In JoVE (1)

Other Publications (1)

Articles by Robert Szulcek in JoVE

Other articles by Robert Szulcek on PubMed

Localized RhoA GTPase Activity Regulates Dynamics of Endothelial Monolayer Integrity

Cardiovascular Research. Aug, 2013  |  Pubmed ID: 23536606

Endothelial cells (ECs) control vascular permeability by forming a monolayer that is sealed by extracellular junctions. Various mediators modulate the endothelial barrier by acting on junctional protein complexes and the therewith connected F-actin cytoskeleton. Different Rho GTPases participate in this modulation, but their mechanisms are still partly resolved. Here, we aimed to elucidate whether the opening and closure of the endothelial barrier are associated with distinct localized RhoA activities at the subcellular level.

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