Ralph Weissleder Center for Systems Biology Massachusetts General Hospital Biography Publications Institution JoVE Articles Ralph Weissleder has not added a biography. If you are Ralph Weissleder and would like to personalize this page please email our Author Liaison for assistance. Publications Bioorthogonal Approach to Identify Unsuspected Drug Targets in Live Cells Angewandte Chemie (International Ed. in English). Aug, 2013 | Pubmed ID: 23960025 Local Proliferation Dominates Lesional Macrophage Accumulation in Atherosclerosis Nature Medicine. Sep, 2013 | Pubmed ID: 23933982 Miniaturized Nuclear Magnetic Resonance Platform for Detection and Profiling of Circulating Tumor Cells Lab on a Chip. Jul, 2013 | Pubmed ID: 23835814 Targeting Cathepsin E in Pancreatic Cancer by a Small Molecule Allows in Vivo Detection Neoplasia (New York, N.Y.). Jul, 2013 | Pubmed ID: 23814481 Nanoparticle PET-CT Detects Rejection and Immunomodulation in Cardiac Allografts Circulation. Cardiovascular Imaging. Jul, 2013 | Pubmed ID: 23771986 BODIPY-tetrazine Derivatives As Superbright Bioorthogonal Turn-on Probes Angewandte Chemie (International Ed. in English). Jul, 2013 | Pubmed ID: 23712730 A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Aug, 2013 | Pubmed ID: 23708196 A Magneto-DNA Nanoparticle System for Rapid Detection and Phenotyping of Bacteria Nature Nanotechnology. May, 2013 | Pubmed ID: 23644570 Monocyte-directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-prone Mice Circulation. May, 2013 | Pubmed ID: 23616627 Magnetic Barcode Assay for Genetic Detection of Pathogens Nature Communications. 2013 | Pubmed ID: 23612293 Upconverting Organic Dye Doped Core-shell Nano-composites for Dual-modality NIR Imaging and Photo-thermal Therapy Theranostics. 2013 | Pubmed ID: 23606913 Single Cell Analysis of Drug Distribution by Intravital Imaging PloS One. 2013 | Pubmed ID: 23593370 Fluorescence Endoscopy of Cathepsin Activity Discriminates Dysplasia from Colitis Inflammatory Bowel Diseases. Jun, 2013 | Pubmed ID: 23591598 Comparison of Select Cancer Biomarkers in Human Circulating and Bulk Tumor Cells Using Magnetic Nanoparticles and a Miniaturized Micro-NMR System Nanomedicine : Nanotechnology, Biology, and Medicine. Apr, 2013 | Pubmed ID: 23570873 μHall Chip for Sensitive Detection of Bacteria Advanced Healthcare Materials. Sep, 2013 | Pubmed ID: 23495188 Nano-SAR Development for Bioactivity of Nanoparticles with Considerations of Decision Boundaries Small (Weinheim an Der Bergstrasse, Germany). May, 2013 | Pubmed ID: 23423856 Single-cell and Subcellular Pharmacokinetic Imaging Allows Insight into Drug Action in Vivo Nature Communications. 2013 | Pubmed ID: 23422672 Angiotensin II Drives the Production of Tumor-Promoting Macrophages Immunity. Jan, 2013 | Pubmed ID: 23333075 Polymeric Nanoparticle PET/MR Imaging Allows Macrophage Detection in Atherosclerotic Plaques Circulation Research. Mar, 2013 | Pubmed ID: 23300273 Dual Imaging and Photoactivated Nanoprobe for Controlled Cell Tracking Small (Weinheim an Der Bergstrasse, Germany). Jan, 2013 | Pubmed ID: 22996932 Noise Suppressed, Multifocus Image Fusion for Enhanced Intraoperative Navigation Journal of Biophotonics. Apr, 2013 | Pubmed ID: 22887724 Efficient (18)F-Labeling of Synthetic Exendin-4 Analogues for Imaging Beta Cells ChemistryOpen. Aug, 2012 | Pubmed ID: 23997998 Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells Molecular Therapy. Nucleic Acids. 2012 | Pubmed ID: 23344621 Painting Blood Vessels and Atherosclerotic Plaques with an Adhesive Drug Depot Proceedings of the National Academy of Sciences of the United States of America. Dec, 2012 | Pubmed ID: 23236189 The Histone Deacetylase SIRT6 is a Tumor Suppressor That Controls Cancer Metabolism Cell. Dec, 2012 | Pubmed ID: 23217706 Microfluidic Cell Sorter (μFCS) for On-chip Capture and Analysis of Single Cells Advanced Healthcare Materials. Jul, 2012 | Pubmed ID: 23184773 Selective Factor XIIa Inhibition Attenuates Silent Brain Ischemia: Application of Molecular Imaging Targeting Coagulation Pathway JACC. Cardiovascular Imaging. Nov, 2012 | Pubmed ID: 23153913 Implantable Microenvironments to Attract Hematopoietic Stem/cancer Cells Proceedings of the National Academy of Sciences of the United States of America. Nov, 2012 | Pubmed ID: 23150542 Protein Typing of Circulating Microvesicles Allows Real-time Monitoring of Glioblastoma Therapy Nature Medicine. Dec, 2012 | Pubmed ID: 23142818 Photocleavable DNA Barcode-antibody Conjugates Allow Sensitive and Multiplexed Protein Analysis in Single Cells Journal of the American Chemical Society. Nov, 2012 | Pubmed ID: 23092113 Improved Intravital Microscopy Via Synchronization of Respiration and Holder Stabilization Journal of Biomedical Optics. Sep, 2012 | Pubmed ID: 23085919 Modeling Biological Activities of Nanoparticles Nano Letters. Nov, 2012 | Pubmed ID: 23039907 Inflammation Modulates Murine Venous Thrombosis Resolution in Vivo: Assessment by Multimodal Fluorescence Molecular Imaging Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2012 | Pubmed ID: 22995524 Real-time in Vivo Imaging of the Beating Mouse Heart at Microscopic Resolution Nature Communications. 