Rolf Bodmer Development, Aging and Regeneration Program Sanford Burnham Prebys Medical Discovery Institute Biography Publications Institution JoVE Articles Rolf Bodmer has not added a biography. If you are Rolf Bodmer and would like to personalize this page please email our Author Liaison for assistance. Publications Transcriptomic Analysis Identifies a Role of PI3K-Akt Signalling in the Responses of Skeletal Muscle to Acute Hypoxia in Vivo The Journal of Physiology. Sep, 2017 | Pubmed ID: 28688178 SLP-2 Interacts with Parkin in Mitochondria and Prevents Mitochondrial Dysfunction in Parkin-deficient Human IPSC-derived Neurons and Drosophila Human Molecular Genetics. Jul, 2017 | Pubmed ID: 28379402 Experimental Evolution and Heart Function in Drosophila Physiological and Biochemical Zoology : PBZ. Mar/Apr, 2017 | Pubmed ID: 28277957 Modest Overexpression of FOXO Maintains Cardiac Proteostasis and Ameliorates Age-associated Functional Decline Aging Cell. Feb, 2017 | Pubmed ID: 28090761 Expression Patterns of Cardiac Aging in Drosophila Aging Cell. Feb, 2017 | Pubmed ID: 28090760 Extracellular Matrix Downregulation in the Drosophila Heart Preserves Contractile Function and Improves Lifespan Matrix Biology : Journal of the International Society for Matrix Biology. Oct, 2017 | Pubmed ID: 27793636 52 Genetic Loci Influencing Myocardial Mass Journal of the American College of Cardiology. Sep, 2016 | Pubmed ID: 27659466 A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila Journal of Molecular Biology. Jun, 2016 | Pubmed ID: 27107639 The Canonical Wingless Signaling Pathway is Required but Not Sufficient for Inflow Tract Formation in the Drosophila Melanogaster Heart Developmental Biology. May, 2016 | Pubmed ID: 26983369 High Throughput Physiological Screening of IPSC-derived Cardiomyocytes for Drug Development Biochimica Et Biophysica Acta. Jul, 2016 | Pubmed ID: 26952934 SPARC-Dependent Cardiomyopathy in Drosophila Circulation. Cardiovascular Genetics. Apr, 2016 | Pubmed ID: 26839388 Genetic Manipulation of Cardiac Ageing The Journal of Physiology. Apr, 2016 | Pubmed ID: 26060055 Gaining Insights into Diabetic Cardiomyopathy from Drosophila Trends in Endocrinology and Metabolism: TEM. Nov, 2015 | Pubmed ID: 26482877 Cardiac Responses to Hypoxia and Reoxygenation in Drosophila American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Dec, 2015 | Pubmed ID: 26377557 Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes PloS One. 2015 | Pubmed ID: 26301956 Cellular Mechanisms of Drosophila Heart Morphogenesis Journal of Cardiovascular Development and Disease. Mar, 2015 | Pubmed ID: 26236710 Obesity-associated Cardiac Dysfunction in Starvation-selected Drosophila Melanogaster American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Sep, 2015 | Pubmed ID: 26136533 Vinculin Network-mediated Cytoskeletal Remodeling Regulates Contractile Function in the Aging Heart Science Translational Medicine. Jun, 2015 | Pubmed ID: 26084806 Clueless, a Protein Required for Mitochondrial Function, Interacts with the