Samuel H. Wilson

Publications

• Watching Right and Wrong Nucleotide Insertion Captures Hidden Polymerase Fidelity Checkpoints
  Nature Communications. 06, 2022  |   Pubmed ID: 35680862
• Structural Basis for Proficient Oxidized Ribonucleotide Insertion in Double Strand Break Repair
  Nature Communications. 08, 2021  |   Pubmed ID: 34417448
• Perspectives on Formaldehyde Dysregulation: Mitochondrial DNA Damage and Repair in Mammalian Cells
  DNA Repair. 09, 2021  |   Pubmed ID: 34116475
• Watching a Double Strand Break Repair Polymerase Insert a Pro-mutagenic Oxidized Nucleotide
  Nature Communications. 04, 2021  |   Pubmed ID: 33824325
• Lysines in the Lyase Active Site of DNA Polymerase β Destabilize Nonspecific DNA Binding, Facilitating Searching and DNA Gap Recognition
  The Journal of Biological Chemistry. 08, 2020  |   Pubmed ID: 32647014
• Preferential DNA Polymerase β Reverse Reaction with Imidodiphosphate
  ACS Omega. Jun, 2020  |   Pubmed ID: 32637805
• Structure of a DNA Polymerase Abortive Complex with the 8OG:dA Base Pair at the Primer Terminus
  Communications Biology. 07, 2020  |   Pubmed ID: 32620932
• Requirements for PARP-1 Covalent Crosslinking to DNA (PARP-1 DPC)
  DNA Repair. 06, 2020  |   Pubmed ID: 32438305
• Mitochondrial Dysfunction and DNA Damage Accompany Enhanced Levels of Formaldehyde in Cultured Primary Human Fibroblasts
  Scientific Reports. 03, 2020  |   Pubmed ID: 32221313
• WITHDRAWN: Requirements for PARP-1 Covalent Crosslinking to DNA (PARP-1 DPC)
  DNA Repair. 05, 2020  |   Pubmed ID: 32151818
• Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant Through the Combined Use of Chemical Biology and X-ray Crystallography
  Biochemistry. 03, 2020  |   Pubmed ID: 31999437
• Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene Via the Crosstalk Between DNA Polymerase β and a DNA Methyltransferase
  Cells. 01, 2020  |   Pubmed ID: 31963223
• Oxidative DNA-protein Crosslinks Formed in Mammalian Cells by Abasic Site Lyases Involved in DNA Repair
  DNA Repair. 03, 2020  |   Pubmed ID: 31945542
• DNA Polymerase β Nucleotide-stabilized Template Misalignment Fidelity Depends on Local Sequence Context
  The Journal of Biological Chemistry. 01, 2020  |   Pubmed ID: 31801827
• Shining Light on the Response to Repair Intermediates in DNA of Living Cells
  DNA Repair. 01, 2020  |   Pubmed ID: 31790865
• DNA Polymerase Beta and Other Gap-filling Enzymes in Mammalian Base Excision Repair
  The Enzymes. 2019  |   Pubmed ID: 31627875
• The Pol β Variant Containing Exon α is Deficient in DNA Polymerase but Has Full DRP Lyase Activity
  Scientific Reports. 07, 2019  |   Pubmed ID: 31289286
• Eukaryotic Base Excision Repair: New Approaches Shine Light on Mechanism
  Annual Review of Biochemistry. 06, 2019  |   Pubmed ID: 31220977
• Molecular Basis for the Faithful Replication of 5-methylcytosine and Its Oxidized Forms by DNA Polymerase β
  The Journal of Biological Chemistry. 05, 2019  |   Pubmed ID: 30885943
• A Transition-State Perspective on Y-Family DNA Polymerase η Fidelity in Comparison with X-Family DNA Polymerases λ and β
  Biochemistry. 04, 2019  |   Pubmed ID: 30839203
• Repair Pathway for PARP-1 DNA-protein Crosslinks
  DNA Repair. 01, 2019  |   Pubmed ID: 30466837
• Pol μ DGTP Mismatch Insertion Opposite T Coupled with Ligation Reveals Promutagenic DNA Repair Intermediate
  Nature Communications. 10, 2018  |   Pubmed ID: 30310068
• DNA Scanning by Base Excision Repair Enzymes and Implications for Pathway Coordination
  DNA Repair. 11, 2018  |   Pubmed ID: 30181039
• Transitions in DNA Polymerase β μs-ms Dynamics Related to Substrate Binding and Catalysis
  Nucleic Acids Research. 08, 2018  |   Pubmed ID: 29917149
• Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State
  Biochemistry. 07, 2018  |   Pubmed ID: 29889506
• Mapping Functional Substrate-Enzyme Interactions in the Pol β Active Site Through Chemical Biology: Structural Responses to Acidity Modification of Incoming DNTPs
  Biochemistry. 07, 2018  |   Pubmed ID: 29874056