2012 | Pubmed ID: 22968700 Optochemogenetics (OCG) Allows More Precise Control of Genetic Engineering in Mice with CreER Regulators Bioconjugate Chemistry. Sep, 2012 | Pubmed ID: 22917215 CT322, a VEGFR-2 Antagonist, Demonstrates Anti-glioma Efficacy in Orthotopic Brain Tumor Model As a Single Agent or in Combination with Temozolomide and Radiation Therapy Journal of Neuro-oncology. Oct, 2012 | Pubmed ID: 22875706 Ultrasensitive Clinical Enumeration of Rare Cells Ex Vivo Using a Micro-hall Detector Science Translational Medicine. Jul, 2012 | Pubmed ID: 22764208 Myocardial Infarction Accelerates Atherosclerosis Nature. Jul, 2012 | Pubmed ID: 22763456 Mechanism of Magnetic Relaxation Switching Sensing ACS Nano. Aug, 2012 | Pubmed ID: 22762250 Sensitive and Direct Detection of Circulating Tumor Cells by Multimarker µ-nuclear Magnetic Resonance Neoplasia (New York, N.Y.). May, 2012 | Pubmed ID: 22745585 A Magnetic Gram Stain for Bacterial Detection Angewandte Chemie (International Ed. in English). Jul, 2012 | Pubmed ID: 22744868 Notch Ligand Delta-like 4 Blockade Attenuates Atherosclerosis and Metabolic Disorders Proceedings of the National Academy of Sciences of the United States of America. Jul, 2012 | Pubmed ID: 22699504 Molecular Imaging of Fibrin Deposition in Deep Vein Thrombosis Using Fibrin-targeted Near-infrared Fluorescence JACC. Cardiovascular Imaging. Jun, 2012 | Pubmed ID: 22698530 Bioorthogonal Imaging of Aurora Kinase A in Live Cells Angewandte Chemie (International Ed. in English). Jul, 2012 | Pubmed ID: 22644700 Regulation of Monocyte Functional Heterogeneity by MiR-146a and Relb Cell Reports. Apr, 2012 | Pubmed ID: 22545247 Oncogenic Kras Maintains Pancreatic Tumors Through Regulation of Anabolic Glucose Metabolism Cell. Apr, 2012 | Pubmed ID: 22541435 Mapping Molecular Agents Distributions in Whole Mice Hearts Using Born-normalized Optical Projection Tomography PloS One. 2012 | Pubmed ID: 22509302 In Vivo Imaging of Drug-induced Mitochondrial Outer Membrane Permeabilization at Single-cell Resolution Cancer Research. Jun, 2012 | Pubmed ID: 22505651 Establishment and Characterization of a Novel Chordoma Cell Line: CH22 Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Oct, 2012 | Pubmed ID: 22504929 Imaging Therapeutic PARP Inhibition in Vivo Through Bioorthogonally Developed Companion Imaging Agents Neoplasia (New York, N.Y.). Mar, 2012 | Pubmed ID: 22496617 Synthesis of [18F]BODIPY: Bifunctional Reporter for Hybrid Optical/positron Emission Tomography Imaging Angewandte Chemie (International Ed. in English). May, 2012 | Pubmed ID: 22473535 Demyelinating Diseases: Myeloperoxidase As an Imaging Biomarker and Therapeutic Target Radiology. May, 2012 | Pubmed ID: 22438365 Orthogonal Amplification of Nanoparticles for Improved Diagnostic Sensing ACS Nano. Apr, 2012 | Pubmed ID: 22424443 Reactive Polymer Enables Efficient in Vivo Bioorthogonal Chemistry Proceedings of the National Academy of Sciences of the United States of America. Mar, 2012 | Pubmed ID: 22411831 Single Reporter for Targeted Multimodal in Vivo Imaging Journal of the American Chemical Society. Mar, 2012 | Pubmed ID: 22397453 Early Window of Diabetes Determinism in NOD Mice, Dependent on the Complement Receptor CRIg, Identified by Noninvasive Imaging Nature Immunology. Apr, 2012 | Pubmed ID: 22366893 Multifunctional Nanoagent for Thrombus-targeted Fibrinolytic Therapy Nanomedicine (London, England). Jul, 2012 | Pubmed ID: 22348271 The Neuropeptide Neuromedin U Promotes Autoantibody-mediated Arthritis Arthritis Research & Therapy. Feb, 2012 | Pubmed ID: 22314006 Origins of Tumor-associated Macrophages and Neutrophils Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012 | Pubmed ID: 22308361 Magnetic Nanoparticles and MicroNMR for Diagnostic Applications Theranostics. 2012 | Pubmed ID: 22272219 Innate Response Activator B Cells Protect Against Microbial Sepsis Science (New York, N.Y.). Feb, 2012 | Pubmed ID: 22245738 PET/MRI of Inflammation in Myocardial Infarction Journal of the American College of Cardiology. Jan, 2012 | Pubmed ID: 22222080 Rapid Monocyte Kinetics in Acute Myocardial Infarction Are Sustained by Extramedullary Monocytopoiesis The Journal of Experimental Medicine. Jan, 2012 | Pubmed ID: 22213805 Bioorthogonal Reaction Pairs Enable Simultaneous, Selective, Multi-target Imaging Angewandte Chemie (International Ed. in English). Jan, 2012 | Pubmed ID: 22162316 Extramedullary Hematopoiesis Generates Ly-6Chigh Monocytes That Infiltrate Atherosclerotic Lesions Circulation. Jan, 2012 | Pubmed ID: 22144566 Vasculitis: Molecular Imaging by Targeting the Inflammatory Enzyme Myeloperoxidase Radiology. Jan, 2012 | Pubmed ID: 22084204 Bevacizumab with Angiostatin-armed OHSV Increases Antiangiogenesis and Decreases Bevacizumab-induced