Schahram Akbarian Department of Neuroscience and Friedman Brain Institute Icahn School of Medicine at Mount Sinai Biography Publications Institution JoVE Articles Schahram Akbarian has not added a biography. If you are Schahram Akbarian and would like to personalize this page please email our Author Liaison for assistance. Publications Comprehensive Identification of Somatic Nucleotide Variants in Human Brain Tissue Genome Biology. Mar, 2021 | Pubmed ID: 33781308 Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection Stem Cell Reports. 03, 2021 | Pubmed ID: 33636110 Parsing the Functional Impact of Noncoding Genetic Variants in the Brain Epigenome Biological Psychiatry. Jan, 2021 | Pubmed ID: 33131715 Common Genetic Variation in Humans Impacts Susceptibility to SARS-CoV-2 Infection BioRxiv : the Preprint Server for Biology. Sep, 2020 | Pubmed ID: 32995783 A Prefrontal-paraventricular Thalamus Circuit Requires Juvenile Social Experience to Regulate Adult Sociability in Mice Nature Neuroscience. 10, 2020 | Pubmed ID: 32868932 Genotype-phenotype Correlation at Codon 1740 of SETD2 American Journal of Medical Genetics. Part A. 09, 2020 | Pubmed ID: 32710489 Epigenetic Clocks in Schizophrenia: Promising Biomarkers, Foggy Clockwork Biological Psychiatry. 08, 2020 | Pubmed ID: 32674842 Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells Advances in Neurobiology. 2020 | Pubmed ID: 32578147 A Computational Tool (H-MAGMA) for Improved Prediction of Brain-disorder Risk Genes by Incorporating Brain Chromatin Interaction Profiles Nature Neuroscience. 04, 2020 | Pubmed ID: 32152537 Prefrontal Parvalbumin Interneurons Require Juvenile Social Experience to Establish Adult Social Behavior Nature Communications. 02, 2020 | Pubmed ID: 32081848 A Chromosomal Connectome for Psychiatric and Metabolic Risk Variants in Adult Dopaminergic Neurons Genome Medicine. 02, 2020 | Pubmed ID: 32075678 Special Volume: The Genomics and Epigenomics of Schizophrenia Schizophrenia Research. 03, 2020 | Pubmed ID: 31813801 CRISPR-based Functional Evaluation of Schizophrenia Risk Variants Schizophrenia Research. 03, 2020 | Pubmed ID: 31277978 Use of the Epigenetic Toolbox to Contextualize Common Variants Associated with Schizophrenia Risk Dialogues in Clinical Neuroscience. 12, 2019 | Pubmed ID: 31949408 Chromatin Profiling of Cortical Neurons Identifies Individual Epigenetic Signatures in Schizophrenia Translational Psychiatry. 10, 2019 | Pubmed ID: 31624234 CommonMind Consortium Provides Transcriptomic and Epigenomic Data for Schizophrenia and Bipolar Disorder Scientific Data. 09, 2019 | Pubmed ID: 31551426 In Vivo Epigenetic Editing of Sema6a Promoter Reverses Transcallosal Dysconnectivity Caused by C11orf46/Arl14ep Risk Gene Nature Communications. 09, 2019 | Pubmed ID: 31511512 Metabolome Signature of Autism in the Human Prefrontal Cortex Communications Biology. 2019 | Pubmed ID: 31263778 Spatial Genome Exploration in the Context of Cognitive and Neurological Disease Current Opinion in Neurobiology. 12, 2019 | Pubmed ID: 31255842 Epigenetic-genetic Chromatin Footprinting Identifies Novel and Subject-specific Genes Active in Prefrontal Cortex Neurons FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 07, 2019 | Pubmed ID: 30970224 Comprehensive Functional Genomic Resource and Integrative Model for the Human Brain Science (New York, N.Y.). 