Ruth S. Slack

Publications

• OPA1-dependent Cristae Modulation is Essential for Cellular Adaptation to Metabolic Demand
  The EMBO Journal. Nov, 2014  |   Pubmed ID: 25298396
• DJ-1 Interacts with and Regulates Paraoxonase-2, an Enzyme Critical for Neuronal Survival in Response to Oxidative Stress
  PloS One. 2014  |   Pubmed ID: 25210784
• Regulation of the VHL/HIF-1 Pathway by DJ-1
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2014  |   Pubmed ID: 24899725
• Regulation of Ischemic Neuronal Death by E2F4-p130 Protein Complexes
  The Journal of Biological Chemistry. Jun, 2014  |   Pubmed ID: 24828495
• Acidosis Overrides Oxygen Deprivation to Maintain Mitochondrial Function and Cell Survival
  Nature Communications. 2014  |   Pubmed ID: 24686499
• Interaction and Antagonistic Roles of NF-κB and Hes6 in the Regulation of Cortical Neurogenesis
  Molecular and Cellular Biology. Jul, 2013  |   Pubmed ID: 23689134
• LXCXE-independent Chromatin Remodeling by Rb/E2f Mediates Neuronal Quiescence
  Cell Cycle (Georgetown, Tex.). May, 2013  |   Pubmed ID: 23574720
• Perturbation of Transcription Factor Nur77 Expression Mediated by Myocyte Enhancer Factor 2D (MEF2D) Regulates Dopaminergic Neuron Loss in Response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
  The Journal of Biological Chemistry. May, 2013  |   Pubmed ID: 23536182
• Conditional Disruption of Calpain in the CNS Alters Dendrite Morphology, Impairs LTP, and Promotes Neuronal Survival Following Injury
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2013  |   Pubmed ID: 23536090
• Opposing Regulation of Sox2 by Cell-cycle Effectors E2f3a and E2f3b in Neural Stem Cells
  Cell Stem Cell. Apr, 2013  |   Pubmed ID: 23499385
• LKB1-regulated Adaptive Mechanisms Are Essential for Neuronal Survival Following Mitochondrial Dysfunction
  Human Molecular Genetics. Mar, 2013  |   Pubmed ID: 23187960
• The Retinoblastoma Protein is Essential for Survival of Postmitotic Neurons
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2012  |   Pubmed ID: 23077065
• Progressive Dopaminergic Cell Loss with Unilateral-to-bilateral Progression in a Genetic Model of Parkinson Disease
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2012  |   Pubmed ID: 23019375
• Directrices Para El Uso E Interpretación De Ensayos Para El Control De La Autofagia
  Autophagy. Apr, 2012  |   Pubmed ID: 22966490
• ROS-dependent Regulation of Parkin and DJ-1 Localization During Oxidative Stress in Neurons
  Human Molecular Genetics. Nov, 2012  |   Pubmed ID: 22872702
• The Rb/E2F Pathway Modulates Neurogenesis Through Direct Regulation of the Dlx1/Dlx2 Bigene Cluster
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2012  |   Pubmed ID: 22699903
• Inactivation of Pink1 Gene in Vivo Sensitizes Dopamine-producing Neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes, Parkin or DJ-1
  The Journal of Biological Chemistry. Jun, 2012  |   Pubmed ID: 22511790
• MCL-1 Regulates the Balance Between Autophagy and Apoptosis
  Autophagy. May, 2011  |   Pubmed ID: 21412051
• MCL-1 is a Stress Sensor That Regulates Autophagy in a Developmentally Regulated Manner
  The EMBO Journal. Jan, 2011  |   Pubmed ID: 21139567
• Rb/E2F Regulates Expression of Neogenin During Neuronal Migration
  Molecular and Cellular Biology. Jan, 2011  |   Pubmed ID: 21059867
• The Mitochondrial Inner Membrane GTPase, Optic Atrophy 1 (Opa1), Restores Mitochondrial Morphology and Promotes Neuronal Survival Following Excitotoxicity
  The Journal of Biological Chemistry. Feb, 2011  |   Pubmed ID: 21041314
• The Role of Cdk5-mediated Apurinic/apyrimidinic Endonuclease 1 Phosphorylation in Neuronal Death
  Nature Cell Biology. Jun, 2010  |   Pubmed ID: 20473298
• Especies Reactivas Del Oxígeno: Atrapado En Medio De La Neurodegeneración
  Journal of Alzheimer's Disease : JAD. 2010  |   Pubmed ID: 20421690
• Sertad1 Juega Un Papel Importante En La Muerte De Las Neuronas Del Desarrollo Y Patológica
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2010  |   Pubmed ID: 20237268
• DJ-1 Protects the Nigrostriatal Axis from the Neurotoxin MPTP by Modulation of the AKT Pathway
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010  |   Pubmed ID: 20133695
• Pim-1 Kinase As Activator of the Cell Cycle Pathway in Neuronal Death Induced by DNA Damage
  Journal of Neurochemistry. Jan, 2010  |   Pubmed ID: 19895669
