Sang Geon Kim College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University Biography Publications Institution JoVE Articles Sang Geon Kim has not added a biography. If you are Sang Geon Kim and would like to personalize this page please email our Author Liaison for assistance. Publications Binge Alcohol Intake After Hypergravity Stress Sustainably Decreases AMPK and Transcription Factors Necessary for Hepatocyte Survival Alcoholism, Clinical and Experimental Research. Jan, 2017 | Pubmed ID: 27901267 Hepcidin Inhibits Smad3 Phosphorylation in Hepatic Stellate Cells by Impeding Ferroportin-mediated Regulation of Akt Nature Communications. Dec, 2016 | Pubmed ID: 28004654 MiRNA-324, a Potential Therapeutic Target for Paracetamol-induced Liver Injury Stem Cell Investigation. 2016 | Pubmed ID: 27868049 Corrigendum: A Load of Mice to Hypergravity Causes AMPKα Repression with Liver Injury, Which is Overcome by Preconditioning Loads Via Nrf2 Scientific Reports. Oct, 2016 | Pubmed ID: 27703208 Farnesoid X Receptor As a Regulator of Fuel Consumption and Mitochondrial Function Archives of Pharmacal Research. Aug, 2016 | Pubmed ID: 27515052 Higher Plasma Bilirubin Predicts Veno-occlusive Disease in Early Childhood Undergoing Hematopoietic Stem Cell Transplantation with Cyclosporine World Journal of Transplantation. Jun, 2016 | Pubmed ID: 27358786 AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550 Molecular and Cellular Biology. Jul, 2016 | Pubmed ID: 27161318 Synthesis and Biological Evaluation of 1,2-dithiol-3-thiones and Pyrrolo[1,2-a]pyrazines As Novel Hypoxia Inducible Factor-1 (HIF-1) Inhibitor Bioorganic & Medicinal Chemistry. Jun, 2016 | Pubmed ID: 27157007 Endoplasmic Reticulum Stress in Hepatic Stellate Cells Promotes Liver Fibrosis Via PERK-Mediated Degradation of HNRNPA1 and Up-regulation of SMAD2 Gastroenterology. Jan, 2016 | Pubmed ID: 26435271 PHLDA3 Overexpression in Hepatocytes by Endoplasmic Reticulum Stress Via IRE1-Xbp1s Pathway Expedites Liver Injury Gut. Aug, 2016 | Pubmed ID: 25966993 Molecular Network of HCC Aggressiveness Oncoscience. 2015 | Pubmed ID: 26682240 A Load of Mice to Hypergravity Causes AMPKα Repression with Liver Injury, Which is Overcome by Preconditioning Loads Via Nrf2 Scientific Reports. Oct, 2015 | Pubmed ID: 26493041 Etoposide Induces Necrosis Through P53-Mediated Antiapoptosis in Human Kidney Proximal Tubule Cells Toxicological Sciences : an Official Journal of the Society of Toxicology. Nov, 2015 | Pubmed ID: 26259609 Gα12 Overexpressed in Hepatocellular Carcinoma Reduces MicroRNA-122 Expression Via HNF4α Inactivation, Which Causes C-Met Induction Oncotarget. Aug, 2015 | Pubmed ID: 25965999 Phytochemical Regulation of Fyn and AMPK Signaling Circuitry Archives of Pharmacal Research. Dec, 2015 | Pubmed ID: 25951818 Phlda3, a Urine-detectable Protein, Causes P53 Accumulation in Renal Tubular Cells Injured by Cisplatin Cell Biology and Toxicology. Apr, 2015 | Pubmed ID: 25809501 Tacrolimus Therapy Causes Hepatotoxicity in Patients with a History of Liver Disease International Journal of Clinical Pharmacology and Therapeutics. May, 2015 | Pubmed ID: 25740263 Increase of MiR-199a-5p by Protoporphyrin IX, a Photocatalyzer, Directly Inhibits E2F3, Sensitizing Mesenchymal Tumor Cells to Anti-cancer Agents Oncotarget. Feb, 2015 | Pubmed ID: 25714015 Specific Oligopeptides in Fermented Soybean Extract Inhibit NF-κB-dependent INOS and Cytokine Induction by Toll-like Receptor Ligands Journal of Medicinal Food. Nov, 2014 | Pubmed ID: 25184943 Autophagy and MicroRNA Dysregulation in Liver Diseases Archives of Pharmacal Research. 