12, 2018 | Pubmed ID: 30545857 Neuron-specific Signatures in the Chromosomal Connectome Associated with Schizophrenia Risk Science (New York, N.Y.). 12, 2018 | Pubmed ID: 30545851 Lipidome Alterations in Human Prefrontal Cortex During Development, Aging, and Cognitive Disorders Molecular Psychiatry. Aug, 2018 | Pubmed ID: 30089790 Evaluation of Chromatin Accessibility in Prefrontal Cortex of Individuals with Schizophrenia Nature Communications. 08, 2018 | Pubmed ID: 30087329 Cell-specific Histone Modification Maps in the Human Frontal Lobe Link Schizophrenia Risk to the Neuronal Epigenome Nature Neuroscience. 08, 2018 | Pubmed ID: 30038276 Chromosomal Conformations and Epigenomic Regulation in Schizophrenia Progress in Molecular Biology and Translational Science. 2018 | Pubmed ID: 29933951 Activity-Induced Regulation of Synaptic Strength Through the Chromatin Reader L3mbtl1 Cell Reports. 06, 2018 | Pubmed ID: 29898393 Landscape of Conditional EQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS American Journal of Human Genetics. 06, 2018 | Pubmed ID: 29805045 Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells Frontiers in Pediatrics. 2018 | Pubmed ID: 29666786 Allele-specific Expression in a Family Quartet with Autism Reveals Mono-to-biallelic Switch and Novel Transcriptional Processes of Autism Susceptibility Genes Scientific Reports. 03, 2018 | Pubmed ID: 29523860 MEF2C Transcription Factor is Associated with the Genetic and Epigenetic Risk Architecture of Schizophrenia and Improves Cognition in Mice Molecular Psychiatry. 01, 2018 | Pubmed ID: 28115742 Antipsychotic-induced Hdac2 Transcription Via NF-κB Leads to Synaptic and Cognitive Side Effects Nature Neuroscience. Sep, 2017 | Pubmed ID: 28783139 Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in HiPSC-Derived NPCs, Neurons, and Astrocytes Stem Cell Reports. 08, 2017 | Pubmed ID: 28757163 The Epigenomics of Schizophrenia, in the Mouse American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. Sep, 2017 | Pubmed ID: 28699694 The Methyltransferase SETDB1 Regulates a Large Neuron-specific Topological Chromatin Domain Nature Genetics. Aug, 2017 | Pubmed ID: 28671686 Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2 Biological Psychiatry. Dec, 2017 | Pubmed ID: 28577753 Phf8 Loss Confers Resistance to Depression-like and Anxiety-like Behaviors in Mice Nature Communications. 05, 2017 | Pubmed ID: 28485378 Intersection of Diverse Neuronal Genomes and Neuropsychiatric Disease: The Brain Somatic Mosaicism Network Science (New York, N.Y.). 04, 2017 | Pubmed ID: 28450582 Practical Guidelines for High-Resolution Epigenomic Profiling of Nucleosomal Histones in Postmortem Human Brain Tissue Biological Psychiatry. 01, 2017 | Pubmed ID: 27113501 Spatial Genome Organization and Cognition Nature Reviews. Neuroscience. 11, 2016 | Pubmed ID: 27708356 Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism PLoS Biology. Sep, 2016 | Pubmed ID: 27685936 Longitudinal Assessment of Neuronal 3D Genomes in Mouse Prefrontal Cortex Nature Communications. 09, 2016 | Pubmed ID: 27597321 Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 12, 2016 | Pubmed ID: 27485686 Insulin-like Growth Factor 1 for Healthy Spines and Healthy Minds? Biological Psychiatry. 08, 2016 | Pubmed ID: 27468627 Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research Biological Psychiatry. 