Ronald L. Klein

Publications

• Entorhinal Tau Pathology Disrupts Hippocampal-prefrontal Oscillatory Coupling During Associative Learning
  Neurobiology of Aging. Jul, 2017  |   Pubmed ID: 28735144
• P62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration
  PloS One. 2017  |   Pubmed ID: 28076378
• Corrigendum: Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B
  Frontiers in Molecular Neuroscience. 2016  |   Pubmed ID: 28008310
• Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B
  Frontiers in Molecular Neuroscience. 2016  |   Pubmed ID: 27867348
• Severe Respiratory Changes at End Stage in a FUS-induced Disease State in Adult Rats
  BMC Neuroscience. Oct, 2016  |   Pubmed ID: 27793099
• Gene Vector 'magic Bullet': Targeted Expression in the Central Nervous System After Peripheral Delivery Using the Synapsin Promoter
  Expert Opinion on Therapeutic Targets. Oct, 2016  |   Pubmed ID: 27424738
• Sequential Adeno-Associated Viral Vector Serotype 9-Green Fluorescent Protein Gene Transfer Causes Massive Inflammation and Intense Immune Response in Rat Striatum
  Human Gene Therapy. Jul, 2016  |   Pubmed ID: 26847924
• AAV9 Supports Wide-scale Transduction of the CNS and TDP-43 Disease Modeling in Adult Rats
  Molecular Therapy. Methods & Clinical Development. 2015  |   Pubmed ID: 26445725
• Initial Gene Vector Dosing for Studying Symptomatology of Amyotrophic Lateral Sclerosis in Non-human Primates
  Journal of Medical Primatology. Apr, 2015  |   Pubmed ID: 25639184
• Selective Forelimb Impairment in Rats Expressing a Pathological TDP-43 25 KDa C-terminal Fragment to Mimic Amyotrophic Lateral Sclerosis
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2013  |   Pubmed ID: 28160795
• Selective Forelimb Impairment in Rats Expressing a Pathological TDP-43 25 kDa C-terminal Fragment to Mimic Amyotrophic Lateral Sclerosis
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2013  |   Pubmed ID: 23689600
• Pre-immunization with an Intramuscular Injection of AAV9-Human Erythropoietin Vectors Reduces the Vector-Mediated Transduction Following Re-Administration in Rat Brain
  PloS One. 2013  |   Pubmed ID: 23667683
• Recombinant AAV9-TLK1B Administration Ameliorates Fractionated Radiation-induced Xerostomia
  Human Gene Therapy. Jun, 2013  |   Pubmed ID: 23614651
• Imaging the Response of the Retina to Electrical Stimulation with Genetically Encoded Calcium Indicators
  Journal of Neurophysiology. Apr, 2013  |   Pubmed ID: 23343890
• A Spirulina-enhanced Diet Provides Neuroprotection in an α-synuclein Model of Parkinson's Disease
  PloS One. 2012  |   Pubmed ID: 23028885
• Adult-onset Focal Expression of Mutated Human Tau in the Hippocampus Impairs Spatial Working Memory of Rats
  Behavioural Brain Research. Jul, 2012  |   Pubmed ID: 22561128
• Isocitrate Dehydrogenase 1 is Downregulated During Early Skin Tumorigenesis Which Can Be Inhibited by Overexpression of Manganese Superoxide Dismutase
  Cancer Science. Aug, 2012  |   Pubmed ID: 22533343
• The Advent of AAV9 Expands Applications for Brain and Spinal Cord Gene Delivery
  Expert Opinion on Biological Therapy. Jun, 2012  |   Pubmed ID: 22519910
• Frontotemporal Lobar Degeneration-related Proteins Induce Only Subtle Memory-related Deficits when Bilaterally Overexpressed in the Dorsal Hippocampus
  Experimental Neurology. Feb, 2012  |   Pubmed ID: 22177996
• Genetic Strategies to Study TDP-43 in Rodents and to Develop Preclinical Therapeutics for Amyotrophic Lateral Sclerosis
  The European Journal of Neuroscience. Oct, 2011  |   Pubmed ID: 21777407
• Focal Expression of Mutated Tau in Entorhinal Cortex Neurons of Rats Impairs Spatial Working Memory
  Behavioural Brain Research. Jan, 2011  |   Pubmed ID: 20727915
• Expansive Gene Transfer in the Rat CNS Rapidly Produces Amyotrophic Lateral Sclerosis Relevant Sequelae when TDP-43 is Overexpressed
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2010  |   Pubmed ID: 20877346
• Circulating Neprilysin Clears Brain Amyloid
  Molecular and Cellular Neurosciences. Oct, 2010  |   Pubmed ID: 20558294
• Transcriptome Analysis of a Tau Overexpression Model in Rats Implicates an Early Pro-inflammatory Response
  Experimental Neurology. Jul, 2010  |   Pubmed ID: 20346943
• Pronounced Microgliosis and Neurodegeneration in Aged Rats After Tau Gene Transfer
  Neurobiology of Aging. Dec, 2010  |   Pubmed ID: 19155101
• Versatile Somatic Gene Transfer for Modeling Neurodegenerative Diseases