Invasion in U87 Glioma Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2012 | Pubmed ID: 21915104 Development of Secreted Protein and Acidic and Rich in Cysteine (SPARC) Targeted Nanoparticles for the Prognostic Molecular Imaging of Metastatic Prostate Cancer Journal of Nanomedicine & Nanotechnology. Aug, 2011 | Pubmed ID: 22319675 Intravital Imaging Cell. Nov, 2011 | Pubmed ID: 22118457 Supramolecular Host-Guest Interaction for Labeling and Detection of Cellular Biomarkers Angewandte Chemie (International Ed. in English). Nov, 2011 | Pubmed ID: 22113923 Interview: Nanomedicine in Oncology: Miniaturized Means to an Enormous End. Interviewed by Cara Sutton Nanomedicine (London, England). Nov, 2011 | Pubmed ID: 22077461 Specific Pathogen Detection Using Bioorthogonal Chemistry and Diagnostic Magnetic Resonance Bioconjugate Chemistry. Dec, 2011 | Pubmed ID: 22043803 89Zr-labeled Dextran Nanoparticles Allow in Vivo Macrophage Imaging Bioconjugate Chemistry. Dec, 2011 | Pubmed ID: 22035047 Different Capacity of Monocyte Subsets to Phagocytose Iron-oxide Nanoparticles PloS One. 2011 | Pubmed ID: 21984904 Therapeutic SiRNA Silencing in Inflammatory Monocytes in Mice Nature Biotechnology. Nov, 2011 | Pubmed ID: 21983520 Ubiquitous Detection of Gram-positive Bacteria with Bioorthogonal Magnetofluorescent Nanoparticles ACS Nano. Nov, 2011 | Pubmed ID: 21967150 Nanoparticle-mediated Measurement of Target-drug Binding in Cancer Cells ACS Nano. Nov, 2011 | Pubmed ID: 21962084 Multicore Assemblies Potentiate Magnetic Properties of Biomagnetic Nanoparticles Advanced Materials (Deerfield Beach, Fla.). Nov, 2011 | Pubmed ID: 21953810 Synthesis and Evaluation of a Series of 1,2,4,5-tetrazines for Bioorthogonal Conjugation Bioconjugate Chemistry. Nov, 2011 | Pubmed ID: 21950520 Bioorthogonal Probes for Polo-like Kinase 1 Imaging and Quantification Angewandte Chemie (International Ed. in English). Sep, 2011 | Pubmed ID: 21948435 A Systems Approach for Tumor Pharmacokinetics PloS One. 2011 | Pubmed ID: 21935441 Modular Strategy for the Construction of Radiometalated Antibodies for Positron Emission Tomography Based on Inverse Electron Demand Diels-Alder Click Chemistry Bioconjugate Chemistry. Oct, 2011 | Pubmed ID: 21877749 In Vivo Detection of Staphylococcus Aureus Endocarditis by Targeting Pathogen-specific Prothrombin Activation Nature Medicine. Sep, 2011 | Pubmed ID: 21857652 Multiplexed Magnetic Labeling Amplification Using Oligonucleotide Hybridization Advanced Materials (Deerfield Beach, Fla.). Sep, 2011 | Pubmed ID: 21780311 Accurate Measurement of Pancreatic Islet Beta-cell Mass Using a Second-generation Fluorescent Exendin-4 Analog Proceedings of the National Academy of Sciences of the United States of America. Aug, 2011 | Pubmed ID: 21768367 In Vivo PET Imaging of Histone Deacetylases by 18F-suberoylanilide Hydroxamic Acid (18F-SAHA) Journal of Medicinal Chemistry. Aug, 2011 | Pubmed ID: 21721525 Analysis of Mitosis and Antimitotic Drug Responses in Tumors by in Vivo Microscopy and Single-cell Pharmacodynamics Cancer Research. Jul, 2011 | Pubmed ID: 21712408 Two-dimensional Intravascular Near-infrared Fluorescence Molecular Imaging of Inflammation in Atherosclerosis and Stent-induced Vascular Injury Journal of the American College of Cardiology. Jun, 2011 | Pubmed ID: 21679853 Dextran-coated Iron Oxide Nanoparticles: a Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy Accounts of Chemical Research. Oct, 2011 | Pubmed ID: 21661727 Biomedical Applications of Tetrazine Cycloadditions Accounts of Chemical Research. Sep, 2011 | Pubmed ID: 21627112 Indocyanine Green Enables Near-infrared Fluorescence Imaging of Lipid-rich, Inflamed Atherosclerotic Plaques Science Translational Medicine. May, 2011 | Pubmed ID: 21613624 Report of the National Heart, Lung, and Blood Institute Working Group on the Translation of Cardiovascular Molecular Imaging Circulation. May, 2011 | Pubmed ID: 21576680 Distinguishing Inflammation from Tumor and Peritumoral Edema by Myeloperoxidase Magnetic Resonance Imaging Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2011 | Pubmed ID: 21558403 Miniature Magnetic Resonance System for Point-of-care Diagnostics Lab on a Chip. Jul, 2011 | Pubmed ID: 21547317 Highly Magnetic Core-shell Nanoparticles with a Unique Magnetization Mechanism Angewandte Chemie (International Ed. in English). May, 2011 | Pubmed ID: 21495138 In Vivo Tomographic Imaging of Red-shifted Fluorescent Proteins Biomedical Optics Express. 