Rolf Bodmer Development, Aging and Regeneration Program Sanford Burnham Prebys Medical Discovery Institute Biography Publications Institution JoVE Articles Rolf Bodmer has not added a biography. If you are Rolf Bodmer and would like to personalize this page please email our Author Liaison for assistance. Publications Transcriptomic Analysis Identifies a Role of PI3K-Akt Signalling in the Responses of Skeletal Muscle to Acute Hypoxia in Vivo The Journal of Physiology. Sep, 2017 | Pubmed ID: 28688178 SLP-2 Interacts with Parkin in Mitochondria and Prevents Mitochondrial Dysfunction in Parkin-deficient Human IPSC-derived Neurons and Drosophila Human Molecular Genetics. Jul, 2017 | Pubmed ID: 28379402 Experimental Evolution and Heart Function in Drosophila Physiological and Biochemical Zoology : PBZ. Mar/Apr, 2017 | Pubmed ID: 28277957 Modest Overexpression of FOXO Maintains Cardiac Proteostasis and Ameliorates Age-associated Functional Decline Aging Cell. Feb, 2017 | Pubmed ID: 28090761 Expression Patterns of Cardiac Aging in Drosophila Aging Cell. Feb, 2017 | Pubmed ID: 28090760 Extracellular Matrix Downregulation in the Drosophila Heart Preserves Contractile Function and Improves Lifespan Matrix Biology : Journal of the International Society for Matrix Biology. Oct, 2017 | Pubmed ID: 27793636 52 Genetic Loci Influencing Myocardial Mass Journal of the American College of Cardiology. Sep, 2016 | Pubmed ID: 27659466 A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila Journal of Molecular Biology. Jun, 2016 | Pubmed ID: 27107639 The Canonical Wingless Signaling Pathway is Required but Not Sufficient for Inflow Tract Formation in the Drosophila Melanogaster Heart Developmental Biology. May, 2016 | Pubmed ID: 26983369 High Throughput Physiological Screening of IPSC-derived Cardiomyocytes for Drug Development Biochimica Et Biophysica Acta. Jul, 2016 | Pubmed ID: 26952934 SPARC-Dependent Cardiomyopathy in Drosophila Circulation. Cardiovascular Genetics. Apr, 2016 | Pubmed ID: 26839388 Genetic Manipulation of Cardiac Ageing The Journal of Physiology. Apr, 2016 | Pubmed ID: 26060055 Gaining Insights into Diabetic Cardiomyopathy from Drosophila Trends in Endocrinology and Metabolism: TEM. Nov, 2015 | Pubmed ID: 26482877 Cardiac Responses to Hypoxia and Reoxygenation in Drosophila American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Dec, 2015 | Pubmed ID: 26377557 Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes PloS One. 2015 | Pubmed ID: 26301956 Cellular Mechanisms of Drosophila Heart Morphogenesis Journal of Cardiovascular Development and Disease. Mar, 2015 | Pubmed ID: 26236710 Obesity-associated Cardiac Dysfunction in Starvation-selected Drosophila Melanogaster American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Sep, 2015 | Pubmed ID: 26136533 Vinculin Network-mediated Cytoskeletal Remodeling Regulates Contractile