PINK1-Parkin Complex in Drosophila Disease Models & Mechanisms. Jun, 2015 | Pubmed ID: 26035866 Cardiac Deficiency of Single Cytochrome Oxidase Assembly Factor Scox Induces P53-dependent Apoptosis in a Drosophila Cardiomyopathy Model Human Molecular Genetics. Jul, 2015 | Pubmed ID: 25792727 PGC-1/Spargel Counteracts High-Fat-Diet-Induced Obesity and Cardiac Lipotoxicity Downstream of TOR and Brummer ATGL Lipase Cell Reports. Mar, 2015 | Pubmed ID: 25753422 Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension American Journal of Respiratory Cell and Molecular Biology. Sep, 2015 | Pubmed ID: 25569851 Drosophila As a Potential Model to Ameliorate Mutant Huntington-mediated Cardiac Amyloidosis Rare Diseases (Austin, Tex.). 2014 | Pubmed ID: 26942103 Cdc42 and Formin Activity Control Non-muscle Myosin Dynamics During Drosophila Heart Morphogenesis The Journal of Cell Biology. Sep, 2014 | Pubmed ID: 25267295 Methods to Assess Drosophila Heart Development, Function and Aging Methods (San Diego, Calif.). Jun, 2014 | Pubmed ID: 24727147 Systems Genomics of Metabolic Phenotypes in Wild-type Drosophila Melanogaster Genetics. Jun, 2014 | Pubmed ID: 24671769 ROS Regulate Cardiac Function Via a Distinct Paracrine Mechanism Cell Reports. Apr, 2014 | Pubmed ID: 24656823 Metabolic and Transcriptional Response to a High-fat Diet in Drosophila Melanogaster Molecular Metabolism. Feb, 2014 | Pubmed ID: 24567903 A Dual Role for Integrin-linked Kinase and β1-integrin in Modulating Cardiac Aging Aging Cell. Jun, 2014 | Pubmed ID: 24400780 Integrin-linked Kinase Modulates Longevity and Thermotolerance in C. Elegans Through Neuronal Control of HSF-1 Aging Cell. Jun, 2014 | Pubmed ID: 24314125 The Role of Pygopus in the Differentiation of Intracardiac Valves in Drosophila Genesis (New York, N.Y. : 2000). Jan, 2014 | Pubmed ID: 24265259 Mechanical and Non-mechanical Functions of Dystrophin Can Prevent Cardiac Abnormalities in Drosophila Experimental Gerontology. Jan, 2014 | Pubmed ID: 24231130 Huntington's Disease Induced Cardiac Amyloidosis is Reversed by Modulating Protein Folding and Oxidative Stress Pathways in the Drosophila Heart PLoS Genetics. 2013 | Pubmed ID: 24367279 Pygopus Maintains Heart Function in Aging Drosophila Independently of Canonical Wnt Signaling Circulation. Cardiovascular Genetics. Oct, 2013 | Pubmed ID: 24046329 Multiplexin Promotes Heart but Not Aorta Morphogenesis by Polarized Enhancement of Slit/robo Activity at the Heart Lumen PLoS Genetics. Jun, 2013 | Pubmed ID: 23825967 Survival Response to Increased Ceramide Involves Metabolic Adaptation Through Novel Regulators of Glycolysis and Lipolysis PLoS Genetics. Jun, 2013 | Pubmed ID: 23818862 Whole-Genome RVISTA: a Tool to Determine Enrichment of Transcription Factor Binding Sites in Gene Promoters from Transcriptomic Data Bioinformatics (Oxford, England). Aug, 2013 | Pubmed ID: 23736530 Complex Genetic Architecture of Cardiac Disease in a Wild Type Inbred Strain of Drosophila Melanogaster PloS One. 2013 | Pubmed ID: 23638165 Declining Signal-dependence of Nrf2-MafS Regulated Gene Expressioncorrelates with Aging Phenotypes Aging Cell. Mar, 2013 | Pubmed ID: 23521918 A Drosophila Model of High Sugar Diet-induced Cardiomyopathy PLoS Genetics. 