07, 2016 | Pubmed ID: 27346079 DNA Methylation Signatures of Early Childhood Malnutrition Associated With Impairments in Attention and Cognition Biological Psychiatry. 11, 2016 | Pubmed ID: 27184921 Understanding the Genetic Liability to Schizophrenia Through the Neuroepigenome Schizophrenia Research. 11, 2016 | Pubmed ID: 26827128 NeuN+ Neuronal Nuclei in Non-human Primate Prefrontal Cortex and Subcortical White Matter After Clozapine Exposure Schizophrenia Research. Feb, 2016 | Pubmed ID: 26776227 Back to the Past in Schizophrenia Genomics Nature Neuroscience. Jan, 2016 | Pubmed ID: 26713739 Pharmacological Modulation of Astrocytes and the Role of Cell Type-specific Histone Modifications for the Treatment of Mood Disorders Current Opinion in Pharmacology. Feb, 2016 | Pubmed ID: 26515273 Epigenetic Basis of Mental Illness The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 10, 2016 | Pubmed ID: 26450593 Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Mar, 2016 | Pubmed ID: 26224620 RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression PloS One. 2015 | Pubmed ID: 26636579 Prefrontal Cortex and Social Cognition in Mouse and Man Frontiers in Psychology. 2015 | Pubmed ID: 26635701 The PsychENCODE Project Nature Neuroscience. Dec, 2015 | Pubmed ID: 26605881 CHRNA7 and CHRFAM7A: Psychosis and Smoking? Blame the Neighbors! The American Journal of Psychiatry. Nov, 2015 | Pubmed ID: 26575444 DNA Methylation Levels of α-synuclein Intron 1 in the Aging Brain Neurobiology of Aging. Dec, 2015 | Pubmed ID: 26422361 Critical Role of Histone Turnover in Neuronal Transcription and Plasticity Neuron. Jul, 2015 | Pubmed ID: 26139371 Quantifying Polymorphism and Divergence from Epigenetic Data: a Framework for Inferring the Action of Selection Frontiers in Genetics. 2015 | Pubmed ID: 26074949 MiR-10b-5p Expression in Huntington's Disease Brain Relates to Age of Onset and the Extent of Striatal Involvement BMC Medical Genomics. Mar, 2015 | Pubmed ID: 25889241 Cognition and Mood-related Behaviors in L3mbtl1 Null Mutant Mice PloS One. 2015 | Pubmed ID: 25849281 Interneuron Epigenomes During the Critical Period of Cortical Plasticity: Implications for Schizophrenia Neurobiology of Learning and Memory. Oct, 2015 | Pubmed ID: 25849095 Neuronal Kmt2a/Mll1 Histone Methyltransferase is Essential for Prefrontal Synaptic Plasticity and Working Memory The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2015 | Pubmed ID: 25834037 Transcriptional Regulation of GAD1 GABA Synthesis Gene in the Prefrontal Cortex of Subjects with Schizophrenia Schizophrenia Research. Sep, 2015 | Pubmed ID: 25458568 Epigenetics and Sex Differences in the Brain: A Genome-wide Comparison of Histone-3 Lysine-4 Trimethylation (H3K4me3) in Male and Female Mice Experimental Neurology. Jun, 2015 | Pubmed ID: 25131640 Conserved Higher-order Chromatin Regulates NMDA Receptor Gene Expression and Cognition Neuron. Dec, 2014 | Pubmed ID: 25467983 A Role for Noncoding Variation in Schizophrenia Cell Reports. Nov, 2014 | Pubmed ID: 25453756 The Future of Neuroepigenetics in the Human Brain Progress in Molecular Biology and Translational Science. 