Ravindra Majeti Biography Publications JoVE Articles Ravindra Majeti has not added a biography. If you are Ravindra Majeti and would like to personalize this page please email our Author Liaison for assistance. Publications Convergent Epigenetic Evolution Drives Relapse in Acute Myeloid Leukemia BioRxiv : the Preprint Server for Biology. Oct, 2023 | Pubmed ID: 37873452 Immune Surveillance of Acute Myeloid Leukemia Is Mediated by HLA-Presented Antigens on Leukemia Progenitor Cells Blood Cancer Discovery. Nov, 2023 | Pubmed ID: 37847741 RUNX1 Loss Renders Hematopoietic and Leukemic Cells Dependent on IL-3 and Sensitive to JAK Inhibition The Journal of Clinical Investigation. Oct, 2023 | Pubmed ID: 37581927 Patient-Derived IPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia Blood Cancer Discovery. Jul, 2023 | Pubmed ID: 37067914 Current Landscape of Translational and Clinical Research in Myelodysplastic Syndromes/neoplasms (MDS): Proceedings from the 1 International Workshop on MDS (iwMDS) Of the International Consortium for MDS (icMDS) Blood Reviews. Mar, 2023 | Pubmed ID: 36934059 MYC-driven Synthesis of Siglec Ligands is a Glycoimmune Checkpoint Proceedings of the National Academy of Sciences of the United States of America. Mar, 2023 | Pubmed ID: 36897988 Reprogramming Cancer into Antigen Presenting Cells As a Novel Immunotherapy Cancer Discovery. Mar, 2023 | Pubmed ID: 36856575 Dysregulated Lipid Synthesis by Oncogenic IDH1 Mutation Is a Targetable Synthetic Lethal Vulnerability Cancer Discovery. Feb, 2023 | Pubmed ID: 36355448 Single-cell Genomics in AML: Extending the Frontiers of AML Research Blood. Jan, 2023 | Pubmed ID: 35926108 An Agenda to Advance Research in MDS: A TOP 10 Priority List from the First International Workshop in MDS (iwMDS) Blood Advances. Oct, 2022 | Pubmed ID: 36260702 Transition to a Mesenchymal State in Neuroblastoma Confers Resistance to Anti-GD2 Antibody Via Reduced Expression of ST8SIA1 Nature Cancer. Aug, 2022 | Pubmed ID: 35817829 The Cell Type-Specific 5hmC Landscape and Dynamics of Healthy Human Hematopoiesis and TET2-Mutant Preleukemia Blood Cancer Discovery. Jul, 2022 | Pubmed ID: 35532363 CytofIn Enables Integrated Analysis of Public Mass Cytometry Datasets Using Generalized Anchors Nature Communications. Feb, 2022 | Pubmed ID: 35177627 Anti-GD2 Synergizes with CD47 Blockade to Mediate Tumor Eradication Nature Medicine. Feb, 2022 | Pubmed ID: 35027753 Clonal Architecture Predicts Clinical Outcomes and Drug Sensitivity in Acute Myeloid Leukemia Nature Communications. Dec, 2021 | Pubmed ID: 34903734 NOT-Gated CD93 CAR T Cells Effectively Target AML with Minimized Endothelial Cross-Reactivity Blood Cancer Discovery. Nov, 2021 | Pubmed ID: 34778803 Monocytic Differentiation and AHR Signaling As Primary Nodes of BET Inhibitor Response in Acute Myeloid Leukemia Blood Cancer Discovery. Sep, 2021 | Pubmed ID: 34568834 Clonal Hematopoiesis: From Mechanisms to Clinical Intervention Cancer Discovery. Dec, 2021 | Pubmed ID: 34407958 The TRACE-Seq Method Tracks Recombination Alleles and Identifies Clonal Reconstitution Dynamics of Gene Targeted Human Hematopoietic Stem Cells Nature Communications. Jan, 2021 | Pubmed ID: 33473139 Targeting LSCs: Peeling Back the Curtain on the Metabolic Complexities of AML Cell Stem Cell. Nov, 2020 | Pubmed ID: 33157042 CD34 Expression Does Not Correlate with Immunophenotypic Stem Cell or Progenitor Content in