Ronald C. Conaway

Publications

• Subunit Architecture and Functional Modular Rearrangements of the Transcriptional Mediator Complex
  Cell. Jun, 2014  |   Pubmed ID: 24882805
• Multiple Modes of Regulation of the Human Ino80 SNF2 ATPase by Subunits of the INO80 Chromatin-remodeling Complex
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2013  |   Pubmed ID: 24297934
• Crosstalk Between NSL Histone Acetyltransferase and MLL/SET Complexes: NSL Complex Functions in Promoting Histone H3K4 Di-methylation Activity by MLL/SET Complexes
  PLoS Genetics. Nov, 2013  |   Pubmed ID: 24244196
• Role for Human Mediator Subunit MED25 in Recruitment of Mediator to Promoters by Endoplasmic Reticulum Stress-responsive Transcription Factor ATF6α
  The Journal of Biological Chemistry. Sep, 2013  |   Pubmed ID: 23864652
• Transcriptional Properties of Mammalian Elongin A and Its Role in Stress Response
  The Journal of Biological Chemistry. Aug, 2013  |   Pubmed ID: 23828199
• A Conserved Mediator-CDK8 Kinase Module Association Regulates Mediator-RNA Polymerase II Interaction
  Nature Structural & Molecular Biology. May, 2013  |   Pubmed ID: 23563140
• Immunoaffinity Purification of Protein Complexes from Mammalian Cells
  Methods in Molecular Biology (Clifton, N.J.). 2013  |   Pubmed ID: 23436370
• The Mediator Complex and Transcription Elongation
  Biochimica Et Biophysica Acta. Jan, 2013  |   Pubmed ID: 22983086
• Activation of the SNF2 Family ATPase ALC1 by Poly(ADP-ribose) in a Stable ALC1·PARP1·nucleosome Intermediate
  The Journal of Biological Chemistry. Dec, 2012  |   Pubmed ID: 23132853
• Transcriptional Elongation Factor Elongin A Regulates Retinoic Acid-induced Gene Expression During Neuronal Differentiation
  Cell Reports. Nov, 2012  |   Pubmed ID: 23122963
• The Human EKC/KEOPS Complex is Recruited to Cullin2 Ubiquitin Ligases by the Human Tumour Antigen PRAME
  PloS One. 2012  |   Pubmed ID: 22912744
• Endoplasmic Reticulum Stress-responsive Transcription Factor ATF6α Directs Recruitment of the Mediator of RNA Polymerase II Transcription and Multiple Histone Acetyltransferase Complexes
  The Journal of Biological Chemistry. Jun, 2012  |   Pubmed ID: 22577136
• The Tumour Antigen PRAME is a Subunit of a Cul2 Ubiquitin Ligase and Associates with Active NFY Promoters
  The EMBO Journal. Sep, 2011  |   Pubmed ID: 21822215
• Origins and Activity of the Mediator Complex
  Seminars in Cell & Developmental Biology. Sep, 2011  |   Pubmed ID: 21821140
• Human Mediator Subunit MED26 Functions As a Docking Site for Transcription Elongation Factors
  Cell. Jul, 2011  |   Pubmed ID: 21729782
• Function and Regulation of the Mediator Complex
  Current Opinion in Genetics & Development. Apr, 2011  |   Pubmed ID: 21330129
• Subunit Organization of the Human INO80 Chromatin Remodeling Complex: an Evolutionarily Conserved Core Complex Catalyzes ATP-dependent Nucleosome Remodeling
  The Journal of Biological Chemistry. Apr, 2011  |   Pubmed ID: 21303910
• O-GlcNAc Transferase Catalyzes Site-specific Proteolysis of HCF-1
  Cell. Feb, 2011  |   Pubmed ID: 21295698
• AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia
  Molecular Cell. Feb, 2010  |   Pubmed ID: 20159561
• Subunit Composition and Substrate Specificity of a MOF-containing Histone Acetyltransferase Distinct from the Male-specific Lethal (MSL) Complex
  The Journal of Biological Chemistry. Feb, 2010  |   Pubmed ID: 20018852
• Distinct Ubiquitin Ligases Act Sequentially for RNA Polymerase II Polyubiquitylation
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009  |   Pubmed ID: 19920177
• Proteomics Reveals a Physical and Functional Link Between Hepatocyte Nuclear Factor 4alpha and Transcription Factor IID
  The Journal of Biological Chemistry. Nov, 2009  |   Pubmed ID: 19805548
• Poly(ADP-ribosyl)ation Directs Recruitment and Activation of an ATP-dependent Chromatin Remodeler
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009  |   Pubmed ID: 19666485
