In JoVE (1)
Other Publications (0)
Articles by Richard I. Morimoto in JoVE
Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans Carmen I. Nussbaum-Krammer1, Mário F. Neto1, Renée M. Brielmann1, Jesper S. Pedersen1, Richard I. Morimoto1 1Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University Prion-like propagation of protein aggregates has recently emerged as being implicated in many neurodegenerative diseases. The goal of this protocol is to describe, how to use the nematode C. elegans as a model system to monitor protein spreading and to investigate prion-like phenomena.