Human Cord Blood Products Blood Advances. Nov, 2020 | Pubmed ID: 33136125 Integrated Analysis of Patient Samples Identifies Biomarkers for Venetoclax Efficacy and Combination Strategies in Acute Myeloid Leukemia Nature Cancer. Aug, 2020 | Pubmed ID: 33123685 Targeting Macrophage Checkpoint Inhibitor SIRPα for Anticancer Therapy JCI Insight. Jun, 2020 | Pubmed ID: 32427583 IL-6 Blockade Reverses Bone Marrow Failure Induced by Human Acute Myeloid Leukemia Science Translational Medicine. Apr, 2020 | Pubmed ID: 32269167 A Dysregulated DNA Methylation Landscape Linked to Gene Expression in MLL-Rearranged AML Epigenetics. Aug, 2020 | Pubmed ID: 32114880 The Phosphatidylethanolamine Biosynthesis Pathway Provides a New Target for Cancer Chemotherapy Journal of Hepatology. Apr, 2020 | Pubmed ID: 31760071 Sufficiency for Inducible Caspase-9 Safety Switch in Human Pluripotent Stem Cells and Disease Cells Gene Therapy. Nov, 2019 | Pubmed ID: 32704085 Use of Polyvinyl Alcohol for Chimeric Antigen Receptor T-cell Expansion Experimental Hematology. Dec, 2019 | Pubmed ID: 31874780 Single-cell Multiomic Analysis Identifies Regulatory Programs in Mixed-phenotype Acute Leukemia Nature Biotechnology. Dec, 2019 | Pubmed ID: 31792411 Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index Scientific Reports. Nov, 2019 | Pubmed ID: 31727951 Single-cell Lineage Tracing by Endogenous Mutations Enriched in Transposase Accessible Mitochondrial DNA ELife. Apr, 2019 | Pubmed ID: 30958261 No Matter How You Splice It, RBM39 Inhibition Targets Spliceosome Mutant AML Cancer Cell. Mar, 2019 | Pubmed ID: 30889374 First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Apr, 2019 | Pubmed ID: 30811285 Data Mining for Mutation-specific Targets in Acute Myeloid Leukemia Leukemia. Apr, 2019 | Pubmed ID: 30728456 Induced Pluripotent Stem Cell Modeling of Malignant Hematopoiesis Experimental Hematology. Mar, 2019 | Pubmed ID: 30659850 CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2019 | Pubmed ID: 30655315 Targeting Cancer Stemness in the Clinic: From Hype to Hope Cell Stem Cell. 01, 2019 | Pubmed ID: 30595497 Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation Cell. May, 2018 | Pubmed ID: 29706549 Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal EBioMedicine. Dec, 2017 | Pubmed ID: 29203377 Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia Frontiers in Oncology. 2017 | Pubmed ID: 29164062 Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist Cancer Discovery. Oct, 2017 | Pubmed ID: 28729405 Systematic Discovery of Mutation-specific Synthetic Lethals by Mining Pan-cancer Human Primary Tumor Data Nature Communications. May, 2017 | Pubmed ID: 28561042 Optimizing Next-Generation AML Therapy: Activity of Mutant IDH2 Inhibitor AG-221 in Preclinical Models Cancer Discovery. May, 2017 | Pubmed ID: 28461409 Biology and Relevance of Human Acute Myeloid Leukemia Stem Cells Blood. Mar, 2017 | Pubmed ID: 28159741 The Role of Mutations in the Cohesin Complex in Acute Myeloid Leukemia International Journal of Hematology. Jan, 2017 | Pubmed ID: 27796738 Sticking It to the Niche: CD98 Mediates Critical Adhesive Signals in AML Cancer Cell. Nov, 2016 | Pubmed ID: 27846387 CRISPR/Cas9 β-globin Gene Targeting in Human Haematopoietic Stem Cells Nature. Nov, 2016 | Pubmed ID: 27820943 Autophagy Mediates Proteolysis of NPM1 and HEXIM1 and Sensitivity to BET Inhibition in AML Cells Oncotarget. Nov, 2016 | Pubmed ID: 27732946 Lineage-specific and Single-cell Chromatin Accessibility Charts Human Hematopoiesis and Leukemia Evolution Nature Genetics. Oct, 2016 | Pubmed ID: 27526324 Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity PloS One. 2016 | Pubmed ID: 27428079 Burning Fat Fuels Leukemic Stem Cell Heterogeneity Cell Stem Cell. Jul, 2016 | Pubmed ID: 27392217 CD47-blocking Immunotherapies Stimulate Macrophage-mediated Destruction of Small-cell Lung Cancer The Journal of Clinical Investigation. Jul, 2016 | Pubmed ID: 27294525 A Humanized Bone Marrow Ossicle Xenotransplantation Model Enables Improved Engraftment of Healthy and Leukemic Human Hematopoietic Cells Nature Medicine. Jul, 2016 | Pubmed ID: 27213817 ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia Cancer Discovery. Jul, 2016 | Pubmed ID: 27154821 SIRPα-Antibody Fusion Proteins Selectively Bind and Eliminate Dual Antigen-Expressing Tumor Cells Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2016 | Pubmed ID: 27126995 Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation Cell Stem Cell. Dec, 2015 | Pubmed ID: 26607380 Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential PloS One. 2015 | Pubmed ID: 26390038 Biology and Clinical Relevance of Acute Myeloid Leukemia Stem Cells Seminars in Hematology. Jul, 2015 | Pubmed ID: 26111462 Reply to Fišer Et Al.: Myeloid Reprogramming of Ph+ B-ALL: A Potential Therapeutic Strategy Proceedings of the National Academy of Sciences of the United States of America. Jul, 2015 | Pubmed ID: 26069209 Reprogramming of Primary Human Philadelphia Chromosome-positive B Cell Acute Lymphoblastic Leukemia Cells into Nonleukemic Macrophages Proceedings of the National Academy of Sciences of the United States of America. Mar, 2015 | Pubmed ID: 25775523 Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands Cell. Mar, 2015 | Pubmed ID: 25728669 Isocitrate Dehydrogenase 1 and 2 Mutations Induce BCL-2 Dependence in Acute Myeloid Leukemia Nature Medicine. Feb, 2015 | Pubmed ID: 25599133 Mutant WT1 is Associated with DNA Hypermethylation of PRC2 Targets in AML and Responds to EZH2 Inhibition Blood. Jan, 2015 | Pubmed ID: 25398938 Clonal Evolution of Pre-leukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia Best Practice & Research. Clinical Haematology. 2014 | Pubmed ID: 25455271 Pre-leukemic Evolution of Hematopoietic Stem Cells: the Importance of Early Mutations in Leukemogenesis Leukemia. Dec, 2014 | Pubmed ID: 25005245 Transient Expression of Bcl6 is Sufficient for Oncogenic Function and Induction of Mature B-cell Lymphoma Nature Communications. Jun, 2014 | Pubmed ID: 24887457 Interaction of TIF-90 and Filamin A in the Regulation of RRNA Synthesis in Leukemic Cells Blood. Jul, 2014 | Pubmed ID: 24850755 Centrosome-kinase Fusions Promote Oncogenic Signaling and Disrupt Centrosome Function in Myeloproliferative Neoplasms PloS One. 2014 | Pubmed ID: 24658090 Preleukemic Mutations in Human Acute Myeloid Leukemia Affect Epigenetic Regulators and Persist in Remission Proceedings of the National Academy of Sciences of the United States of America. Feb, 2014 | Pubmed ID: 24550281 Role of DNMT3A, TET2, and IDH1/2 Mutations in Pre-leukemic Stem Cells in Acute Myeloid Leukemia International Journal of Hematology. Dec, 2013 | Pubmed ID: 23949914 The Cancer Stem Cell Model: B Cell Acute Lymphoblastic Leukaemia Breaks the Mould EMBO Molecular Medicine. Jan, 2013 | Pubmed ID: 