Function in the Aging Heart Science Translational Medicine. Jun, 2015 | Pubmed ID: 26084806 Clueless, a Protein Required for Mitochondrial Function, Interacts with the PINK1-Parkin Complex in Drosophila Disease Models & Mechanisms. Jun, 2015 | Pubmed ID: 26035866 Cardiac Deficiency of Single Cytochrome Oxidase Assembly Factor Scox Induces P53-dependent Apoptosis in a Drosophila Cardiomyopathy Model Human Molecular Genetics. Jul, 2015 | Pubmed ID: 25792727 PGC-1/Spargel Counteracts High-Fat-Diet-Induced Obesity and Cardiac Lipotoxicity Downstream of TOR and Brummer ATGL Lipase Cell Reports. Mar, 2015 | Pubmed ID: 25753422 Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension American Journal of Respiratory Cell and Molecular Biology. Sep, 2015 | Pubmed ID: 25569851 Drosophila As a Potential Model to Ameliorate Mutant Huntington-mediated Cardiac Amyloidosis Rare Diseases (Austin, Tex.). 2014 | Pubmed ID: 26942103 Cdc42 and Formin Activity Control Non-muscle Myosin Dynamics During Drosophila Heart Morphogenesis The Journal of Cell Biology. Sep, 2014 | Pubmed ID: 25267295 Methods to Assess Drosophila Heart Development, Function and Aging Methods (San Diego, Calif.). Jun, 2014 | Pubmed ID: 24727147 Systems Genomics of Metabolic Phenotypes in Wild-type Drosophila Melanogaster Genetics. Jun, 2014 | Pubmed ID: 24671769 ROS Regulate Cardiac Function Via a Distinct Paracrine Mechanism Cell Reports. Apr, 2014 | Pubmed ID: 24656823 Metabolic and Transcriptional Response to a High-fat Diet in Drosophila Melanogaster Molecular Metabolism. Feb, 2014 | Pubmed ID: 24567903 A Dual Role for Integrin-linked Kinase and β1-integrin in Modulating Cardiac Aging Aging Cell. Jun, 2014 | Pubmed ID: 24400780 Integrin-linked Kinase Modulates Longevity and Thermotolerance in C. Elegans Through Neuronal Control of HSF-1 Aging Cell. Jun, 2014 | Pubmed ID: 24314125 The Role of Pygopus in the Differentiation of Intracardiac Valves in Drosophila Genesis (New York, N.Y. : 2000). Jan, 2014 | Pubmed ID: 24265259 Mechanical and Non-mechanical Functions of Dystrophin Can Prevent Cardiac Abnormalities in Drosophila Experimental Gerontology. Jan, 2014 | Pubmed ID: 24231130 Huntington's Disease Induced Cardiac Amyloidosis is Reversed by Modulating Protein Folding and Oxidative Stress Pathways in the Drosophila Heart PLoS Genetics. 2013 | Pubmed ID: 24367279 Pygopus Maintains Heart Function in Aging Drosophila Independently of Canonical Wnt Signaling Circulation. Cardiovascular Genetics. Oct, 2013 | Pubmed ID: 24046329 Multiplexin Promotes Heart but Not Aorta Morphogenesis by Polarized Enhancement of Slit/robo Activity at the Heart Lumen PLoS Genetics. Jun, 2013 | Pubmed ID: 23825967 Survival Response to Increased Ceramide Involves Metabolic Adaptation Through Novel Regulators of Glycolysis and Lipolysis PLoS Genetics. Jun, 2013 | Pubmed ID: 23818862 Whole-Genome