Scott I. Simon Department of Biomedical Engineering University of California Davis Biography Publications Institution JoVE Articles Scott I. Simon has not added a biography. If you are Scott I. Simon and would like to personalize this page please email our Author Liaison for assistance. Publications Selectin-Targeting Peptide-Glycosaminoglycan Conjugates Modulate Neutrophil-Endothelial Interactions Cellular and Molecular Bioengineering. 2019 | Pubmed ID: 30740185 Is CCR6 Required for the Development of Psoriasiform Dermatitis in Mice? The Journal of Investigative Dermatology. Feb, 2019 | Pubmed ID: 30193756 Neutrophils in Hot Pursuit of MRSA in the Lymph Nodes Proceedings of the National Academy of Sciences of the United States of America. 03, 2018 | Pubmed ID: 29476009 Selectin Catch-bonds Mechanotransduce Integrin Activation and Neutrophil Arrest on Inflamed Endothelium Under Shear Flow Blood. 11, 2017 | Pubmed ID: 28811304 α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Infected Wounds Journal of Immunology (Baltimore, Md. : 1950). 09, 2017 | Pubmed ID: 28733486 Multifactorial Experimental Design to Optimize the Anti-Inflammatory and Proangiogenic Potential of Mesenchymal Stem Cell Spheroids Stem Cells (Dayton, Ohio). 06, 2017 | Pubmed ID: 28276602 Streptolysin O Rapidly Impairs Neutrophil Oxidative Burst and Antibacterial Responses to Group A Streptococcus Frontiers in Immunology. 2015 | Pubmed ID: 26635795 Infection-induced Type I Interferons Activate CD11b on B-1 Cells for Subsequent Lymph Node Accumulation Nature Communications. Nov, 2015 | Pubmed ID: 26612263 CD11c/CD18 Signals Very Late Antigen-4 Activation To Initiate Foamy Monocyte Recruitment During the Onset of Hypercholesterolemia Journal of Immunology (Baltimore, Md. : 1950). Dec, 2015 | Pubmed ID: 26519532 Glycopeptide Analogues of PSGL-1 Inhibit P-selectin in Vitro and in Vivo Nature Communications. Mar, 2015 | Pubmed ID: 25824568 Coronary Artery Endothelial Cells and Microparticles Increase Expression of VCAM-1 in Myocardial Infarction Thrombosis and Haemostasis. Mar, 2015 | Pubmed ID: 25413339 Triglyceride-rich Lipoprotein Modulates Endothelial Vascular Cell Adhesion Molecule (VCAM)-1 Expression Via Differential Regulation of Endoplasmic Reticulum Stress PloS One. 2013 | Pubmed ID: 24205197 Clocking Leukocytes Reveal Dynamics of Integrin Braking Biophysical Journal. Sep, 2013 | Pubmed ID: 24010651 On-chip Phenotypic Analysis of Inflammatory Monocytes in Atherogenesis and Myocardial Infarction Proceedings of the National Academy of Sciences of the United States of America. Aug, 2013 | Pubmed ID: 23918401 Neutrophil-derived IL-1β is Sufficient for Abscess Formation in Immunity Against Staphylococcus Aureus in Mice PLoS Pathogens. 2012 | Pubmed ID: 23209417 IRF-1 and MiRNA126 Modulate VCAM-1 Expression in Response to a High-fat Meal Circulation Research. Sep, 2012 | Pubmed ID: 22874466 Chemokines, Selectins and Intracellular Calcium Flux: Temporal and Spatial Cues for Leukocyte Arrest Frontiers in Immunology. 2012 | Pubmed ID: 22787461 Bone Marrow Research. 2012 | Pubmed ID: 22762001 Journal of Neurophysiology. Jun, 2012 | Pubmed ID: 22402651 Biochemical and Biophysical Research Communications. Jul, 2011 | Pubmed ID: 21683067 Migrational Guidance of Neutrophils is Mechanotransduced Via High-affinity LFA-1 and Calcium Flux Journal of Immunology (Baltimore, Md. : 1950). Jul, 2011 | Pubmed ID: 21632714 Functional Characterization of Embryonic Stem Cell-derived Endothelial Cells Journal of Vascular Research. 