Sabine Gilch Dept. of Ecosystem and Public Health, Calgary Prion Research Units, Faculty of Veterinary Medicine University of Calgary Biography Publications Institution JoVE Articles Sabine Gilch has not added a biography. If you are Sabine Gilch and would like to personalize this page please email our Author Liaison for assistance. Publications Destabilizing Polymorphism in Cervid Prion Protein Hydrophobic Core Determines Prion Conformation and Conversion Efficiency PLoS Pathogens. Aug, 2017 | Pubmed ID: 28800624 High Prevalence of Prion Protein Genotype Associated with Resistance to Chronic Wasting Disease in One Alberta Woodland Caribou Population Prion. Mar, 2017 | Pubmed ID: 28350512 Early and Non-Invasive Detection of Chronic Wasting Disease Prions in Elk Feces by Real-Time Quaking Induced Conversion PloS One. 2016 | Pubmed ID: 27829062 Prion Infection Impairs Lysosomal Degradation Capacity by Interfering with Rab7 Membrane Attachment in Neuronal Cells Scientific Reports. Feb, 2016 | Pubmed ID: 26865414 Cholesterol Balance in Prion Diseases and Alzheimer's Disease Viruses. Nov, 2014 | Pubmed ID: 25419621 Assessing Proteinase K Resistance of Fish Prion Proteins in a Scrapie-infected Mouse Neuroblastoma Cell Line Viruses. Nov, 2014 | Pubmed ID: 25402173 Early Detection of Chronic Wasting Disease Prions in Urine of Pre-symptomatic Deer by Real-time Quaking-induced Conversion Assay Prion. May-Jun, 2013 | Pubmed ID: 23764839 A Genome-wide Survey for Prion-regulated MiRNAs Associated with Cholesterol Homeostasis BMC Genomics. Sep, 2012 | Pubmed ID: 22985096 Failure of Prion Protein Oxidative Folding Guides the Formation of Toxic Transmembrane Forms The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22955286 Severe Acute Respiratory Syndrome Coronavirus Replication is Severely Impaired by MG132 Due to Proteasome-independent Inhibition of M-calpain Journal of Virology. Sep, 2012 | Pubmed ID: 22787216 Proteasomal Dysfunction and Endoplasmic Reticulum Stress Enhance Trafficking of Prion Protein Aggregates Through the Secretory Pathway and Increase Accumulation of Pathologic Prion Protein The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21835918 Chronic Wasting Disease Topics in Current Chemistry. 2011 | Pubmed ID: 21598099 Prion Protein Interaction with Stress-inducible Protein 1 Enhances Neuronal Protein Synthesis Via MTOR Proceedings of the National Academy of Sciences of the United States of America. Jul, 2010 | Pubmed ID: 20615969 Inhibition of Cholesterol Recycling Impairs Cellular PrP(Sc) Propagation Cellular and Molecular Life Sciences : CMLS. Dec, 2009 | Pubmed ID: 19823766 Prion-induced Activation of Cholesterogenic Gene Expression by Srebp2 in Neuronal Cells The Journal of Biological Chemistry. Nov, 2009 | Pubmed ID: 19748890 Aptamers Against Prion Proteins and Prions Cellular and Molecular Life Sciences : CMLS. Aug, 2009 | Pubmed ID: 19396399 Therapy in Prion Diseases: from Molecular and Cellular Biology to Therapeutic Targets Infectious Disorders Drug Targets. Feb, 2009 | Pubmed ID: 19200010 Autophagy Induction by Trehalose Counteracts Cellular Prion Infection Autophagy. Apr, 2009 | Pubmed ID: 19182537 Targeting Prion Proteins in Neurodegenerative Disease Expert Opinion on Biological Therapy. Jul, 2008 | Pubmed ID: 18549323 Neuroendocrine Cultured Cells Counteract Persistent Prion Infection by Down-regulation of PrPc Molecular and Cellular Neurosciences. May, 2008 | Pubmed ID: 18387818 Cell Type-specific Cleavage of Nucleocapsid Protein by Effector Caspases During SARS Coronavirus Infection Journal of Molecular