• Transcriptional Mutagenesis Mediated by 8-oxoG Induces Translational Errors in Mammalian Cells
  Proceedings of the National Academy of Sciences of the United States of America. 04, 2018  |   Pubmed ID: 29610342
• XRCC1 Phosphorylation Affects Aprataxin Recruitment and DNA Deadenylation Activity
  DNA Repair. 04, 2018  |   Pubmed ID: 29477978
• DNA Polymerase β: A Missing Link of the Base Excision Repair Machinery in Mammalian Mitochondria
  DNA Repair. 12, 2017  |   Pubmed ID: 29100041
• Role of DNA Polymerase β Oxidized Nucleotide Insertion in DNA Ligation Failure
  Journal of Radiation Research. Sep, 2017  |   Pubmed ID: 28992331
• Complementation of Aprataxin Deficiency by Base Excision Repair Enzymes in Mitochondrial Extracts
  Nucleic Acids Research. Sep, 2017  |   Pubmed ID: 28973450
• Assay to Measure DNA Polymerase β Nucleotide Insertion Coupled with the DNA Ligation Reaction During Base Excision Repair
  Bio-protocol. Jun, 2017  |   Pubmed ID: 28835905
• Time-lapse Crystallography Snapshots of a Double-strand Break Repair Polymerase in Action
  Nature Communications. 08, 2017  |   Pubmed ID: 28811466
• DNA Polymerase β Uses Its Lyase Domain in a Processive Search for DNA Damage
  Nucleic Acids Research. 04, 2017  |   Pubmed ID: 28119421
• Revealing the Role of the Product Metal in DNA Polymerase β Catalysis
  Nucleic Acids Research. 03, 2017  |   Pubmed ID: 28108654
• Oxidized Nucleotide Insertion by Pol β Confounds Ligation During Base Excision Repair
  Nature Communications. 01, 2017  |   Pubmed ID: 28067232
• Hiding in Plain Sight: The Bimetallic Magnesium Covalent Bond in Enzyme Active Sites
  Inorganic Chemistry. Jan, 2017  |   Pubmed ID: 27976880
• DNA Polymerase β Contains a Functional Nuclear Localization Signal at Its N-terminus
  Nucleic Acids Research. Feb, 2017  |   Pubmed ID: 27956495
• Impact of Ribonucleotide Backbone on Translesion Synthesis and Repair of 7,8-Dihydro-8-oxoguanine
  The Journal of Biological Chemistry. Nov, 2016  |   Pubmed ID: 27660390
• Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism
  Structure (London, England : 1993). 11, 2016  |   Pubmed ID: 27642161
• Combined Effects of High-Dose Bisphenol A and Oxidizing Agent (KBrO3) on Cellular Microenvironment, Gene Expression, and Chromatin Structure of Ku70-deficient Mouse Embryonic Fibroblasts
  Environmental Health Perspectives. Aug, 2016  |   Pubmed ID: 27082013
• Insertion of Oxidized Nucleotide Triggers Rapid DNA Polymerase Opening
  Nucleic Acids Research. 05, 2016  |   Pubmed ID: 27034465
• Oxidized DNTPs and the OGG1 and MUTYH DNA Glycosylases Combine to Induce CAG/CTG Repeat Instability
  Nucleic Acids Research. 06, 2016  |   Pubmed ID: 26980281
• Enzymatic Activity Assays for Base Excision Repair Enzymes in Cell Extracts from Vertebrate Cells
  Bio-protocol. 2015  |   Pubmed ID: 27390764
• Capturing Snapshots of APE1 Processing DNA Damage
  Nature Structural & Molecular Biology. Nov, 2015  |   Pubmed ID: 26458045
• Requirement for Transient Metal Ions Revealed Through Computational Analysis for DNA Polymerase Going in Reverse
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2015  |   Pubmed ID: 26351676
• Intrinsic Mutagenic Properties of 5-chlorocytosine: A Mechanistic Connection Between Chronic Inflammation and Cancer
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2015  |   Pubmed ID: 26243878
• New Structural Snapshots Provide Molecular Insights into the Mechanism of High Fidelity DNA Synthesis
  DNA Repair. Aug, 2015  |   Pubmed ID: 26002198
• Two Scaffolds from Two Flips: (α,β)/(β,γ) CH2/NH "Met-Im" Analogues of DTTP
  Organic Letters. Jun, 2015  |   Pubmed ID: 25970636
• Structures of Human DNA Polymerases ν and θ Expose Their End Game
  Nature Structural & Molecular Biology. Apr, 2015  |   Pubmed ID: 25837870
• Uncovering the Polymerase-induced Cytotoxicity of an Oxidized Nucleotide
  Nature. Jan, 2015  |   Pubmed ID: 25409153
• Phylogenetic Analysis and Evolutionary Origins of DNA Polymerase X-family Members
  DNA Repair. Oct, 2014  |   Pubmed ID: 25112931
• The Dark Side of DNA Repair
  ELife. May, 2014  |   Pubmed ID: 24844708
