Rashmi Kothary Regenerative Medicine Program Ottawa Hospital Research Institute Biography Publications Institution JoVE Articles Rashmi Kothary has not added a biography. If you are Rashmi Kothary and would like to personalize this page please email our Author Liaison for assistance. Publications More Than a Bystander: the Contributions of Intrinsic Skeletal Muscle Defects in Motor Neuron Diseases Frontiers in Physiology. 2013 | Pubmed ID: 24391590 Transgenic Expression of Neuronal Dystonin Isoform 2 Partially Rescues the Disease Phenotype of the Dystonia Musculorum Mouse Model of Hereditary Sensory Autonomic Neuropathy VI Human Molecular Genetics. Dec, 2013 | Pubmed ID: 24381311 Early Onset Muscle Weakness and Disruption of Muscle Proteins in Mouse Models of Spinal Muscular Atrophy Skeletal Muscle. 2013 | Pubmed ID: 24119341 Supraphysiological Expression of Survival Motor Neuron Protein from an Adenovirus Vector Does Not Adversely Affect Cell Function Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. Aug, 2013 | Pubmed ID: 23859020 Six1 Regulates MyoD Expression in Adult Muscle Progenitor Cells PloS One. 2013 | Pubmed ID: 23840772 Distinct Roles for Ste20-like Kinase SLK in Muscle Function and Regeneration Skeletal Muscle. 2013 | Pubmed ID: 23815977 Integrin-Linked Kinase Regulates Process Extension in Oligodendrocytes Via Control of Actin Cytoskeletal Dynamics The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2013 | Pubmed ID: 23739974 Cellular and Molecular Biology of Neuronal Dystonin International Review of Cell and Molecular Biology. 2013 | Pubmed ID: 23273860 A Novel Function for the Survival Motoneuron Protein As a Translational Regulator Human Molecular Genetics. Feb, 2013 | Pubmed ID: 23136128 Defects in Neuromuscular Junction Remodelling in the Smn(2B/-) Mouse Model of Spinal Muscular Atrophy Neurobiology of Disease. Aug, 2012 | Pubmed ID: 22960106 Glucose Metabolism and Pancreatic Defects in Spinal Muscular Atrophy Annals of Neurology. Aug, 2012 | Pubmed ID: 22926856 A Novel Role for the Cytoskeletal Linker Protein Dystonin in the Maintenance of Microtubule Stability and the Regulation of ER-Golgi Transport Bioarchitecture. Jan, 2012 | Pubmed ID: 22754620 The Rb/E2F Pathway Modulates Neurogenesis Through Direct Regulation of the Dlx1/Dlx2 Bigene Cluster The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2012 | Pubmed ID: 22699903 Untethering the Nuclear Envelope and Cytoskeleton: Biologically Distinct Dystonias Arising from a Common Cellular Dysfunction International Journal of Cell Biology. 2012 | Pubmed ID: 22611399 Microtubule Stability, Golgi Organization, and Transport Flux Require Dystonin-a2-MAP1B Interaction The Journal of Cell Biology. Mar, 2012 | Pubmed ID: 22412020 Fasudil Improves Survival and Promotes Skeletal Muscle Development in a Mouse Model of Spinal Muscular Atrophy BMC Medicine. 2012 | Pubmed ID: 22397316 A Novel Whole-cell Lysate Kinase Assay Identifies Substrates of the P38 MAPK in Differentiating Myoblasts Skeletal Muscle. 