2011 | Pubmed ID: 21625175 Neutrophil Survival and C-kit(+)-progenitor Proliferation in Staphylococcus Aureus-infected Skin Wounds Promote Resolution Blood. Mar, 2011 | Pubmed ID: 21278352 The Journal of Investigative Dermatology. Apr, 2011 | Pubmed ID: 21191403 American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2011 | Pubmed ID: 21169396 Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2011 | Pubmed ID: 21030716 A Mouse Model of Post-arthroplasty Staphylococcus Aureus Joint Infection to Evaluate in Vivo the Efficacy of Antimicrobial Implant Coatings PloS One. 2010 | Pubmed ID: 20830204 Mightier Than the Sickle Cell Blood. Sep, 2010 | Pubmed ID: 20829378 A Day (or 5) in a Neutrophil's Life Blood. Jul, 2010 | Pubmed ID: 20671133 Orai1 Regulates Intracellular Calcium, Arrest, and Shape Polarization During Neutrophil Recruitment in Shear Flow Blood. Jan, 2010 | Pubmed ID: 19965684 Cancer Research. Dec, 2009 | Pubmed ID: 19934331 Vav1 is Essential for Mechanotactic Crawling and Migration of Neutrophils out of the Inflamed Microvasculature Journal of Immunology (Baltimore, Md. : 1950). Jun, 2009 | Pubmed ID: 19454683 Functional Role of CD11c+ Monocytes in Atherogenesis Associated with Hypercholesterolemia Circulation. May, 2009 | Pubmed ID: 19433759 Dynamics of Neutrophil Extravasation and Vascular Permeability Are Uncoupled During Aseptic Cutaneous Wounding American Journal of Physiology. Cell Physiology. Apr, 2009 | Pubmed ID: 19176758 Leucocyte Recruitment Under Fluid Shear: Mechanical and Molecular Regulation Within the Inflammatory Synapse Clinical and Experimental Pharmacology & Physiology. Feb, 2009 | Pubmed ID: 19018799 Transmigration of Neutrophils Across Inflamed Endothelium is Signaled Through LFA-1 and Src Family Kinase Journal of Immunology (Baltimore, Md. : 1950). Dec, 2008 | Pubmed ID: 19050286 Blood. Nov, 2008 | Pubmed ID: 18948585 Microcirculation (New York, N.Y. : 1994). May, 2008 | Pubmed ID: 18464160 Annals of Biomedical Engineering. Apr, 2008 | Pubmed ID: 18317931 Annals of Biomedical Engineering. Apr, 2008 | Pubmed ID: 18278555 Annals of Biomedical Engineering. Apr, 2008 | Pubmed ID: 18253835 SLIC-1/sorting Nexin 20: a Novel Sorting Nexin That Directs Subcellular Distribution of PSGL-1 European Journal of Immunology. Feb, 2008 | Pubmed ID: 18196517 Dynamics of Neutrophil Infiltration During Cutaneous Wound Healing and Infection Using Fluorescence Imaging The Journal of Investigative Dermatology. Jul, 2008 | Pubmed ID: 18185533 Journal of Leukocyte Biology. Jan, 2008 | Pubmed ID: 17928459 Journal of Cellular Physiology. Feb, 2008 | Pubmed ID: 17676580 Methods in Molecular Biology (Clifton, N.J.). 2007 | Pubmed ID: 18453113 Vascular Mimetics Based on Microfluidics for Imaging the Leukocyte--endothelial Inflammatory Response Lab on a Chip. Apr, 2007 | Pubmed ID: 17389960 Journal of Leukocyte Biology. Jun, 2007 | Pubmed ID: 17389580 Mechanisms of B-cell Synapse Formation Predicted by Monte Carlo Simulation Biophysical Journal. Jun, 2007 | Pubmed ID: 17384077 Dynamics of Neutrophil Membrane Compliance and Microstructure Probed with a Micropipet-based Piconewton Force Transducer Annals of Biomedical Engineering. Apr, 2007 | Pubmed ID: 17370125 Circulation Research. Feb, 