In JoVE (2)
Other Publications (0)
Articles by Sébastien Tremblay in JoVE
A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat Maggie Roy1, Scott Nugent1, Sébastien Tremblay2, Maxime Descoteaux3, Jean-François Beaudoin2, Luc Tremblay2, Roger Lecomte2,4, Stephen C Cunnane1 1Research Center on Aging and Department of Physiology and Biophysics, Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center, Étienne-Le Bel Clinical Research Center, Université de Sherbrooke, 3Department of Computer Science, Université de Sherbrooke, 4Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke Small-animal positron emission tomography enables the assessment of the brain's two main energy substrates: glucose and ketones. In the present method, 11C-acetoacetate and 18F-fluorodeoxyglucose are injected sequentially in each animal, and their uptake is measured quantitatively in specific brain regions determined from the magnetic resonance images.
The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism Sara Tremblay1, Vincent Beaulé1, Sébastien Proulx2, Louis-Philippe Lafleur1, Julien Doyon1, Małgorzata Marjańska3, Hugo Théoret1 1Department of Psychology, University of Montréal, 2Montreal Neurological Institute, McGill University, 3Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota This article aims to describe a basic protocol for combining transcranial direct current stimulation (tDCS) with proton magnetic resonance spectroscopy (1H-MRS) measurements to investigate the effects of bilateral stimulation on primary motor cortex metabolism.