2012 | Pubmed ID: 22394512 Neuronal Dystonin Isoform 2 is a Mediator of Endoplasmic Reticulum Structure and Function Molecular Biology of the Cell. Feb, 2012 | Pubmed ID: 22190742 A Critical Smn Threshold in Mice Dictates Onset of an Intermediate Spinal Muscular Atrophy Phenotype Associated with a Distinct Neuromuscular Junction Pathology Neuromuscular Disorders : NMD. Nov, 2011 | Pubmed ID: 22071333 Use of Cre/loxP Recombination to Swap Cell Binding Motifs on the Adenoviral Capsid Protein IX Virology. Nov, 2011 | Pubmed ID: 21968200 MAP1B and Clathrin Are Novel Interacting Partners of the Giant Cyto-linker Dystonin Journal of Proteome Research. Nov, 2011 | Pubmed ID: 21936565 The Myogenic Kinome: Protein Kinases Critical to Mammalian Skeletal Myogenesis Skeletal Muscle. 2011 | Pubmed ID: 21902831 Motor Unit Abnormalities in Dystonia Musculorum Mice PloS One. 2011 | Pubmed ID: 21698255 Integrin Signaling in Oligodendrocytes and Its Importance in CNS Myelination Journal of Signal Transduction. 2011 | Pubmed ID: 21637375 The Proteolipid Protein Promoter Drives Expression Outside of the Oligodendrocyte Lineage During Embryonic and Early Postnatal Development PloS One. 2011 | Pubmed ID: 21572962 Biochemical, Proteomic, Structural, and Thermodynamic Characterizations of Integrin-linked Kinase (ILK): Cross-validation of the Pseudokinase The Journal of Biological Chemistry. Jun, 2011 | Pubmed ID: 21524996 Wnt11 Promotes Cardiomyocyte Development by Caspase-mediated Suppression of Canonical Wnt Signals Molecular and Cellular Biology. Jan, 2011 | Pubmed ID: 21041481 Smn Deficiency Causes Neuritogenesis and Neurogenesis Defects in the Retinal Neurons of a Mouse Model of Spinal Muscular Atrophy Developmental Neurobiology. Feb, 2011 | Pubmed ID: 20862739 Mouse Survival Motor Neuron Alleles That Mimic SMN2 Splicing and Are Inducible Rescue Embryonic Lethality Early in Development but Not Late PloS One. 2010 | Pubmed ID: 21249120 Retargeting of Adenovirus Vectors Through Genetic Fusion of a Single-chain or Single-domain Antibody to Capsid Protein IX Journal of Virology. Oct, 2010 | Pubmed ID: 20631131 Hearts of Dystonia Musculorum Mice Display Normal Morphological and Histological Features but Show Signs of Cardiac Stress PloS One. 2010 | Pubmed ID: 20209123 Identification of Novel Interacting Protein Partners of SMN Using Tandem Affinity Purification Journal of Proteome Research. Apr, 2010 | Pubmed ID: 20201562 Production of Mouse Chimeras by Injection of Embryonic Stem Cells into the Perivitelline Space of One-cell Stage Embryos Transgenic Research. Dec, 2010 | Pubmed ID: 20143261 Rho-kinase Inactivation Prolongs Survival of an Intermediate SMA Mouse Model Human Molecular Genetics. Apr, 2010 | Pubmed ID: 20097679 Neurodevelopmental Consequences of Smn Depletion in a Mouse Model of Spinal Muscular Atrophy Journal of Neuroscience Research. Jan, 2010 | Pubmed ID: 19642194 Mice with Podocyte-specific Overexpression of Wild Type Alpha-actinin-4 Are Healthy Controls for K256E-alpha-actinin-4 Mutant Transgenic Mice Transgenic Research. Apr, 2010 | Pubmed ID: 19585264 Cdx2 Regulation of Posterior Development Through Non-Hox Targets Development (Cambridge, England). Dec, 2009 | Pubmed ID: 19906845 Bin1 SRC Homology 3 Domain Acts As a Scaffold for Myofiber Sarcomere Assembly The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19633357 SMN, Profilin IIa and Plastin 3: a Link Between the Deregulation of Actin Dynamics and SMA Pathogenesis Molecular and Cellular Neurosciences. Sep, 2009 | Pubmed ID: 19497369 The Role of Conserved Water Molecules in the Catalytic Domain of Protein Kinases Proteins. Aug, 2009 | Pubmed ID: 19425109 Dystonin/Bpag1 is a Necessary Endoplasmic Reticulum/nuclear