• Direct Inhibition of RNA Polymerase II Transcription by RECQL5
  The Journal of Biological Chemistry. Aug, 2009  |   Pubmed ID: 19570979
• Mediator Comes out from the Shadows
  Structure (London, England : 1993). Apr, 2009  |   Pubmed ID: 19368880
• The INO80 Chromatin Remodeling Complex in Transcription, Replication and Repair
  Trends in Biochemical Sciences. Feb, 2009  |   Pubmed ID: 19062292
• MED19 and MED26 Are Synergistic Functional Targets of the RE1 Silencing Transcription Factor in Epigenetic Silencing of Neuronal Gene Expression
  The Journal of Biological Chemistry. Jan, 2009  |   Pubmed ID: 19049968
• Mammalian Elongin A Complex Mediates DNA-damage-induced Ubiquitylation and Degradation of Rpb1
  The EMBO Journal. Dec, 2008  |   Pubmed ID: 19037258
• Distinct Modes of Regulation of the Uch37 Deubiquitinating Enzyme in the Proteasome and in the Ino80 Chromatin-remodeling Complex
  Molecular Cell. Sep, 2008  |   Pubmed ID: 18922472
• New Clues to Actin Function in Chromatin Regulation
  Nature Structural & Molecular Biology. May, 2008  |   Pubmed ID: 18461045
• Probabilistic Assembly of Human Protein Interaction Networks from Label-free Quantitative Proteomics
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008  |   Pubmed ID: 18218781
• Characterization of Cullin-box Sequences That Direct Recruitment of Cul2-Rbx1 and Cul5-Rbx2 Modules to Elongin BC-based Ubiquitin Ligases
  The Journal of Biological Chemistry. Mar, 2008  |   Pubmed ID: 18187417
• Neuralized-like 1 (Neurl1) Targeted to the Plasma Membrane by N-myristoylation Regulates the Notch Ligand Jagged1
  The Journal of Biological Chemistry. Feb, 2008  |   Pubmed ID: 18077452
• YY1 Functions with INO80 to Activate Transcription
  Nature Structural & Molecular Biology. Sep, 2007  |   Pubmed ID: 17721549
• Identification and Characterization of a Schizosaccharomyces Pombe RNA Polymerase II Elongation Factor with Similarity to the Metazoan Transcription Factor ELL
  The Journal of Biological Chemistry. Feb, 2007  |   Pubmed ID: 17150956
• RNA Polymerase II: a "nobel" Enzyme Demystified
  Molecular Cell. Dec, 2006  |   Pubmed ID: 17157247
• Quantitative Proteomic Analysis of Distinct Mammalian Mediator Complexes Using Normalized Spectral Abundance Factors
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006  |   Pubmed ID: 17138671
• Purification and Assay of the Human INO80 and SRCAP Chromatin Remodeling Complexes
  Methods (San Diego, Calif.). Dec, 2006  |   Pubmed ID: 17101442
• Proteasome Recruitment and Activation of the Uch37 Deubiquitinating Enzyme by Adrm1
  Nature Cell Biology. Sep, 2006  |   Pubmed ID: 16906146
• Purification of a Human SRCAP Complex That Remodels Chromatin by Incorporating the Histone Variant H2A.Z into Nucleosomes
  Biochemistry. May, 2006  |   Pubmed ID: 16634648
• In and Out: Histone Variant Exchange in Chromatin
  Trends in Biochemical Sciences. Dec, 2005  |   Pubmed ID: 16257529
• A Mammalian Chromatin Remodeling Complex with Similarities to the Yeast INO80 Complex
  The Journal of Biological Chemistry. Dec, 2005  |   Pubmed ID: 16230350
• ELL-associated Factors 1 and 2 Are Positive Regulators of RNA Polymerase II Elongation Factor ELL
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2005  |   Pubmed ID: 16006523
• The Mammalian Mediator Complex and Its Role in Transcriptional Regulation
  Trends in Biochemical Sciences. May, 2005  |   Pubmed ID: 15896743
• The Mammalian Mediator Complex
  FEBS Letters. Feb, 2005  |   Pubmed ID: 15680972
• The Mammalian YL1 Protein is a Shared Subunit of the TRRAP/TIP60 Histone Acetyltransferase and SRCAP Complexes
  The Journal of Biological Chemistry. Apr, 2005  |   Pubmed ID: 15647280
• Regulation of Heat Shock Gene Expression by RNA Polymerase II Elongation Factor, Elongin A
  The Journal of Biological Chemistry. Feb, 2005  |   Pubmed ID: 15611125
• ASB2 is an Elongin BC-interacting Protein That Can Assemble with Cullin 5 and Rbx1 to Reconstitute an E3 Ubiquitin Ligase Complex
  The Journal of Biological Chemistry. Feb, 2005  |   Pubmed ID: 15590664