2011 | Pubmed ID: 21483611 Facile Synthesis of Monofunctional Pentamethine Carbocyanine Fluorophores Dyes and Pigments : an International Journal. Apr, 2011 | Pubmed ID: 21475610 Molecular Detection of Biomarkers and Cells Using Magnetic Nanoparticles and Diagnostic Magnetic Resonance Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21424441 High-yielding, Two-step 18F Labeling Strategy for 18F-PARP1 Inhibitors ChemMedChem. Mar, 2011 | Pubmed ID: 21360818 Probing Intracellular Biomarkers and Mediators of Cell Activation Using Nanosensors and Bioorthogonal Chemistry ACS Nano. Apr, 2011 | Pubmed ID: 21351804 Micro-NMR for Rapid Molecular Analysis of Human Tumor Samples Science Translational Medicine. Feb, 2011 | Pubmed ID: 21346169 Synthesis and in Vivo Imaging of a 18F-labeled PARP1 Inhibitor Using a Chemically Orthogonal Scavenger-assisted High-performance Method Angewandte Chemie (International Ed. in English). Feb, 2011 | Pubmed ID: 21328671 Detection of Macrophages in Aortic Aneurysms by Nanoparticle Positron Emission Tomography-computed Tomography Arteriosclerosis, Thrombosis, and Vascular Biology. Apr, 2011 | Pubmed ID: 21252070 Enhanced in Vivo Imaging of Metabolically Biotinylated Cell Surface Reporters Analytical Chemistry. Feb, 2011 | Pubmed ID: 21214190 High-Yielding, Two-Step (18)F Labeling Strategy for (18)F-PARP1 Inhibitors ChemMedChem. Jan, 2011 | Pubmed ID: 21207434 Dragon (repulsive Guidance Molecule B) Inhibits IL-6 Expression in Macrophages Journal of Immunology (Baltimore, Md. : 1950). Feb, 2011 | Pubmed ID: 21187450 Noninvasive Imaging of Pancreatic Islet Inflammation in Type 1A Diabetes Patients The Journal of Clinical Investigation. Jan, 2011 | Pubmed ID: 21123946 Human Embryonic Stem Cell-derived Microvascular Grafts for Cardiac Tissue Preservation After Myocardial Infarction Biomaterials. Feb, 2011 | Pubmed ID: 21035182 Bone Marrow Stromal Cell Transplants Prevent Experimental Enterocolitis and Require Host CD11b+ Splenocytes Gastroenterology. Mar, 2011 | Pubmed ID: 20955701 Self-assembled Magnetic Filter for Highly Efficient Immunomagnetic Separation Lab on a Chip. Jan, 2011 | Pubmed ID: 20949198 Quantitating Antibody Uptake in Vivo: Conditional Dependence on Antigen Expression Levels Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Aug, 2011 | Pubmed ID: 20809210 Intraoperative Near-infrared Fluorescent Cholangiography (NIRFC) in Mouse Models of Bile Duct Injury: Reply World Journal of Surgery. Mar, 2011 | Pubmed ID: 20645091 MRI with Magnetic Nanoparticles Monitors Downstream Anti-angiogenic Effects of MTOR Inhibition Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Apr, 2011 | Pubmed ID: 20559742 Magnetic Nanoparticles for Biomedical NMR-based Diagnostics Beilstein Journal of Nanotechnology. 2010 | Pubmed ID: 21977404 WNT5A/JNK and FGF/MAPK Pathways Regulate the Cellular Events Shaping the Vertebrate Limb Bud Current Biology : CB. Nov, 2010 | Pubmed ID: 21055947 Bioorthogonal Small-molecule Ligands for PARP1 Imaging in Living Cells Chembiochem : a European Journal of Chemical Biology. Nov, 2010 | Pubmed ID: 20967817 High-resolution Magnetic Resonance Imaging Enhanced with Superparamagnetic Nanoparticles Measures Macrophage Burden in Atherosclerosis Circulation. Oct, 2010 | Pubmed ID: 20937980 Angiotensin-converting Enzyme Inhibition Prevents the Release of Monocytes from Their Splenic Reservoir in Mice with Myocardial Infarction Circulation Research. Nov, 2010 | Pubmed ID: 20930148 Detection Limits of Intraoperative Near Infrared Imaging for Tumor Resection Journal of Surgical Oncology. Dec, 2010 | Pubmed ID: 20872807 In Vivo Imaging in Cancer Cold Spring Harbor Perspectives in Biology. Dec, 2010 | Pubmed ID: 20861158 Carboxymethylated Polyvinyl Alcohol Stabilizes Doped Ferrofluids for Biological Applications Advanced Materials (Deerfield Beach, Fla.). Dec, 2010 | Pubmed ID: 20859943 Quantitative Nanostructure-activity Relationship Modeling ACS Nano. Oct, 2010 | Pubmed ID: 20857979 Targeted Nanoagents for the Detection of Cancers Molecular Oncology. Dec, 2010 | Pubmed ID: 20851695 A Light-activated Theranostic Nanoagent for Targeted Macrophage Ablation in Inflammatory Atherosclerosis Small (Weinheim an Der Bergstrasse, Germany). Sep, 2010 | Pubmed ID: 20721949 Pioglitazone Suppresses Inflammation in Vivo in Murine Carotid Atherosclerosis: Novel Detection by Dual-target Fluorescence Molecular Imaging Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2010 | Pubmed ID: 20689078 Bioorthogonal Chemistry Amplifies Nanoparticle Binding and Enhances the Sensitivity of Cell Detection Nature Nanotechnology. Sep, 2010 | Pubmed ID: 20676091 Arterial and Aortic Valve Calcification Inversely Correlates with Osteoporotic Bone Remodelling: a Role for Inflammation European Heart Journal. Aug, 2010 | Pubmed ID: 20601388 Near-infrared Fluorescent Probe for Imaging of Pancreatic Beta Cells Bioconjugate Chemistry. Jul, 2010 | Pubmed ID: 20583828 Myeloperoxidase-rich Ly-6C+ Myeloid Cells Infiltrate Allografts and Contribute to an Imaging Signature of Organ Rejection in Mice The Journal of Clinical Investigation. Jul, 2010 | Pubmed ID: 20577051 Molecular Imaging of Atherosclerosis: a Progress Report Texas Heart Institute Journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital. 2010 | Pubmed ID: 20548813 The Phosphoinositide 3-kinase Regulatory Subunit P85alpha Can Exert Tumor Suppressor Properties Through Negative Regulation of Growth Factor Signaling Cancer Research. Jul, 2010 | Pubmed ID: 20530665 