2014 | Pubmed ID: 25015129 MicroRNA-148a Dysregulation Discriminates Poor Prognosis of Hepatocellular Carcinoma in Association with USP4 Overexpression Oncotarget. May, 2014 | Pubmed ID: 24798342 Discovery of an Integrative Network of MicroRNAs and Transcriptomics Changes for Acute Kidney Injury Kidney International. Nov, 2014 | Pubmed ID: 24759152 Mitigation of Carbon Tetrachloride-induced Hepatic Injury by Methylene Blue, a Repurposed Drug, is Mediated by Dual Inhibition of GSK3β Downstream of PKA British Journal of Pharmacology. Jun, 2014 | Pubmed ID: 24641162 Gα12gep Oncogene Inhibits FOXO1 in Hepatocellular Carcinoma As a Consequence of MiR-135b and MiR-194 Dysregulation Cellular Signalling. Jul, 2014 | Pubmed ID: 24631529 SIRT1 Activation by Methylene Blue, a Repurposed Drug, Leads to AMPK-mediated Inhibition of Steatosis and Steatohepatitis European Journal of Pharmacology. Mar, 2014 | Pubmed ID: 24486702 The Gep Proto-oncogene Gα12 Mediates LPA-stimulated Activation of CREB in Ovarian Cancer Cells Cellular Signalling. Jan, 2014 | Pubmed ID: 24055910 Structural Requirements Within Protoporphyrin IX in the Inhibition of Heat Shock Protein 90 Chemico-biological Interactions. Jun, 2013 | Pubmed ID: 23624237 The Role of Sphingolipids in Drug Metabolism and Transport Expert Opinion on Drug Metabolism & Toxicology. Mar, 2013 | Pubmed ID: 23289866 An Active Metabolite of Oltipraz (M2) Increases Mitochondrial Fuel Oxidation and Inhibits Lipogenesis in the Liver by Dually Activating AMPK British Journal of Pharmacology. Apr, 2013 | Pubmed ID: 23145499 Design, Synthesis, and Biological Evaluation of Novel Deguelin-based Heat Shock Protein 90 (HSP90) Inhibitors Targeting Proliferation and Angiogenesis Journal of Medicinal Chemistry. Dec, 2012 | Pubmed ID: 23186287 Efficacy and Tolerability of Diphenyl-dimethyldicarboxylate Plus Garlic Oil in Patients with Chronic Hepatitis International Journal of Clinical Pharmacology and Therapeutics. Nov, 2012 | Pubmed ID: 22943930 Roles of Toll-like Receptors in Cancer: a Double-edged Sword for Defense and Offense Archives of Pharmacal Research. Aug, 2012 | Pubmed ID: 22941474 Decrease of MicroRNA-122 Causes Hepatic Insulin Resistance by Inducing Protein Tyrosine Phosphatase 1B, Which is Reversed by Licorice Flavonoid Hepatology (Baltimore, Md.). Dec, 2012 | Pubmed ID: 22807119 Enhanced Antioxidant Effect of Prenylated Polyphenols As Fyn Inhibitor Free Radical Biology & Medicine. Sep, 2012 | Pubmed ID: 22771471 Fyn Inhibition by Cycloalkane-fused 1,2-dithiole-3-thiones Enhances Antioxidant Capacity and Protects Mitochondria from Oxidative Injury Molecular Pharmacology. Jul, 2012 | Pubmed ID: 22474169 E-cadherin Inhibits Nuclear Accumulation of Nrf2: Implications for Chemoresistance of Cancer Cells Journal of Cell Science. Mar, 2012 | Pubmed ID: 22302998 FXR Protects Hepatocytes from Injury by Repressing MiR-199a-3p, Which Increases Levels of LKB1 Gastroenterology. Jan, 2012 | Pubmed ID: 22265968 Hypoxia-inducible Factor-1α Inhibition by a Pyrrolopyrazine Metabolite of Oltipraz As a Consequence of MicroRNAs 199a-5p and 20a Induction Carcinogenesis. Mar, 2012 | Pubmed ID: 22223846 Effects of Poloxamer 407-induced Hyperlipidemia on the Pharmacokinetics of Carbamazepine and Its 10,11-epoxide Metabolite in Rats: Impact of Decreased Expression of Both CYP3A1/2 and Microsomal Epoxide Hydrolase European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. Jun, 2012 | Pubmed ID: 22137858 DA6034 Promotes Gastric Epithelial Cell Migration and Wound-healing Through the MTOR Pathway Journal of Gastroenterology and Hepatology. Feb, 2012 | Pubmed ID: 21793913 Hemin, an Iron-binding Porphyrin, Inhibits HIF-1α Induction Through Its Binding with Heat Shock Protein 90 International Journal of Cancer. Feb, 2012 | Pubmed ID: 21413014 Clinical Outcomes of Occupational Exposure to N,n-dimethylformamide: Perspectives from Experimental Toxicology Safety and Health at Work. Jun, 2011 | Pubmed ID: 22953193 Rimonabant, a Cannabinoid Receptor Type 1 Inverse Agonist, Inhibits Hepatocyte Lipogenesis by Activating Liver Kinase B1 and AMP-activated Protein Kinase Axis Downstream of Gα I/o Inhibition Molecular Pharmacology. Nov, 2011 | Pubmed ID: 21803969 Sphingosine 1-phosphate Regulates Matrix Metalloproteinase-9 Expression and Breast Cell Invasion Through S1P3-Gαq Coupling Journal of Cell Science. Jul, 2011 | Pubmed ID: 21652634 Farnesoid X Receptor Activation by Chenodeoxycholic Acid Induces Detoxifying Enzymes Through AMP-activated Protein Kinase and Extracellular Signal-regulated Kinase 1/2-mediated Phosphorylation of CCAAT/enhancer Binding Protein β Drug Metabolism and Disposition: the Biological Fate of Chemicals. Aug, 2011 | Pubmed ID: 21596890 Nrf2 