2013 | Pubmed ID: 23326243 APJ Acts As a Dual Receptor in Cardiac Hypertrophy Nature. Aug, 2012 | Pubmed ID: 22810587 Statin Treatment Increases Lifespan and Improves Cardiac Health in Drosophila by Decreasing Specific Protein Prenylation PloS One. 2012 | Pubmed ID: 22737247 Regulation of Parkin and PINK1 by Neddylation Human Molecular Genetics. Jun, 2012 | Pubmed ID: 22388932 肥満に関連する心臓機能障害の遺伝的メカニズムを研究するモデルとしてショウジョウバエ Journal of Cellular and Molecular Medicine. Feb, 2012 | Pubmed ID: 22303936 ショウジョウバエにおける心筋症のポリジーン根拠を探る Journal of Cellular and Molecular Medicine. Jan, 2012 | Pubmed ID: 22268758 拡張機能障害を調査するためにショウジョウバエの受動的心筋硬さを測定する Journal of Cellular and Molecular Medicine. Jan, 2012 | Pubmed ID: 22225769 DSCAMとCOL6A2の過剰発現は協調的に先天性心臓欠陥を生成します。 PLoS Genetics. Nov, 2011 | Pubmed ID: 22072978 哺乳類とショウジョウバエのLipotoxicityと心機能障害 Critical Reviews in Biochemistry and Molecular Biology. Oct, 2011 | Pubmed ID: 21851295 The UNC-45 Chaperone is Critical for Establishing Myosin-based Myofibrillar Organization and Cardiac Contractility in the Drosophila Heart Model PloS One. 2011 | Pubmed ID: 21799905 ATP感受性カリウムチャネル(K(ATP))依存Cardiotropicウイルス感染の制御 Proceedings of the National Academy of Sciences of the United States of America. Jul, 2011 | Pubmed ID: 21719711 Cdc42のmiR - 1およびアップストリーム経由Tinman/Nkx2-5行為は種を越えて心機能を調節する The Journal of Cell Biology. Jun, 2011 | Pubmed ID: 21690310 マイティ·ハートスモール:大人キイロショウジョウバエの心臓プロテオーム PloS One. 2011 | Pubmed ID: 21541028 リン脂質ホメオスタシスとLipotoxic心筋症:バランスの問題 Fly. Jul-Sep, 2011 | Pubmed ID: 21494094 リン脂質の恒常性は、ショウジョウバエのSREBPシグナリングを通して脂質代謝および心臓機能を調節する Genes & Development. Jan, 2011 | Pubmed ID: 21245170 心臓の老化を研究するモデルとしてショウジョウバエ Experimental Gerontology. May, 2011 | Pubmed ID: 21130861 高脂肪食餌誘導性肥満や心臓機能障害は、ショウジョウバエのTOR経路によって調節される Cell Metabolism. Nov, 2010 | Pubmed ID: 21035763 ストレスと老化の間の交差点Sestrins Aging. Jun, 2010 | Pubmed ID: 20606249 SAMD4B、小説SAM含有タンパク質は、AP-1、P53-P21と媒介転写活性を阻害 BMB Reports. May, 2010 | Pubmed ID: 20510020 生体ショウジョウバエRNAiの画面のGlobalは、心臓機能の保存食·レギュレータとしてNOT3を識別します Cell. Apr, 2010 | Pubmed ID: 20371351 加齢病態を防止TORのフィードバック阻害剤としてSestrin Science (New York, N.Y.). Mar, 2010 | Pubmed ID: 20203043 KBTBD7、新規ヒトBTB-ケルヒタンパク質は、SREとAP-1の転写活性をアクティブにします BMB Reports. Jan, 2010 | Pubmed ID: 20132730 D4eBPはショウジョウバエの心臓機能の老化を調節するためにデストラクタとDFoxo両方の下流行為 Aging Cell. Sep, 2009 | Pubmed ID: 19594484 GATA因子パニエの部分的な損失は、ショウジョウバエで大人の心機能を損なう Human Molecular Genetics. Sep, 2009 | Pubmed ID: 19494035 ショウジョウバエ、ゼブラフィッシュ、及びマウス胎児心臓のハートビートパラメータの検出および定量化のための新しい方法 BioTechniques. Feb, 2009 | Pubmed ID: 19317655 大人のミバエの心臓のリズム、収縮と形態の非自律変調 Developmental Biology. Apr, 2009 | Pubmed ID: 19233157 脊椎動物Islet1のショウジョウバエホモログは、早期心臓発生に重要な要素である Development (Cambridge, England). Jan, 2009 | Pubmed ID: 19088091 転写因子Neuromancer/TBX20は、人間の心臓病のための含意を持つショウジョウバエの心臓機能が必要です Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19074289 強筋および心臓で発現新規ヒトBTB-ケルヒタンパク質KLHL31は、TREとSREの転写活性を阻害する Molecules and Cells. Nov, 2008 | Pubmed ID: 18719355 ドーパミン作動性ニューロンの生存におけるLRRK2のキナーゼ活性のショウジョウバエのオルソログする不要役割 Molecular Neurodegeneration. 