• VHL-box and SOCS-box Domains Determine Binding Specificity for Cul2-Rbx1 and Cul5-Rbx2 Modules of Ubiquitin Ligases
  Genes & Development. Dec, 2004  |   Pubmed ID: 15601820
• In Vivo Requirement of the RNA Polymerase II Elongation Factor Elongin A for Proper Gene Expression and Development
  Molecular and Cellular Biology. Nov, 2004  |   Pubmed ID: 15509793
• Both BC-box Motifs of Adenovirus Protein E4orf6 Are Required to Efficiently Assemble an E3 Ligase Complex That Degrades P53
  Molecular and Cellular Biology. Nov, 2004  |   Pubmed ID: 15485928
• Identification of Elongin C and Skp1 Sequences That Determine Cullin Selection
  The Journal of Biological Chemistry. Oct, 2004  |   Pubmed ID: 15280393
• A Set of Consensus Mammalian Mediator Subunits Identified by Multidimensional Protein Identification Technology
  Molecular Cell. Jun, 2004  |   Pubmed ID: 15175163
• A Unified Nomenclature for Protein Subunits of Mediator Complexes Linking Transcriptional Regulators to RNA Polymerase II
  Molecular Cell. Jun, 2004  |   Pubmed ID: 15175151
• A Mammalian Mediator Subunit That Shares Properties with Saccharomyces Cerevisiae Mediator Subunit Cse2
  The Journal of Biological Chemistry. Feb, 2004  |   Pubmed ID: 14638676
• Preparation and Assay of RNA Polymerase II Elongation Factors Elongin and ELL
  Methods in Enzymology. 2003  |   Pubmed ID: 14712707
• Assays for Investigating the Mechanism of Promoter Escape by RNA Polymerase II
  Methods in Enzymology. 2003  |   Pubmed ID: 14712687
• A Mammalian Homolog of Drosophila Melanogaster Transcriptional Coactivator Intersex is a Subunit of the Mammalian Mediator Complex
  The Journal of Biological Chemistry. Dec, 2003  |   Pubmed ID: 14576168
• Identification of New Subunits of the Multiprotein Mammalian TRRAP/TIP60-containing Histone Acetyltransferase Complex
  The Journal of Biological Chemistry. Oct, 2003  |   Pubmed ID: 12963728
• TFIIS and GreB: Two Like-minded Transcription Elongation Factors with Sticky Fingers
  Cell. Aug, 2003  |   Pubmed ID: 12914690
• The RNA Polymerase II Elongation Complex
  Annual Review of Biochemistry. 2003  |   Pubmed ID: 12676794
• Von Hippel-Lindau Protein Binds Hyperphosphorylated Large Subunit of RNA Polymerase II Through a Proline Hydroxylation Motif and Targets It for Ubiquitination
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2003  |   Pubmed ID: 12604794
• Identification of Mammalian Mediator Subunits with Similarities to Yeast Mediator Subunits Srb5, Srb6, Med11, and Rox3
  The Journal of Biological Chemistry. Apr, 2003  |   Pubmed ID: 12584197
• Multiple Splice Variants of the Human HIF-3 Alpha Locus Are Targets of the Von Hippel-Lindau E3 Ubiquitin Ligase Complex
  The Journal of Biological Chemistry. Mar, 2003  |   Pubmed ID: 12538644
• The Von Hippel-Lindau Tumor Suppressor Complex and Regulation of Hypoxia-inducible Transcription
  Advances in Cancer Research. 2002  |   Pubmed ID: 12374282
• Biochemical Purification and Pharmacological Inhibition of a Mammalian Prolyl Hydroxylase Acting on Hypoxia-inducible Factor
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002  |   Pubmed ID: 12351678
• Mammalian Mediator Subunit MMED8 is an Elongin BC-interacting Protein That Can Assemble with Cul2 and Rbx1 to Reconstitute a Ubiquitin Ligase
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2002  |   Pubmed ID: 12149480
• A Molecular Basis for Stabilization of the Von Hippel-Lindau (VHL) Tumor Suppressor Protein by Components of the VHL Ubiquitin Ligase
  The Journal of Biological Chemistry. Aug, 2002  |   Pubmed ID: 12048197
• Emerging Roles of Ubiquitin in Transcription Regulation
  Science (New York, N.Y.). May, 2002  |   Pubmed ID: 12016299
• Structure of the Cul1-Rbx1-Skp1-F BoxSkp2 SCF Ubiquitin Ligase Complex
  Nature. Apr, 2002  |   Pubmed ID: 11961546
• Roles of SCF and VHL Ubiquitin Ligases in Regulation of Cell Growth
  Progress in Molecular and Subcellular Biology. 2002  |   Pubmed ID: 11908068