  Neurotoxicity Research. Oct, 2009  |   Pubmed ID: 19669852
• Bilateral Effects of Unilateral GDNF Administration on Dopamine- and GABA-regulating Proteins in the Rat Nigrostriatal System
  Experimental Neurology. Sep, 2009  |   Pubmed ID: 19460370
• PET Imaging in Rats to Discern Temporal Onset Differences Between 6-hydroxydopamine and Tau Gene Vector Neurodegeneration Models
  Brain Research. Mar, 2009  |   Pubmed ID: 19368808
• Mimicking Aspects of Frontotemporal Lobar Degeneration and Lou Gehrig's Disease in Rats Via TDP-43 Overexpression
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2009  |   Pubmed ID: 19223871
• Effect of CNTF on Retinal Ganglion Cell Survival in Experimental Glaucoma
  Investigative Ophthalmology & Visual Science. May, 2009  |   Pubmed ID: 19060281
• Tau Expression Levels from Various Adeno-associated Virus Vector Serotypes Produce Graded Neurodegenerative Disease States
  The European Journal of Neuroscience. Apr, 2008  |   Pubmed ID: 18380664
• AAV8, 9, Rh10, Rh43 Vector Gene Transfer in the Rat Brain: Effects of Serotype, Promoter and Purification Method
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2008  |   Pubmed ID: 17955025
• Memory-related Deficits Following Selective Hippocampal Expression of Swedish Mutation Amyloid Precursor Protein in the Rat
  Experimental Neurology. Aug, 2006  |   Pubmed ID: 16780838
• Parkin is Protective for Substantia Nigra Dopamine Neurons in a Tau Gene Transfer Neurodegeneration Model
  Neuroscience Letters. Jun, 2006  |   Pubmed ID: 16554120
• Efficient Neuronal Gene Transfer with AAV8 Leads to Neurotoxic Levels of Tau or Green Fluorescent Proteins
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2006  |   Pubmed ID: 16325474
• Tau Gene Transfer, but Not Alpha-synuclein, Induces Both Progressive Dopamine Neuron Degeneration and Rotational Behavior in the Rat
  Neurobiology of Disease. Oct, 2005  |   Pubmed ID: 16137567
• Adeno-associated Viruses Containing BFGF or BDNF Are Neuroprotective Against Excitotoxicity
  Current Eye Research. Dec, 2004  |   Pubmed ID: 15764082
• Recombinant Adeno-associated Virus Serotype 2 Effectively Transduces Primary Rat Brain Astrocytes and Microglia
  Brain Research. Brain Research Protocols. Nov, 2004  |   Pubmed ID: 15519948
• Rapid Neurofibrillary Tangle Formation After Localized Gene Transfer of Mutated Tau
  The American Journal of Pathology. Jan, 2004  |   Pubmed ID: 14695347
• Long-term Neuronal Effects and Disposition of Ectopic PreproNGF Gene Transfer into the Rat Septum
  Human Gene Therapy. Oct, 2003  |   Pubmed ID: 14577926
• Gene Therapy with Brain-derived Neurotrophic Factor As a Protection: Retinal Ganglion Cells in a Rat Glaucoma Model
  Investigative Ophthalmology & Visual Science. Oct, 2003  |   Pubmed ID: 14507880
• Adeno-associated Virus Vector Expressing Nerve Growth Factor Enhances Cholinergic Axonal Sprouting After Cortical Injury in Rats
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2003  |   Pubmed ID: 12684466
• Suppression of Insult-induced Neurogenesis in Adult Rat Brain by Brain-derived Neurotrophic Factor
  Experimental Neurology. Sep, 2002  |   Pubmed ID: 12429205
• Particle Detection, Number Estimation, and Feature Measurement in Gene Transfer Studies: Optical Fractionator Stereology Integrated with Digital Image Processing and Analysis
  Methods (San Diego, Calif.). Oct, 2002  |   Pubmed ID: 12413429
• Measurements of Vector-derived Neurotrophic Factor and Green Fluorescent Protein Levels in the Brain
  Methods (San Diego, Calif.). Oct, 2002  |   Pubmed ID: 12413428
• Gene Delivery to the Eye Using Adeno-associated Viral Vectors
  Methods (San Diego, Calif.). Oct, 2002  |   Pubmed ID: 12413426
• Pre- and Post-synaptic Modification by Neurotrophins
  Neuroscience Research. Jul, 2002  |   Pubmed ID: 12103437
• Dose and Promoter Effects of Adeno-associated Viral Vector for Green Fluorescent Protein Expression in the Rat Brain
  Experimental Neurology. Jul, 2002  |   Pubmed ID: 12093083
• Dopaminergic Cell Loss Induced by Human A30P Alpha-synuclein Gene Transfer to the Rat Substantia Nigra
  Human Gene Therapy. Mar, 2002  |   Pubmed ID: 11916484
• Neuropathological and Behavioral Consequences of Adeno-associated Viral Vector-mediated Continuous Intrastriatal Neurotrophin Delivery in a Focal Ischemia Model in Rats
  Neurobiology of Disease. Mar, 2002  |   Pubmed ID: 11895371