expression and Genomic Analysis for the Identification of Cancer Targets PloS One. 2009 | Pubmed ID: 19357772 Tiling Path Genomic Profiling of Grade 3 Invasive Ductal Breast Cancers Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2009 | Pubmed ID: 19318498 PPM1D 卵巣明細胞癌における潜在的な治療上のターゲットです。 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2009 | Pubmed ID: 19293255 Loss of 16q in High Grade Breast Cancer is Associated with Estrogen Receptor Status: Evidence for Progression in Tumors with a Luminal Phenotype? Genes, Chromosomes & Cancer. Apr, 2009 | Pubmed ID: 19156836 ESR1 Gene Amplification in Breast Cancer: a Common Phenomenon? Nature Genetics. Jul, 2008 | Pubmed ID: 18583966 Genomic Analysis of the HER2/TOP2A Amplicon in Breast Cancer and Breast Cancer Cell Lines Laboratory Investigation; a Journal of Technical Methods and Pathology. May, 2008 | Pubmed ID: 18332872 Resistance to Therapy Caused by Intragenic Deletion in BRCA2 Nature. Feb, 2008 | Pubmed ID: 18264088 Multifaceted Dysregulation of the Epidermal Growth Factor Receptor Pathway in Clear Cell Sarcoma of the Kidney Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2007 | Pubmed ID: 17646270 Chromogenic and Fluorescent in Situ Hybridization in Breast Cancer Human Pathology. Aug, 2007 | Pubmed ID: 17640550 Getting It Right: Designing Microarray (and Not 'microawry') Comparative Genomic Hybridization Studies for Cancer Research Laboratory Investigation; a Journal of Technical Methods and Pathology. Aug, 2007 | Pubmed ID: 17558419 Delineation of a 1Mb Breakpoint Region at 1p13 in Wilms Tumors by Fine-tiling Oligonucleotide Array CGH Genes, Chromosomes & Cancer. Jun, 2007 | Pubmed ID: 17370329 増幅と過剰発現 CACNA1E 良好な組織型ウイルムス腫瘍の再発を相互に関連付けます。 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2006 | Pubmed ID: 17189400 Blastemal Expression of Type I Insulin-like Growth Factor Receptor in Wilms' Tumors is Driven by Increased Copy Number and Correlates with Relapse Cancer Research. Dec, 2006 | Pubmed ID: 17145858 Unlocking Pathology Archives for Molecular Genetic Studies: a Reliable Method to Generate Probes for Chromogenic and Fluorescent in Situ Hybridization Laboratory Investigation; a Journal of Technical Methods and Pathology. Apr, 2006 | Pubmed ID: 16446704 Array CGH Using Whole Genome Amplification of Fresh-frozen and Formalin-fixed, Paraffin-embedded Tumor DNA Genomics. Feb, 2006 | Pubmed ID: 16271290 Prognostic Classification of Relapsing Favorable Histology Wilms Tumor Using CDNA Microarray Expression Profiling and Support Vector Machines Genes, Chromosomes & Cancer. Sep, 2004 | Pubmed ID: 15236318 High-resolution Deletion Mapping of 15q13.2-q21.1 in Transitional Cell Carcinoma of the Bladder Cancer Research. Nov, 2003 | Pubmed ID: 14633686 癌細胞スフェロイド培養における潜在的に新規薬剤標的を同定するためのスクリーニング機能ゲノミクスを利用 Eamonn Morrison1,2, Patty Wai1,2, Andri Leonidou1,2, Philip Bland1,2, Saira Khalique1,2, Gillian Farnie3, Frances Daley1, Barrie Peck1,2, Rachael Natrajan1,2 1The Breast Cancer Now Toby Robins Research Centre, Division of Breast Cancer, The Institute of Cancer Research, 2Division of Molecular Pathology, The Institute of Cancer Research, 3Institute of Cancer Sciences, University of Manchester Cancer Research
癌細胞スフェロイド培養における潜在的に新規薬剤標的を同定するためのスクリーニング機能ゲノミクスを利用 Eamonn Morrison1,2, Patty Wai1,2, Andri Leonidou1,2, Philip Bland1,2, Saira Khalique1,2, Gillian Farnie3, Frances Daley1, Barrie Peck1,2, Rachael Natrajan1,2 1The Breast Cancer Now Toby Robins Research Centre, Division of Breast Cancer, The Institute of Cancer Research, 2Division of Molecular Pathology, The Institute of Cancer Research, 3Institute of Cancer Sciences, University of Manchester Cancer Research