RVISTA: a Tool to Determine Enrichment of Transcription Factor Binding Sites in Gene Promoters from Transcriptomic Data Bioinformatics (Oxford, England). Aug, 2013 | Pubmed ID: 23736530 Complex Genetic Architecture of Cardiac Disease in a Wild Type Inbred Strain of Drosophila Melanogaster PloS One. 2013 | Pubmed ID: 23638165 Declining Signal-dependence of Nrf2-MafS Regulated Gene Expressioncorrelates with Aging Phenotypes Aging Cell. Mar, 2013 | Pubmed ID: 23521918 A Drosophila Model of High Sugar Diet-induced Cardiomyopathy PLoS Genetics. 2013 | Pubmed ID: 23326243 APJ Acts As a Dual Receptor in Cardiac Hypertrophy Nature. Aug, 2012 | Pubmed ID: 22810587 Statin Treatment Increases Lifespan and Improves Cardiac Health in Drosophila by Decreasing Specific Protein Prenylation PloS One. 2012 | Pubmed ID: 22737247 Regulation of Parkin and PINK1 by Neddylation Human Molecular Genetics. Jun, 2012 | Pubmed ID: 22388932 果蝇作为模型来研究肥胖患者心功能不全的遗传机制。 Journal of Cellular and Molecular Medicine. Feb, 2012 | Pubmed ID: 22303936 探讨心肌在果蝇的基因基础。 Journal of Cellular and Molecular Medicine. Jan, 2012 | Pubmed ID: 22268758 测量被动心肌刚度在黑腹果蝇调查舒张功能不全。 Journal of Cellular and Molecular Medicine. Jan, 2012 | Pubmed ID: 22225769 DSCAM 和 COL6A2 的过量表达合作生成先天性心脏病。 PLoS Genetics. Nov, 2011 | Pubmed ID: 22072978 在哺乳动物和果蝇脂毒性及心脏功能障碍。 Critical Reviews in Biochemistry and Molecular Biology. Oct, 2011 | Pubmed ID: 21851295 UNC 45 伴侣是在果蝇心脏模型建立基于肌球蛋白的鲢鱼组织和心肌收缩力的关键。 PloS One. 2011 | Pubmed ID: 21799905 ATP 敏感钾通道 (K(ATP))-取决于监管的心性病毒感染。 Proceedings of the National Academy of Sciences of the United States of America. Jul, 2011 | Pubmed ID: 21719711 钦曼/Nkx2-5 通过和平号空间站 1 和上游 Cdc42 跨物种调节心脏功能的行为。 The Journal of Cell Biology. Jun, 2011 | Pubmed ID: 21690310 强大的小心脏: 成人黑腹果蝇心脏蛋白质。 PloS One. 2011 | Pubmed ID: 21541028 磷脂稳态和脂毒性心肌病: 一个均衡的问题。 Fly. Jul-Sep, 2011 | Pubmed ID: 21494094 磷脂稳态调节脂质代谢及通过固醇信号在果蝇心脏功能。 Genes & Development. Jan, 2011 | Pubmed ID: 21245170 果蝇作为模型来研究心脏衰老。 Experimental Gerontology. May, 2011 | Pubmed ID: 21130861 TOR 路径在果蝇中受高脂肪饮食诱导的肥胖和心功能不全。 Cell Metabolism. Nov, 2010 | Pubmed ID: 21035763 在应激与衰老十字路口的 Sestrins。 Aging. Jun, 2010 | Pubmed ID: 20606249 SAMD4B,一种新型的 SAM 含有蛋白质,抑制 AP-1-p53 和 P21 介导的转录活性。 BMB Reports. May, 2010 | Pubmed ID: 20510020 全球的体内果蝇 RNAi 屏幕作为一个保守的心功能监管标识 NOT3。 Cell. Apr, 2010 | Pubmed ID: 20371351 作为一种反馈抑制剂可以防止与年龄有关的病症的 TOR Sestrin。 Science (New York, N.Y.). Mar, 2010 | Pubmed ID: 20203043 KBTBD7,一种新型的人类 BTB Kelch 蛋白质,激活 SRE 和 AP-1 转录活动。 BMB Reports. Jan, 2010 | Pubmed ID: 20132730 D4eBP 下游的行为开始和 DFoxo 调节在果蝇心脏功能老化。 Aging Cell. Sep, 2009 | Pubmed ID: 19594484 神经系统因子电的部分损失损害果蝇成人心脏功能。 Human Molecular Genetics. Sep, 2009 | Pubmed ID: 19494035 用于检测和定量确定在果蝇、 斑马鱼、 和小鼠胚胎心心跳参数的新方法。 BioTechniques. Feb, 2009 | Pubmed ID: 19317655 心脏节律、 收缩功能和形态的成年果蝇的非自治调制。 Developmental Biology. Apr, 2009 | Pubmed ID: 19233157 果蝇同系物的脊椎动物 Islet1 是早期心脏发育中的一个关键组件。 