Biology. Feb, 2008 | Pubmed ID: 18155731 Toxic Effects of Intracerebral PrP Antibody Administration During the Course of BSE Infection in Mice Prion. Jul-Sep, 2007 | Pubmed ID: 19164902 CpG and LPS Can Interfere Negatively with Prion Clearance in Macrophage and Microglial Cells The FEBS Journal. Nov, 2007 | Pubmed ID: 17944938 The Tyrosine Kinase Inhibitor Imatinib Mesylate Delays Prion Neuroinvasion by Inhibiting Prion Propagation in the Periphery Journal of Neurovirology. Aug, 2007 | Pubmed ID: 17849316 Peptide Aptamers Expressed in the Secretory Pathway Interfere with Cellular PrPSc Formation Journal of Molecular Biology. Aug, 2007 | Pubmed ID: 17574575 Strategies for Eliminating PrP(c) As Substrate for Prion Conversion and for Enhancing PrP(Sc) Degradation Veterinary Microbiology. Aug, 2007 | Pubmed ID: 17493775 Vaccination with Prion Peptide-displaying Papillomavirus-like Particles Induces Autoantibodies to Normal Prion Protein That Interfere with Pathologic Prion Protein Production in Infected Cells The FEBS Journal. Apr, 2007 | Pubmed ID: 17313482 Antibodies to a Nonconjugated Prion Protein Peptide 95-123 Interfere with PrP( Sc ) Propagation in Prion-infected Cells Cellular and Molecular Neurobiology. May, 2007 | Pubmed ID: 17205391 Prion Infection Influences Murine Endogenous Retrovirus Expression in Neuronal Cells Biochemical and Biophysical Research Communications. May, 2006 | Pubmed ID: 16564028 The Prion Protein Requires Cholesterol for Cell Surface Localization Molecular and Cellular Neurosciences. Feb, 2006 | Pubmed ID: 16278084 The Tyrosine Kinase Inhibitor STI571 Induces Cellular Clearance of PrPSc in Prion-infected Cells The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15247213 Recognition of Lumenal Prion Protein Aggregates by Post-ER Quality Control Mechanisms is Mediated by the Preoctarepeat Region of PrP Traffic (Copenhagen, Denmark). Apr, 2004 | Pubmed ID: 15030571 Prion Diseases: from Molecular Biology to Intervention Strategies Chembiochem : a European Journal of Chemical Biology. Dec, 2003 | Pubmed ID: 14661267 Promising Developments Bringing Prion Diseases Closer to Therapy and Prophylaxis Trends in Molecular Medicine. Sep, 2003 | Pubmed ID: 13129701 Polyclonal Anti-PrP Auto-antibodies Induced with Dimeric PrP Interfere Efficiently with PrPSc Propagation in Prion-infected Cells The Journal of Biological Chemistry. May, 2003 | Pubmed ID: 12637572 Essential Role of the Prion Protein N Terminus in Subcellular Trafficking and Half-life of Cellular Prion Protein The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12431994 Prion-protein-specific Aptamer Reduces PrPSc Formation Chembiochem : a European Journal of Chemical Biology. Aug, 2002 | Pubmed ID: 12203970 Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material Yo Ching Cheng*1, Samia Hannaoui*1, Theodore Ralph John2, Sandor Dudas3, Stefanie Czub3, Sabine Gilch1 1Dept. of Ecosystem and Public Health, Calgary Prion Research Units, Faculty of Veterinary Medicine, University of Calgary, 2Dept. of Molecular Biology, University of Wyoming, 3Canadian Food Inspection Agency, Lethbridge Laboratories JoVE 56373 Immunology and Infection
Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material Yo Ching Cheng*1, Samia Hannaoui*1, Theodore Ralph John2, Sandor Dudas3, Stefanie Czub3, Sabine Gilch1 1Dept. of Ecosystem and Public Health, Calgary Prion Research Units, Faculty of Veterinary Medicine, University of Calgary, 2Dept. of Molecular Biology, University of Wyoming, 3Canadian Food Inspection Agency, Lethbridge Laboratories JoVE 56373 Immunology and Infection