Development of a Bioorthogonal and Highly Efficient Conjugation Method for Quantum Dots Using Tetrazine-norbornene Cycloaddition Journal of the American Chemical Society. Jun, 2010 | Pubmed ID: 20481508 The Vascular Biology of Atherosclerosis and Imaging Targets Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. May, 2010 | Pubmed ID: 20395349 Rapid Biocompatibility Analysis of Materials Via in Vivo Fluorescence Imaging of Mouse Models PloS One. 2010 | Pubmed ID: 20386609 Hybrid PET-optical Imaging Using Targeted Probes Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010 | Pubmed ID: 20385821 Impaired Infarct Healing in Atherosclerotic Mice with Ly-6C(hi) Monocytosis Journal of the American College of Cardiology. Apr, 2010 | Pubmed ID: 20378083 Imaging of Molecular Probe Activity with Born-normalized Fluorescence Optical Projection Tomography Optics Letters. Apr, 2010 | Pubmed ID: 20364226 Magnetic Nanoparticle Biosensors Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. May-Jun, 2010 | Pubmed ID: 20336708 Bioorthogonal Turn-On Probes for Imaging Small Molecules Inside Living Cells Angewandte Chemie (International Ed. in English). Apr, 2010 | Pubmed ID: 20306505 Imaging Primary Lung Cancers in Mice to Study Radiation Biology International Journal of Radiation Oncology, Biology, Physics. Mar, 2010 | Pubmed ID: 20206017 Activin A Promotes Multiple Myeloma-induced Osteolysis and is a Promising Target for Myeloma Bone Disease Proceedings of the National Academy of Sciences of the United States of America. Mar, 2010 | Pubmed ID: 20194748 The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis Via Hif1alpha Cell. Jan, 2010 | Pubmed ID: 20141841 A Novel Molecule Integrating Therapeutic and Diagnostic Activities Reveals Multiple Aspects of Stem Cell-based Therapy Stem Cells (Dayton, Ohio). Apr, 2010 | Pubmed ID: 20127797 Intraoperative Near-infrared Fluorescent Cholangiography (NIRFC) in Mouse Models of Bile Duct Injury World Journal of Surgery. Feb, 2010 | Pubmed ID: 20033407 Binding Affinity and Kinetic Analysis of Targeted Small Molecule-modified Nanoparticles Bioconjugate Chemistry. Jan, 2010 | Pubmed ID: 20028085 Early Identification of Aortic Valve Sclerosis Using Iron Oxide Enhanced MRI Journal of Magnetic Resonance Imaging : JMRI. Jan, 2010 | Pubmed ID: 20027578 Activatable Magnetic Resonance Imaging Agents for Myeloperoxidase Sensing: Mechanism of Activation, Stability, and Toxicity Journal of the American Chemical Society. Jan, 2010 | Pubmed ID: 19968300 Near-infrared Fluorescence: Application to in Vivo Molecular Imaging Current Opinion in Chemical Biology. Feb, 2010 | Pubmed ID: 19879798 Enhanced Antitumor Efficacy of Vasculostatin (Vstat120) Expressing Oncolytic HSV-1 Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2010 | Pubmed ID: 19844198 Self-assembled Multifunctional Fe/MgO Nanospheres for Magnetic Resonance Imaging and Hyperthermia Nanomedicine : Nanotechnology, Biology, and Medicine. Apr, 2010 | Pubmed ID: 19800988 Intravital Molecular Imaging of Small-diameter Tissue-engineered Vascular Grafts in Mice: a Feasibility Study Tissue Engineering. Part C, Methods. Aug, 2010 | Pubmed ID: 19751103 High Throughput Transmission Optical Projection Tomography Using Low Cost Graphics Processing Unit Optics Express. Dec, 2009 | Pubmed ID: 20052155 Unbiased Discovery of in Vivo Imaging Probes Through in Vitro Profiling of Nanoparticle Libraries Integrative Biology : Quantitative Biosciences from Nano to Macro. Apr, 2009 | Pubmed ID: 20023731 Diffractionless Beam in Free Space with Adiabatic Changing Refractive Index in a Single Mode Tapered Slab Waveguide Optics Express. Nov, 2009 | Pubmed ID: 19997414 Multicolor Fluorescent Intravital Live Microscopy (FILM) for Surgical Tumor Resection in a Mouse Xenograft Model PloS One. 2009 | Pubmed ID: 19956597 Molecular MRI Detects Low Levels of Cardiomyocyte Apoptosis in a Transgenic Model of Chronic Heart Failure Circulation. Cardiovascular Imaging. Nov, 2009 | Pubmed ID: 19920045 Molecular MRI of Cardiomyocyte Apoptosis with Simultaneous Delayed-enhancement MRI Distinguishes Apoptotic and Necrotic Myocytes in Vivo: Potential for Midmyocardial Salvage in Acute Ischemia Circulation. Cardiovascular Imaging. Nov, 2009 | Pubmed ID: 19920044 A Wortmannin-cetuximab As a Double Drug Bioconjugate Chemistry. Nov, 2009 | Pubmed ID: 19883074 18F-4V for PET-CT Imaging of VCAM-1 Expression in Atherosclerosis JACC. Cardiovascular Imaging. Oct, 2009 | Pubmed ID: 19833312 Oxazine Conjugated Nanoparticle Detects in Vivo Hypochlorous Acid and Peroxynitrite Generation Journal of the American Chemical Society. Nov, 2009 | Pubmed ID: 19817443 Enhancing Navigation in Biomedical Databases by Community Voting and Database-driven Text Classification BMC Bioinformatics. 