Sally A. Cowley Sir William Dunn School of Pathology University of Oxford Biography Publications Institution JoVE Articles Sally A. Cowley http://www.wsjlab.com/meet-the-lab/sally-cowley/ Publications Tissue-resident Macrophages Regulate Lymphatic Vessel Growth and Patterning in the Developing Heart Development (Cambridge, England). Feb, 2021 | Pubmed ID: 33462113 Honing the Double-Edged Sword: Improving Human IPSC-Microglia Models Frontiers in Immunology. Month, 2020 | Pubmed ID: 33363548 TREM2 Alzheimer's Variant R47H Causes Similar Transcriptional Dysregulation to Knockout, Yet Only Subtle Functional Phenotypes in Human IPSC-derived Macrophages Alzheimer's Research & Therapy. 11, 2020 | Pubmed ID: 33198789 ADAM17-triggered TNF Signalling Protects the Ageing Drosophila Retina from Lipid Droplet-mediated Degeneration The EMBO Journal. Sep, 2020 | Pubmed ID: 32715522 Large-Scale Production of Human IPSC-Derived Macrophages for Drug Screening International Journal of Molecular Sciences. Jul, 2020 | Pubmed ID: 32645954 Profiling of Naïve and Primed Human Pluripotent Stem Cells Reveals State-associated MiRNAs Scientific Reports. 06, 2020 | Pubmed ID: 32601281 Rates of Homology Directed Repair of CRISPR-Cas9 Induced Double Strand Breaks Are Lower in Naïve Compared to Primed Human Pluripotent Stem Cells Stem Cell Research. 07, 2020 | Pubmed ID: 32521498 Correction of Amyotrophic Lateral Sclerosis Related Phenotypes in Induced Pluripotent Stem Cell-derived Motor Neurons Carrying a Hexanucleotide Expansion Mutation in C9orf72 by CRISPR/Cas9 Genome Editing Using Homology-directed Repair Human Molecular Genetics. Aug, 2020 | Pubmed ID: 32504093 Generation of Twenty Four Induced Pluripotent Stem Cell Lines from Twenty Four Members of the Lothian Birth Cohort 1936 Stem Cell Research. 07, 2020 | Pubmed ID: 32450543 Patient Fibroblast Circadian Rhythms Predict Lithium Sensitivity in Bipolar Disorder Molecular Psychiatry. May, 2020 | Pubmed ID: 32404948 LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages Stem Cell Reports. 05, 2020 | Pubmed ID: 32359446 Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in IPS-Derived Motor Neurons from Patients with ALS/FTD Stem Cell Reports. 05, 2020 | Pubmed ID: 32330447 A Causal Role for TRESK Loss of Function in Migraine Mechanisms Brain : a Journal of Neurology. 12, 2019 | Pubmed ID: 31742594 Application of CRISPR/Cas9 Editing and Digital Droplet PCR in Human IPSCs to Generate Novel Knock-in Reporter Lines to Visualize Dopaminergic Neurons Stem Cell Research. 12, 2019 | Pubmed ID: 31733438 RNA Sequencing Reveals MMP2 and TGFB1 Downregulation in LRRK2 G2019S Parkinson's IPSC-derived Astrocytes Neurobiology of Disease. 09, 2019 | Pubmed ID: 31085228 An Integrated Transcriptomics and Proteomics Analysis Reveals Functional Endocytic Dysregulation Caused by Mutations in LRRK2 Neurobiology of Disease. 07, 2019 | Pubmed ID: 30954703 Proteolytic Shedding of the Prion Protein Via Activation of Metallopeptidase ADAM10 Reduces Cellular Binding and Toxicity of Amyloid-β Oligomers The Journal of Biological Chemistry. 04, 2019 | Pubmed ID: 30872401 Cellular α-synuclein Pathology is Associated with Bioenergetic Dysfunction in Parkinson's IPSC-derived Dopamine Neurons Human Molecular Genetics. 06, 2019 | Pubmed ID: 30753527 Microglial Inflammation and Phagocytosis in Alzheimer's Disease: Potential Therapeutic Targets British Journal of Pharmacology. 09, 2019 | Pubmed ID: 30740661 Single-Cell Sequencing of IPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 As a Regulator of Parkinson Cell Phenotypes Cell Stem Cell. 01, 2019 | Pubmed ID: 30503143 Lentiviral Gene Therapy Vector with UCOE Stably Restores Function in IPSC-derived Neutrophils of a CDG Patient Matters. Month, 2018 | Pubmed ID: 31008103 RIPK1 is a Critical Modulator of Both Tonic and TLR-responsive Inflammatory and Cell Death Pathways in Human Macrophage Differentiation Cell Death & Disease. 09, 2018 | Pubmed ID: 30250197 Neurodegeneration in SCA14 is Associated with Increased PKCγ Kinase Activity, Mislocalization and Aggregation Acta Neuropathologica Communications. 09, 2018 | Pubmed ID: 30249303 Genome Editing in Induced Pluripotent Stem Cells Rescues TAF1 Levels in X-linked Dystonia-parkinsonism Movement Disorders : Official Journal of the Movement Disorder Society. 07, 2018 | Pubmed ID: 30153385 FRMD8 Promotes Inflammatory and Growth Factor Signalling by Stabilising the IRhom/ADAM17 Sheddase Complex ELife. 