• Role of Polymerase β in Complementing Aprataxin Deficiency During Abasic-site Base Excision Repair
  Nature Structural & Molecular Biology. May, 2014  |   Pubmed ID: 24777061
• Structure and Mechanism of DNA Polymerase β
  Biochemistry. May, 2014  |   Pubmed ID: 24717170
• Understanding the Loss-of-function in a Triple Missense Mutant of DNA Polymerase β Found in Prostate Cancer
  International Journal of Oncology. Oct, 2013  |   Pubmed ID: 23877444
• Preventing Oxidation of Cellular XRCC1 Affects PARP-mediated DNA Damage Responses
  DNA Repair. Sep, 2013  |   Pubmed ID: 23871146
• Observing a DNA Polymerase Choose Right from Wrong
  Cell. Jul, 2013  |   Pubmed ID: 23827680
• Interaction Between DNA Polymerase β and BRCA1
  PloS One. 2013  |   Pubmed ID: 23826138
• Insights into the Conformation of Aminofluorene-deoxyguanine Adduct in a DNA Polymerase Active Site
  The Journal of Biological Chemistry. Aug, 2013  |   Pubmed ID: 23798703
• Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction
  Journal of the American Chemical Society. May, 2013  |   Pubmed ID: 23647366
• DNA Polymerase Minor Groove Interactions Modulate Mutagenic Bypass of a Templating 8-oxoguanine Lesion
  Nucleic Acids Research. Feb, 2013  |   Pubmed ID: 23267011
• Predicting Enhanced Cell Killing Through PARP Inhibition
  Molecular Cancer Research : MCR. Jan, 2013  |   Pubmed ID: 23193155
• Identification of One of the Apurinic/apyrimidinic Lyase Active Sites of Topoisomerase V by Structural and Functional Studies
  Nucleic Acids Research. Jan, 2013  |   Pubmed ID: 23125368
• Perspective: Pre-chemistry Conformational Changes in DNA Polymerase Mechanisms
  Theoretical Chemistry Accounts. Nov, 2012  |   Pubmed ID: 23459563
• Hyperactivation of PARP Triggers Nonhomologous End-joining in Repair-deficient Mouse Fibroblasts
  PloS One. 2012  |   Pubmed ID: 23145148
• Evidence for Abasic Site Sugar Phosphate-mediated Cytotoxicity in Alkylating Agent Treated Saccharomyces Cerevisiae
  PloS One. 2012  |   Pubmed ID: 23144716
• DNA Polymerase β Gap-filling Translesion DNA Synthesis
  Chemical Research in Toxicology. Dec, 2012  |   Pubmed ID: 23121263
• Effect of β,γ-CHF- and β,γ-CHCl-dGTP Halogen Atom Stereochemistry on the Transition State of DNA Polymerase β
  Biochemistry. Oct, 2012  |   Pubmed ID: 23043620
• Pol β Associated Complex and Base Excision Repair Factors in Mouse Fibroblasts
  Nucleic Acids Research. Dec, 2012  |   Pubmed ID: 23042675
• DNA Sequence Context Effects on the Glycosylase Activity of Human 8-oxoguanine DNA Glycosylase
  The Journal of Biological Chemistry. Oct, 2012  |   Pubmed ID: 22989888
• Structures of DNTP Intermediate States During DNA Polymerase Active Site Assembly
  Structure (London, England : 1993). Nov, 2012  |   Pubmed ID: 22959623
• HMGN1 Protein Regulates Poly(ADP-ribose) Polymerase-1 (PARP-1) Self-PARylation in Mouse Fibroblasts
  The Journal of Biological Chemistry. Aug, 2012  |   Pubmed ID: 22736760
• β,γ-CHF- and β,γ-CHCl-dGTP Diastereomers: Synthesis, Discrete 31P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases
  Journal of the American Chemical Society. May, 2012  |   Pubmed ID: 22397499
• Stereospecific Formation of a Ternary Complex of (S)-α,β-fluoromethylene-dATP with DNA Pol β
  Chembiochem : a European Journal of Chemical Biology. Mar, 2012  |   Pubmed ID: 22315190
• DNA Base Excision Repair: a Mechanism of Trinucleotide Repeat Expansion
  Trends in Biochemical Sciences. Apr, 2012  |   Pubmed ID: 22285516
• Increased PARP-1 Association with DNA in Alkylation Damaged, PARP-inhibited Mouse Fibroblasts
  Molecular Cancer Research : MCR. Mar, 2012  |   Pubmed ID: 22246237
• Binary Complex Crystal Structure of DNA Polymerase β Reveals Multiple Conformations of the Templating 8-oxoguanine Lesion
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2012  |   Pubmed ID: 22178760
• Metal-induced DNA Translocation Leads to DNA Polymerase Conformational Activation
  Nucleic Acids Research. Apr, 2012  |   Pubmed ID: 22169953