2009 | Pubmed ID: 19799796 Transillumination Fluorescence Imaging in Mice Using Biocompatible Upconverting Nanoparticles Optics Letters. Sep, 2009 | Pubmed ID: 19724491 MRI of a Novel Murine Working Heart Transplant Model Circulation. Heart Failure. May, 2009 | Pubmed ID: 19718275 Fast and Sensitive Pretargeted Labeling of Cancer Cells Through a Tetrazine/trans-cyclooctene Cycloaddition Angewandte Chemie (International Ed. in English). 2009 | Pubmed ID: 19697389 High-yielding Syntheses of Hydrophilic Conjugatable Chlorins and Bacteriochlorins Organic & Biomolecular Chemistry. Sep, 2009 | Pubmed ID: 19675897 Enzyme-sensitive Magnetic Resonance Imaging Targeting Myeloperoxidase Identifies Active Inflammation in Experimental Rabbit Atherosclerotic Plaques Circulation. Aug, 2009 | Pubmed ID: 19652086 Abrogation of Antibody-induced Arthritis in Mice by a Self-activating Viridin Prodrug and Association with Impaired Neutrophil and Endothelial Cell Function Arthritis and Rheumatism. Aug, 2009 | Pubmed ID: 19644878 Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites Science (New York, N.Y.). Jul, 2009 | Pubmed ID: 19644120 Rapid Detection and Profiling of Cancer Cells in Fine-needle Aspirates Proceedings of the National Academy of Sciences of the United States of America. Jul, 2009 | Pubmed ID: 19620715 Synthesis and Photophysical Properties of Sulfonamidophenyl Porphyrins As Models for Activatable Photosensitizers The Journal of Organic Chemistry. Aug, 2009 | Pubmed ID: 19610602 Hybrid in Vivo FMT-CT Imaging of Protease Activity in Atherosclerosis with Customized Nanosensors Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2009 | Pubmed ID: 19608968 A DNA-binding Gd Chelate for the Detection of Cell Death by MRI Chemical Communications (Cambridge, England). Aug, 2009 | Pubmed ID: 19597620 Upconverting Luminescent Nanomaterials: Application to in Vivo Bioimaging Chemical Communications (Cambridge, England). Jul, 2009 | Pubmed ID: 19585016 Nuclear Microscopy: a Novel Technique for Quantitative Imaging of Gadolinium Distribution Within Tissue Sections Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. Aug, 2009 | Pubmed ID: 19575834 Lymphotropic Nanoparticle-enhanced Magnetic Resonance Imaging (LNMRI) Identifies Occult Lymph Node Metastases in Prostate Cancer Patients Prior to Salvage Radiation Therapy Clinical Imaging. Jul-Aug, 2009 | Pubmed ID: 19559353 Ultrasensitive Detection of Bacteria Using Core-shell Nanoparticles and an NMR-filter System Angewandte Chemie (International Ed. in English). 2009 | Pubmed ID: 19554581 Efficacy of Sunitinib and Radiotherapy in Genetically Engineered Mouse Model of Soft-tissue Sarcoma International Journal of Radiation Oncology, Biology, Physics. Jul, 2009 | Pubmed ID: 19545786 On the Dual Contrast Enhancement Mechanism in Frequency-selective Inversion-recovery Magnetic Resonance Angiography (IRON-MRA) Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Aug, 2009 | Pubmed ID: 19526511 A Stabilized Demethoxyviridin Derivative Inhibits PI3 Kinase Bioorganic & Medicinal Chemistry Letters. Aug, 2009 | Pubmed ID: 19523825 The Antiproliferative Cytostatic Effects of a Self-activating Viridin Prodrug Molecular Cancer Therapeutics. Jun, 2009 | Pubmed ID: 19509266 Monocyte Subset Dynamics in Human Atherosclerosis Can Be Profiled with Magnetic Nano-sensors PloS One. 2009 | Pubmed ID: 19461894 Multimodal Nanoagents for the Detection of Intravascular Thrombi Bioconjugate Chemistry. Jun, 2009 | Pubmed ID: 19456115 Implantable Diagnostic Device for Cancer Monitoring Biosensors & Bioelectronics. Jul, 2009 | Pubmed ID: 19442510 Behavior of Endogenous Tumor-associated Macrophages Assessed in Vivo Using a Functionalized Nanoparticle Neoplasia (New York, N.Y.). May, 2009 | Pubmed ID: 19412430 Genetically Engineered T Cells to Target EGFRvIII Expressing Glioblastoma Journal of Neuro-oncology. Sep, 2009 | Pubmed ID: 19387557 Heterogeneous in Vivo Behavior of Monocyte Subsets in Atherosclerosis Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2009 | Pubmed ID: 19372462 Optical and Multimodality Molecular Imaging: Insights into Atherosclerosis Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2009 | Pubmed ID: 19359659 Molecular Imaging of Innate Immune Cell Function in Transplant Rejection Circulation. Apr, 2009 | Pubmed ID: 19332470 Nanoparticle-target Interactions Parallel Antibody-protein Interactions Analytical Chemistry. May, 2009 | Pubmed ID: 19323458 Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease Circulation. Apr, 2009 | Pubmed ID: 19307473 Assessment of Therapeutic Efficacy and Fate of Engineered Human Mesenchymal Stem Cells for Cancer Therapy Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19264968 Mutant Sodium Channel for Tumor Therapy Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2009 | Pubmed ID: 19259066 Oncogenic EGFR Signaling Cooperates with Loss of Tumor Suppressor Gene Functions in Gliomagenesis Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009 | Pubmed ID: 19196966 Normalized Born Ratio for Fluorescence Optical Projection Tomography Optics Letters. Feb, 2009 | Pubmed ID: 19183644 Combined Magnetic Resonance and Fluorescence Imaging of the Living Mouse Brain