2008 | Pubmed ID: 18257932 ショウジョウバエのジストロフィン欠損は寿命を削減し、拡張型心筋症の表現型を引き起こす Aging Cell. Mar, 2008 | Pubmed ID: 18221418 ZNF418、新規ヒトKRAB/C2H2ジンクフィンガータンパク質は、MAPKシグナル伝達経路を抑制 Molecular and Cellular Biochemistry. Mar, 2008 | Pubmed ID: 18084723 ショウジョウバエの筋肉LIMタンパク質、Mlp84Bは、心臓の機能に必須である The Journal of Experimental Biology. Jan, 2008 | Pubmed ID: 18083727 中胚葉偶数スキップ発現の空間的な特異性は、複数のリプレッサーのサイトに依存している Developmental Biology. Jan, 2008 | Pubmed ID: 18067885 ショウジョウバエの加齢2006/2007 Experimental Gerontology. Jan, 2008 | Pubmed ID: 18061385 ミオシントランスデューサ変異は差のある運動機能、筋原繊維の構造、骨格や心臓筋肉のパフォーマンスに影響を与える Molecular Biology of the Cell. Feb, 2008 | Pubmed ID: 18045988 ショウジョウバエにおける心機能障害のための遺伝的変異 PloS One. 2007 | Pubmed ID: 17622346 ショウジョウバエの心臓の機能と老化の遺伝的制御 Trends in Cardiovascular Medicine. Jul, 2007 | Pubmed ID: 17574126 KCNQカリウムチャネルの変異が加齢の効果を模倣するショウジョウバエの心臓不整脈を引き起こす Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007 | Pubmed ID: 17360457 心臓の老化 Seminars in Cell & Developmental Biology. Feb, 2007 | Pubmed ID: 17275368 加齢に伴う心臓の劣化:ショウジョウバエからの洞察 Frontiers in Bioscience : a Journal and Virtual Library. 2007 | Pubmed ID: 17127282 ショウジョウバエの加齢に伴う心臓疾患モデル Mechanisms of Ageing and Development. Jan, 2007 | Pubmed ID: 17125816 ショウジョウバエの加齢2005/06 Experimental Gerontology. Dec, 2006 | Pubmed ID: 17126511 Cardioblast-固有のブリキ職人の活動は、ショウジョウバエにおける心筋細胞の適切な多様化と分化を制御する Development (Cambridge, England). Oct, 2006 | Pubmed ID: 16987868 ショウジョウバエの心臓の開発における亜鉛フィンガーホメオドメイン遺伝子Zfh1/SIP1の機能保全 Development Genes and Evolution. Nov, 2006 | Pubmed ID: 16957952 抗酸化保護ショウジョウバエのPINK1依存ドーパミン作動性ニューロン Proceedings of the National Academy of Sciences of the United States of America. Sep, 2006 | Pubmed ID: 16938835 活性化FOXO媒介インスリン抵抗性はTOR活性の低下によってブロックされている Cell Metabolism. Aug, 2006 | Pubmed ID: 16890541 ATP感受性カリウム(KATP)チャネル符号化されたDSUR遺伝子は、ショウジョウバエの心臓機能のために必要とされ、ブリキ職人によって調節されている Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006 | Pubmed ID: 16882722 循環器内科の画像:リアルタイム光コヒーレンストモグラフィと大人キイロショウジョウバエの心臓のin Vivoイメージング Circulation. Jul, 2006 | Pubmed ID: 16831991 ショウジョウバエ心膜細胞増殖におけるSVPの役割 Yi Chuan Xue Bao = Acta Genetica Sinica. Jan, 2006 | Pubmed ID: 16450585 ハリネズミとRAS経路が心臓前駆細胞の前後の仕様とポジショニングに協力する Developmental Biology. Feb, 2006 | Pubmed ID: 16387294 スリットアンドロボコントロール心筋細胞極性と形態形成 Current Biology : CB. Dec, 2005 | Pubmed ID: 16360689 胚であってもスキップされた依存筋や心臓の細胞の運命は、正常成人の活動、心機能、寿命に必要な、 Circulation Research. Nov, 2005 | Pubmed ID: 16239588 ショウジョウバエの翅のマージンの開発時にカットと対話する遺伝子座の同定 Genetics. Aug, 2005 | Pubmed ID: 15956666 ニューロマンサーTbx20関連遺伝子(H15/midline)はショウジョウバエの心臓の細胞運命の仕様と形態形成を促進する Developmental Biology. Mar, 2005 | Pubmed ID: 15733676 エージングショウジョウバエの心臓機能のインスリン調節 Nature Genetics. Dec, 2004 | Pubmed ID: 15565107 ショウジョウバエ、心疾患の新興モデル Gene. Nov, 2004 | Pubmed ID: 15527959 ショウジョウバエの心臓機能の変異体のスクリーニングアッセイ BioTechniques. Jul, 2004 | Pubmed ID: 15283201 Cux2発現のダイナミクスは、SVZ前駆体の初期のプールがアッパー皮質層ニューロンになるために運命であることを示唆している Cerebral Cortex (New York, N.Y. : 1991). Dec, 2004 | Pubmed ID: 15238450 筋細胞の運命は、細胞分裂の有無にかかわらず、のみ、ショウジョウバエの心臓の非対称系統のノッチによって拮抗される Development (Cambridge, England). Jul, 2003 | Pubmed ID: 12756185 GATA因子のパニエは心臓前駆細胞形成のための能力を確立するために必要です Development (Cambridge, England). Jul, 2003 | Pubmed ID: 12756184 AmphiNk2錫、心筋前駆細胞に発現ナメクジウオホメオボックス遺伝子:脊椎動物心臓の進化の洞察 Developmental Biology. Mar, 2003 | Pubmed ID: 12618138 相互抑制によって変調されたコンピテンスの転写統合は、心原性中胚葉内の細胞型特異性を生成します。 