Roland Brosch

Publications

• TBCAP; Tuberculosis Annotation Project
  Tuberculosis (Edinburgh, Scotland). Jan, 2013  |   Pubmed ID: 23332402
• Genomic Analysis of Smooth Tubercle Bacilli Provides Insights into Ancestry and Pathoadaptation of Mycobacterium Tuberculosis
  Nature Genetics. Feb, 2013  |   Pubmed ID: 23291586
• The ESX-5 Associated EccB-EccC Locus is Essential for Mycobacterium Tuberculosis Viability
  PloS One. 2012  |   Pubmed ID: 23284869
• ESX-1 Dependent Impairment of Autophagic Flux by Mycobacterium Tuberculosis in Human Dendritic Cells
  Autophagy. Sep, 2012  |   Pubmed ID: 22885411
• Multidrug-resistant Tuberculosis in Admitted Patients at a Tertiary Referral Hospital of Bangladesh
  PloS One. 2012  |   Pubmed ID: 22808189
• ESX-1-mediated Translocation to the Cytosol Controls Virulence of Mycobacteria
  Cellular Microbiology. Aug, 2012  |   Pubmed ID: 22524898
• Strong Immunogenicity and Cross-reactivity of Mycobacterium Tuberculosis ESX-5 Type VII Secretion: Encoded PE-PPE Proteins Predicts Vaccine Potential
  Cell Host & Microbe. Apr, 2012  |   Pubmed ID: 22520463
• Characterization of Mycobacterium Orygis As M. Tuberculosis Complex Subspecies
  Emerging Infectious Diseases. Apr, 2012  |   Pubmed ID: 22469053
• Disruption of the ESX-5 System of Mycobacterium Tuberculosis Causes Loss of PPE Protein Secretion, Reduction of Cell Wall Integrity and Strong Attenuation
  Molecular Microbiology. Mar, 2012  |   Pubmed ID: 22340629
• Phagosomal Rupture by Mycobacterium Tuberculosis Results in Toxicity and Host Cell Death
  PLoS Pathogens. Feb, 2012  |   Pubmed ID: 22319448
• Activation of the NLRP3 Inflammasome by Mycobacterium Tuberculosis is Uncoupled from Susceptibility to Active Tuberculosis
  European Journal of Immunology. Feb, 2012  |   Pubmed ID: 22101787
• P62 and NDP52 Proteins Target Intracytosolic Shigella and Listeria to Different Autophagy Pathways
  The Journal of Biological Chemistry. Jul, 2011  |   Pubmed ID: 21646350
• Deciphering the Role of IS6110 in a Highly Transmissible Mycobacterium Tuberculosis Beijing Strain, GC1237
  Tuberculosis (Edinburgh, Scotland). Mar, 2011  |   Pubmed ID: 21256084
• ESAT-6 Secretion-independent Impact of ESX-1 Genes EspF and EspG1 on Virulence of Mycobacterium Tuberculosis
  The Journal of Infectious Diseases. Apr, 2011  |   Pubmed ID: 21196469
• Overexpression of Proinflammatory TLR-2-signalling Lipoproteins in Hypervirulent Mycobacterial Variants
  Cellular Microbiology. May, 2011  |   Pubmed ID: 21143571
• Entrapment of Intracytosolic Bacteria by Septin Cage-like Structures
  Cell Host & Microbe. Nov, 2010  |   Pubmed ID: 21075354
• Synthesis, Biological Activity, and Evaluation of the Mode of Action of Novel Antitubercular Benzofurobenzopyrans Substituted on A Ring
  European Journal of Medicinal Chemistry. Dec, 2010  |   Pubmed ID: 20961671
• High Content Phenotypic Cell-based Visual Screen Identifies Mycobacterium Tuberculosis Acyltrehalose-containing Glycolipids Involved in Phagosome Remodeling
  PLoS Pathogens. 2010  |   Pubmed ID: 20844580
• High Content Screening Identifies Decaprenyl-phosphoribose 2' Epimerase As a Target for Intracellular Antimycobacterial Inhibitors