Development (Cambridge, England). Jan, 2009 | Pubmed ID: 19088091 转录因子 Neuromancer/TBX20 是需要在果蝇心脏功能与人类心脏疾病的影响。 Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19074289 一种新型的人类 BTB Kelch 蛋白质 KLHL31,表示强烈的肌肉和心脏,抑制转录活动的槟知和斯雷。 Molecules and Cells. Nov, 2008 | Pubmed ID: 18719355 果蝇 Ortholog LRRK2 激酶活性的多巴胺能神经元的生存的不可替代的作用。 Molecular Neurodegeneration. 2008 | Pubmed ID: 18257932 在果蝇抗肌萎缩蛋白缺乏症减少寿命和导致扩张型心肌病表型。 Aging Cell. Mar, 2008 | Pubmed ID: 18221418 ZNF418、 新型人类 KRAB/C2H2 锌指蛋白,抑制 MAPK 信号转导通路。 Molecular and Cellular Biochemistry. Mar, 2008 | Pubmed ID: 18084723 果蝇肌肉 LIM 蛋白,Mlp84B,是心脏功能的必要条件。 The Journal of Experimental Biology. Jan, 2008 | Pubmed ID: 18083727 胚层甚至跳过表达的空间特异性依赖于多个相关站点。 Developmental Biology. Jan, 2008 | Pubmed ID: 18067885 果蝇老化 2006年/2007 年。 Experimental Gerontology. Jan, 2008 | Pubmed ID: 18061385 肌球蛋白传感器突变差异影响运动功能、 肌原纤维结构和性能的骨骼肌、 心肌。 Molecular Biology of the Cell. Feb, 2008 | Pubmed ID: 18045988 在果蝇心脏功能障碍的遗传变异。 PloS One. 2007 | Pubmed ID: 17622346 心功能及在果蝇老化的遗传控制。 Trends in Cardiovascular Medicine. Jul, 2007 | Pubmed ID: 17574126 KCNQ 钾通道突变导致心律失常中模仿的老化影响的果蝇。 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007 | Pubmed ID: 17360457 心脏衰老。 Seminars in Cell & Developmental Biology. Feb, 2007 | Pubmed ID: 17275368 与年龄相关的心脏恶化: 从果蝇的见解。 Frontiers in Bioscience : a Journal and Virtual Library. 2007 | Pubmed ID: 17127282 与年龄相关的心脏疾病模型的果蝇。 Mechanisms of Ageing and Development. Jan, 2007 | Pubmed ID: 17125816 老化 2005年/06 年度的果蝇。 Experimental Gerontology. Dec, 2006 | Pubmed ID: 17126511 Cardioblast 固有钦曼活动控制适当的多样化和果蝇心肌细胞分化。 Development (Cambridge, England). Oct, 2006 | Pubmed ID: 16987868 锌指 Homeodomain 基因 Zfh1/SIP1 果蝇心脏发育中的功能保护。 Development Genes and Evolution. Nov, 2006 | Pubmed ID: 16957952 抗氧化剂保护果蝇 PINK1 依赖的多巴胺能神经元。 Proceedings of the National Academy of Sciences of the United States of America. Sep, 2006 | Pubmed ID: 16938835 激活的 FOXO 介导的胰岛素抵抗,被 TOR 活动减少。 Cell Metabolism. Aug, 2006 | Pubmed ID: 16890541 ATP 敏感钾 (KATP) 通道编码 DSUR 基因果蝇心脏功能需要和受钦曼。 Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006 | Pubmed ID: 16882722 心血管医学图像: 活体成像实时光学相干层析成像的成人果蝇果蝇心脏。 Circulation. Jul, 2006 | Pubmed ID: 16831991 Svp 在果蝇心包细胞生长的作用。 Yi Chuan Xue Bao = Acta Genetica Sinica. Jan, 2006 | Pubmed ID: 16450585 刺猬和 RAS 通路合作前后规格和定位的心脏祖细胞。 Developmental Biology. Feb, 2006 | Pubmed ID: 16387294 缝和 Robo 控制心脏细胞极性和形态发生。 Current Biology : CB. Dec, 2005 | Pubmed ID: 16360689 胚胎甚至跳过依赖肌肉和心脏的细胞命运都需要正常成人活动、 心功能和使用寿命。 Circulation Research. Nov, 2005 | Pubmed ID: 16239588 与交互的遗传基因位点鉴定切在果蝇翅膀边缘的发展过程。 Genetics. Aug, 2005 | Pubmed ID: 15956666 Neuromancer Tbx20 相关基因 (H15/中线) 促进细胞命运规格和果蝇心脏的形态。 Developmental Biology. Mar, 2005 | Pubmed ID: 15733676 胰岛素调节心脏功能的老化果蝇。 Nature Genetics. Dec, 2004 | Pubmed ID: 15565107 果蝇心脏疾病的一种新兴模型。 Gene. Nov, 2004 | Pubmed ID: 15527959 在果蝇心脏功能突变筛查检测方法。 BioTechniques. Jul, 2004 | Pubmed ID: 15283201 Cux2 表达的动态表明早期池 SVZ 前体的是注定要成为上层皮层神经元。 