Rajanikanth Vadigepalli Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Anatomy, and Cell Biology Thomas Jefferson University Biography Publications Institution JoVE Articles Rajanikanth Vadigepalli has not added a biography. If you are Rajanikanth Vadigepalli and would like to personalize this page please email our Author Liaison for assistance. Publications A Spatial Model of Hepatic Calcium Signaling and Glucose Metabolism Under Autonomic Control Reveals Functional Consequences of Varying Liver Innervation Patterns Across Species Frontiers in Physiology. 2021 | Pubmed ID: 34899380 Single Cell Scale Neuronal and Glial Gene Expression and Putative Cell Phenotypes and Networks in the Nucleus Tractus Solitarius in an Alcohol Withdrawal Time Series Frontiers in Systems Neuroscience. 2021 | Pubmed ID: 34867221 Dysregulation of MiR-21-associated MiRNA Regulatory Networks by Chronic Ethanol Consumption Impairs Liver Regeneration Physiological Genomics. 12, 2021 | Pubmed ID: 34796728 Retinoic Acid Fluctuation Activates an Uneven, Direction-Dependent Network-Wide Robustness Response in Early Embryogenesis Frontiers in Cell and Developmental Biology. 2021 | Pubmed ID: 34746144 Analyzing the Relationships Between City Opioid Deaths and Socioeconomic Factors Journal of Opioid Management. Sep-Oct, 2021 | Pubmed ID: 34714537 3D Single Cell Scale Anatomical Map of Sex-dependent Variability of the Rat Intrinsic Cardiac Nervous System IScience. Jul, 2021 | Pubmed ID: 34355144 A Single Cell Transcriptomics Map of Paracrine Networks in the Intrinsic Cardiac Nervous System IScience. Jul, 2021 | Pubmed ID: 34337356 Mapping the Little Brain at the Heart by an Interdisciplinary Systems Biology Team IScience. May, 2021 | Pubmed ID: 34113808 Input-output Signal Processing Plasticity of Vagal Motor Neurons in Response to Cardiac Ischemic Injury IScience. Mar, 2021 | Pubmed ID: 33665562 Innervation and Neuronal Control of the Mammalian Sinoatrial Node a Comprehensive Atlas Circulation Research. 04, 2021 | Pubmed ID: 33629877 Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis Gastroenterology. 04, 2021 | Pubmed ID: 33309778 Credible Practice of Modeling and Simulation in Healthcare: Ten Rules from a Multidisciplinary Perspective Journal of Translational Medicine. 09, 2020 | Pubmed ID: 32993675 Hepatic Lipocalin 2 Promotes Liver Fibrosis and Portal Hypertension Scientific Reports. 09, 2020 | Pubmed ID: 32968110 Investigating the Effects of Brainstem Neuronal Adaptation on Cardiovascular Homeostasis Frontiers in Neuroscience. 2020 | Pubmed ID: 32508573 Diurnal Patterns of Gene Expression in the Dorsal Vagal Complex and the Central Nucleus of the Amygdala - Non-rhythm-generating Brain Regions Frontiers in Neuroscience. 2020 | Pubmed ID: 32477043 A Comprehensive Integrated Anatomical and Molecular Atlas of Rat Intrinsic Cardiac Nervous System IScience. Jun, 2020 | Pubmed ID: 32460006 Inflammation-associated Suppression of Metabolic Gene Networks in Acute and Chronic Liver Disease Archives of Toxicology. Jan, 2020 | Pubmed ID: 31919559 A Novel Mouse Model of Acute-on-Chronic Cholestatic Alcoholic Liver Disease: A Systems Biology Comparison With Human Alcoholic Hepatitis Alcoholism, Clinical and Experimental Research. Jan, 2020 | Pubmed ID: 31710124 Single-Cell Glia and Neuron Gene Expression in the Central Amygdala in Opioid Withdrawal Suggests Inflammation With Correlated Gut Dysbiosis Frontiers in Neuroscience. 2019 | Pubmed ID: 31333398 Model-based Virtual Patient Analysis of Human Liver Regeneration Predicts Critical Perioperative Factors Controlling the Dynamic Mode of Response to Resection BMC Systems Biology. 01, 2019 | Pubmed ID: 30651095 Single-Cell Gene Expression Analysis Identifies Chronic Alcohol-Mediated Shift in Hepatocyte Molecular States After Partial Hepatectomy Gene Expression. 