Richard W. Vachet Department of Chemistry University of Massachusetts Amherst Biography Publications Institution JoVE Articles Richard W. Vachet has not added a biography. If you are Richard W. Vachet and would like to personalize this page please email our Author Liaison for assistance. Publications Enhanced and Selective MALDI-MS Detection of Peptides Via the Nanomaterial-Dependent Coffee Ring Effect Journal of the American Society for Mass Spectrometry. May, 2021 | Pubmed ID: 34048651 A Programmable Chemical Switch Based on Triggerable Michael Acceptors Chemical Science. Jan, 2020 | Pubmed ID: 34123298 MEMBRANE PROTEIN STRUCTURES AND INTERACTIONS FROM COVALENT LABELING COUPLED WITH MASS SPECTROMETRY Mass Spectrometry Reviews. Nov, 2020 | Pubmed ID: 33145813 Protein-Ligand Affinity Determinations Using Covalent Labeling-Mass Spectrometry Journal of the American Society for Mass Spectrometry. Jul, 2020 | Pubmed ID: 32501685 Covalent Labeling/Mass Spectrometry of Monoclonal Antibodies with Diethylpyrocarbonate: Reaction Kinetics for Ensuring Protein Structural Integrity Journal of the American Society for Mass Spectrometry. Jun, 2020 | Pubmed ID: 32310649 Reconstruction, Analysis, and Segmentation of LA-ICP-MS Imaging Data Using Python for the Identification of Sub-organ Regions in Tissues The Analyst. May, 2020 | Pubmed ID: 32270789 Measuring the Energy Barrier of the Structural Change That Initiates Amyloid Formation Analytical Chemistry. 04, 2020 | Pubmed ID: 32159946 Epigallocatechin-3-gallate Inhibits Cu(II)-Induced β-2-Microglobulin Amyloid Formation by Binding to the Edge of Its β-Sheets Biochemistry. 03, 2020 | Pubmed ID: 32100530 Higher-Order Structure Influences the Kinetics of Diethylpyrocarbonate Covalent Labeling of Proteins Journal of the American Society for Mass Spectrometry. Mar, 2020 | Pubmed ID: 32013423 Polymeric Nanoassemblies for Enrichment and Detection of Peptides and Proteins in Human Breast Milk Analytical and Bioanalytical Chemistry. Feb, 2020 | Pubmed ID: 31925489 Structural Heterogeneity in the Preamyloid Oligomers of β-2-Microglobulin Journal of Molecular Biology. 01, 2020 | Pubmed ID: 31711963 In Vivo Editing of Macrophages Through Systemic Delivery of CRISPR-Cas9-Ribonucleoprotein-Nanoparticle Nanoassemblies Advanced Therapeutics. Oct, 2019 | Pubmed ID: 34095457 Efficient Enrichment of Glycopeptides by Supramolecular Nanoassemblies That Use Proximity-assisted Covalent Binding The Analyst. Oct, 2019 | Pubmed ID: 31552921 Covalent Labeling with Diethylpyrocarbonate: Sensitive to the Residue Microenvironment, Providing Improved Analysis of Protein Higher Order Structure by Mass Spectrometry Analytical Chemistry. 07, 2019 | Pubmed ID: 31150223 Covalent Labeling and Mass Spectrometry Reveal Subtle Higher Order Structural Changes for Antibody Therapeutics MAbs. 04, 2019 | Pubmed ID: 30636503 Covalent Labeling-mass Spectrometry with Non-specific Reagents for Studying Protein Structure and Interactions Methods (San Diego, Calif.). 07, 2018 | Pubmed ID: 29630925 Disruption of the Open Conductance in the β-tongue Mutants of Cytolysin A Scientific Reports. 02, 2018 | Pubmed ID: 29491391 Small Molecule-mediated Inhibition of β-2-microglobulin-based Amyloid Fibril Formation The Journal of Biological Chemistry. 06, 2017 | Pubmed ID: 28468825 Increased β-Sheet Dynamics and D-E Loop Repositioning Are Necessary for Cu(II)-Induced Amyloid Formation by β-2-Microglobulin Biochemistry. 02, 2017 | Pubmed ID: 28168880 Gradient and Patterned Protein Films Stabilized Via Nanoimprint Lithography for Engineered Interactions with Cells ACS Applied Materials & Interfaces. 