Ramon Lopez Perez Clinical Cooperation Unit Molecular and Radiation Oncology German Cancer Research Center (DKFZ) Biography Publications Institution JoVE Articles Ramon Lopez Perez Ramon Lopez Perez is Deputy Head of the Clinical Cooperation Unit Molecular Radiation and Oncology at the German Cancer Research Center. He studied Biotechnology at the Mannheim University of Applied Sciences and graduated with a diploma in 2009. He received his Ph.D. at the Heidelberg University in 2015, with a thesis on the biological effects of carbon ion radiation in glioblastoma cells, performed at the German Cancer Research Center.The research interests of Dr. Lopez Perez range from basic research on DNA damage and repair using new technologies, such as superresolution microscopy, to translational research in the field of radiotherapy. His unit, headed by Peter Huber, investigates radiation and drug effects in tumors and normal tissue with the aim to improve the efficacy of radiotherapy, to reduce normal tissue damage and to prevent side effects, such as fibrosis. In recent years, Dr. Lopez Perez and his unit have focused their research on the response of mesenchymal stem cells and the innate immune system to radiochemotherapeutic treatments, and on the potential of connective tissue growth factor inhibition to prevent radiation-induced fibrosis. Publications Mesenchymal stem cells preserve their stem cell traits after exposure to antimetabolite chemotherapy Stem Cell Res . Aug,2019 | Pubmed ID: 31437767 Differential response of esophageal cancer cells to particle irradiation Radiat Oncol. Jul,2019 | Pubmed ID: 31286978 The therapeutic potential of mesenchymal stromal cells in the treatment of chemotherapy-induced tissue damage Stem Cell Rev Rep. Jun,2019 | Pubmed ID: 30937640 DNA damage response of clinical carbon ion versus photon radiation in human glioblastoma cells Radiother Oncol. Apr,2019 | Pubmed ID: 30935585 The current understanding of mesenchymal stem cells as potential attenuators of chemotherapy-induced toxicity Int J Cancer. Dec,2018 | Pubmed ID: 29931767 The radiation resistance of mesenchymal stem cells is independent of their tissue of origin Int J Radiat Oncol Biol Phys. Apr,2018 | Pubmed ID: 29452769 Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab Respir Res. Jan,2018 | Pubmed ID: 29347981 Human mesenchymal stem cells lose their functional properties after paclitaxel treatment Sci Rep. Jan,2018 | Pubmed ID: 29321693 Cisplatin radiosensitizes radioresistant human mesenchymal stem cells Oncotarget. Sep,2017 | Pubmed ID: 29152122 Superresolution light microscopy shows nanostructure of carbon ion radiation-induced DNA double-strand break repair foci in glioblastoma FASEB J. Aug,2016 | Pubmed ID: 27166088 Mesenchymal stem cells are sensitive to bleomycin treatment Sci Rep. May,2016 | Pubmed ID: 27215195 Mesenchymal stem cells exhibit resistance to topoisomerase inhibition Cancer Lett. Apr,2016 | Pubmed ID: 26876302 Mesenchymal stem cells maintain their defining stem cell characteristics after treatment with cisplatin Sci Rep. Jan,2016 | Pubmed ID: 26805490 Combined inhibition of TGFβ and PDGF signaling attenuates radiation-induced pulmonary fibrosis Oncoimmunology. Dec,2015 | Pubmed ID: 27467922 Mesenchymal stem cells - A new hope for radiotherapy-induced tissue damage? Cancer Lett. Oct,2015 | Pubmed ID: 26166559 Radio-resistant mesenchymal stem cells: mechanisms of resistance and potential implications for the clinic Oncotarget. Aug,2015 | Pubmed ID: 26203772 Multi-pathway inhibition as a novel strategy to attenuate radiation-induced pulmonary fibrosis Int J Radiat Oncol. Sep,2014 | Pubmed ID: Natural variation in monoterpene synthesis in kiwifruit: transcriptional regulation of terpene synthases by NAC and ETHYLENE-INTENSIVE3-like transcription factors Plant Physiol. Apr,2015 | Pubmed ID: 25649633 Mesenchymal stem cells are resistant to carbon ion radiotherapy Oncotarget. Feb,2015 | Pubmed ID: 25504442 Mesenchymal stem cells are sensitive to treatment with kinase inhibitors and ionizing radiation Strahlenther Onkol. Oct,2014 | Pubmed ID: 24863573 Mesenchymal stem cells retain their defining stem cell characteristics after exposure to ionizing radiation Int J Radiat Oncol Biol Phys. Dec,2013 | Pubmed ID: 24351412 In vivo efficacy of the histone deacetylase inhibitor suberoylanilide hydroxamic acid in combination with radiotherapy in a malignant rhabdoid tumor mouse model Radiat Oncol. Mar,2012 | Pubmed ID: 22458853 Suberoylanilide hydroxamic acid affects γH2AX expression in osteosarcoma, atypical teratoid rhabdoid tumor and normal tissue cell lines after irradiation Strahlenther Onkol. Feb,2012 | Pubmed ID: 22249335 Combination of suberoylanilide hydroxamic acid with heavy ion therapy shows promising effects in infantile sarcoma cell lines Radiat Oncol. Sep,2011 | Pubmed ID: 21933400 Characterisation of an (S)-linalool synthase from kiwifruit (Actinidia arguta) that catalyses the first committed step in the production of floral lilac compoundsFunct Plant Biol . Feb,2010 | Pubmed ID: Cell Cycle-specific Measurement of γH2AX and Apoptosis After Genotoxic Stress by Flow Cytometry Ramon Lopez Perez1,2, Franziska Münz1,2, Jonas Kroschke1,2, Jannek Brauer1,2, Nils H. Nicolay1,2,3, Peter E. Huber1,2 1CCU Molecular and Radiation Oncology, German Cancer Research Center, 2Department of Radiation Oncology, Heidelberg University Hospital, 3Department of Radiation Oncology, Freiburg University Medical Center JoVE 59968 Cancer Research
Cell Cycle-specific Measurement of γH2AX and Apoptosis After Genotoxic Stress by Flow Cytometry Ramon Lopez Perez1,2, Franziska Münz1,2, Jonas Kroschke1,2, Jannek Brauer1,2, Nils H. Nicolay1,2,3, Peter E. Huber1,2 1CCU Molecular and Radiation Oncology, German Cancer Research Center, 2Department of Radiation Oncology, Heidelberg University Hospital, 3Department of Radiation Oncology, Freiburg University Medical Center JoVE 59968 Cancer Research