Reveals Glioma Response to Chemotherapy NeuroImage. Apr, 2009 | Pubmed ID: 19154791 18F Labeled Nanoparticles for in Vivo PET-CT Imaging Bioconjugate Chemistry. Feb, 2009 | Pubmed ID: 19138113 Improved Detection of Ovarian Cancer Metastases by Intraoperative Quantitative Fluorescence Protease Imaging in a Pre-clinical Model Gynecologic Oncology. Mar, 2009 | Pubmed ID: 19135233 A Multifunctional Single-attachment-point Reagent for Controlled Protein Biotinylation Bioconjugate Chemistry. Jan, 2009 | Pubmed ID: 19072220 Non-invasive Optical Detection of Cathepsin K-mediated Fluorescence Reveals Osteoclast Activity in Vitro and in Vivo Bone. Feb, 2009 | Pubmed ID: 19007918 Notch Signaling in Cardiovascular Disease and Calcification Current Cardiology Reviews. Aug, 2008 | Pubmed ID: 19936191 Development of a Time Domain Fluorimeter for Fluorescent Lifetime Multiplexing Analysis IEEE Transactions on Biomedical Circuits and Systems. Sep, 2008 | Pubmed ID: 19830273 Design and Demonstration of a Small-animal Up-conversion Imager Optics Express. Dec, 2008 | Pubmed ID: 19104605 BRAF Activation Initiates but Does Not Maintain Invasive Prostate Adenocarcinoma PloS One. 2008 | Pubmed ID: 19079609 Monofunctional Carbocyanine Dyes for Bio- and Bioorthogonal Conjugation Bioconjugate Chemistry. Dec, 2008 | Pubmed ID: 19053316 Tetrazine-based Cycloadditions: Application to Pretargeted Live Cell Imaging Bioconjugate Chemistry. Dec, 2008 | Pubmed ID: 19053305 Real-time Assessment of Inflammation and Treatment Response in a Mouse Model of Allergic Airway Inflammation The Journal of Clinical Investigation. Dec, 2008 | Pubmed ID: 19033674 Effective Use of PI3K and MEK Inhibitors to Treat Mutant Kras G12D and PIK3CA H1047R Murine Lung Cancers Nature Medicine. Dec, 2008 | Pubmed ID: 19029981 Early Photon Tomography Allows Fluorescence Detection of Lung Carcinomas and Disease Progression in Mice in Vivo Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19015534 Tracking the Inflammatory Response in Stroke in Vivo by Sensing the Enzyme Myeloperoxidase Proceedings of the National Academy of Sciences of the United States of America. Nov, 2008 | Pubmed ID: 19011099 Targeting Multiple Pathways in Gliomas with Stem Cell and Viral Delivered S-TRAIL and Temozolomide Molecular Cancer Therapeutics. Nov, 2008 | Pubmed ID: 19001440 MiR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial Cells Cancer Cell. Nov, 2008 | Pubmed ID: 18977327 Magnetic Resonance Imaging Monitors Physiological Changes with Antihedgehog Therapy in Pancreatic Adenocarcinoma Xenograft Model Pancreas. Nov, 2008 | Pubmed ID: 18953259 Regression of Drug-resistant Lung Cancer by the Combination of Rosiglitazone and Carboplatin Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2008 | Pubmed ID: 18927287 Real-time Catheter Molecular Sensing of Inflammation in Proteolytically Active Atherosclerosis Circulation. Oct, 2008 | Pubmed ID: 18852366 Simplified Syntheses of Complex Multifunctional Nanomaterials Chemical Communications (Cambridge, England). Oct, 2008 | Pubmed ID: 18830495 Integrated Nanosensors to Determine Levels and Functional Activity of Human Telomerase Neoplasia (New York, N.Y.). Oct, 2008 | Pubmed ID: 18813356 Off-resonance Angiography: a New Method to Depict Vessels--phantom and Rabbit Studies Radiology. Nov, 2008 | Pubmed ID: 18780823 Live Imaging of Cysteine-cathepsin Activity Reveals Dynamics of Focal Inflammation, Angiogenesis, and Polyp Growth PloS One. 2008 | Pubmed ID: 18698347 Noninvasive Detection of Macrophage-rich Atherosclerotic Plaque in Hyperlipidemic Rabbits Using "positive Contrast" Magnetic Resonance Imaging Journal of the American College of Cardiology. Aug, 2008 | Pubmed ID: 18672170 Near Infrared Fluorescence-based Bacteriophage Particles for Ratiometric PH Imaging Bioconjugate Chemistry. Aug, 2008 | Pubmed ID: 18666791 Human Breast Cancer Tumor Models: Molecular Imaging of Drug Susceptibility and Dosing During HER2/neu-targeted Therapy Radiology. Sep, 2008 | Pubmed ID: 18647846 Targeted Imaging of Myocardial Damage Nature Clinical Practice. Cardiovascular Medicine. Aug, 2008 | Pubmed ID: 18641609 In Vivo Quantitative Microvasculature Phenotype Imaging of Healthy and Malignant Tissues Using a Fiber-optic Confocal Laser Microprobe Translational Oncology. Jul, 2008 | Pubmed ID: 18633456 Slow Self-activation Enhances the Potency of Viridin Prodrugs Journal of Medicinal Chemistry. Aug, 2008 | Pubmed ID: 18630894 Chip-NMR Biosensor for Detection and Molecular Analysis of Cells Nature Medicine. Aug, 2008 | Pubmed ID: 18607350 Electrode Chemistry Yields a Nanoparticle-based NMR Sensor for Calcium Langmuir : the ACS Journal of Surfaces and Colloids. Jul, 2008 | Pubmed ID: 18558729 Multifunctional Magnetic Nanoparticles for Targeted Imaging and Therapy Advanced Drug Delivery Reviews. Aug, 2008 | Pubmed ID: 18508157 Perturbational Profiling of Nanomaterial Biologic Activity Proceedings of the National Academy of Sciences of the United States of America. May, 2008 | Pubmed ID: 18492802 Bimodal Viral Vectors and in Vivo Imaging Reveal the Fate of Human Neural Stem Cells in Experimental Glioma Model The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2008 | Pubmed ID: 18434519 Sensitive NMR Sensors Detect Antibodies to Influenza Angewandte Chemie (International Ed. in English). 