• Single-nucleotide Base Excision Repair DNA Polymerase Activity in C. Elegans in the Absence of DNA Polymerase β
  Nucleic Acids Research. Jan, 2012  |   Pubmed ID: 21917855
• Lucanthone and Its Derivative Hycanthone Inhibit Apurinic Endonuclease-1 (APE1) by Direct Protein Binding
  PloS One. 2011  |   Pubmed ID: 21935361
• Molecular Insights into DNA Polymerase Deterrents for Ribonucleotide Insertion
  The Journal of Biological Chemistry. Sep, 2011  |   Pubmed ID: 21733843
• Requirement for NBS1 in the S Phase Checkpoint Response to DNA Methylation Combined with PARP Inhibition
  DNA Repair. Feb, 2011  |   Pubmed ID: 21130714
• Substrate Channeling in Mammalian Base Excision Repair Pathways: Passing the Baton
  The Journal of Biological Chemistry. Dec, 2010  |   Pubmed ID: 20952393
• Base Excision Repair and Design of Small Molecule Inhibitors of Human DNA Polymerase β
  Cellular and Molecular Life Sciences : CMLS. Nov, 2010  |   Pubmed ID: 20844920
• Mutagenesis Dependent Upon the Combination of Activation-induced Deaminase Expression and a Double-strand Break
  Molecular Immunology. Nov-Dec, 2010  |   Pubmed ID: 20828826
• DNA Polymerases Beta and Lambda Mediate Overlapping and Independent Roles in Base Excision Repair in Mouse Embryonic Fibroblasts
  PloS One. 2010  |   Pubmed ID: 20805875
• Synthesis and Biological Evaluation of Fluorinated Deoxynucleotide Analogs Based on Bis-(difluoromethylene)triphosphoric Acid
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010  |   Pubmed ID: 20724659
• DNA Polymerase Structure-based Insight on the Mutagenic Properties of 8-oxoguanine
  Mutation Research. Nov, 2010  |   Pubmed ID: 20696268
• Alkylation DNA Damage in Combination with PARP Inhibition Results in Formation of S-phase-dependent Double-strand Breaks
  DNA Repair. Aug, 2010  |   Pubmed ID: 20573551
• Mutagenic Conformation of 8-oxo-7,8-dihydro-2'-dGTP in the Confines of a DNA Polymerase Active Site
  Nature Structural & Molecular Biology. Jul, 2010  |   Pubmed ID: 20526335
• DNA Polymerase Beta Ribonucleotide Discrimination: Insertion, Misinsertion, Extension, and Coding
  The Journal of Biological Chemistry. Aug, 2010  |   Pubmed ID: 20519499
• Halogenated Beta,gamma-methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase Beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues
  Journal of the American Chemical Society. Jun, 2010  |   Pubmed ID: 20465217
• FEN1 Functions in Long Patch Base Excision Repair Under Conditions of Oxidative Stress in Vertebrate Cells
  Molecular Cancer Research : MCR. Feb, 2010  |   Pubmed ID: 20145043
• HMGB1: Roles in Base Excision Repair and Related Function
  Biochimica Et Biophysica Acta. Jan-Feb, 2010  |   Pubmed ID: 20123074
• DNA Polymerase Beta-dependent Long Patch Base Excision Repair in Living Cells
  DNA Repair. Feb, 2010  |   Pubmed ID: 20006562
• DNA Polymerase Beta Substrate Specificity: Side Chain Modulation of the "A-rule"
  The Journal of Biological Chemistry. Nov, 2009  |   Pubmed ID: 19759017
• DNA Polymerase Beta and PARP Activities in Base Excision Repair in Living Cells
  DNA Repair. Nov, 2009  |   Pubmed ID: 19748837
• PARP Inhibition During Alkylation-induced Genotoxic Stress Signals a Cell Cycle Checkpoint Response Mediated by ATM
  DNA Repair. Nov, 2009  |   Pubmed ID: 19717351
• A Real-time Fluorescence Method for Enzymatic Characterization of Specialized Human DNA Polymerases
  Nucleic Acids Research. Oct, 2009  |   Pubmed ID: 19684079
• Coordination Between Polymerase Beta and FEN1 Can Modulate CAG Repeat Expansion
  The Journal of Biological Chemistry. Oct, 2009  |   Pubmed ID: 19674974
• Gastrointestinal Hyperplasia with Altered Expression of DNA Polymerase Beta
  PloS One. 2009  |   Pubmed ID: 19654874
• Characterization of DNA Polymerase Beta Splicing Variants in Gastric Cancer: the Most Frequent Exon 2-deleted Isoform is a Non-coding RNA
  Mutation Research. Nov, 2009  |   Pubmed ID: 19635489
• Alpha,beta-difluoromethylene Deoxynucleoside 5'-triphosphates: a Convenient Synthesis of Useful Probes for DNA Polymerase Beta Structure and Function