Envelope Protein in Sensory Neurons Experimental Cell Research. Sep, 2008 | Pubmed ID: 18638474 A SMNDelta7 Read-through Product Confers Functionality to the SMNDelta7 Protein Neuroscience Letters. Sep, 2008 | Pubmed ID: 18601974 Neurodevelopmental Abnormalities in Neurosphere-derived Neural Stem Cells from SMN-depleted Mice Journal of Neuroscience Research. Oct, 2008 | Pubmed ID: 18521935 Conservation, Variability and the Modeling of Active Protein Kinases PloS One. 2007 | Pubmed ID: 17912359 Smn Depletion Alters Profilin II Expression and Leads to Upregulation of the RhoA/ROCK Pathway and Defects in Neuronal Integrity Journal of Molecular Neuroscience : MN. 2007 | Pubmed ID: 17873296 Dystonin/Bpag1--a Link to What? Cell Motility and the Cytoskeleton. Dec, 2007 | Pubmed ID: 17849487 Re: "A Possible Cellular Mechanism of Neuronal Loss in the Dorsal Root Ganglia of Dystonia Musculorum (dt) Mice" Journal of Neuropathology and Experimental Neurology. Mar, 2007 | Pubmed ID: 17356386 Disruption of MEF2 Activity in Cardiomyoblasts Inhibits Cardiomyogenesis Journal of Cell Science. Oct, 2006 | Pubmed ID: 17003108 The Mouse Dystrophin Muscle Promoter/enhancer Drives Expression of Mini-dystrophin in Transgenic Mdx Mice and Rescues the Dystrophy in These Mice Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2006 | Pubmed ID: 16807118 Dominant-negative Beta1 Integrin Mice Have Region-specific Myelin Defects Accompanied by Alterations in MAPK Activity Glia. Jun, 2006 | Pubmed ID: 16575886 Trafficking of Macromolecules and Organelles in Cultured Dystonia Musculorum Sensory Neurons is Normal The Journal of Comparative Neurology. Feb, 2006 | Pubmed ID: 16374799 A Bpag1 Isoform Involved in Cytoskeletal Organization Surrounding the Nucleus Experimental Cell Research. Jan, 2006 | Pubmed ID: 16289082 Genetic Alterations at the Bpag1 Locus in Dt Mice and Their Impact on Transcript Expression Mammalian Genome : Official Journal of the International Mammalian Genome Society. Dec, 2005 | Pubmed ID: 16341670 Hypomorphic Smn Knockdown C2C12 Myoblasts Reveal Intrinsic Defects in Myoblast Fusion and Myotube Morphology Experimental Cell Research. Nov, 2005 | Pubmed ID: 16219305 Characterization of Liver Histopathology in a Transgenic Mouse Model Expressing Genotype 1a Hepatitis C Virus Core and Envelope Proteins 1 and 2 The Journal of General Virology. Aug, 2005 | Pubmed ID: 16033966 A 1.3 Kb Promoter Fragment Confers Spatial and Temporal Expression of Utrophin A MRNA in Mouse Skeletal Muscle Fibers Neuromuscular Disorders : NMD. Jun, 2005 | Pubmed ID: 15907291 Physiological Maturation of Photoreceptors Depends on the Voltage-gated Sodium Channel NaV1.6 (Scn8a) The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2005 | Pubmed ID: 15901786 Active Kinase Proteome Screening Reveals Novel Signal Complexity in Cardiomyopathy Molecular & Cellular Proteomics : MCP. May, 2005 | Pubmed ID: 15722372 Spectrin Repeat Proteins in the Nucleus BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Feb, 2005 | Pubmed ID: 15666356 Chx10 Repression of Mitf is Required for the Maintenance of Mammalian Neuroretinal Identity Development (Cambridge, England). Jan, 2005 | Pubmed ID: 15576400 The Mouse Dystrophin Muscle Enhancer-1 Imparts Skeletal Muscle, but Not Cardiac Muscle, Expression Onto the Dystrophin Purkinje Promoter in Transgenic Mice Human Molecular