Sarah K. Wootton

Publications

• Oncolytic Orf Virus Licenses NK Cells Via CDC1 to Activate Innate and Adaptive Antitumor Mechanisms and Extends Survival in a Murine Model of Late-stage Ovarian Cancer
  Journal for Immunotherapy of Cancer. Mar, 2022  |   Pubmed ID: 35296558
• AAV-Vectored Expression of the Vascular Normalizing Agents 3TSR and Fc3TSR, and the Anti-Angiogenic Bevacizumab Extends Survival in a Murine Model of End-Stage Epithelial Ovarian Carcinoma
  Biomedicines. Feb, 2022  |   Pubmed ID: 35203573
• Addition of an Fc-IgG Induces Receptor Clustering and Increases the in Vitro Efficacy and in Vivo Anti-tumor Properties of the Thrombospondin-1 Type I Repeats (3TSR) in a Mouse Model of Advanced Stage Ovarian Cancer
  Gynecologic Oncology. 01, 2022  |   Pubmed ID: 34799137
• Using a Prime-Boost Vaccination Strategy That Proved Effective for High Resolution Epitope Mapping to Characterize the Elusive Immunogenicity of Survivin
  Cancers. Dec, 2021  |   Pubmed ID: 34944889
• Process Development for Newcastle Disease Virus-Vectored Vaccines in Serum-Free Vero Cell Suspension Cultures
  Vaccines. Nov, 2021  |   Pubmed ID: 34835266
• Production and Purification of High-titer OrfV for Preclinical Studies in Vaccinology and Cancer Therapy
  Molecular Therapy. Methods & Clinical Development. Dec, 2021  |   Pubmed ID: 34786436
• Macrophage Depletion Via Clodronate Pretreatment Reduces Transgene Expression from AAV Vectors In Vivo
  Viruses. 10, 2021  |   Pubmed ID: 34696433
• Intranasal Vaccination with a Newcastle Disease Virus-vectored Vaccine Protects Hamsters from SARS-CoV-2 Infection and Disease
  IScience. Nov, 2021  |   Pubmed ID: 34632328
• Safety and Tolerability of the Adeno-Associated Virus Vector, AAV6.2FF, Expressing a Monoclonal Antibody in Murine and Ovine Animal Models
  Biomedicines. Sep, 2021  |   Pubmed ID: 34572372
• Gene Therapy for Fabry Disease: Progress, Challenges, and Outlooks on Gene-editing
  Molecular Genetics and Metabolism. Sep-Oct, 2021  |   Pubmed ID: 34340879
• Efficient Transduction of Alveolar Type 2 Cells with Adeno-associated Virus for the Study of Lung Regeneration
  American Journal of Respiratory Cell and Molecular Biology. 07, 2021  |   Pubmed ID: 34241584
• A Novel Mouse AAV6 HACE2 Transduction Model of Wild-type SARS-CoV-2 Infection Studied Using SynDNA Immunogens
  IScience. Jul, 2021  |   Pubmed ID: 34124612
• The Role of Type I Interferon Signaling in Regulating Cytokine Production and Cell Survival in Bone Marrow-Derived Macrophages
  Viral Immunology. Jun, 2021  |   Pubmed ID: 34097550
• Type I Interferon-Mediated Regulation of Antiviral Capabilities of Neutrophils
  International Journal of Molecular Sciences. Apr, 2021  |   Pubmed ID: 33946935
• Combining Vanadyl Sulfate with Newcastle Disease Virus Potentiates Rapid Innate Immune-mediated Regression with Curative Potential in Murine Cancer Models
  Molecular Therapy Oncolytics. Mar, 2021  |   Pubmed ID: 33614913
• AAV-mediated Delivery of Actoxumab and Bezlotoxumab Results in Serum and Mucosal Antibody Concentrations That Provide Protection from C. Difficile Toxin Challenge
  Gene Therapy. Feb, 2021  |   Pubmed ID: 33608675
• AAV Vectored Immunoprophylaxis for Filovirus Infections
  Tropical Medicine and Infectious Disease. Nov, 2020  |   Pubmed ID: 33182447
• JSRV Intragenic Enhancer Element Increases Expression from a Heterologous Promoter and Promotes High Level AAV-mediated Transgene Expression in the Lung and Liver of Mice
  Viruses. 11, 2020  |   Pubmed ID: 33172105
• Engineered AAV8 Capsid Acquires Heparin and AVB Sepharose Binding Capacity but Has Altered in Vivo Transduction Efficiency
  Gene Therapy. Oct, 2020  |   Pubmed ID: 33028973
• Tumour Vasculature: Friend or Foe of Oncolytic Viruses?
