Robert F. Margolskee

Publications

• Activation of Intestinal Tuft Cell-expressed Sucnr1 Triggers Type 2 Immunity in the Mouse Small Intestine
  Proceedings of the National Academy of Sciences of the United States of America. 05, 2018  |   Pubmed ID: 29735652
• Aggravated Gut Inflammation in Mice Lacking the Taste Signaling Protein α-gustducin
  Brain, Behavior, and Immunity. Jul, 2018  |   Pubmed ID: 29678794
• Gli3 is a Negative Regulator of Tas1r3-expressing Taste Cells
  PLoS Genetics. 02, 2018  |   Pubmed ID: 29415007
• Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae
  Neuroscience. Jan, 2018  |   Pubmed ID: 29113930
• Bacterial D-amino Acids Suppress Sinonasal Innate Immunity Through Sweet Taste Receptors in Solitary Chemosensory Cells
  Science Signaling. Sep, 2017  |   Pubmed ID: 28874606
• Whole Transcriptome Profiling of Taste Bud Cells
  Scientific Reports. Aug, 2017  |   Pubmed ID: 28790351
• Transcriptome Analyses of Taste Organoids Reveal Multiple Pathways Involved in Taste Cell Generation
  Scientific Reports. Jun, 2017  |   Pubmed ID: 28638111
• Taste Cell-expressed α-glucosidase Enzymes Contribute to Gustatory Responses to Disaccharides
  Proceedings of the National Academy of Sciences of the United States of America. May, 2016  |   Pubmed ID: 27162343
• Amiloride-Insensitive Salt Taste Is Mediated by Two Populations of Type III Taste Cells with Distinct Transduction Mechanisms
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2016  |   Pubmed ID: 26865617
• Tuft Cells, Taste-chemosensory Cells, Orchestrate Parasite Type 2 Immunity in the Gut
  Science (New York, N.Y.). Mar, 2016  |   Pubmed ID: 26847546
• Functional Analyses of Bitter Taste Receptors in Domestic Cats (Felis Catus)
  PloS One. 2015  |   Pubmed ID: 26488302
• Characterization of the Binding Site of Aspartame in the Human Sweet Taste Receptor
  Chemical Senses. Oct, 2015  |   Pubmed ID: 26377607
• Sugar-induced Cephalic-phase Insulin Release is Mediated by a T1r2+T1r3-independent Taste Transduction Pathway in Mice
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Sep, 2015  |   Pubmed ID: 26157055
• Leptin Suppresses Mouse Taste Cell Responses to Sweet Compounds
  Diabetes. Nov, 2015  |   Pubmed ID: 26116698
• Glucagon-like Peptide-1 is Specifically Involved in Sweet Taste Transmission
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2015  |   Pubmed ID: 25678625
• Single Lgr5- or Lgr6-expressing Taste Stem/progenitor Cells Generate Taste Bud Cells Ex Vivo
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2014  |   Pubmed ID: 25368147
• Differential Contribution of TRPM4 and TRPM5 Nonselective Cation Channels to the Slow Afterdepolarization in Mouse Prefrontal Cortex Neurons
  Frontiers in Cellular Neuroscience. 2014  |   Pubmed ID: 25237295
• Expression and Nuclear Translocation of Glucocorticoid Receptors in Type 2 Taste Receptor Cells
  Neuroscience Letters. Jun, 2014  |   Pubmed ID: 24814581
• The Bamboo-eating Giant Panda (Ailuropoda Melanoleuca) Has a Sweet Tooth: Behavioral and Molecular Responses to Compounds That Taste Sweet to Humans
  PloS One. 2014  |   Pubmed ID: 24671207
• Effects of Roux-en-Y Gastric Bypass on Energy and Glucose Homeostasis Are Preserved in Two Mouse Models of Functional Glucagon-like Peptide-1 Deficiency
  Molecular Metabolism. Apr, 2014  |   Pubmed ID: 24634822
• Bitter and Sweet Taste Receptors Regulate Human Upper Respiratory Innate Immunity
  The Journal of Clinical Investigation. Mar, 2014  |   Pubmed ID: 24531552
• Endocrine Taste Cells
  The British Journal of Nutrition. Jun, 2014  |   Pubmed ID: 24382120
• Mouse Nasal Epithelial Innate Immune Responses to Pseudomonas Aeruginosa Quorum-sensing Molecules Require Taste Signaling Components
  Innate Immunity. Aug, 2014  |   Pubmed ID: 24045336
• Genetic Loss or Pharmacological Blockade of Testes-expressed Taste Genes Causes Male Sterility
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013  |   Pubmed ID: 23818598
• Lgr5-EGFP Marks Taste Bud Stem/progenitor Cells in Posterior Tongue
  Stem Cells (Dayton, Ohio). May, 2013  |   Pubmed ID: 23377989
• Gustducin Couples Fatty Acid Receptors to GLP-1 Release in Colon
  American Journal of Physiology. Endocrinology and Metabolism. Mar, 2013  |   Pubmed ID: 23341498
• The Role of T1r3 and Trpm5 in Carbohydrate-induced Obesity in Mice
  Physiology & Behavior. Aug, 2012  |   Pubmed ID: 22683548
• Targeted Taste Cell-specific Overexpression of Brain-derived Neurotrophic Factor in Adult Taste Buds Elevates Phosphorylated TrkB Protein Levels in Taste Cells, Increases Taste Bud Size, and Promotes Gustatory Innervation
  The Journal of Biological Chemistry. May, 2012  |   Pubmed ID: 22442142
• Major Taste Loss in Carnivorous Mammals
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2012  |   Pubmed ID: 22411809
• A Conditioned Aversion Study of Sucrose and SC45647 Taste in TRPM5 Knockout Mice
  Chemical Senses. Jun, 2012  |   Pubmed ID: 21987728
• Glucose Transporters and ATP-gated K+ (KATP) Metabolic Sensors Are Present in Type 1 Taste Receptor 3 (T1r3)-expressing Taste Cells
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2011  |   Pubmed ID: 21383163
• REEP2 Enhances Sweet Receptor Function by Recruitment to Lipid Rafts
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2010  |   Pubmed ID: 20943918
• Gut T1R3 Sweet Taste Receptors Do Not Mediate Sucrose-conditioned Flavor Preferences in Mice
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Dec, 2010  |   Pubmed ID: 20926763
• Gustation Genetics: Sweet Gustducin!
  Chemical Senses. Sep, 2010  |   Pubmed ID: 20660058
• Action Potential-enhanced ATP Release from Taste Cells Through Hemichannels
  Journal of Neurophysiology. Aug, 2010  |   Pubmed ID: 20519578
• Phenoxy Herbicides and Fibrates Potently Inhibit the Human Chemosensory Receptor Subunit T1R3
  Journal of Medicinal Chemistry. Nov, 2009  |   Pubmed ID: 19817384
• Role of Olfaction in the Conditioned Sucrose Preference of Sweet-ageusic T1R3 Knockout Mice
  Chemical Senses. Oct, 2009  |   Pubmed ID: 19736224
• Expression of the Voltage-gated Potassium Channel KCNQ1 in Mammalian Taste Bud Cells and the Effect of Its Null-mutation on Taste Preferences
  The Journal of Comparative Neurology. Jan, 2009  |   Pubmed ID: 19006182
• Involvement of T1R3 in Calcium-magnesium Taste
  Physiological Genomics. Aug, 2008  |   Pubmed ID: 18593862