23229878 Clonal Evolution of Acute Leukemia Genomes Oncogene. Jan, 2013 | Pubmed ID: 22349821 Clonal Evolution of Preleukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia Science Translational Medicine. Aug, 2012 | Pubmed ID: 22932223 Antibody Therapy Targeting the CD47 Protein is Effective in a Model of Aggressive Metastatic Leiomyosarcoma Proceedings of the National Academy of Sciences of the United States of America. Apr, 2012 | Pubmed ID: 22451919 The CD47-SIRPα Pathway in Cancer Immune Evasion and Potential Therapeutic Implications Current Opinion in Immunology. Apr, 2012 | Pubmed ID: 22310103 Programmed Cell Removal: a New Obstacle in the Road to Developing Cancer Nature Reviews. Cancer. Jan, 2012 | Pubmed ID: 22158022 Treatment Advances Have Not Improved the Early Death Rate in Acute Promyelocytic Leukemia Haematologica. Jan, 2012 | Pubmed ID: 21993679 Surprise! HSC Are Aberrant in Chronic Lymphocytic Leukemia Cancer Cell. Aug, 2011 | Pubmed ID: 21840478 Prospective Separation of Normal and Leukemic Stem Cells Based on Differential Expression of TIM3, a Human Acute Myeloid Leukemia Stem Cell Marker Proceedings of the National Academy of Sciences of the United States of America. Mar, 2011 | Pubmed ID: 21383193 Single-cell Phospho-specific Flow Cytometric Analysis Demonstrates Biochemical and Functional Heterogeneity in Human Hematopoietic Stem and Progenitor Compartments Blood. Apr, 2011 | Pubmed ID: 21357764 Human Acute Myelogenous Leukemia Stem Cells Revisited: There's More Than Meets the Eye Cancer Cell. Jan, 2011 | Pubmed ID: 21251611 Monoclonal Antibody Therapy Directed Against Human Acute Myeloid Leukemia Stem Cells Oncogene. Mar, 2011 | Pubmed ID: 21076471 Association of a Leukemic Stem Cell Gene Expression Signature with Clinical Outcomes in Acute Myeloid Leukemia JAMA. Dec, 2010 | Pubmed ID: 21177505 Metastatic Cancer Stem Cells: an Opportunity for Improving Cancer Treatment? Cell Stem Cell. Jun, 2010 | Pubmed ID: 20569685 CD47 is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells Cell. Jul, 2009 | Pubmed ID: 19632179 CD47 is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis Cell. Jul, 2009 | Pubmed ID: 19632178 The Adhesion Molecule Esam1 is a Novel Hematopoietic Stem Cell Marker Stem Cells (Dayton, Ohio). Mar, 2009 | Pubmed ID: 19074415 Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis JoVE 65874 Medicine Engineering oncogene heterozygote gain-of-function mutaties in menselijke hematopoietische stam- en voorlopercellen Tommaso Sconocchia1, Johannes Foßelteder1, Thomas Köhnke2, Ravindra Majeti2, Andreas Reinisch1,3 1Division of Hematology, Department of Internal Medicine, Medical University of Graz, 2Division of Hematology, Stanford Cancer Institute, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 3Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz JoVE 64558 Cancer Research
Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis JoVE 65874 Medicine
Engineering oncogene heterozygote gain-of-function mutaties in menselijke hematopoietische stam- en voorlopercellen Tommaso Sconocchia1, Johannes Foßelteder1, Thomas Köhnke2, Ravindra Majeti2, Andreas Reinisch1,3 1Division of Hematology, Department of Internal Medicine, Medical University of Graz, 2Division of Hematology, Stanford Cancer Institute, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 3Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz JoVE 64558 Cancer Research