  Cytokine & Growth Factor Reviews. 12, 2020  |   Pubmed ID: 32893095
• Characterization of the Impact of Oncolytic Vesicular Stomatitis Virus on the Trafficking, Phenotype, and Antigen Presentation Potential of Neutrophils and Their Ability to Acquire a Non-Structural Viral Protein
  International Journal of Molecular Sciences. Sep, 2020  |   Pubmed ID: 32882969
• VHSV IVb Infection and Autophagy Modulation in the Rainbow Trout Gill Epithelial Cell Line RTgill-W1
  Journal of Fish Diseases. Oct, 2020  |   Pubmed ID: 32794227
• A Lung Tropic AAV Vector Improves Survival in a Mouse Model of Surfactant B Deficiency
  Nature Communications. 08, 2020  |   Pubmed ID: 32764559
• Interference Chromatography: a Novel Approach to Optimizing Chromatographic Selectivity and Separation Performance for Virus Purification
  BMC Biotechnology. 06, 2020  |   Pubmed ID: 32552807
• Optimized Pre-Clinical Grade Production of Two Novel Lentiviral Vector Pseudotypes for Lung Gene Delivery
  Human Gene Therapy. 04, 2020  |   Pubmed ID: 32000531
• AAV-mediated Expression of 3TSR Inhibits Tumor and Metastatic Lesion Development and Extends Survival in a Murine Model of Epithelial Ovarian Carcinoma
  Cancer Gene Therapy. 05, 2020  |   Pubmed ID: 31160686
• The U3 and Env Proteins of Jaagsiekte Sheep Retrovirus and Enzootic Nasal Tumor Virus Both Contribute to Tissue Tropism
  Viruses. 11, 2019  |   Pubmed ID: 31739606
• Quantifying Antibody Responses Induced by Antigen-Agnostic Immunotherapies
  Molecular Therapy. Methods & Clinical Development. Sep, 2019  |   Pubmed ID: 31388514
• Myeloid Cells During Viral Infections and Inflammation
  Viruses. 02, 2019  |   Pubmed ID: 30791481
• Quantifying Antigen-Specific T Cell Responses When Using Antigen-Agnostic Immunotherapies
  Molecular Therapy. Methods & Clinical Development. Jun, 2019  |   Pubmed ID: 30788384
• AAV-Mediated Gene Delivery to the Lung
  Methods in Molecular Biology (Clifton, N.J.). 2019  |   Pubmed ID: 30783985
• Combining Vascular Normalization with an Oncolytic Virus Enhances Immunotherapy in a Preclinical Model of Advanced-Stage Ovarian Cancer
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 03, 2019  |   Pubmed ID: 30206160
• The Effects of in Ovo Administration of Encapsulated Toll-like Receptor 21 Ligand As an Adjuvant with Marek's Disease Vaccine
  Scientific Reports. 11, 2018  |   Pubmed ID: 30401976
• Use of Precision-Cut Lung Slices As an Tool for Evaluating Viruses and Viral Vectors for Gene and Oncolytic Therapy
  Molecular Therapy. Methods & Clinical Development. Sep, 2018  |   Pubmed ID: 30112421
• A Novel Triple-Mutant AAV6 Capsid Induces Rapid and Potent Transgene Expression in the Muscle and Respiratory Tract of Mice
  Molecular Therapy. Methods & Clinical Development. Jun, 2018  |   Pubmed ID: 30038936
• In Ovo Administration of Toll-like Receptor Ligands Encapsulated in PLGA Nanoparticles Impede Tumor Development in Chickens Infected with Marek's Disease Virus
  Vaccine. 06, 2018  |   Pubmed ID: 29859800
• Production and Purification of High-Titer Newcastle Disease Virus for Use in Preclinical Mouse Models of Cancer
  Molecular Therapy. Methods & Clinical Development. Jun, 2018  |   Pubmed ID: 29556508
• Intramuscular Adeno-Associated Virus-Mediated Expression of Monoclonal Antibodies Provides 100% Protection Against Ebola Virus Infection in Mice
  The Journal of Infectious Diseases. 03, 2018  |   Pubmed ID: 29365142
• Critical Interactions Between Immunogenic Cancer Cell Death, Oncolytic Viruses, and the Immune System Define the Rational Design of Combination Immunotherapies
  Journal of Immunology (Baltimore, Md. : 1950). 01, 2018  |   Pubmed ID: 29311387
• Enhancing Immune Responses to Cancer Vaccines Using Multi-Site Injections