Cerebral Cortex (New York, N.Y. : 1991). Dec, 2004 | Pubmed ID: 15238450 成肌细胞命运是仅在果蝇心脏,有无细胞分裂的不对称谱系中不悦的槽口。 Development (Cambridge, England). Jul, 2003 | Pubmed ID: 12756185 神经系统因素电是必须要建立心脏前体细胞形成的能力。 Development (Cambridge, England). Jul, 2003 | Pubmed ID: 12756184 AmphiNk2-沙田、 文昌鱼同源盒基因在心肌前体细胞中表示: 演化的脊椎动物的心洞察。 Developmental Biology. Mar, 2003 | Pubmed ID: 12618138 转录集成调制的相互压制能力的生成心源性中胚层内的细胞类型特异性。 Developmental Biology. Dec, 2002 | Pubmed ID: 12482712 翼式的模式,decapentaplegic 和钦曼的位置果蝇心脏。 Mechanisms of Development. Jun, 2002 | Pubmed ID: 12175486 MBLR,类似于哺乳动物 Polycomb 基因产品,新的无名指蛋白受依赖细胞周期的磷酸化。 Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Aug, 2002 | Pubmed ID: 12167161 丧失的基因,神经选择器基因剪切、 潜在目标有助于猪鬃形态发生。 Genetics. May, 2002 | Pubmed ID: 12019237 [利用 RNAi 技术研究果蝇心脏相关基因的功能]。 Yi Chuan Xue Bao = Acta Genetica Sinica. Jan, 2002 | Pubmed ID: 11838373 A Late Role for a Subset of Neurogenic Genes to Limit Sensory Precursor Recruitments in Drosophila Embryos Roux's Archives of Developmental Biology : the Official Organ of the EDBO. Aug, 1993 | Pubmed ID: 28306050 Morphological Differentiation of the Embryonic Peripheral Neurons in Drosophila Roux's Archives of Developmental Biology : the Official Organ of the EDBO. Feb, 1987 | Pubmed ID: 28305460 高脂膳食喂养和高通量三测定在果蝇中的含量 Soda Balla Diop1, Ryan T. Birse1, Rolf Bodmer1 1Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute JoVE 56029 Genetics 荧光标记的果蝇心结构 Nakissa N. Alayari1,2, Georg Vogler2, Ouarda Taghli-Lamallem2, Karen Ocorr2, Rolf Bodmer2, Anthony Cammarato1,2 1Biology Department, San Diego State University, 2Development and Aging Program, NASCR Center, The Sanford Burnham Institute for Medical Research JoVE 1423 Biology 半自动小红桃光学心跳分析 Karen Ocorr1, Martin Fink2, Anthony Cammarato1,3, Sanford I. Bernstein3, Rolf Bodmer1 1Development and Aging Program, The Sanford Burnham Institute for Medical Research, 2Cardiac Electrophysiology Group, Dept. of Physiology, Anatomy and Genetics, The Sanford Burnham Institute for Medical Research, 3Biology Department and Heart Institute, San Diego State University JoVE 1435 Biology
高脂膳食喂养和高通量三测定在果蝇中的含量 Soda Balla Diop1, Ryan T. Birse1, Rolf Bodmer1 1Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute JoVE 56029 Genetics
荧光标记的果蝇心结构 Nakissa N. Alayari1,2, Georg Vogler2, Ouarda Taghli-Lamallem2, Karen Ocorr2, Rolf Bodmer2, Anthony Cammarato1,2 1Biology Department, San Diego State University, 2Development and Aging Program, NASCR Center, The Sanford Burnham Institute for Medical Research JoVE 1423 Biology
半自动小红桃光学心跳分析 Karen Ocorr1, Martin Fink2, Anthony Cammarato1,3, Sanford I. Bernstein3, Rolf Bodmer1 1Development and Aging Program, The Sanford Burnham Institute for Medical Research, 2Cardiac Electrophysiology Group, Dept. of Physiology, Anatomy and Genetics, The Sanford Burnham Institute for Medical Research, 3Biology Department and Heart Institute, San Diego State University JoVE 1435 Biology