2008 | Pubmed ID: 18428168 Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma PLoS Medicine. Apr, 2008 | Pubmed ID: 18416599 Imaging in the Era of Molecular Oncology Nature. Apr, 2008 | Pubmed ID: 18385732 Detection of Early Prostate Cancer Using a Hepsin-targeted Imaging Agent Cancer Research. Apr, 2008 | Pubmed ID: 18381435 Magnetic Nanoparticles for MR Imaging: Agents, Techniques and Cardiovascular Applications Basic Research in Cardiology. Mar, 2008 | Pubmed ID: 18324368 MR-optical Imaging of Cardiovascular Molecular Targets Basic Research in Cardiology. Mar, 2008 | Pubmed ID: 18324364 Magnetic Microparticle Aggregation for Viscosity Determination by MR Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Mar, 2008 | Pubmed ID: 18306403 Pilot Study Evaluating Use of Lymphotrophic Nanoparticle-enhanced Magnetic Resonance Imaging for Assessing Lymph Nodes in Renal Cell Cancer Urology. Apr, 2008 | Pubmed ID: 18295316 A Novel Method of Imaging Calcium Urolithiasis Using Fluorescence The Journal of Urology. Apr, 2008 | Pubmed ID: 18295253 Transglutaminase Activity in Acute Infarcts Predicts Healing Outcome and Left Ventricular Remodelling: Implications for FXIII Therapy and Antithrombin Use in Myocardial Infarction European Heart Journal. Feb, 2008 | Pubmed ID: 18276618 Activatable Magnetic Resonance Imaging Agent Reports Myeloperoxidase Activity in Healing Infarcts and Noninvasively Detects the Antiinflammatory Effects of Atorvastatin on Ischemia-reperfusion Injury Circulation. Mar, 2008 | Pubmed ID: 18268141 Myeloperoxidase-targeted Imaging of Active Inflammatory Lesions in Murine Experimental Autoimmune Encephalomyelitis Brain : a Journal of Neurology. Apr, 2008 | Pubmed ID: 18234693 A Secreted Luciferase for Ex Vivo Monitoring of in Vivo Processes Nature Methods. Feb, 2008 | Pubmed ID: 18204457 Noninvasive in Vivo Imaging of Monocyte Trafficking to Atherosclerotic Lesions Circulation. Jan, 2008 | Pubmed ID: 18172031 Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis Circulation. Jan, 2008 | Pubmed ID: 18158358 Noninvasive Imaging of Apoptosis in Cardiovascular Disease Heart Failure Reviews. Jun, 2008 | Pubmed ID: 18074226 A Highly Selective Fluorescent Probe for Thiol Bioimaging Organic Letters. Jan, 2008 | Pubmed ID: 18062694 Utility of a New Bolus-injectable Nanoparticle for Clinical Cancer Staging Neoplasia (New York, N.Y.). Dec, 2007 | Pubmed ID: 18084623 Mast Cells Are an Essential Hematopoietic Component for Polyp Development Proceedings of the National Academy of Sciences of the United States of America. Dec, 2007 | Pubmed ID: 18077429 Effect of Tumor Microenvironment Modulation on the Efficacy of Oncolytic Virus Therapy Journal of the National Cancer Institute. Dec, 2007 | Pubmed ID: 18042934 Osteogenesis Associates with Inflammation in Early-stage Atherosclerosis Evaluated by Molecular Imaging in Vivo Circulation. Dec, 2007 | Pubmed ID: 18040026 The Healing Myocardium Sequentially Mobilizes Two Monocyte Subsets with Divergent and Complementary Functions The Journal of Experimental Medicine. Nov, 2007 | Pubmed ID: 18025128 A Fluorescent Probe for the Detection of Myeloperoxidase Activity in Atherosclerosis-associated Macrophages Chemistry & Biology. Nov, 2007 | Pubmed ID: 18022561 Would Near-infrared Fluorescence Signals Propagate Through Large Human Organs for Clinical Studies? Errata Optics Letters. Sep, 2002 | Pubmed ID: 18026531 Fast Analytical Approximation for Arbitrary Geometries in Diffuse Optical Tomography Optics Letters. Apr, 2002 | Pubmed ID: 18007854 Would Near-infrared Fluorescence Signals Propagate Through Large Human Organs for Clinical Studies? Optics Letters. Mar, 2002 | Pubmed ID: 18007794 Microfluidic On-chip Capture-cycloaddition Reaksjon på reversibelt Immobilize små molekyler eller flerkomponent Profiler for Biosensor Applications Carlos Tassa1, Monty Liong1, Scott Hilderbrand1, Jason E. Sandler1, Thomas Reiner1, Edmund J. Keliher1, Ralph Weissleder1, Stanley Y. Shaw1 1Center for Systems Biology, Massachusetts General Hospital JoVE 50772 Chemistry Mesoscopic Fluorescence Tomography for In-vivo Imaging of Developing Drosophila JoVE 1510 Biology Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging JoVE 1389 Biology
Microfluidic On-chip Capture-cycloaddition Reaksjon på reversibelt Immobilize små molekyler eller flerkomponent Profiler for Biosensor Applications Carlos Tassa1, Monty Liong1, Scott Hilderbrand1, Jason E. Sandler1, Thomas Reiner1, Edmund J. Keliher1, Ralph Weissleder1, Stanley Y. Shaw1 1Center for Systems Biology, Massachusetts General Hospital JoVE 50772 Chemistry
Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging JoVE 1389 Biology