06, 2018 | Pubmed ID: 29897336 LRRK2 is a Negative Regulator of Phagosome Maturation in Macrophages The EMBO Journal. Jun, 2018 | Pubmed ID: 29789389 Stem Cell Modeling of Mitochondrial Parkinsonism Reveals Key Functions of OPA1 Annals of Neurology. 05, 2018 | Pubmed ID: 29604226 A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells Cerebellum (London, England). Aug, 2018 | Pubmed ID: 29397531 Alpha-synuclein Induces the Unfolded Protein Response in Parkinson's Disease SNCA Triplication IPSC-derived Neurons Human Molecular Genetics. 11, 2017 | Pubmed ID: 28973645 Excess α-synuclein Compromises Phagocytosis in IPSC-derived Macrophages Scientific Reports. 08, 2017 | Pubmed ID: 28827786 MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in IPSC-Derived Dopamine Neurons Stem Cell Reports. 08, 2017 | Pubmed ID: 28689993 A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response Stem Cell Reports. 06, 2017 | Pubmed ID: 28591653 LRRK2 in Peripheral and Central Nervous System Innate Immunity: Its Link to Parkinson's Disease Biochemical Society Transactions. Feb, 2017 | Pubmed ID: 28202666 Multiplex High-Throughput Targeted Proteomic Assay To Identify Induced Pluripotent Stem Cells Analytical Chemistry. 02, 2017 | Pubmed ID: 28192931 Transcriptomic Profiling of Purified Patient-derived Dopamine Neurons Identifies Convergent Perturbations and Therapeutics for Parkinson's Disease Human Molecular Genetics. 02, 2017 | Pubmed ID: 28096185 Variant U1 SnRNAs Are Implicated in Human Pluripotent Stem Cell Maintenance and Neuromuscular Disease Nucleic Acids Research. 12, 2016 | Pubmed ID: 27536002 C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Stem Cells (Dayton, Ohio). 08, 2016 | Pubmed ID: 27097283 ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's IPSC-Derived Dopamine Neurons Stem Cell Reports. Mar, 2016 | Pubmed ID: 26905200 The Current State of Naïve Human Pluripotency Stem Cells (Dayton, Ohio). Nov, 2015 | Pubmed ID: 26119873 CRISPR-mediated Genotypic and Phenotypic Correction of a Chronic Granulomatous Disease Mutation in Human IPS Cells Experimental Hematology. Oct, 2015 | Pubmed ID: 26101162 Physiological Characterisation of Human IPS-derived Dopaminergic Neurons PloS One. Month, 2014 | Pubmed ID: 24586273 The Productive Entry Pathway of HIV-1 in Macrophages is Dependent on Endocytosis Through Lipid Rafts Containing CD4 PloS One. Month, 2014 | Pubmed ID: 24465876 Efficient, Long Term Production of Monocyte-derived Macrophages from Human Pluripotent Stem Cells Under Partly-defined and Fully-defined Conditions PloS One. Month, 2013 | Pubmed ID: 23951090 Differentially Expressed, Variant U1 SnRNAs Regulate Gene Expression in Human Cells Genome Research. Feb, 2013 | Pubmed ID: 23070852 Cellular Reprogramming: a New Approach to Modelling Parkinson's Disease Biochemical Society Transactions. Oct, 2012 | Pubmed ID: 22988881 Transportin 3 Promotes a Nuclear Maturation Step Required for Efficient HIV-1 Integration PLoS Pathogens. Aug, 2011 | Pubmed ID: 21901095 Episomal Transgene Expression in Pluripotent Stem Cells Methods in Molecular Biology (Clifton, N.J.). Month, 2011 | Pubmed ID: 21822889 Protein Kinase C and NF-κB-dependent CD4 Downregulation in Macrophages Induced by T Cell-derived Soluble Factors: Consequences for HIV-1 Infection Journal of Immunology (Baltimore, Md. : 1950). Jul, 2011 | Pubmed ID: 21666058 Derivation and Characterisation of the Human Embryonic Stem Cell Line, OxF1 In Vitro Cellular & Developmental Biology. Animal. Apr, 2010 | Pubmed ID: 20333479 In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages Hazel Hall-Roberts1,2,3, Elena Di Daniel2, William S. James1, John B. Davis2, Sally A. Cowley1 1James Martin Stem Cell Facility, Sir William Dunn School of Pathology, University of Oxford, 2Alzheimer’s Research UK Oxford Drug Discovery Institute, Nuffield Department of Medicine Research Building, University of Oxford, 3UK Dementia Research Institute, Cardiff University JoVE 62217 Neuroscience
In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages Hazel Hall-Roberts1,2,3, Elena Di Daniel2, William S. James1, John B. Davis2, Sally A. Cowley1 1James Martin Stem Cell Facility, Sir William Dunn School of Pathology, University of Oxford, 2Alzheimer’s Research UK Oxford Drug Discovery Institute, Nuffield Department of Medicine Research Building, University of Oxford, 3UK Dementia Research Institute, Cardiff University JoVE 62217 Neuroscience