• Dining in with BCL-2: New Guests at the Autophagy Table
  Clinical Science (London, England : 1979). Feb, 2010  |   Pubmed ID: 19845510
• Mitochondria: Joining Forces to Thwart Cell Death
  Biochimica Et Biophysica Acta. Jan, 2010  |   Pubmed ID: 19747972
• Essential Role of Cytoplasmic Cdk5 and Prx2 in Multiple Ischemic Injury Models, in Vivo
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009  |   Pubmed ID: 19812325
• Leucina-rich Repeat Kinase 2 Interactúa Con Parkin, DJ-1 Y PINK-1 En Un Modelo De Drosophila Melanogaster De La Enfermedad De Parkinson
  Human Molecular Genetics. Nov, 2009  |   Pubmed ID: 19692353
• The P107/E2F Pathway Regulates Fibroblast Growth Factor 2 Responsiveness in Neural Precursor Cells
  Molecular and Cellular Biology. Sep, 2009  |   Pubmed ID: 19564414
• E2F4 is Required for Early Eye Patterning
  Developmental Neuroscience. 2009  |   Pubmed ID: 19325228
• Mcl-1 is a Key Regulator of Apoptosis During CNS Development and After DNA Damage
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2008  |   Pubmed ID: 18550749
• HES1 Regulates 5-HT1A Receptor Gene Transcription at a Functional Polymorphism: Essential Role in Developmental Expression
  Molecular and Cellular Neurosciences. Jul, 2008  |   Pubmed ID: 18499474
• CITED2 Signals Through Peroxisome Proliferator-activated Receptor-gamma to Regulate Death of Cortical Neurons After DNA Damage
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2008  |   Pubmed ID: 18495890
• Cytoplasmic Pink1 Activity Protects Neurons from Dopaminergic Neurotoxin MPTP
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008  |   Pubmed ID: 18218782
• Delayed Combinatorial Treatment with Flavopiridol and Minocycline Provides Longer Term Protection for Neuronal Soma but Not Dendrites Following Global Ischemia
  Journal of Neurochemistry. May, 2008  |   Pubmed ID: 18205749
• Required Roles of Bax and JNKs in Central and Peripheral Nervous System Death of Retinoblastoma-deficient Mice
  The Journal of Biological Chemistry. Jan, 2008  |   Pubmed ID: 17984095
• The Parkinson's Disease Gene DJ-1 is Also a Key Regulator of Stroke-induced Damage
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2007  |   Pubmed ID: 18003894
• Specific in Vivo Roles for E2Fs in Differentiation and Development
  Cell Cycle (Georgetown, Tex.). Dec, 2007  |   Pubmed ID: 17993781
• The Phosphorylation State of Drp1 Determines Cell Fate
  EMBO Reports. Oct, 2007  |   Pubmed ID: 17906671
• Role of Cdk5-mediated Phosphorylation of Prx2 in MPTP Toxicity and Parkinson's Disease
  Neuron. Jul, 2007  |   Pubmed ID: 17610816
• The Retinoblastoma Family Member P107 Regulates the Rate of Progenitor Commitment to a Neuronal Fate
  The Journal of Cell Biology. Jul, 2007  |   Pubmed ID: 17591923
• Cell Cycle Regulator E2F4 is Essential for the Development of the Ventral Telencephalon
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2007  |   Pubmed ID: 17537963
• Mitofusin 2 Protects Cerebellar Granule Neurons Against Injury-induced Cell Death
  The Journal of Biological Chemistry. Aug, 2007  |   Pubmed ID: 17537722
• Mitochondrial Dynamics in the Regulation of Neuronal Cell Death
  Apoptosis : an International Journal on Programmed Cell Death. May, 2007  |   Pubmed ID: 17453163
• Unique Requirement for Rb/E2F3 in Neuronal Migration: Evidence for Cell Cycle-independent Functions
  Molecular and Cellular Biology. Jul, 2007  |   Pubmed ID: 17452454
• Urine Concentrating Defect in Prostaglandin EP1-deficient Mice
  American Journal of Physiology. Renal Physiology. Feb, 2007  |   Pubmed ID: 16885154
• The Chk1/Cdc25A Pathway As Activators of the Cell Cycle in Neuronal Death Induced by Camptothecin
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2006  |   Pubmed ID: 16928871
• Dissociating the Dual Roles of Apoptosis-inducing Factor in Maintaining Mitochondrial Structure and Apoptosis
  The EMBO Journal. Sep, 2006  |   Pubmed ID: 16917506
• Novel Functions for Cell Cycle Genes in Nervous System Development
  Cell Cycle (Georgetown, Tex.). Jul, 2006  |   Pubmed ID: 16861920
• Calpain-regulated P35/cdk5 Plays a Central Role in Dopaminergic Neuron Death Through Modulation of the Transcription Factor Myocyte Enhancer Factor 2
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2006  |   Pubmed ID: 16407541