Inhibits LXRα-dependent Hepatic Lipogenesis by Competing with FXR for Acetylase Binding Antioxidants & Redox Signaling. Oct, 2011 | Pubmed ID: 21504366 Oltipraz Therapy in Patients with Liver Fibrosis or Cirrhosis: a Randomized, Double-blind, Placebo-controlled Phase II Trial The Journal of Pharmacy and Pharmacology. May, 2011 | Pubmed ID: 21492164 Toll-like Receptor Modulators: a Patent Review (2006-2010) Expert Opinion on Therapeutic Patents. Jun, 2011 | Pubmed ID: 21406035 Phenethyl Isothiocyanate Inhibits 12-O-tetradecanoylphorbol-13-acetate-induced Inflammatory Responses in Mouse Skin Journal of Medicinal Food. Apr, 2011 | Pubmed ID: 21303260 G(alpha)12/13 Induction of CYR61 in Association with Arteriosclerotic Intimal Hyperplasia: Effect of Sphingosine-1-phosphate Arteriosclerosis, Thrombosis, and Vascular Biology. Apr, 2011 | Pubmed ID: 21212405 Nrf2-mediated Liver Protection by Sauchinone, an Antioxidant Lignan, from Acetaminophen Toxicity Through the PKCδ-GSK3β Pathway British Journal of Pharmacology. Aug, 2011 | Pubmed ID: 21039417 Inhibition of LXRα-dependent Steatosis and Oxidative Injury by Liquiritigenin, a Licorice Flavonoid, As Mediated with Nrf2 Activation Antioxidants & Redox Signaling. Mar, 2011 | Pubmed ID: 20677908 Ajoene, a Stable Garlic By-product, Inhibits High Fat Diet-induced Hepatic Steatosis and Oxidative Injury Through LKB1-dependent AMPK Activation Antioxidants & Redox Signaling. Jan, 2011 | Pubmed ID: 20560786 Applications of Genetically Modified Tools to Safety Assessment in Drug Development Toxicological Research. Mar, 2010 | Pubmed ID: 24278499 E-cadherin Antagonizes Transforming Growth Factor β1 Gene Induction in Hepatic Stellate Cells by Inhibiting RhoA-dependent Smad3 Phosphorylation Hepatology (Baltimore, Md.). Dec, 2010 | Pubmed ID: 20890948 Transactivation of Genes Encoding for Phase II Enzymes and Phase III Transporters by Phytochemical Antioxidants Molecules (Basel, Switzerland). Sep, 2010 | Pubmed ID: 20877225 Inhibition of Liver X Receptor-α-dependent Hepatic Steatosis by Isoliquiritigenin, a Licorice Antioxidant Flavonoid, As Mediated by JNK1 Inhibition Free Radical Biology & Medicine. Dec, 2010 | Pubmed ID: 20840863 AMPK-Dependent Metabolic Regulation by PPAR Agonists PPAR Research. 2010 | Pubmed ID: 20814441 AMPK-associated Signaling to Bridge the Gap Between Fuel Metabolism and Hepatocyte Viability World Journal of Gastroenterology. Aug, 2010 | Pubmed ID: 20698033 Negligible Effect of Oral Garlic Oil on the Oral Absorption of Pyridoxine in Metadoxine in Rats Archives of Pharmacal Research. Jul, 2010 | Pubmed ID: 20661709 G(alpha)12/13 Inhibition Enhances the Anticancer Effect of Bortezomib Through PSMB5 Downregulation Carcinogenesis. Jul, 2010 | Pubmed ID: 20478922 Simultaneous Quantitative Monitoring of Drug-induced Caspase Cascade Pathways in Carcinoma Cells Integrative Biology : Quantitative Biosciences from Nano to Macro. Jan, 2010 | Pubmed ID: 20473412 Ajoene, a Stable Garlic By-product, Has an Antioxidant Effect Through Nrf2-mediated Glutamate-cysteine Ligase Induction in HepG2 Cells and Primary Hepatocytes The Journal of Nutrition. Jul, 2010 | Pubmed ID: 20463144 Galpha12 is Critical for TCR-induced IL-2 Production and Differentiation of T Helper 2 and T Helper 17 Cells Biochemical and Biophysical Research Communications. Apr, 2010 | Pubmed ID: 20233578 Protective Effects of Magnesium Lithospermate B Against Diabetic Atherosclerosis Via Nrf2-ARE-NQO1 Transcriptional Pathway Atherosclerosis. Jul, 2010 | Pubmed ID: 20172524 Synergistic Hepatotoxicity of N,N-dimethylformamide with Carbon Tetrachloride in Association with Endoplasmic Reticulum Stress Chemico-biological Interactions. Mar, 2010 | Pubmed ID: 20097184 The NRF2-heme Oxygenase-1 System Modulates Cyclosporin A-induced Epithelial-mesenchymal Transition and Renal Fibrosis Free Radical Biology & Medicine. Apr, 2010 | Pubmed ID: 20096777 Antioxidant and Mitochondrial Protective Effects of Oxidized Metabolites of Oltipraz Expert Opinion on Drug Metabolism & Toxicology. Feb, 2010 | Pubmed ID: 20095791 The G12 Family Proteins Upregulate Matrix Metalloproteinase-2 Via P53 Leading to Human Breast Cell Invasion Breast