04, 2019 | Pubmed ID: 30189915 Modeling the Dynamics of Human Liver Failure Post Liver Resection Processes (Basel, Switzerland). Aug, 2018 | Pubmed ID: 31131255 Causality Analysis and Cell Network Modeling of Spatial Calcium Signaling Patterns in Liver Lobules Frontiers in Physiology. 2018 | Pubmed ID: 30337879 Cellular Network Modeling and Single Cell Gene Expression Analysis Reveals Novel Hepatic Stellate Cell Phenotypes Controlling Liver Regeneration Dynamics BMC Systems Biology. 10, 2018 | Pubmed ID: 30285726 Credibility, Replicability, and Reproducibility in Simulation for Biomedicine and Clinical Applications in Neuroscience Frontiers in Neuroinformatics. 2018 | Pubmed ID: 29713272 SPSNet: Subpopulation-sensitive Network-based Analysis of Heterogeneous Gene Expression Data BMC Systems Biology. 03, 2018 | Pubmed ID: 29560831 Introduction to the Virtual Issue Alcohol and Epigenetic Regulation: Do the Products of Alcohol Metabolism Drive Epigenetic Control of Gene Expression in Alcohol-Related Disorders? Alcoholism, Clinical and Experimental Research. 05, 2018 | Pubmed ID: 29532481 Novel Influences of IL-10 on CNS Inflammation Revealed by Integrated Analyses of Cytokine Networks and Microglial Morphology Frontiers in Cellular Neuroscience. 2017 | Pubmed ID: 28855862 A Data-driven Modeling Approach to Identify Disease-specific Multi-organ Networks Driving Physiological Dysregulation PLoS Computational Biology. Jul, 2017 | Pubmed ID: 28732007 Pattern Analysis Uncovers a Chronic Ethanol-induced Disruption of the Switch-like Dynamics of C/EBP-β and C/EBP-α Genome-wide Binding During Liver Regeneration Physiological Genomics. 01, 2017 | Pubmed ID: 27815535 Modeling Cytokine Regulatory Network Dynamics Driving Neuroinflammation in Central Nervous System Disorders Drug Discovery Today. Disease Models. 2016 | Pubmed ID: 28947907 Single-Cell Transcriptional Analysis Reveals Novel Neuronal Phenotypes and Interaction Networks Involved in the Central Circadian Clock Frontiers in Neuroscience. 2016 | Pubmed ID: 27826225 Inhibition of MiR-21 Rescues Liver Regeneration After Partial Hepatectomy in Ethanol-fed Rats American Journal of Physiology. Gastrointestinal and Liver Physiology. 11, 2016 | Pubmed ID: 27634014 Integrated Live Imaging and Molecular Profiling of Embryoid Bodies Reveals a Synchronized Progression of Early Differentiation Scientific Reports. 08, 2016 | Pubmed ID: 27530599 Systemic Leukotriene B Receptor Antagonism Lowers Arterial Blood Pressure and Improves Autonomic Function in the Spontaneously Hypertensive Rat The Journal of Physiology. 10, 2016 | Pubmed ID: 27230966 Computational Modeling of Spatiotemporal Ca(2+) Signal Propagation Along Hepatocyte Cords IEEE Transactions on Bio-medical Engineering. 10, 2016 | Pubmed ID: 27076052 HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells Molecular Cancer Research : MCR. 07, 2016 | Pubmed ID: 27053682 A Novel Comparative Pattern Analysis Approach Identifies Chronic Alcohol Mediated Dysregulation of Transcriptomic Dynamics During Liver Regeneration BMC Genomics. Mar, 2016 | Pubmed ID: 27012785 A Novel Comparative Pattern Count Analysis Reveals a Chronic Ethanol-induced Dynamic Shift in Immediate Early NF-κB Genome-wide Promoter Binding During Liver Regeneration Molecular BioSystems. Mar, 2016 | Pubmed ID: 26847025 Erratum To: Molecular Variability Elicits a Tunable Switch with Discrete Neuromodulatory Response Phenotypes Journal of Computational Neuroscience. Feb, 2016 | Pubmed ID: 26791519 Molecular Variability Elicits a Tunable Switch with Discrete Neuromodulatory Response Phenotypes Journal of Computational Neuroscience. Feb, 2016 | Pubmed ID: 26621106 Systems Analysis of Non-parenchymal Cell