Genetics. Nov, 2004 | Pubmed ID: 15385445 Bpag1 Localization to Actin Filaments and to the Nucleus is Regulated by Its N-terminus Journal of Cell Science. Nov, 2003 | Pubmed ID: 14576348 Impaired Fast Axonal Transport in Neurons of the Sciatic Nerves from Dystonia Musculorum Mice Journal of Neurochemistry. Aug, 2003 | Pubmed ID: 12859670 Development of a Gene Therapy Strategy for the Restoration of Survival Motor Neuron Protein Expression: Implications for Spinal Muscular Atrophy Therapy Human Gene Therapy. Jan, 2003 | Pubmed ID: 12614569 Transgenic Expression of the Activating Natural Killer Receptor Ly49H Confers Resistance to Cytomegalovirus in Genetically Susceptible Mice The Journal of Experimental Medicine. Feb, 2003 | Pubmed ID: 12591908 Differentiation Potential of Primary Myogenic Cells Derived from Skeletal Muscle of Dystonia Musculorum Mice Differentiation; Research in Biological Diversity. Aug, 2002 | Pubmed ID: 12190986 Characterization of Transgene Expression and Cre Recombinase Activity in a Panel of Thy-1 Promoter-Cre Transgenic Mice Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jun, 2002 | Pubmed ID: 12112467 Alterations in Myelination in the Central Nervous System of Dystonia Musculorum Mice Journal of Neuroscience Research. Jul, 2002 | Pubmed ID: 12111805 Mouse Dystrophin Enhancer Preferentially Targets LacZ Expression in Skeletal and Cardiac Muscle Developmental Dynamics : an Official Publication of the American Association of Anatomists. May, 2002 | Pubmed ID: 11984871 SRp30c-dependent Stimulation of Survival Motor Neuron (SMN) Exon 7 Inclusion is Facilitated by a Direct Interaction with HTra2 Beta 1 Human Molecular Genetics. Mar, 2002 | Pubmed ID: 11875052 Neurodevelopmental Defects Resulting from ATRX Overexpression in Transgenic Mice Human Molecular Genetics. Feb, 2002 | Pubmed ID: 11823444 Рассечение мышц Transversus Abdominis для анализа нервно-мышечной развязки Lyndsay Murray1, Thomas H Gillingwater2, Rashmi Kothary1 1Regenerative Medicine Program, Ottawa Hospital Research Institute, 2Centre for Integrative Physiology, University of Edinburgh JoVE 51162 Neuroscience Вывод Обогащенный олигодендроцитов культур и олигодендроцитов / Нейрон Myelinating сотрудничества культур от Послеродовые мышей тканей Ryan W. O'Meara1,2, Scott D. Ryan1, Holly Colognato3, Rashmi Kothary1,2,4 1Regenerative Medicine Program, Ottawa Hospital Research Institute, 2Department of Cellular and Molecular Medicine, University of Ottawa, 3Department of Pharmacological Sciences, Stony Brook University, 4Department of Medicine, University of Ottawa JoVE 3324 Neuroscience
Рассечение мышц Transversus Abdominis для анализа нервно-мышечной развязки Lyndsay Murray1, Thomas H Gillingwater2, Rashmi Kothary1 1Regenerative Medicine Program, Ottawa Hospital Research Institute, 2Centre for Integrative Physiology, University of Edinburgh JoVE 51162 Neuroscience
Вывод Обогащенный олигодендроцитов культур и олигодендроцитов / Нейрон Myelinating сотрудничества культур от Послеродовые мышей тканей Ryan W. O'Meara1,2, Scott D. Ryan1, Holly Colognato3, Rashmi Kothary1,2,4 1Regenerative Medicine Program, Ottawa Hospital Research Institute, 2Department of Cellular and Molecular Medicine, University of Ottawa, 3Department of Pharmacological Sciences, Stony Brook University, 4Department of Medicine, University of Ottawa JoVE 3324 Neuroscience