Developmental Biology. Dec, 2002 | Pubmed ID: 12482712 、遠近軸に沿ったデカペンタプレジック、そしてブリキ職人の位置のパターンショウジョウバエのハート Mechanisms of Development. Jun, 2002 | Pubmed ID: 12175486 MBLR、哺乳類ポリコーム遺伝子産物のような新しいRINGフィンガータンパク質は、細胞周期依存性リン酸化によって調節されている Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Aug, 2002 | Pubmed ID: 12167161 奪われた遺伝子、神経セレクター遺伝子カットの潜在的なターゲットは、毛の形態形成に貢献 Genetics. May, 2002 | Pubmed ID: 12019237 [ショウジョウバエの心臓関連遺伝子の機能を研究する手法としてRNAiの使用] Yi Chuan Xue Bao = Acta Genetica Sinica. Jan, 2002 | Pubmed ID: 11838373 A Late Role for a Subset of Neurogenic Genes to Limit Sensory Precursor Recruitments in Drosophila Embryos Roux's Archives of Developmental Biology : the Official Organ of the EDBO. Aug, 1993 | Pubmed ID: 28306050 Morphological Differentiation of the Embryonic Peripheral Neurons in Drosophila Roux's Archives of Developmental Biology : the Official Organ of the EDBO. Feb, 1987 | Pubmed ID: 28305460 高脂肪食給餌とキイロショウジョウバエの高スループット Triacylglyceride 試金 Soda Balla Diop1, Ryan T. Birse1, Rolf Bodmer1 1Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute JoVE 56029 Genetics の蛍光標識ショウジョウバエハートの構造 Nakissa N. Alayari1,2, Georg Vogler2, Ouarda Taghli-Lamallem2, Karen Ocorr2, Rolf Bodmer2, Anthony Cammarato1,2 1Biology Department, San Diego State University, 2Development and Aging Program, NASCR Center, The Sanford Burnham Institute for Medical Research JoVE 1423 Biology スモールハーツの半自動光ビート解析 Karen Ocorr1, Martin Fink2, Anthony Cammarato1,3, Sanford I. Bernstein3, Rolf Bodmer1 1Development and Aging Program, The Sanford Burnham Institute for Medical Research, 2Cardiac Electrophysiology Group, Dept. of Physiology, Anatomy and Genetics, The Sanford Burnham Institute for Medical Research, 3Biology Department and Heart Institute, San Diego State University JoVE 1435 Biology
高脂肪食給餌とキイロショウジョウバエの高スループット Triacylglyceride 試金 Soda Balla Diop1, Ryan T. Birse1, Rolf Bodmer1 1Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute JoVE 56029 Genetics
の蛍光標識ショウジョウバエハートの構造 Nakissa N. Alayari1,2, Georg Vogler2, Ouarda Taghli-Lamallem2, Karen Ocorr2, Rolf Bodmer2, Anthony Cammarato1,2 1Biology Department, San Diego State University, 2Development and Aging Program, NASCR Center, The Sanford Burnham Institute for Medical Research JoVE 1423 Biology
スモールハーツの半自動光ビート解析 Karen Ocorr1, Martin Fink2, Anthony Cammarato1,3, Sanford I. Bernstein3, Rolf Bodmer1 1Development and Aging Program, The Sanford Burnham Institute for Medical Research, 2Cardiac Electrophysiology Group, Dept. of Physiology, Anatomy and Genetics, The Sanford Burnham Institute for Medical Research, 3Biology Department and Heart Institute, San Diego State University JoVE 1435 Biology