Cancer Research and Treatment. Nov, 2010 | Pubmed ID: 20044778 AMPK-mediated GSK3beta Inhibition by Isoliquiritigenin Contributes to Protecting Mitochondria Against Iron-catalyzed Oxidative Stress Biochemical Pharmacology. May, 2010 | Pubmed ID: 20026081 Inhibition of SREBP-1c-mediated Hepatic Steatosis and Oxidative Stress by Sauchinone, an AMPK-activating Lignan in Saururus Chinensis Free Radical Biology & Medicine. Feb, 2010 | Pubmed ID: 20005944 Oltipraz and Dithiolethione Congeners Inhibit Hypoxia-inducible Factor-1alpha Activity Through P70 Ribosomal S6 Kinase-1 Inhibition and H2O2-scavenging Effect Molecular Cancer Therapeutics. Oct, 2009 | Pubmed ID: 19789218 A Special Issue Edited by Dr. Louis J. Ignarro, A Nobel Prize Laureate Archives of Pharmacal Research. Aug, 2009 | Pubmed ID: 19727600 Resveratrol Protects Mitochondria Against Oxidative Stress Through AMP-activated Protein Kinase-mediated Glycogen Synthase Kinase-3beta Inhibition Downstream of Poly(ADP-ribose)polymerase-LKB1 Pathway Molecular Pharmacology. Oct, 2009 | Pubmed ID: 19620254 Efficacy of Sauchinone As a Novel AMPK-activating Lignan for Preventing Iron-induced Oxidative Stress and Liver Injury Free Radical Biology & Medicine. Oct, 2009 | Pubmed ID: 19616619 Metadoxine, an Ion-pair of Pyridoxine and L-2-pyrrolidone-5-carboxylate, Blocks Adipocyte Differentiation in Association with Inhibition of the PKA-CREB Pathway Archives of Biochemistry and Biophysics. Aug, 2009 | Pubmed ID: 19607801 Therapeutic Potential of Dithiolethiones for Hepatic Diseases Pharmacology & Therapeutics. Oct, 2009 | Pubmed ID: 19563826 H89, an Inhibitor of PKA and MSK, Inhibits Cyclic-AMP Response Element Binding Protein-mediated MAPK Phosphatase-1 Induction by Lipopolysaccharide Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]. Dec, 2009 | Pubmed ID: 19547917 Galpha13 Regulates Methacholine-induced Contraction of Bronchial Smooth Muscle Via Phosphorylation of MLC20 Biochemical Pharmacology. May, 2009 | Pubmed ID: 19426687 Oltipraz Promotion of Liver Regeneration After Partial Hepatectomy: The Role of PI3-kinase-dependent C/EBPbeta and Cyclin E Regulation Archives of Pharmacal Research. Apr, 2009 | Pubmed ID: 19407981 Role of Adenosine Monophosphate-activated Protein Kinase-p70 Ribosomal S6 Kinase-1 Pathway in Repression of Liver X Receptor-alpha-dependent Lipogenic Gene Induction and Hepatic Steatosis by a Novel Class of Dithiolethiones Hepatology (Baltimore, Md.). Jun, 2009 | Pubmed ID: 19378344 Oxidized Metabolites of Oltipraz Exert Cytoprotective Effects Against Arachidonic Acid Through AMP-activated Protein Kinase-dependent Cellular Antioxidant Effect and Mitochondrial Protection Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jun, 2009 | Pubmed ID: 19299524 Liquiritigenin, a Flavonoid Aglycone from Licorice, Has a Choleretic Effect and the Ability to Induce Hepatic Transporters and Phase-II Enzymes American Journal of Physiology. Gastrointestinal and Liver Physiology. Feb, 2009 | Pubmed ID: 19074639 Inhibition of Arachidonic Acid and Iron-induced Mitochondrial Dysfunction and Apoptosis by Oltipraz and Novel 1,2-dithiole-3-thione Congeners Molecular Pharmacology. Jan, 2009 | Pubmed ID: 18945820 A Novel Mitogen-activated Protein Kinase Phosphatase-1 and Glucocorticoid Receptor (GR) Interacting Protein-1-dependent Combinatorial Mechanism of Gene Transrepression by GR Molecular Endocrinology (Baltimore, Md.). Jan, 2009 | Pubmed ID: 18945810 Drug-induced Hyperbilirubinemia and the Clinical Influencing Factors Drug Metabolism Reviews. 2008 | Pubmed ID: 18821100 The Identification of C/EBPbeta As a Transcription Factor Necessary for the Induction of MAPK Phosphatase-1 by Toll-like Receptor-4 Ligand Archives of Biochemistry and Biophysics. Nov, 2008 | Pubmed ID: 18761321 Compound C Inhibits Clonal Expansion of Preadipocytes by Increasing P21 Level Irrespectively of AMPK Inhibition Archives of Biochemistry and Biophysics. Nov, 2008 | Pubmed ID: 18721791 Regulation of Thymus-dependent and Thymus-independent Production of Immunoglobulin G Subclasses by Galpha12 and Galpha13 Journal of Molecular Signaling. Jul, 2008 | Pubmed ID: 18620589 A Novel Mechanism of PPARgamma Regulation of TGFbeta1: Implication in Cancer Biology PPAR Research. 