Ravi Mahadeva Department of Respiratory Medicine University of Cambridge - Addenbrooke's Hospital Biography Publications Institution JoVE Articles Ravi Mahadeva has not added a biography. If you are Ravi Mahadeva and would like to personalize this page please email our Author Liaison for assistance. Publications Pneumothorax After Endobronchial Valve Treatment: No Drain, No Gain? Respiration; International Review of Thoracic Diseases. 2014 | Pubmed ID: 24903903 Acute-phase Protein α1-antitrypsin--a Novel Regulator of Angiopoietin-like Protein 4 Transcription and Secretion Journal of Immunology (Baltimore, Md. : 1950). Jun, 2014 | Pubmed ID: 24760148 Z α1-antitrypsin Confers a Proinflammatory Phenotype That Contributes to Chronic Obstructive Pulmonary Disease American Journal of Respiratory and Critical Care Medicine. Apr, 2014 | Pubmed ID: 24592811 Anti-inflammatory and Immunomodulatory Properties of α1-antitrypsin Without Inhibition of Elastase Proceedings of the National Academy of Sciences of the United States of America. Sep, 2013 | Pubmed ID: 23975926 Preventing and Reversing the Cellular Consequences of Z Alpha-1 Antitrypsin Accumulation by Targeting S4A Journal of Hepatology. Jul, 2012 | Pubmed ID: 22425623 The Serpinopathies Studying Serpin Polymerization in Vivo Methods in Enzymology. 2011 | Pubmed ID: 22078544 Targeting Serpins in High-throughput and Structure-based Drug Design Methods in Enzymology. 2011 | Pubmed ID: 22078534 Acute-phase Protein α1-antitrypsin Inhibits Neutrophil Calpain I and Induces Random Migration Molecular Medicine (Cambridge, Mass.). Sep-Oct, 2011 | Pubmed ID: 21494752 Oxidation of Z α1-antitrypsin by Cigarette Smoke Induces Polymerization: a Novel Mechanism of Early-onset Emphysema American Journal of Respiratory Cell and Molecular Biology. Aug, 2011 | Pubmed ID: 20971880 Tonsillar Cyst: an Unusual Cause of Ventilatory Failure JRSM Short Reports. 2010 | Pubmed ID: 21103137 Cholesterol Rich Lipid Raft Microdomains Are Gateway for Acute Phase Protein, SERPINA1 The International Journal of Biochemistry & Cell Biology. Sep, 2010 | Pubmed ID: 20561599 Oxidized {alpha}1-antitrypsin Stimulates the Release of Monocyte Chemotactic Protein-1 from Lung Epithelial Cells: Potential Role in Emphysema American Journal of Physiology. Lung Cellular and Molecular Physiology. Aug, 2009 | Pubmed ID: 19525388 Small-molecule Peptides Inhibit Z Alpha1-antitrypsin Polymerization Journal of Cellular and Molecular Medicine. Aug, 2009 | Pubmed ID: 19120695 Acupuncture Induced Pneumothorax - a Case Report Acupuncture in Medicine : Journal of the British Medical Acupuncture Society. Sep, 2008 | Pubmed ID: 18818566 Pulmonary Fibrosis Secondary to Siderosis Causing Symptomatic Respiratory Disease: a Case Report Journal of Medical Case Reports. 2008 | Pubmed ID: 18681950 Sirolimus-induced Pulmonary Hypersensitivity Associated with a CD4 T-cell Infiltrate Chest. Jun, 2006 | Pubmed ID: 16778294 Identification of a 4-mer Peptide Inhibitor That Effectively Blocks the Polymerization of Pathogenic Z Alpha1-antitrypsin American Journal of Respiratory Cell and Molecular Biology. Nov, 2006 | Pubmed ID: 16778151 Animal Models of Pulmonary Emphysema Current Drug Targets. Inflammation and Allergy. Dec, 2005 | Pubmed ID: 17305522 Polymers of Z Alpha1-antitrypsin Co-localize with Neutrophils in Emphysematous Alveoli and Are Chemotactic in Vivo The American Journal of Pathology. Feb, 2005 | Pubmed ID: 15681822 Inhibiting Polymerization: New Therapeutic Strategies for Z Alpha1-antitrypsin-related Emphysema American Journal of Respiratory Cell and Molecular Biology. Aug, 2004 | Pubmed ID: 15016619 Targeting a Surface Cavity of Alpha 1-antitrypsin to Prevent Conformational Disease The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12807889 Alpha(1)-antitrypsin Deficiency, Liver Disease and Emphysema The International Journal of Biochemistry & Cell Biology. Jul, 2003 | Pubmed ID: 12672469 Alpha1-antitrypsin Polymerization and the Serpinopathies: Pathobiology and Prospects for Therapy The Journal of Clinical Investigation. Dec, 2002 | Pubmed ID: 12464660 Polymers of Alpha(1)-antitrypsin Are Chemotactic for Human Neutrophils: a New Paradigm for the Pathogenesis of Emphysema American Journal of Respiratory Cell and Molecular Biology. Jun, 2002 | Pubmed ID: 12034572 Mutant Neuroserpin (S49P) That Causes Familial Encephalopathy with Neuroserpin Inclusion Bodies is a Poor Proteinase Inhibitor and Readily Forms Polymers in Vitro The Journal of Biological Chemistry. May, 2002 | Pubmed ID: 11880376 6-mer Peptide Selectively Anneals to a Pathogenic Serpin Conformation and Blocks Polymerization. Implications for the Prevention of Z Alpha(1)-antitrypsin-related Cirrhosis The Journal of Biological Chemistry. Mar, 2002 | Pubmed ID: 11773044 Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice Maria E. Laucho-Contreras1, Katherine L. Taylor1, Ravi Mahadeva2, Steve S. Boukedes3, Caroline A. Owen1,4 1Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital - Harvard Medical School, 2Department of Respiratory Medicine, University of Cambridge - Addenbrooke's Hospital, 3Lung Transplant Program, Brigham and Women's Hospital - Harvard Medical School, 4COPD and IPF Programs, Lovelace Respiratory Research Institute JoVE 52236 Medicine
Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice Maria E. Laucho-Contreras1, Katherine L. Taylor1, Ravi Mahadeva2, Steve S. Boukedes3, Caroline A. Owen1,4 1Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital - Harvard Medical School, 2Department of Respiratory Medicine, University of Cambridge - Addenbrooke's Hospital, 3Lung Transplant Program, Brigham and Women's Hospital - Harvard Medical School, 4COPD and IPF Programs, Lovelace Respiratory Research Institute JoVE 52236 Medicine