  Organic Letters. May, 2009  |   Pubmed ID: 19351147
• Human DNA Polymerase Theta Possesses 5'-dRP Lyase Activity and Functions in Single-nucleotide Base Excision Repair in Vitro
  Nucleic Acids Research. Apr, 2009  |   Pubmed ID: 19188258
• Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates As Noncleavable Substrates for DNA Polymerases: Isolation, Characterization, and Stability Studies of Novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT
  Journal of Medicinal Chemistry. Oct, 2008  |   Pubmed ID: 18811136
• Interaction Between PARP-1 and ATR in Mouse Fibroblasts is Blocked by PARP Inhibition
  DNA Repair. Nov, 2008  |   Pubmed ID: 18691676
• Mutagenesis is Elevated in Male Germ Cells Obtained from DNA Polymerase-beta Heterozygous Mice
  Biology of Reproduction. Nov, 2008  |   Pubmed ID: 18650495
• Folate Deficiency Induces Neurodegeneration and Brain Dysfunction in Mice Lacking Uracil DNA Glycosylase
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2008  |   Pubmed ID: 18614692
• Structures of DNA Polymerase Beta with Active-site Mismatches Suggest a Transient Abasic Site Intermediate During Misincorporation
  Molecular Cell. May, 2008  |   Pubmed ID: 18471977
• Negligible Impact of Pol Iota Expression on the Alkylation Sensitivity of Pol Beta-deficient Mouse Fibroblast Cells
  DNA Repair. Jun, 2008  |   Pubmed ID: 18434259
• DNA Damage Response Protein ASCIZ Links Base Excision Repair with Immunoglobulin Gene Conversion
  Biochemical and Biophysical Research Communications. Jun, 2008  |   Pubmed ID: 18433721
• Incorrect Nucleotide Insertion at the Active Site of a G:A Mismatch Catalyzed by DNA Polymerase Beta
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008  |   Pubmed ID: 18391201
• XRCC1 and DNA Polymerase Beta in Cellular Protection Against Cytotoxic DNA Single-strand Breaks
  Cell Research. Jan, 2008  |   Pubmed ID: 18166976
• DNA Polymerase Beta Fidelity: Halomethylene-modified Leaving Groups in Pre-steady-state Kinetic Analysis Reveal Differences at the Chemical Transition State
  Biochemistry. Jan, 2008  |   Pubmed ID: 18161950
• Exploring the Role of Large Conformational Changes in the Fidelity of DNA Polymerase Beta
  Proteins. Jan, 2008  |   Pubmed ID: 17671961
• (R)-beta,gamma-fluoromethylene-dGTP-DNA Ternary Complex with DNA Polymerase Beta
  Journal of the American Chemical Society. Dec, 2007  |   Pubmed ID: 18031037
• HMGB1 is a Cofactor in Mammalian Base Excision Repair
  Molecular Cell. Sep, 2007  |   Pubmed ID: 17803946
• Comparative Assessment of Plasmid and Oligonucleotide DNA Substrates in Measurement of in Vitro Base Excision Repair Activity
  Nucleic Acids Research. 2007  |   Pubmed ID: 17720705
• Stimulation of NEIL2-mediated Oxidized Base Excision Repair Via YB-1 Interaction During Oxidative Stress
  The Journal of Biological Chemistry. Sep, 2007  |   Pubmed ID: 17686777
• The X Family Portrait: Structural Insights into Biological Functions of X Family Polymerases
  DNA Repair. Dec, 2007  |   Pubmed ID: 17631059
• Different Structural States in Oligonucleosomes Are Required for Early Versus Late Steps of Base Excision Repair
  Nucleic Acids Research. 2007  |   Pubmed ID: 17576692
• Ochratoxin A-induced Mutagenesis in Mammalian Cells is Consistent with the Production of Oxidative Stress
  Chemical Research in Toxicology. Jul, 2007  |   Pubmed ID: 17567156
• OGG1 Initiates Age-dependent CAG Trinucleotide Expansion in Somatic Cells
  Nature. May, 2007  |   Pubmed ID: 17450122
• Interplay Between DNA Polymerases Beta and Lambda in Repair of Oxidation DNA Damage in Chicken DT40 Cells
  DNA Repair. Jun, 2007  |   Pubmed ID: 17363341
• Coordination of Steps in Single-nucleotide Base Excision Repair Mediated by Apurinic/apyrimidinic Endonuclease 1 and DNA Polymerase Beta
  The Journal of Biological Chemistry. May, 2007  |   Pubmed ID: 17355977
• Differing Conformational Pathways Before and After Chemistry for Insertion of DATP Versus DCTP Opposite 8-oxoG in DNA Polymerase Beta
  Biophysical Journal. May, 2007  |   Pubmed ID: 17293403