2008 | Pubmed ID: 18615188 Isoliquiritigenin Suppresses Cocaine-induced Extracellular Dopamine Release in Rat Brain Through GABA(B) Receptor European Journal of Pharmacology. Jun, 2008 | Pubmed ID: 18495107 Abrogation of Hyperosmotic Impairment of Insulin Signaling by a Novel Class of 1,2-dithiole-3-thiones Through the Inhibition of S6K1 Activation Molecular Pharmacology. May, 2008 | Pubmed ID: 18252807 3,3'-Diindolylmethane Suppresses the Inflammatory Response to Lipopolysaccharide in Murine Macrophages The Journal of Nutrition. Jan, 2008 | Pubmed ID: 18156398 Identification of a Novel Class of Dithiolethiones That Prevent Hepatic Insulin Resistance Via the Adenosine Monophosphate-activated Protein Kinase-p70 Ribosomal S6 Kinase-1 Pathway Hepatology (Baltimore, Md.). Sep, 2007 | Pubmed ID: 17668885 Functional Induction of P-glycoprotein in the Blood-brain Barrier of Streptozotocin-induced Diabetic Rats: Evidence for the Involvement of Nuclear Factor-kappaB, a Nitrosative Stress-sensitive Transcription Factor, in the Regulation Drug Metabolism and Disposition: the Biological Fate of Chemicals. Nov, 2007 | Pubmed ID: 17664251 Metformin Prevents an Adaptive Increase in GSH and Induces Apoptosis Under the Conditions of GSH Deficiency in H4IIE Cells Journal of Toxicology and Environmental Health. Part A. Aug, 2007 | Pubmed ID: 17654257 Induction of Glutathione Transferase in Insulin-like Growth Factor Type I Receptor-overexpressed Hepatoma Cells Molecular Pharmacology. Oct, 2007 | Pubmed ID: 17615245 Combined Metadoxine and Garlic Oil Treatment Efficaciously Abrogates Alcoholic Steatosis and CYP2E1 Induction in Rat Liver with Restoration of AMPK Activity Chemico-biological Interactions. Aug, 2007 | Pubmed ID: 17606256 Role of Galpha12 and Galpha13 As Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor Molecular and Cellular Biology. Sep, 2007 | Pubmed ID: 17591699 The Potent Protective Effect of Wild Ginseng (Panax Ginseng C.A. Meyer) Against Benzo[alpha]pyrene-induced Toxicity Through Metabolic Regulation of CYP1A1 and GSTs Journal of Ethnopharmacology. Jul, 2007 | Pubmed ID: 17590295 G Alpha 12/13 Basally Regulates P53 Through Mdm4 Expression Molecular Cancer Research : MCR. May, 2007 | Pubmed ID: 17510313 Identifying Drugs Needing Pharmacogenetic Monitoring in a Korean Hospital American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists. Jan, 2007 | Pubmed ID: 17215467 PI3K, RSK, and MTOR Signal Networks for the GST Gene Regulation Toxicological Sciences : an Official Journal of the Society of Toxicology. Apr, 2007 | Pubmed ID: 17122411 Galpha12 Specifically Regulates COX-2 Induction by Sphingosine 1-phosphate. Role for JNK-dependent Ubiquitination and Degradation of IkappaBalpha The Journal of Biological Chemistry. Jan, 2007 | Pubmed ID: 17098744 Inhibition of TGFbeta1-mediated PAI-1 Induction by Oltipraz Through Selective Interruption of Smad 3 Activation Cytokine. Sep, 2006 | Pubmed ID: 17095240 Activating Transcription Factor 2 Mediates Matrix Metalloproteinase-2 Transcriptional Activation Induced by P38 in Breast Epithelial Cells Cancer Research. Nov, 2006 | Pubmed ID: 17079470 Effects of Glucose Supplementation on the Pharmacokinetics of Intravenous Chlorzoxazone in Rats with Water Deprivation for 72 H Life Sciences. Nov, 2006 | Pubmed ID: 16914164 A Novel INOS and COX-2 Inhibitor from the Aerial Parts of Rodgersia Podophylla Bioorganic & Medicinal Chemistry Letters. Sep, 2006 | Pubmed ID: 16784852 Differential Effects of the Oxidized Metabolites of Oltipraz on the Activation of CCAAT/enhancer Binding Protein-beta and NF-E2-related Factor-2 for GSTA2 Gene Induction Drug Metabolism and Disposition: the Biological Fate of Chemicals. Aug, 2006 | Pubmed ID: 16714377 Liquiritigenin, an Aglycone of Liquiritin in Glycyrrhizae Radix, Prevents Acute Liver Injuries in Rats Induced by Acetaminophen with or Without Buthionine Sulfoximine Chemico-biological Interactions. Jun, 2006 | Pubmed ID: 16647697 Expression of Microsomal Epoxide Hydrolase is Elevated in Alzheimer's Hippocampus and Induced by Exogenous Beta-amyloid and Trimethyl-tin