2007 | Pubmed ID: 17234968 Molecular Imaging. Jul, 2006 | Pubmed ID: 16954028 Immunity. Aug, 2006 | Pubmed ID: 16901726 CRP Promotes Monocyte-endothelial Cell Adhesion Via Fcgamma Receptors in Human Aortic Endothelial Cells Under Static and Shear Flow Conditions American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2006 | Pubmed ID: 16603696 Ultrasound Radiation Force Enables Targeted Deposition of Model Drug Carriers Loaded on Microbubbles Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2006 | Pubmed ID: 16380187 Blood. Mar, 2006 | Pubmed ID: 16269618 Molecular Mechanics and Dynamics of Leukocyte Recruitment During Inflammation Annual Review of Biomedical Engineering. 2005 | Pubmed ID: 16004569 The Journal of Biological Chemistry. Aug, 2005 | Pubmed ID: 15955822 Mathematical Biosciences. Mar, 2005 | Pubmed ID: 15836865 American Journal of Physiology. Cell Physiology. Aug, 2005 | Pubmed ID: 15788481 Annals of Biomedical Engineering. Sep, 2004 | Pubmed ID: 15493506 Shear-dependent Capping of L-selectin and P-selectin Glycoprotein Ligand 1 by E-selectin Signals Activation of High-avidity Beta2-integrin on Neutrophils Journal of Immunology (Baltimore, Md. : 1950). Jun, 2004 | Pubmed ID: 15187162 Inflammatory Potential of Neutrophils Detected in Sickle Cell Disease American Journal of Hematology. Jun, 2004 | Pubmed ID: 15164377 Blood. Apr, 2003 | Pubmed ID: 12480703 American Journal of Physiology. Cell Physiology. Mar, 2003 | Pubmed ID: 12431911 Hydrodynamic Shear and Tethering Through E-selectin Signals Phosphorylation of P38 MAP Kinase and Adhesion of Human Neutrophils Annals of Biomedical Engineering. Sep, 2002 | Pubmed ID: 12449760 Leukocyte Adhesion Dynamics in Shear Flow Annals of Biomedical Engineering. Mar, 2002 | Pubmed ID: 12051617 The Journal of Biological Chemistry. Jun, 2002 | Pubmed ID: 11929876 Laboratory Investigation; a Journal of Technical Methods and Pathology. Mar, 2002 | Pubmed ID: 11896209 Neutrophil Tethering on E-selectin Activates Beta 2 Integrin Binding to ICAM-1 Through a Mitogen-activated Protein Kinase Signal Transduction Pathway Journal of Immunology (Baltimore, Md. : 1950). Apr, 2000 | Pubmed ID: 10754335 A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection Leif S. Anderson1, Mack B. Reynolds1, Kathryn R. Rivara1, Lloyd S. Miller2, Scott I. Simon1 1Department of Biomedical Engineering, University of California Davis, 2Department of Dermatology, Johns Hopkins University School of Medicine JoVE 59015 Immunology and Infection On-Chip Endothelial Inflammatory Phenotyping J. Sherrod DeVerse*1, Keith A. Bailey*1, Greg A. Foster1, Vaishali Mittal1, Stuart M. Altman1, Scott I. Simon1, Anthony G. Passerini1 1Department of Biomedical Engineering, University of California, Davis JoVE 4169 Bioengineering
A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection Leif S. Anderson1, Mack B. Reynolds1, Kathryn R. Rivara1, Lloyd S. Miller2, Scott I. Simon1 1Department of Biomedical Engineering, University of California Davis, 2Department of Dermatology, Johns Hopkins University School of Medicine JoVE 59015 Immunology and Infection
On-Chip Endothelial Inflammatory Phenotyping J. Sherrod DeVerse*1, Keith A. Bailey*1, Greg A. Foster1, Vaishali Mittal1, Stuart M. Altman1, Scott I. Simon1, Anthony G. Passerini1 1Department of Biomedical Engineering, University of California, Davis JoVE 4169 Bioengineering