01, 2017 | Pubmed ID: 28009164 Polymer-mediated Ternary Supramolecular Interactions for Sensitive Detection of Peptides The Analyst. 12, 2016 | Pubmed ID: 27874898 Quantitative Differentiation of Cell Surface-Bound and Internalized Cationic Gold Nanoparticles Using Mass Spectrometry ACS Nano. 07, 2016 | Pubmed ID: 27337000 Quantitative Imaging of 2 Nm Monolayer-protected Gold Nanoparticle Distributions in Tissues Using Laser Ablation Inductively-coupled Plasma Mass Spectrometry (LA-ICP-MS) The Analyst. Apr, 2016 | Pubmed ID: 26979648 Inkjet-printed Gold Nanoparticle Surfaces for the Detection of Low Molecular Weight Biomolecules by Laser Desorption/ionization Mass Spectrometry Journal of the American Society for Mass Spectrometry. Nov, 2015 | Pubmed ID: 26202457 Molecular Histology: More Than a Picture Nature Nanotechnology. Feb, 2015 | Pubmed ID: 25652167 Mass Spectrometric Detection of Nanoparticle Host-guest Interactions in Cells Analytical Chemistry. Jul, 2014 | Pubmed ID: 24873526 Exploring Salt Bridge Structures of Gas-phase Protein Ions Using Multiple Stages of Electron Transfer and Collision Induced Dissociation Journal of the American Society for Mass Spectrometry. Apr, 2014 | Pubmed ID: 24496600 Identifying Zn-bound Histidine Residues in Metalloproteins Using Hydrogen-deuterium Exchange Mass Spectrometry Analytical Chemistry. Jan, 2014 | Pubmed ID: 24313328 Characterization of Surface Ligands on Functionalized Magnetic Nanoparticles Using Laser Desorption/ionization Mass Spectrometry (LDI-MS) Nanoscale. Jun, 2013 | Pubmed ID: 23640282 Coordination Sphere Tuning of the Electron Transfer Dissociation Behavior of Cu(II)-peptide Complexes Journal of the American Society for Mass Spectrometry. Feb, 2012 | Pubmed ID: 22161629 Electron Transfer Dissociation of Modified Peptides and Proteins Current Pharmaceutical Biotechnology. Oct, 2011 | Pubmed ID: 21542796 Matrix-assisted Laser Desorption Ionization-mass Spectrometry Signal Enhancement of Peptides After Selective Extraction with Polymeric Reverse Micelles Analytical Chemistry. May, 2010 | Pubmed ID: 20377192 Probing Protein Structure by Amino Acid-specific Covalent Labeling and Mass Spectrometry Mass Spectrometry Reviews. Sep-Oct, 2009 | Pubmed ID: 19016300 Protein Surface Mapping Using Diethylpyrocarbonate with Mass Spectrometric Detection Analytical Chemistry. Apr, 2008 | Pubmed ID: 18338903 Cu(II) Organizes Beta-2-microglobulin Oligomers but is Released Upon Amyloid Formation Protein Science : a Publication of the Protein Society. Apr, 2008 | Pubmed ID: 18305198 The Effect of Histidine Oxidation on the Dissociation Patterns of Peptide Ions Journal of the American Society for Mass Spectrometry. Mar, 2007 | Pubmed ID: 17157528 Transition Metal-peptide Binding Studied by Metal-catalyzed Oxidation Reactions and Mass Spectrometry Analytical Chemistry. Apr, 2006 | Pubmed ID: 16579630 Using Mass Spectrometry to Study Copper-protein Binding Under Native and Non-native Conditions: Beta-2-microglobulin Analytical Chemistry. Jul, 2004 | Pubmed ID: 15228316 通过质谱学研究蛋白质高阶结构，与二乙基碳酸酯共价标签 Zachary J. Kirsch1, Blaise G. Arden1, Richard W. Vachet*1,2, Patanachai Limpikirati*3 1Department of Chemistry, University of Massachusetts Amherst, 2Molecular and Cellular Biology Program, University of Massachusetts Amherst, 3Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University JoVE 61983 Chemistry
通过质谱学研究蛋白质高阶结构，与二乙基碳酸酯共价标签 Zachary J. Kirsch1, Blaise G. Arden1, Richard W. Vachet*1,2, Patanachai Limpikirati*3 1Department of Chemistry, University of Massachusetts Amherst, 2Molecular and Cellular Biology Program, University of Massachusetts Amherst, 3Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University JoVE 61983 Chemistry