The European Journal of Neuroscience. Apr, 2006 | Pubmed ID: 16630050 Peroxisome Proliferator-activated Receptor-gamma and Retinoic Acid X Receptor Alpha Represses the TGFbeta1 Gene Via PTEN-mediated P70 Ribosomal S6 Kinase-1 Inhibition: Role for Zf9 Dephosphorylation Molecular Pharmacology. Jul, 2006 | Pubmed ID: 16611854 Role of P90 Ribosomal S6-kinase-1 in Oltipraz-induced Specific Phosphorylation of CCAAT/enhancer Binding Protein-beta for GSTA2 Gene Transactivation Molecular Pharmacology. Jan, 2006 | Pubmed ID: 16246908 Molecular Mechanism of Nrf2 Activation by Oxidative Stress Antioxidants & Redox Signaling. Nov-Dec, 2005 | Pubmed ID: 16356128 G-protein Signaling in INOS Gene Expression Methods in Enzymology. 2005 | Pubmed ID: 16291247 NO Signaling in ARE-mediated Gene Expression Methods in Enzymology. 2005 | Pubmed ID: 16291243 Repression by Oxidative Stress of INOS and Cytokine Gene Induction in Macrophages Results from AP-1 and NF-kappaB Inhibition Mediated by B Cell Translocation Gene-1 Activation Free Radical Biology & Medicine. Dec, 2005 | Pubmed ID: 16274887 Pharmacokinetics of Theophylline in Diabetes Mellitus Rats: Induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric Acid Formation European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Sep, 2005 | Pubmed ID: 15985363 Enhanced CCAAT/enhancer-binding Protein Beta-liver-enriched Inhibitory Protein Production by Oltipraz, Which Accompanies CUG Repeat-binding Protein-1 (CUGBP1) RNA-binding Protein Activation, Leads to Inhibition of Preadipocyte Differentiation Molecular Pharmacology. Sep, 2005 | Pubmed ID: 15961673 Garlic Oil and DDB, Comprised in a Pharmaceutical Composition for the Treatment of Patients with Viral Hepatitis, Prevents Acute Liver Injuries Potentiated by Glutathione Deficiency in Rats Chemico-biological Interactions. Jun, 2005 | Pubmed ID: 15950962 Meso-dihydroguaiaretic Acid from Machilus Thunbergii Down-regulates TGF-beta1 Gene Expression in Activated Hepatic Stellate Cells Via Inhibition of AP-1 Activity Planta Medica. May, 2005 | Pubmed ID: 15931574 Bovine Type I Collagen Inhibits Raw264.7 Cell Proliferation Through Phosphoinositide 3-kinase- and Mitogen-activated Protein Kinase-dependent Down-regulation of Cyclins D1, A and B1 Biochimica Et Biophysica Acta. May, 2005 | Pubmed ID: 15878397 Glucocorticoid Receptor (GR)-associated SMRT Binding to C/EBPbeta TAD and Nrf2 Neh4/5: Role of SMRT Recruited to GR in GSTA2 Gene Repression Molecular and Cellular Biology. May, 2005 | Pubmed ID: 15870285 Lack of Therapeutic Improvement of Liver Fibrosis in Rats by Dexamethasone in Spite of Ascites Amelioration Chemico-biological Interactions. Feb, 2005 | Pubmed ID: 15766921 Deprenyl, a Therapeutic Agent for Parkinson's Disease, Inhibits Arsenic Toxicity Potentiated by GSH Depletion Via Inhibition of JNK Activation Journal of Toxicology and Environmental Health. Part A. Dec, 2004 | Pubmed ID: 15513899 Hyaluronic Acid Inhibits Adhesion of Hepatic Stellate Cells in Spite of Its Stimulation of DNA Synthesis Tissue & Cell. Oct, 2004 | Pubmed ID: 15385147 PKC Downstream of Pl3-kinase Regulates Peroxynitrite Formation for Nrf2-mediated GSTA2 Induction Archives of Pharmacal Research. Jul, 2004 | Pubmed ID: 15357004 Ceramide, an Apoptotic Rheostat, Inhibits CCAAT/enhancer Binding Protein-beta and NF-E2-related Factor-2 Activation: the Role in Glutathione S-transferase A2 Gene Repression Drug Metabolism and Disposition: the Biological Fate of Chemicals. Sep, 2004 | Pubmed ID: 15319326 Arctigenin, a Phenylpropanoid Dibenzylbutyrolactone Lignan, Inhibits MAP Kinases and AP-1 Activation Via Potent MKK Inhibition: the Role in TNF-alpha Inhibition International Immunopharmacology. Oct, 2004 | Pubmed ID: 15313439 Synthesis and Anti-inflammatory Effects of Novel Pimarane Diterpenoid Analogs Bioorganic & Medicinal Chemistry Letters. Jul, 2004 | Pubmed ID: 15177458 Induction of Cyclooxygenase-2 by Bovine Type I Collagen in Macrophages Via C/EBP and CREB Activation by Multiple Cell Signaling Pathways Biochemical Pharmacology. Jun, 2004 | Pubmed ID: 15163555 Ceramide Negatively Regulates Glutathione S-transferase Gene Transactivation Via Repression of