  PLoS Pathogens. Oct, 2009  |   Pubmed ID: 19876393
• Systematic Genetic Nomenclature for Type VII Secretion Systems
  PLoS Pathogens. Oct, 2009  |   Pubmed ID: 19876390
• [A Promising New Class of Antituberculous Molecules]
  Médecine Sciences : M/S. Aug-Sep, 2009  |   Pubmed ID: 19765374
• Mycobacterial PE, PPE and ESX Clusters: Novel Insights into the Secretion of These Most Unusual Protein Families
  Molecular Microbiology. Aug, 2009  |   Pubmed ID: 19602151
• Non Mycobacterial Virulence Genes in the Genome of the Emerging Pathogen Mycobacterium Abscessus
  PloS One. 2009  |   Pubmed ID: 19543527
• Myths and Misconceptions: the Origin and Evolution of Mycobacterium Tuberculosis
  Nature Reviews. Microbiology. Jul, 2009  |   Pubmed ID: 19483712
• Benzothiazinones Kill Mycobacterium Tuberculosis by Blocking Arabinan Synthesis
  Science (New York, N.Y.). May, 2009  |   Pubmed ID: 19299584
• Pathogenicity in the Tubercle Bacillus: Molecular and Evolutionary Determinants
  BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Apr, 2009  |   Pubmed ID: 19274661
• ESX/type VII Secretion Systems and Their Role in Host-pathogen Interaction
  Current Opinion in Microbiology. Feb, 2009  |   Pubmed ID: 19155186
• Functional Analysis of a Clonal Deletion in an Epidemic Strain of Mycobacterium Bovis Reveals a Role in Lipid Metabolism
  Microbiology (Reading, England). Dec, 2008  |   Pubmed ID: 19047741
• Insights from the Complete Genome Sequence of Mycobacterium Marinum on the Evolution of Mycobacterium Tuberculosis
  Genome Research. May, 2008  |   Pubmed ID: 18403782
• Control of M. Tuberculosis ESAT-6 Secretion and Specific T Cell Recognition by PhoP
  PLoS Pathogens. Feb, 2008  |   Pubmed ID: 18282096
• Cutting-edge Science and the Future of Tuberculosis Control
  Bulletin of the World Health Organization. May, 2007  |   Pubmed ID: 17639231
• ESAT-6 from Mycobacterium Tuberculosis Dissociates from Its Putative Chaperone CFP-10 Under Acidic Conditions and Exhibits Membrane-lysing Activity
  Journal of Bacteriology. Aug, 2007  |   Pubmed ID: 17557817
• Genome Plasticity of BCG and Impact on Vaccine Efficacy
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007  |   Pubmed ID: 17372194
• "A Re-evaluation of M. Prototuberculosis": Continuing the Debate
  PLoS Pathogens. Sep, 2006  |   Pubmed ID: 17009866
• Horizontal Transfer of a Virulence Operon to the Ancestor of Mycobacterium Tuberculosis
  Molecular Biology and Evolution. Jun, 2006  |   Pubmed ID: 16520338
• Dissection of ESAT-6 System 1 of Mycobacterium Tuberculosis and Impact on Immunogenicity and Virulence
  Infection and Immunity. Jan, 2006  |   Pubmed ID: 16368961
• Ancient Origin and Gene Mosaicism of the Progenitor of Mycobacterium Tuberculosis
  PLoS Pathogens. Sep, 2005  |   Pubmed ID: 16201017
• Tuberculosis: from Genome to Vaccine
  Expert Review of Vaccines. Aug, 2005  |   Pubmed ID: 16117711
• Functional Analysis of Early Secreted Antigenic Target-6, the Dominant T-cell Antigen of Mycobacterium Tuberculosis, Reveals Key Residues Involved in Secretion, Complex Formation, Virulence, and Immunogenicity
  The Journal of Biological Chemistry. Oct, 2005  |   Pubmed ID: 16048998