• ATR Signaling Mediates an S-phase Checkpoint After Inhibition of Poly(ADP-ribose) Polymerase Activity
  DNA Repair. Jun, 2007  |   Pubmed ID: 17292679
• Modifying the Beta,gamma Leaving-group Bridging Oxygen Alters Nucleotide Incorporation Efficiency, Fidelity, and the Catalytic Mechanism of DNA Polymerase Beta
  Biochemistry. Jan, 2007  |   Pubmed ID: 17209556
• Magnesium-cationic Dummy Atom Molecules Enhance Representation of DNA Polymerase Beta in Molecular Dynamics Simulations: Improved Accuracy in Studies of Structural Features and Mutational Effects
  Journal of Molecular Biology. Feb, 2007  |   Pubmed ID: 17174326
• Down-regulation of DNA Polymerase Beta Accompanies Somatic Hypermutation in Human BL2 Cell Lines
  DNA Repair. Feb, 2007  |   Pubmed ID: 17127106
• Hypersensitivity Phenotypes Associated with Genetic and Synthetic Inhibitor-induced Base Excision Repair Deficiency
  DNA Repair. Apr, 2007  |   Pubmed ID: 17113833
• Regulation of DNA Repair Fidelity by Molecular Checkpoints: "gates" in DNA Polymerase Beta's Substrate Selection
  Biochemistry. Dec, 2006  |   Pubmed ID: 17176036
• Structure of DNA Polymerase Beta with a Benzo[c]phenanthrene Diol Epoxide-adducted Template Exhibits Mutagenic Features
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006  |   Pubmed ID: 17079493
• Vertebrate POLQ and POLbeta Cooperate in Base Excision Repair of Oxidative DNA Damage
  Molecular Cell. Oct, 2006  |   Pubmed ID: 17018297
• NEIL2-initiated, APE-independent Repair of Oxidized Bases in DNA: Evidence for a Repair Complex in Human Cells
  DNA Repair. Dec, 2006  |   Pubmed ID: 16982218
• Energy Analysis of Chemistry for Correct Insertion by DNA Polymerase Beta
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2006  |   Pubmed ID: 16938895
• Haploinsufficiency in DNA Polymerase Beta Increases Cancer Risk with Age and Alters Mortality Rate
  Cancer Research. Aug, 2006  |   Pubmed ID: 16885342
• Disease-first: a New Paradigm for Environmental Health Science Research
  Environmental Health Perspectives. Jul, 2006  |   Pubmed ID: 16835037
• Activities and Mechanism of DNA Polymerase Beta
  Methods in Enzymology. 2006  |   Pubmed ID: 16793365
• Determination of Lysine PK Values Using [5-13C]lysine: Application to the Lyase Domain of DNA Pol Beta
  Journal of the American Chemical Society. Jun, 2006  |   Pubmed ID: 16787052
• Magnesium-induced Assembly of a Complete DNA Polymerase Catalytic Complex
  Structure (London, England : 1993). Apr, 2006  |   Pubmed ID: 16615916
• Structure and Mechanism of DNA Polymerase Beta
  Chemical Reviews. Feb, 2006  |   Pubmed ID: 16464010
• The Werner Syndrome Protein Operates in Base Excision Repair and Cooperates with DNA Polymerase Beta
  Nucleic Acids Research. 2006  |   Pubmed ID: 16449207
• A Thymine Isostere in the Templating Position Disrupts Assembly of the Closed DNA Polymerase Beta Ternary Complex
  Biochemistry. Nov, 2005  |   Pubmed ID: 16285726
• Syn-full Behavior by T7 DNA Polymerase
  Structure (London, England : 1993). Nov, 2005  |   Pubmed ID: 16271879
• Framework for Environmental Exposure Research: the Disease-first Approach
  Molecular Interventions. Oct, 2005  |   Pubmed ID: 16249520
• The Need for Exposure Health Sciences
  Environmental Health Perspectives. Oct, 2005  |   Pubmed ID: 16203220
• Mismatch-induced Conformational Distortions in Polymerase Beta Support an Induced-fit Mechanism for Fidelity
  Biochemistry. Oct, 2005  |   Pubmed ID: 16201758
• Structural Insight into the DNA Polymerase Beta Deoxyribose Phosphate Lyase Mechanism
  DNA Repair. Dec, 2005  |   Pubmed ID: 16172026
• Nucleotide-induced DNA Polymerase Active Site Motions Accommodating a Mutagenic DNA Intermediate
  Structure (London, England : 1993). Aug, 2005  |   Pubmed ID: 16084394
• Strategic Planning: Establishing Need and Clarifying Motivation
  Environmental Health Perspectives. Aug, 2005  |   Pubmed ID: 16079048
• DNA Polymerase Lambda Protects Mouse Fibroblasts Against Oxidative DNA Damage and is Recruited to Sites of DNA Damage/repair
  The Journal of Biological Chemistry. Sep, 2005  |   Pubmed ID: 16002405