Modulation of Liver Repair Across Multiple Regeneration Modes BMC Systems Biology. Oct, 2015 | Pubmed ID: 26493454 Intracellular Information Processing Through Encoding and Decoding of Dynamic Signaling Features PLoS Computational Biology. Oct, 2015 | Pubmed ID: 26491963 In Vivo Zonal Variation and Liver Cell-Type Specific NF-κB Localization After Chronic Adaptation to Ethanol and Following Partial Hepatectomy PloS One. 2015 | Pubmed ID: 26452159 Computational Modeling of Cytokine Signaling in Microglia Molecular BioSystems. Dec, 2015 | Pubmed ID: 26440115 A Novel, Dynamic Pattern-based Analysis of NF-κB Binding During the Priming Phase of Liver Regeneration Reveals Switch-like Functional Regulation of Target Genes Frontiers in Physiology. 2015 | Pubmed ID: 26217230 MicroRNA Network Changes in the Brain Stem Underlie the Development of Hypertension Physiological Genomics. Sep, 2015 | Pubmed ID: 26126791 Adiponectin Fine-tuning of Liver Regeneration Dynamics Revealed Through Cellular Network Modelling The Journal of Physiology. Jan, 2015 | Pubmed ID: 25630259 Multiscale Model of Dynamic Neuromodulation Integrating Neuropeptide-induced Signaling Pathway Activity with Membrane Electrophysiology Biophysical Journal. Jan, 2015 | Pubmed ID: 25564868 Identifying Functional Gene Regulatory Network Phenotypes Underlying Single Cell Transcriptional Variability Progress in Biophysics and Molecular Biology. Jan, 2015 | Pubmed ID: 25433230 Inputs Drive Cell Phenotype Variability Genome Research. Jun, 2014 | Pubmed ID: 24671852 Molecular Modeling of ErbB4/HER4 Kinase in the Context of the HER4 Signaling Network Helps Rationalize the Effects of Clinically Identified HER4 Somatic Mutations on the Cell Phenotype Biotechnology Journal. Dec, 2013 | Pubmed ID: 24318637 Ethanol Diverts Early Neuronal Differentiation Trajectory of Embryonic Stem Cells by Disrupting the Balance of Lineage Specifiers PloS One. 2013 | Pubmed ID: 23724002 Ethanol Alters the Balance of Sox2, Oct4, and Nanog Expression in Distinct Subpopulations During Differentiation of Embryonic Stem Cells Stem Cells and Development. Aug, 2013 | Pubmed ID: 23470161 Coordinated Dynamic Gene Expression Changes in the Central Nucleus of the Amygdala During Alcohol Withdrawal Alcoholism, Clinical and Experimental Research. Jan, 2013 | Pubmed ID: 22827539 Chronic Ethanol Feeding Alters MiRNA Expression Dynamics During Liver Regeneration Alcoholism, Clinical and Experimental Research. Jan, 2013 | Pubmed ID: 22823254 MicroRNA Profiling in Lung Cancer Reveals New Molecular Markers for Diagnosis Acta Cytologica. 2012 | Pubmed ID: 23207443 Decorin Protein Core Affects the Global Gene Expression Profile of the Tumor Microenvironment in a Triple-negative Orthotopic Breast Carcinoma Xenograft Model PloS One. 2012 | Pubmed ID: 23029096 Chronic Ethanol Feeding Enhances MiR-21 Induction During Liver Regeneration While Inhibiting Proliferation in Rats American Journal of Physiology. Gastrointestinal and Liver Physiology. Sep, 2012 | Pubmed ID: 22790595 Integrative Gene Regulatory Network Analysis Reveals Light-induced Regional Gene Expression Phase Shift Programs in the Mouse Suprachiasmatic Nucleus PloS One. 2012 | Pubmed ID: 22662235 Effects of Developmental Lead Exposure on the Hippocampal Transcriptome: Influences of Sex, Developmental Period, and Lead Exposure Level Toxicological Sciences : an Official Journal of the Society of Toxicology. Sep, 2012 | Pubmed ID: 22641619 Temporal Changes in Innate Immune Signals in a Rat Model of Alcohol Withdrawal in Emotional and Cardiorespiratory Homeostatic Nuclei Journal of Neuroinflammation. May, 2012 | Pubmed ID: 22626265 Rapid Temporal Changes in the Expression of a Set of Neuromodulatory Genes During Alcohol Withdrawal in the Dorsal Vagal Complex: Molecular Evidence of Homeostatic Disturbance Alcoholism, Clinical and Experimental Research. Oct, 2012 | Pubmed ID: 22486438 Adaptive Transcriptional Dynamics of A2 Neurons and Central Cardiovascular Control Pathways Experimental Physiology. Apr, 2012 | Pubmed ID: 22002872 Robust Dynamic Balance of AP-1 Transcription Factors in a Neuronal Gene Regulatory Network BMC Systems Biology. Dec, 2010 | Pubmed ID: 21167049 Temporal and Functional Profile of the Transcriptional Regulatory Network in the Early Regenerative Response to Partial Hepatectomy in the Rat BMC Genomics. Nov, 2008 | Pubmed ID: 18990226 Transcriptional Regulatory Network Analysis During Epithelial-mesenchymal Transformation of Retinal Pigment Epithelium Molecular Vision. Aug, 2008 | Pubmed ID: 18682805 Dynamic Transcriptomic Response to Acute Hypertension in the Nucleus Tractus Solitarius American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jul, 2008 | Pubmed ID: 18434436 From Promoter Analysis to Transcriptional Regulatory Network Prediction Using PAINT Methods in Molecular Biology (Clifton, N.J.). 2007 | Pubmed ID: 18314577 Bladder Inflammatory Transcriptome in Response to Tachykinins: Neurokinin 1 Receptor-dependent Genes and Transcription Regulatory Elements BMC Urology. May, 2007 | Pubmed ID: 17519035 Epidermal Growth Factor Receptor-induced Circadian-time-dependent Gene Regulation in Suprachiasmatic Nucleus Neuroreport. Sep, 2006 | Pubmed ID: 16932154 Systems Analysis of Circadian Time-dependent Neuronal Epidermal Growth Factor Receptor Signaling Genome Biology. 2006 | Pubmed ID: 16784547 The Inflammatory and Normal Transcriptome of Mouse Bladder Detrusor and Mucosa BMC Physiology. Jan, 2006 | Pubmed ID: 16420690 Chronic Alcohol Exposure Alters Transcription Broadly in a Key Integrative Brain Nucleus for Homeostasis: the Nucleus Tractus Solitarius Physiological Genomics. Dec, 2005 | Pubmed ID: 16189278 Erythroid-induced Commitment of K562 Cells Results in Clusters of Differentially Expressed Genes Enriched for Specific Transcription Regulatory Elements Physiological Genomics. Sep, 2004 | Pubmed ID: 15252187 PAINT: a Promoter Analysis and Interaction Network Generation Tool for Gene Regulatory Network Identification Omics : a Journal of Integrative Biology. 2003 | Pubmed ID: 14583114 Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods Sean J. O'Sullivan*1,2,3, Ankita Srivastava*1, Rajanikanth Vadigepalli1, James S. Schwaber1 1Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 2Sidney Kimmel Medical College, Thomas Jefferson University, 3Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine JoVE 64014 Neuroscience Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence Sean J. O'Sullivan1,2, Beverly A.S. Reyes3, Rajanikanth Vadigepalli1, Elisabeth J. Van Bockstaele3, James S. Schwaber1 1Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 2Sidney Kimmel Medical College, Thomas Jefferson University, 3Department of Pharmacology & Physiology, Drexel University College of Medicine JoVE 60612 Genetics
Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods Sean J. O'Sullivan*1,2,3, Ankita Srivastava*1, Rajanikanth Vadigepalli1, James S. Schwaber1 1Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 2Sidney Kimmel Medical College, Thomas Jefferson University, 3Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine JoVE 64014 Neuroscience
Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence Sean J. O'Sullivan1,2, Beverly A.S. Reyes3, Rajanikanth Vadigepalli1, Elisabeth J. Van Bockstaele3, James S. Schwaber1 1Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 2Sidney Kimmel Medical College, Thomas Jefferson University, 3Department of Pharmacology & Physiology, Drexel University College of Medicine JoVE 60612 Genetics