  Scientific Reports. 08, 2017  |   Pubmed ID: 28814733
• AAV Vector Distribution in the Mouse Respiratory Tract Following Four Different Methods of Administration
  BMC Biotechnology. 05, 2017  |   Pubmed ID: 28506256
• Prevalence of Small Ruminant Lentivirus and Subsp. Co-infection in Ontario Dairy Sheep and Dairy Goats
  Canadian Journal of Veterinary Research = Revue Canadienne De Recherche Veterinaire. Apr, 2017  |   Pubmed ID: 28408784
• Truncation of the Enzootic Nasal Tumor Virus Envelope Protein Cytoplasmic Tail Increases Env-mediated Fusion and Infectivity
  The Journal of General Virology. 01, 2017  |   Pubmed ID: 27902399
• Construction of a Molecular Clone of Ovine Enzootic Nasal Tumor Virus
  Virology Journal. 12, 2016  |   Pubmed ID: 28038674
• Akt Isoform Specific Effects in Ovarian Cancer Progression
  Oncotarget. Nov, 2016  |   Pubmed ID: 27533079
• Seroconversion of Sheep Experimentally Infected with Enzootic Nasal Tumor Virus
  BMC Research Notes. Jan, 2016  |   Pubmed ID: 26744306
• Effects of Interferon-γ Knockdown on Vaccine-induced Immunity Against Marek's Disease in Chickens
  Canadian Journal of Veterinary Research = Revue Canadienne De Recherche Veterinaire. Jan, 2015  |   Pubmed ID: 25673902
• The Sheep Tetherin Paralog OBST2B Blocks Envelope Glycoprotein Incorporation into Nascent Retroviral Virions
  Journal of Virology. Jan, 2015  |   Pubmed ID: 25339764
• Immunogenetics of Small Ruminant Lentiviral Infections
  Viruses. Aug, 2014  |   Pubmed ID: 25153344
• Development of an Ante-mortem Diagnostic Test for Enzootic Nasal Tumor Virus and Detection of Neutralizing Antibodies in Host Serum
  The Journal of General Virology. Aug, 2014  |   Pubmed ID: 24836673
• Opposing Functions of Akt Isoforms in Lung Tumor Initiation and Progression
  PloS One. 2014  |   Pubmed ID: 24722238
• Jaagsiekte Sheep Retrovirus Detected in Human Lung Cancer Tissue Arrays
  BMC Research Notes. Mar, 2014  |   Pubmed ID: 24642139
• Experimental Transmission of Enzootic Nasal Adenocarcinoma in Sheep
  Veterinary Research. Jul, 2013  |   Pubmed ID: 23899161
• Genetic Characterization of Small Ruminant Lentiviruses Circulating in Naturally Infected Sheep and Goats in Ontario, Canada
  Virus Research. Jul, 2013  |   Pubmed ID: 23583225
• Small Interfering RNA-mediated Knockdown of Chicken Interferon-γ Expression
  Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Jun, 2013  |   Pubmed ID: 23458611
• Adeno-associated Virus Vector Mediated Expression of an Oncogenic Retroviral Envelope Protein Induces Lung Adenocarcinomas in Immunocompetent Mice
  PloS One. 2012  |   Pubmed ID: 23251519
• Jaagsiekte Sheep Retrovirus and Enzootic Nasal Tumor Virus Promoters Drive Gene Expression in All Airway Epithelial Cells of Mice but Only Induce Tumors in the Alveolar Region of the Lungs
  Journal of Virology. Aug, 2011  |   Pubmed ID: 21593165
• Full-length Genome Sequence Analysis of Enzootic Nasal Tumor Virus Reveals an Unusually High Degree of Genetic Stability
  Virus Research. Jul, 2010  |   Pubmed ID: 20398709
• Colocalization and Interaction of the Porcine Arterivirus Nucleocapsid Protein with the Small Nucleolar RNA-associated Protein Fibrillarin
  Journal of Virology. Nov, 2003  |   Pubmed ID: 14581554
• Homo-oligomerization of the Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Protein and the Role of Disulfide Linkages
  Journal of Virology. Apr, 2003  |   Pubmed ID: 12663761
• Phosphorylation of the Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Protein
  Journal of Virology. Oct, 2002  |   Pubmed ID: 12239338
• Antigenic Structure of the Nucleocapsid Protein of Porcine Reproductive and Respiratory Syndrome Virus
  Clinical and Diagnostic Laboratory Immunology. Nov, 1998  |   Pubmed ID: 9801333