• Regulation of Axotomy-induced Dopaminergic Neuron Death and C-Jun Phosphorylation by Targeted Inhibition of Cdc42 or Mixed Lineage Kinase
  Journal of Neurochemistry. Jan, 2006  |   Pubmed ID: 16336220
• Un Requisito De La Célula Autónoma De La Proteína Reguladoras Del Ciclo Celular, Rb, En La Migración Neuronal
  The EMBO Journal. Dec, 2005  |   Pubmed ID: 16308563
• Differential Roles of Nuclear and Cytoplasmic Cyclin-dependent Kinase 5 in Apoptotic and Excitotoxic Neuronal Death
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2005  |   Pubmed ID: 16192386
• Multiple Cyclin-dependent Kinases Signals Are Critical Mediators of Ischemia/hypoxic Neuronal Death in Vitro and in Vivo
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2005  |   Pubmed ID: 16166266
• Factor Inductor De Apoptosis Es Un Factor Clave En La Muerte Celular Neuronal Propagada Por Mecanismos Dependientes De BAX Y BAX Independiente
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2005  |   Pubmed ID: 15703386
• The Chromatin-remodeling Protein ATRX is Critical for Neuronal Survival During Corticogenesis
  The Journal of Clinical Investigation. Feb, 2005  |   Pubmed ID: 15668733
• C-Jun N-terminal Kinase 3 Deficiency Protects Neurons from Axotomy-induced Death in Vivo Through Mechanisms Independent of C-Jun Phosphorylation
  The Journal of Biological Chemistry. Jan, 2005  |   Pubmed ID: 15528206
• P53 Activation Domain 1 is Essential for PUMA Upregulation and P53-mediated Neuronal Cell Death
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2004  |   Pubmed ID: 15525786
• Emerging Role for ERK As a Key Regulator of Neuronal Apoptosis
  Science's STKE : Signal Transduction Knowledge Environment. Sep, 2004  |   Pubmed ID: 15383672
• P107 Regulates Neural Precursor Cells in the Mammalian Brain
  The Journal of Cell Biology. Sep, 2004  |   Pubmed ID: 15353549
• Cell-specific Effects of RB or RB/p107 Loss on Retinal Development Implicate an Intrinsically Death-resistant Cell-of-origin in Retinoblastoma
  Cancer Cell. Jun, 2004  |   Pubmed ID: 15193257
• The Proapoptotic Gene SIVA is a Direct Transcriptional Target for the Tumor Suppressors P53 and E2F1
  The Journal of Biological Chemistry. Jul, 2004  |   Pubmed ID: 15105421
• Role of AIF in Caspase-dependent and Caspase-independent Cell Death
  Oncogene. Apr, 2004  |   Pubmed ID: 15077142
• Nuclear Factor-(kappa)B Modulates the P53 Response in Neurons Exposed to DNA Damage
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2004  |   Pubmed ID: 15044535
• Cyclin-dependent Kinase 5 is a Mediator of Dopaminergic Neuron Loss in a Mouse Model of Parkinson's Disease
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2003  |   Pubmed ID: 14595022
• Ataxia Telangiectasia-mutated Protein Can Regulate P53 and Neuronal Death Independent of Chk2 in Response to DNA Damage
  The Journal of Biological Chemistry. Sep, 2003  |   Pubmed ID: 12857758
• Growth Factors: Can They Promote Neurogenesis?
  Trends in Neurosciences. Jun, 2003  |   Pubmed ID: 12798593
• Inhibition of Calpains Prevents Neuronal and Behavioral Deficits in an MPTP Mouse Model of Parkinson's Disease
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2003  |   Pubmed ID: 12764095
• Calpains Mediate P53 Activation and Neuronal Death Evoked by DNA Damage
  The Journal of Biological Chemistry. Jul, 2003  |   Pubmed ID: 12721303
• Caspase 3 Activity is Required for Skeletal Muscle Differentiation
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2002  |   Pubmed ID: 12177420
• Apoptosis-inducing Factor is Involved in the Regulation of Caspase-independent Neuronal Cell Death
  The Journal of Cell Biology. Aug, 2002  |   Pubmed ID: 12147675
• Telencephalon-specific Rb Knockouts Reveal Enhanced Neurogenesis, Survival and Abnormal Cortical Development
  The EMBO Journal. Jul, 2002  |   Pubmed ID: 12093735
• Interaction of the C-Jun/JNK Pathway and Cyclin-dependent Kinases in Death of Embryonic Cortical Neurons Evoked by DNA Damage
  The Journal of Biological Chemistry. Sep, 2002  |   Pubmed ID: 12091388
• The Neuronal Apoptosis Inhibitory Protein is a Direct Inhibitor of Caspases 3 and 7
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2002  |   Pubmed ID: 11896143
• Inhibition of Cyclin-dependent Kinases Improves CA1 Neuronal Survival and Behavioral Performance After Global Ischemia in the Rat
  Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Feb, 2002  |   Pubmed ID: 11823715