Hepatic Nuclear Factor-1 That is Degraded by the Ubiquitin Proteasome System Molecular Pharmacology. Jun, 2004 | Pubmed ID: 15155840 Transactivation of the PPAR-responsive Enhancer Module in Chemopreventive Glutathione S-transferase Gene by the Peroxisome Proliferator-activated Receptor-gamma and Retinoid X Receptor Heterodimer Cancer Research. May, 2004 | Pubmed ID: 15150131 Cytoprotective Effects of Glycyrrhizae Radix Extract and Its Active Component Liquiritigenin Against Cadmium-induced Toxicity (effects on Bad Translocation and Cytochrome C-mediated PARP Cleavage) Toxicology. May, 2004 | Pubmed ID: 15033546 Scaffolding of Keap1 to the Actin Cytoskeleton Controls the Function of Nrf2 As Key Regulator of Cytoprotective Phase 2 Genes Proceedings of the National Academy of Sciences of the United States of America. Feb, 2004 | Pubmed ID: 14764898 Effects of Colchicine on Liver Functions of Cirrhotic Rats: Beneficial Effects Result from Stellate Cell Inactivation and Inhibition of TGF Beta1 Expression Chemico-biological Interactions. Jan, 2004 | Pubmed ID: 14726149 Pharmacokinetic Interaction Between Oltipraz and Dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene Dioxybiphenyl-2,2'-dicarboxylate (DDB) After Single Intravenous and Oral Administration to Rats The Journal of Pharmacy and Pharmacology. Sep, 2003 | Pubmed ID: 14604467 Ginsenoside Rg3 Inhibits Phenylephrine-induced Vascular Contraction Through Induction of Nitric Oxide Synthase British Journal of Pharmacology. Oct, 2003 | Pubmed ID: 14534150 2-Oxo-3,23-isopropylidene-asiatate (AS2006A), a Wound-healing Asiatate Derivative, Exerts Anti-inflammatory Effect by Apoptosis of Macrophages International Immunopharmacology. Oct, 2003 | Pubmed ID: 12946439 Oltipraz Inhibits 3-methylcholanthrene Induction of CYP1A1 by CCAAT/enhancer-binding Protein Activation The Journal of Biological Chemistry. Nov, 2003 | Pubmed ID: 12941938 Cadmium-induced Non-apoptotic Cell Death Mediated by Oxidative Stress Under the Condition of Sulfhydryl Deficiency Toxicology Letters. Oct, 2003 | Pubmed ID: 12927350 The Suppressed Expression and Functional Activity of Hepatic P-glycoprotein in Rats with Protein-calorie Malnutrition Journal of Pharmaceutical Sciences. Jul, 2003 | Pubmed ID: 12820137 Effects of Recombinant Human Growth Hormone on the Pharmacokinetics of Intravenous Chlorzoxazone in Rats with Acute Renal Failure Induced by Uranyl Nitrate Life Sciences. Jun, 2003 | Pubmed ID: 12757833 Effects of Acute Renal Failure on the Pharmacokinetics of Chlorzoxazone in Rats Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jun, 2003 | Pubmed ID: 12756212 Inhibition of Lipopolysaccharide-inducible Nitric Oxide Synthase, TNF-alpha and COX-2 Expression by Sauchinone Effects on I-kappaBalpha Phosphorylation, C/EBP and AP-1 Activation British Journal of Pharmacology. May, 2003 | Pubmed ID: 12746218 Effects of Cysteine on the Pharmacokinetics of Intravenous 2-(allylthio)pyrazine, a New Chemoprotective Agent, in Rats with Protein-calorie Malnutrition International Journal of Pharmaceutics. Apr, 2003 | Pubmed ID: 12672597 Activation of CCAAT/enhancer-binding Protein Beta by 2'-amino-3'-methoxyflavone (PD98059) Leads to the Induction of Glutathione S-transferase A2 Carcinogenesis. Mar, 2003 | Pubmed ID: 12663507 Potentiation of Lipopolysaccharide-inducible Cyclooxygenase 2 Expression by C2-ceramide Via C-Jun N-terminal Kinase-mediated Activation of CCAAT/enhancer Binding Protein Beta in Macrophages Molecular Pharmacology. Mar, 2003 | Pubmed ID: 12606757 Thrombin Induces Nitric-oxide Synthase Via Galpha12/13-coupled Protein Kinase C-dependent I-kappaBalpha Phosphorylation and JNK-mediated I-kappaBalpha Degradation The Journal of Biological Chemistry. May, 2003 | Pubmed ID: 12606553 Hepatocyte Growth Factor Activates CCAAT Enhancer Binding Protein and Cell Replication Via PI3-kinase Pathway Hepatology (Baltimore, Md.). Mar, 2003 | Pubmed ID: 12601366 Essential Role of Phosphatidylinositol 3-kinase-dependent CCAAT/enhancer Binding Protein Beta Activation in the Induction of Glutathione S-transferase by Oltipraz Journal of the National Cancer Institute. Jan, 2003 | Pubmed ID: 12509401 Effects