• Personalized Exposure Assessment: Promising Approaches for Human Environmental Health Research
  Environmental Health Perspectives. Jul, 2005  |   Pubmed ID: 16002370
• Involvement of Poly(ADP-ribose) Polymerase Activity in Regulating Chk1-dependent Apoptotic Cell Death
  DNA Repair. Sep, 2005  |   Pubmed ID: 16002346
• REV1 Mediated Mutagenesis in Base Excision Repair Deficient Mouse Fibroblast
  DNA Repair. Sep, 2005  |   Pubmed ID: 15950550
• DNA Polymerase Lambda Mediates a Back-up Base Excision Repair Activity in Extracts of Mouse Embryonic Fibroblasts
  The Journal of Biological Chemistry. May, 2005  |   Pubmed ID: 15749700
• Human Base Excision Repair Enzymes Apurinic/apyrimidinic Endonuclease1 (APE1), DNA Polymerase Beta and Poly(ADP-ribose) Polymerase 1: Interplay Between Strand-displacement DNA Synthesis and Proofreading Exonuclease Activity
  Nucleic Acids Research. 2005  |   Pubmed ID: 15731342
• Poly(ADP-ribose) Polymerase Activity Prevents Signaling Pathways for Cell Cycle Arrest After DNA Methylating Agent Exposure
  The Journal of Biological Chemistry. Apr, 2005  |   Pubmed ID: 15701627
• Base Excision Repair in Nucleosomes Lacking Histone Tails
  DNA Repair. Feb, 2005  |   Pubmed ID: 15590328
• DNA Polymerase Beta and Flap Endonuclease 1 Enzymatic Specificities Sustain DNA Synthesis for Long Patch Base Excision Repair
  The Journal of Biological Chemistry. Feb, 2005  |   Pubmed ID: 15561706
• Structural Insights into DNA Polymerase Beta Deterrents for Misincorporation Support an Induced-fit Mechanism for Fidelity
  Structure (London, England : 1993). Oct, 2004  |   Pubmed ID: 15458631
• In Situ Analysis of Repair Processes for Oxidative DNA Damage in Mammalian Cells
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2004  |   Pubmed ID: 15365186
• AP Endonuclease-independent DNA Base Excision Repair in Human Cells
  Molecular Cell. Jul, 2004  |   Pubmed ID: 15260972
• Identification of Small Molecule Synthetic Inhibitors of DNA Polymerase Beta by NMR Chemical Shift Mapping
  The Journal of Biological Chemistry. Sep, 2004  |   Pubmed ID: 15258144
• Dynamic Characterization of a DNA Repair Enzyme: NMR Studies of [methyl-13C]methionine-labeled DNA Polymerase Beta
  Biochemistry. Jul, 2004  |   Pubmed ID: 15248749
• Critical Role of Magnesium Ions in DNA Polymerase Beta's Closing and Active Site Assembly
  Journal of the American Chemical Society. Jul, 2004  |   Pubmed ID: 15238001
• The Environmental Genome Project: Phase I and Beyond
  Molecular Interventions. Jun, 2004  |   Pubmed ID: 15210868
• Increased Postischemic Brain Injury in Mice Deficient in Uracil-DNA Glycosylase
  The Journal of Clinical Investigation. Jun, 2004  |   Pubmed ID: 15199406
• Highly Organized but Pliant Active Site of DNA Polymerase Beta: Compensatory Mechanisms in Mutant Enzymes Revealed by Dynamics Simulations and Energy Analyses
  Biophysical Journal. Jun, 2004  |   Pubmed ID: 15189842
• Influence of DNA Structure on DNA Polymerase Beta Active Site Function: Extension of Mutagenic DNA Intermediates
  The Journal of Biological Chemistry. Jul, 2004  |   Pubmed ID: 15145936
• AP Endonuclease and Poly(ADP-ribose) Polymerase-1 Interact with the Same Base Excision Repair Intermediate
  DNA Repair. Jun, 2004  |   Pubmed ID: 15135726
• Shaping Science Policy in the Age of Genomics
  Nature Reviews. Genetics. Apr, 2004  |   Pubmed ID: 15134075
• Recombinogenic Phenotype of Human Activation-induced Cytosine Deaminase
  Journal of Immunology (Baltimore, Md. : 1950). Apr, 2004  |   Pubmed ID: 15034045
• High-level Expression and Purification of Untagged and Histidine-tagged HIV-1 Reverse Transcriptase
  Protein Expression and Purification. Mar, 2004  |   Pubmed ID: 14766302
• Base Excision Repair Deficiency Caused by Polymerase Beta Haploinsufficiency: Accelerated DNA Damage and Increased Mutational Response to Carcinogens
  Cancer Research. Sep, 2003  |   Pubmed ID: 14522902
• Cloning and Characterization of a Novel Member of the Human ATF/CREB Family: ATF2 Deletion, a Potential Regulator of the Human DNA Polymerase Beta Promoter