2014 | Pubmed ID: 25410546 Epigenetic Mechanisms in Schizophrenia Dialogues in Clinical Neuroscience. Sep, 2014 | Pubmed ID: 25364289 Analytical Tools and Current Challenges in the Modern Era of Neuroepigenomics Nature Neuroscience. Nov, 2014 | Pubmed ID: 25349914 Regulation of Histone H3K4 Methylation in Brain Development and Disease Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Sep, 2014 | Pubmed ID: 25135975 Chromatin-bound RNA and the Neurobiology of Psychiatric Disease Neuroscience. Apr, 2014 | Pubmed ID: 23831425 The Genome in Three Dimensions: A New Frontier in Human Brain Research Biological Psychiatry. Aug, 2013 | Pubmed ID: 23958183 Conserved Chromosome 2q31 Conformations Are Associated with Transcriptional Regulation of GAD1 GABA Synthesis Enzyme and Altered in Prefrontal Cortex of Subjects with Schizophrenia The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2013 | Pubmed ID: 23864674 The Neuroepigenetics of Suicide The American Journal of Psychiatry. May, 2013 | Pubmed ID: 23632831 精神分裂症及相关的疾病的基因表达的表观遗传学与转录时异常。 Neurobiology of Disease. Dec, 2011 | Pubmed ID: 22182689 自闭症的表观遗传特征码： Trimethylated H3K4 前额叶神经元的风景。 Archives of General Psychiatry. Nov, 2011 | Pubmed ID: 22065254 推进精神分裂症药物的发现。 Annals of the New York Academy of Sciences. Oct, 2011 | Pubmed ID: 22032400 平衡在精神病治疗中的组蛋白甲基化活动。 Trends in Molecular Medicine. Jul, 2011 | Pubmed ID: 21429800 Setdb1 介导的组蛋白 H3K9 甲基化神经元恶化 Mecp2 基因缺陷小鼠神经表型。 Neuropharmacology. Jun, 2011 | Pubmed ID: 20869373 白色物质神经元变化精神分裂症及相关的疾病。 International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience. May, 2011 | Pubmed ID: 20691252 表观遗传学的精神分裂症。 Current Topics in Behavioral Neurosciences. 2010 | Pubmed ID: 21312415 C 终端 TDP 43 片段有高聚合的倾向和神经元损害的一种显性负机制。 PloS One. 2010 | Pubmed ID: 21209826 MAPK 上保持磷，很快乐。 Nature Medicine. Nov, 2010 | Pubmed ID: 21052065 性别的减少的雌激素敏感小 RNA，和平号空间站-30b，科目与精神分裂症患者。 Schizophrenia Bulletin. Aug, 2010 | Pubmed ID: 20732949 RPP25 发育前额叶皮层中作出了规定，在自闭症谱系障碍的水平下降表示。 Autism Research : Official Journal of the International Society for Autism Research. Aug, 2010 | Pubmed ID: 20632321 染色质蛋白 L3MBTL1 是可有可无的发展和对小鼠肿瘤的抑制。 The Journal of Biological Chemistry. Sep, 2010 | Pubmed ID: 20592034 Setdb1 组蛋白甲基转移酶调节情绪相关行为及 NMDA 受体亚型 NR2B 表达。 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2010 | Pubmed ID: 20505083 改进的 Anti-methyl 组蛋白抗体特异性的简单方法。 Epigenetics : Official Journal of the DNA Methylation Society. Jul, 2010 | Pubmed ID: 20458167 发育调控和前额叶皮层神经元 H3K4me3 图谱的个体差异。 Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20421462 RAAV9 — — 高效转基因表达鼠标扣带皮层的人源性腺相关病毒载体。 Cold Spring Harbor Protocols. Apr, 2010 | Pubmed ID: 20360371 分子病理学精神分裂症 — — 重点放在组蛋白和 DNA 进行修改。 Brain Research Bulletin. Sep, 2010 | Pubmed ID: 19729053 可卡因诱导的代谢活化的科尔蒂索边电路增加后暴露于组蛋白去乙酰酶抑制剂，丁酸钠。 Neuroscience Letters. Nov, 2009 | Pubmed ID: 19638299 扣带白色物质神经元的精神分裂症和躁郁症。 Biological Psychiatry. Sep, 2009 | Pubmed ID: 19559403 安基前额叶皮层的精神分裂症患者的基因表达水平及分子决定因素。 Biological Psychiatry. Jun, 2009 | Pubmed ID: 19121517 在人类的大脑-重点组蛋白赖氨酸甲基化的表观遗传调控。 Biological Psychiatry. Feb, 2009 | Pubmed ID: 18814864 恢复安基信号与精神分裂症患者的神经细胞同步性。 The American Journal of Psychiatry. Dec, 2008 | Pubmed ID: 19047328 表观遗传学在中枢神经系统中。 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2008 | Pubmed ID: 19005036 接近的分子病理学的自杀。 Biological Psychiatry. Oct, 2008 | Pubmed ID: 18926170 差异表达 Mirna，包括和平号空间站-30a-5 P 前, 额叶皮层 BDNF 转录抑制剂作为一组。 Human Molecular Genetics. Oct, 2008 | Pubmed ID: 18632683 从脑组织神经元染色质的分离。 BMC Neuroscience. 2008 | Pubmed ID: 18442397 精神分裂症和躁郁症的 DNA 甲基化变化。 Epigenetics : Official Journal of the DNA Methylation Society. Mar-Apr, 2008 | Pubmed ID: 18398310 药物诱导多巴胺 D(1) 受体信号的激活和抑制作用的一类 / 二组蛋白去乙酰酶诱使染色质重塑的奖赏系统和调制可卡因相关行为。 Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Nov, 2008 | Pubmed ID: 18288092 精神分裂症患者前额叶功能障碍涉及混合细胞性白血病 1 调节组蛋白甲基化在安基基因启动子。 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2007 | Pubmed ID: 17942719 在人类的大脑皮质中的 DNA 甲基化动态调节整个寿命和涉及分化的神经元。 PloS One. 2007 | Pubmed ID: 17878930 GAD1 基因表达和 DNA 甲基化在前额叶皮层的精神分裂症患者。 PloS One. 2007 | Pubmed ID: 17726539 抗抑郁药样的组蛋白去乙酰酶抑制剂，丁酸钠，鼠标中的影响。 Biological Psychiatry. Jul, 2007 | Pubmed ID: 16945350 Rett 综合征的分子病理学： 简介和更新。 Neuromolecular Medicine. 2006 | Pubmed ID: 17028371 改变 GAD1/GAD67 表达的精神分裂症及相关的疾病的分子和细胞机制。 Brain Research Reviews. Sep, 2006 | Pubmed ID: 16759710 NT 3 方便通过调节大脑海马可塑性及学习和记忆。 Learning & Memory (Cold Spring Harbor, N.Y.). May-Jun, 2006 | Pubmed ID: 16705139 染色质沉淀在死后的脑中。 Journal of Neuroscience Methods. Sep, 2006 | Pubmed ID: 16574239 严重赤字的 5 HT2A-介导的 BDNF 条件突变小鼠的感受器。 Journal of Neurobiology. Mar, 2006 | Pubmed ID: 16408297 染色质变化与精神分裂症患者前额叶皮层下调代谢基因表达相关联。 Archives of General Psychiatry. Aug, 2005 | Pubmed ID: 16061760 组蛋白甲基化在基因启动子是与发育调控和离子型和代谢型谷氨酸受体在人脑中的特定区域的表达式相关联的。 Journal of Neurochemistry. Jul, 2005 | Pubmed ID: 15998284 多巴胺 D2 像拮抗剂诱使染色质重塑的纹状体神经元通过环磷酸腺苷-蛋白激酶 A 和 NMDA 受体信号。 Journal of Neurochemistry. Sep, 2004 | Pubmed ID: 15312167 Rett 综合征神经生物学。 The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. Feb, 2003 | Pubmed ID: 12580340 对 Rett 紊乱的临床专家。 Pediatric Rehabilitation. Apr-Jun, 2002 | Pubmed ID: 12596822 Rett 综合征小鼠模型的转录分析揭示了大脑中转录的微妙变化。 Proceedings of the National Academy of Sciences of the United States of America. Nov, 2002 | Pubmed ID: 12432090 思维和大脑疾病： Rett 的综合征，第二部分。 The American Journal of Psychiatry. Aug, 2002 | Pubmed ID: 12153818 为减少 DARPP 32 精神分裂症患者前额叶皮层的证据。 Archives of General Psychiatry. Aug, 2002 | Pubmed ID: 12150646 思维和大脑疾病： Rett 的综合征。 The American Journal of Psychiatry. Jul, 2002 | Pubmed ID: 12091185 脑源性神经营养因子对鸦片剂诱导神经元可塑性的去甲肾上腺素能至关重要。 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2002 | Pubmed ID: 12019333 神经营养素 3 促进脑缺血、 氧-葡萄糖剥夺和氧化应激诱导细胞死亡： 可能参与的氧自由基。 Neurobiology of Disease. Feb, 2002 | Pubmed ID: 11848682 使用荧光激活的细胞核分选从新鲜冷冻的皮质中分离出成年人类星形胶质细胞群 Zarmeen Mussa1,2, Jessica Tome-Garcia1,2, Yan Jiang3, Schahram Akbarian2,4, Nadejda M. Tsankova1,2 1Department of Pathology, Icahn School of Medicine at Mount Sinai, 2Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 3Institutes of Brian Science, Fudan University, 4Department of Psychiatry, Icahn School of Medicine at Mount Sinai JoVE 62405 Neuroscience 从人死后脑组织神经元细胞核分离 Anouch Matevossian1, Schahram Akbarian1 1Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School JoVE 914 Biology 一个人脑组织中的染色质含量 Anouch Matevossian1, Schahram Akbarian1 1Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School JoVE 717 Biology
使用荧光激活的细胞核分选从新鲜冷冻的皮质中分离出成年人类星形胶质细胞群 Zarmeen Mussa1,2, Jessica Tome-Garcia1,2, Yan Jiang3, Schahram Akbarian2,4, Nadejda M. Tsankova1,2 1Department of Pathology, Icahn School of Medicine at Mount Sinai, 2Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 3Institutes of Brian Science, Fudan University, 4Department of Psychiatry, Icahn School of Medicine at Mount Sinai JoVE 62405 Neuroscience
从人死后脑组织神经元细胞核分离 Anouch Matevossian1, Schahram Akbarian1 1Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School JoVE 914 Biology
一个人脑组织中的染色质含量 Anouch Matevossian1, Schahram Akbarian1 1Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School JoVE 717 Biology