of Acute Renal Failure Induced by Uranyl Nitrate on the Pharmacokinetics of Intravenous Theophylline in Rats: the Role of CYP2E1 Induction in 1,3-dimethyluric Acid Formation The Journal of Pharmacy and Pharmacology. Dec, 2002 | Pubmed ID: 12542900 Effect of Nitric Oxide on the Sinusoidal Uptake of Organic Cations and Anions by Isolated Hepatocytes Archives of Pharmacal Research. Dec, 2002 | Pubmed ID: 12510858 Hepatobiliary Excretion of Tributylmethylamonium in Rats with Lipopolysaccharide-induced Acute Inflammation Archives of Pharmacal Research. Dec, 2002 | Pubmed ID: 12510855 Peroxynitrite Activates NF-E2-related Factor 2/antioxidant Response Element Through the Pathway of Phosphatidylinositol 3-kinase: the Role of Nitric Oxide Synthase in Rat Glutathione S-transferase A2 Induction Nitric Oxide : Biology and Chemistry. Dec, 2002 | Pubmed ID: 12446173 The Anti-fibrogenic Effect of a Pharmaceutical Composition of [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] (oltipraz) and Dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene Dioxybiphenyl-2,2'-dicarboxylate (DDB) Archives of Pharmacal Research. Oct, 2002 | Pubmed ID: 12433201 Oltipraz Regenerates Cirrhotic Liver Through CCAAT/enhancer Binding Protein-mediated Stellate Cell Inactivation FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2002 | Pubmed ID: 12397085 Phosphatidylinositol 3-kinase Regulates Nuclear Translocation of NF-E2-related Factor 2 Through Actin Rearrangement in Response to Oxidative Stress Molecular Pharmacology. Nov, 2002 | Pubmed ID: 12391262 Mechanism of the Reduced Elimination Clearance of Benzylpenicillin from Cerebrospinal Fluid in Rats with Intracisternal Administration of Lipopolysaccharide Drug Metabolism and Disposition: the Biological Fate of Chemicals. Nov, 2002 | Pubmed ID: 12386127 Increase in Urea in Conjunction with L-arginine Metabolism in the Liver Leads to Induction of Cytochrome P450 2E1 (CYP2E1): the Role of Urea in CYP2E1 Induction by Acute Renal Failure Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jun, 2002 | Pubmed ID: 12019204 JunB/AP-1 and NF-kappa B-mediated Induction of Nitric Oxide Synthase by Bovine Type I Collagen in Serum-stimulated Murine Macrophages Nitric Oxide : Biology and Chemistry. May, 2002 | Pubmed ID: 12009850 Induction of Microsomal Epoxide Hydrolase by Sulfur Amino Acid Deprivation Via the Pathway of C-Jun N-terminal Kinase and Its Extracellular Exposure During Cell Death Free Radical Biology & Medicine. May, 2002 | Pubmed ID: 12008117 Alterations in Cellular Ca(2+) and Free Iron Pool by Sulfur Amino Acid Deprivation: the Role of Ferritin Light Chain Down-regulation in Prooxidant Production Biochemical Pharmacology. Feb, 2002 | Pubmed ID: 11992632 Identification of Genes Enhanced by Protein-calorie Malnutrition by Differential Display Polymerase Chain Reaction (expression of Fibrinogen B Beta Chain, B Cell Translocation Gene 1 and Thyroid Hormone Responsive Protein Genes) Molecular and Cellular Biochemistry. Feb, 2002 | Pubmed ID: 11952159 Inhibition of Dimethylnitrosamine-induced Liver Fibrosis by [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] (oltipraz) in Rats: Suppression of Transforming Growth Factor-beta1 and Tumor Necrosis Factor-alpha Expression Chemico-biological Interactions. Jan, 2002 | Pubmed ID: 11803029 Potent Inhibition of Lipopolysaccharide-inducible Nitric Oxide Synthase Expression by Dibenzylbutyrolactone Lignans Through Inhibition of I-kappaBalpha Phosphorylation and of P65 Nuclear Translocation in Macrophages International Immunopharmacology. Jan, 2002 | Pubmed ID: 11789661 Oligopeptide Competition Assay for Phosphorylation Site Determination Min Sung Joo1, Ja Hyun Koo1, Sol-Bi Shin2, Hyungshin Yim2, Sang Geon Kim1 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 2College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University JoVE 55708 Biochemistry
Oligopeptide Competition Assay for Phosphorylation Site Determination Min Sung Joo1, Ja Hyun Koo1, Sol-Bi Shin2, Hyungshin Yim2, Sang Geon Kim1 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 2College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University JoVE 55708 Biochemistry