• Modulation of the Host Immune Response by a Transient Intracellular Stage of Mycobacterium Ulcerans: the Contribution of Endogenous Mycolactone Toxin
  Cellular Microbiology. Aug, 2005  |   Pubmed ID: 16008585
• Structure and Mechanism of the Alkyl Hydroperoxidase AhpC, a Key Element of the Mycobacterium Tuberculosis Defense System Against Oxidative Stress
  The Journal of Biological Chemistry. Jul, 2005  |   Pubmed ID: 15886207
• Influence of ESAT-6 Secretion System 1 (RD1) of Mycobacterium Tuberculosis on the Interaction Between Mycobacteria and the Host Immune System
  Journal of Immunology (Baltimore, Md. : 1950). Mar, 2005  |   Pubmed ID: 15749894
• Common Evolutionary Origin for the Unstable Virulence Plasmid PMUM Found in Geographically Diverse Strains of Mycobacterium Ulcerans
  Journal of Bacteriology. Mar, 2005  |   Pubmed ID: 15716437
• ESAT-6 Proteins: Protective Antigens and Virulence Factors?
  Trends in Microbiology. Nov, 2004  |   Pubmed ID: 15488391
• Enhanced Protection Against Tuberculosis by Vaccination with Recombinant Mycobacterium Microti Vaccine That Induces T Cell Immunity Against Region of Difference 1 Antigens
  The Journal of Infectious Diseases. Jul, 2004  |   Pubmed ID: 15195250
• Cell Envelope Protein PPE68 Contributes to Mycobacterium Tuberculosis RD1 Immunogenicity Independently of a 10-kilodalton Culture Filtrate Protein and ESAT-6
  Infection and Immunity. Apr, 2004  |   Pubmed ID: 15039340
• Macro-array and Bioinformatic Analyses Reveal Mycobacterial 'core' Genes, Variation in the ESAT-6 Gene Family and New Phylogenetic Markers for the Mycobacterium Tuberculosis Complex
  Microbiology (Reading, England). Feb, 2004  |   Pubmed ID: 14766927
• Genotypic Analysis of Mycobacterium Tuberculosis in Bangladesh and Prevalence of the Beijing Strain
  Journal of Clinical Microbiology. Feb, 2004  |   Pubmed ID: 14766836
• Giant Plasmid-encoded Polyketide Synthases Produce the Macrolide Toxin of Mycobacterium Ulcerans
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2004  |   Pubmed ID: 14736915
• Recombinant BCG Exporting ESAT-6 Confers Enhanced Protection Against Tuberculosis
  Nature Medicine. May, 2003  |   Pubmed ID: 12692540
• Is Mycobacterium Africanum Subtype II (Uganda I and Uganda II) a Genetically Well-defined Subspecies of the Mycobacterium Tuberculosis Complex?
  Journal of Clinical Microbiology. Mar, 2003  |   Pubmed ID: 12624085
• Loss of RD1 Contributed to the Attenuation of the Live Tuberculosis Vaccines Mycobacterium Bovis BCG and Mycobacterium Microti
  Molecular Microbiology. Nov, 2002  |   Pubmed ID: 12410828
• Bacterial Artificial Chromosome-based Comparative Genomic Analysis Identifies Mycobacterium Microti As a Natural ESAT-6 Deletion Mutant
  Infection and Immunity. Oct, 2002  |   Pubmed ID: 12228284
• Rapid and Simple Approach for Identification of Mycobacterium Tuberculosis Complex Isolates by PCR-based Genomic Deletion Analysis
  Journal of Clinical Microbiology. Jul, 2002  |   Pubmed ID: 12089245
• Royal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 18th January 2001. Pathogen Genomes and Human Health. Mycobacterial Genomics
  Transactions of the Royal Society of Tropical Medicine and Hygiene. Jan-Feb, 2002  |   Pubmed ID: 11925980