  Gene. Jul, 2003  |   Pubmed ID: 12909347
• Base Excision Repair Intermediates Induce P53-independent Cytotoxic and Genotoxic Responses
  The Journal of Biological Chemistry. Oct, 2003  |   Pubmed ID: 12882965
• Suppressed Catalytic Activity of Base Excision Repair Enzymes on Rotationally Positioned Uracil in Nucleosomes
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2003  |   Pubmed ID: 12799467
• Localization of the Deoxyribose Phosphate Lyase Active Site in Human DNA Polymerase Iota by Controlled Proteolysis
  The Journal of Biological Chemistry. Aug, 2003  |   Pubmed ID: 12777390
• Structural Insights into the Origins of DNA Polymerase Fidelity
  Structure (London, England : 1993). May, 2003  |   Pubmed ID: 12737815
• The Base Substitution Fidelity of DNA Polymerase Beta-dependent Single Nucleotide Base Excision Repair
  The Journal of Biological Chemistry. Jul, 2003  |   Pubmed ID: 12734201
• Report on the First US-Japan DNA Repair Meeting. Sendai, Japan, October 27-31, 2002
  DNA Repair. May, 2003  |   Pubmed ID: 12713820
• Regulated Over-expression of DNA Polymerase Beta Mediates Early Onset Cataract in Mice
  DNA Repair. May, 2003  |   Pubmed ID: 12713817
• DNA Polymerase Beta Gene Expression: the Promoter Activator CREB-1 is Upregulated in Chinese Hamster Ovary Cells by DNA Alkylating Agent-induced Stress
  Biological Chemistry. Jan, 2003  |   Pubmed ID: 12674496
• The Werner Syndrome Protein Stimulates DNA Polymerase Beta Strand Displacement Synthesis Via Its Helicase Activity
  The Journal of Biological Chemistry. Jun, 2003  |   Pubmed ID: 12665521
• Structure of DNA Polymerase Beta with the Mutagenic DNA Lesion 8-oxodeoxyguanine Reveals Structural Insights into Its Coding Potential
  Structure (London, England : 1993). Jan, 2003  |   Pubmed ID: 12517346
• Hypersensitivity of DNA Polymerase Beta Null Mouse Fibroblasts Reflects Accumulation of Cytotoxic Repair Intermediates from Site-specific Alkyl DNA Lesions
  DNA Repair. Jan, 2003  |   Pubmed ID: 12509266
• Rapid Segmental and Subdomain Motions of DNA Polymerase Beta
  The Journal of Biological Chemistry. Feb, 2003  |   Pubmed ID: 12458221
• Involvement of DNA Polymerase Beta in Protection Against the Cytotoxicity of Oxidative DNA Damage
  DNA Repair. Apr, 2002  |   Pubmed ID: 12509250
• Mapping of the Interaction Interface of DNA Polymerase Beta with XRCC1
  Structure (London, England : 1993). Dec, 2002  |   Pubmed ID: 12467578
• Efficiency of Correct Nucleotide Insertion Governs DNA Polymerase Fidelity
  The Journal of Biological Chemistry. Dec, 2002  |   Pubmed ID: 12370169
• Binary System for Selective Photoaffinity Labeling of Base Excision Repair DNA Polymerases
  Nucleic Acids Research. Jul, 2002  |   Pubmed ID: 12136121
• Direct Interaction Between Mammalian DNA Polymerase Beta and Proliferating Cell Nuclear Antigen
  The Journal of Biological Chemistry. Aug, 2002  |   Pubmed ID: 12063248
• Mutations Associated with Base Excision Repair Deficiency and Methylation-induced Genotoxic Stress
  Proceedings of the National Academy of Sciences of the United States of America. May, 2002  |   Pubmed ID: 11983862
• Polymerase Beta Simulations Suggest That Arg258 Rotation is a Slow Step Rather Than Large Subdomain Motions Per Se
  Journal of Molecular Biology. Apr, 2002  |   Pubmed ID: 11955015
• 1H, 13C and 15N Resonance Assignments for the Perdeuterated 22 KD Palm-thumb Domain of DNA Polymerase Beta
  Journal of Biomolecular NMR. Feb, 2002  |   Pubmed ID: 11883786
• DNA Polymerase Beta
  The International Journal of Biochemistry & Cell Biology. Apr, 2002  |   Pubmed ID: 11854030
• Loss of DNA Polymerase Beta Stacking Interactions with Templating Purines, but Not Pyrimidines, Alters Catalytic Efficiency and Fidelity
  The Journal of Biological Chemistry. Mar, 2002  |   Pubmed ID: 11756435
• The Domain Organization and Properties of Individual Domains of DNA Topoisomerase V, a Type 1B Topoisomerase with DNA Repair Activities
  The Journal of Biological Chemistry. Feb, 2002  |   Pubmed ID: 11733530